Balancing Access to Data And Privacy. A review of the issues and approaches for the future

Access to sensitive micro data should be provided using remote access data enclaves. These enclaves should be built to facilitate the productive, high-quality usage of microdata. In other words, they should support a collaborative environment that facilitates the development and exchange of knowledge about data among data producers and consumers. The experience of the physical and life sciences has shown that it is possible to develop a research community and a knowledge infrastructure around both research questions and the different types of data necessary to answer policy questions. In sum, establishing a virtual organization approach would provided the research community with the ability to move away from individual, or artisan, science, towards the more generally accepted community based approach. Enclave should include a number of features: metadata documentation capacity so that knowledge about data can be shared; capacity to add data so that the data infrastructure can be augmented; communication capacity, such as wikis, blogs and discussion groups so that knowledge about the data can be deepened and incentives for information sharing so that a community of practice can be built. The opportunity to transform micro-data based research through such a organizational infrastructure could potentially be as far-reaching as the changes that have taken place in the biological and astronomical sciences. It is, however, an open research question how such an organization should be established: whether the approach should be centralized or decentralized. Similarly, it is an open research question as to the appropriate metrics of success, and the best incentives to put in place to achieve success.Methodology for Collecting, Estimating, Organizing Microeconomic Data

How do I enhance motivation to learn and higher order cognition among students of Science through the use of a virtual learning environment?

In this paper I explore the capacity of Moodle to enhance the teaching and learning of Leaving Certificate Biology within a small urban secondary school. I simultaneously investigate the potential of the technology to enhance higher-order cognition and motivation to learn among the students. Adopting an action research approach has led me to a much deeper understanding of the tacit knowledge that inspires my work. The chief stimulus to my research was the realisation that my explicit practice was in negation of my implicit values. I have come to know my practice and over time changed it. I can now see evidence of a greater congruence between my espoused core educational values and my explicit actions. Cycle one of the research focuses on setting up and introducing Moodle to a group of Biology students. The second cycle shows the feasibility of a community of enquiry through a discussion-forum. A process of social validation runs concurrently, in which interested individuals substantiate my claim that my core educational values are being translated into my practice. Throughout I learn to strike a balance between co-learner and guide. Consequently the students come to act as co-authors in moving away from authoritarian dissemination of facts. This facilitates a community of inquiry, revolving around the collaborative negotiation of meaning. There is clear evidence of increased higher-order cognition and motivation to learn among the participants within this virtual community

Who do they think they're talking to? framings of the audience by social media users

This paper examines the understandings and meanings of personal information sharing online using a predominantly symbolic interactionist analytic perspective and focusing on writers’ conceptions of their relationships with their audiences. It draws on an analysis of in-depth interviews with 23 personal bloggers. They were found to have limited interest in gathering information about their audiences, appearing to assume that readers are sympathetic. A comprehensive and grounded typology of imagined relationships with audiences was devised. Although the blogs of those interviewed were all public, some appear to frame their blogging practice as primarily self-directed, with their potential audiences playing a marginal role. These factors provide one explanation for some forms of potentially risky self-exposure that have been observed among social media user

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, making them an attractive target for the development of targeted and immunotherapeutic cancer treatments. Some MAGE proteins are thought to play an active role in driving cancer, modulating the activity of E3 ubiquitin ligases on targets related to apoptosis. Here we determined the crystal structures of MAGE- A3 and MAGE-A4. Both proteins crystallized with a terminal peptide bound in a deep cleft between two tandem-arranged winged helix domains. MAGE-A3 (but not MAGE-A4), is pre- dominantly dimeric in solution. Comparison of MAGE-A3 and MAGE-A3 with a structure of an effector-bound MAGE-G1 suggests that a major conformational rearrangement is required for binding, and that this conformational plasticity may be targeted by allosteric binders

Balancing Access to Data and Privacy: a review of the issues and approaches for the future

"Access to sensitive micro data should be provided using remote access data enclaves. These enclaves should be built to facilitate the productive, high-quality usage of microdata. In other words, they should support a collaborative environment that facilitates the development and exchange of knowledge about data among data producers and consumers. The experience of the physical and life sciences has shown that it is possible to develop a research community and a knowledge infrastructure around both research questions and the different types of data necessary to answer policy questions. In sum, establishing a virtual organization approach would provided the research community with the ability to move away from individual, or artisan, science, towards the more generally accepted community based approach. Enclave should include a number of features: metadata documentation capacity so that knowledge about data can be shared; capacity to add data so that the data infrastructure can be augmented; communication capacity, such as wikis, blogs and discussion groups so that knowledge about the data can be deepened and incentives for information sharing so that a community of practice can be built. The opportunity to transform micro-data based research through such a organizational infrastructure could potentially be as far-reaching as the changes that have taken place in the biological and astronomical sciences. It is, however, an open research question how such an organization should be established: whether the approach should be centralized or decentralized. Similarly, it is an open research question as to the appropriate metrics of success, and the best incentives to put in place to achieve success." (author's abstract

Auctor in Fabula: Umberto Eco and the Intentio of Foucault\u27s Pendulum

Umberto Eco’s 1988 novel Foucault’s Pendulum weaves together a wide range of philosophical and literary threads. Many of these threads find their other ends in Eco’s nonfiction works, which focus primarily on the question of interpretation and the source of meaning. The novel, which follows three distinctly overinterpretive characters as they descend into ruin, has been read by some as a retraction or parody of Eco’s own position. However, if Foucault’s Pendulum is indeed polemical, it must be taken as an argument against the mindset which Eco has termed the “hermetic”. Through an examination of his larger theoretical body, including its themes and intellectual heritage, it will be seen that Eco preserves his philosophical consistency across his fictive and non-fictive work

What's [Yet] to Be Seen? Re-Using Qualitative Data

This paper considers current debates about re-using qualitative research data by reflecting on its implications for the nature of social science knowledge created in this process and the ways in which the disclosure of researchers\' practices are linked with the making of professional academic careers. It examines a research project using two different approaches – a \'virtual\' and a \'classic\' ethnography – to argue that issues concerned with re-use of data depend on the methods employed and the overall processes of investigation. The paper argues for an appreciation of the contexts involved in the generation of research material which takes into account both the development of the study and related fieldwork processes as well as the academic context in which knowledge is produced, particularly those involved in the construction of academic selves and professional careers, which are part of a wider situation bearing upon scientific enquiry.Secondary Data Analysis, Ethnography, Visual Methodology, Academic Careers

Using Blogs to Foster Inquiry, Collaboration, and Feedback in Pre-Service Teacher Education

This chapter presents a critical case study on the use of information technology in a pre-service teacher education program. The authors integrated Weblogs (blogs) into two constructivist-oriented teacher preparation courses with the goal of helping students learn to think like a teacher through enhanced inquiry, collaboration, and feedback. The authors found that, through the use of blogs, pre-service teaching candidates grew in their abilities to reflect on their own teaching and to provide constructive comments to peers. The authors’ experience also indicated that while instructor and peer feedback via blogs was valuable, it functioned best when paired with face-to-face meetings between the instructors and students. They discussed design principles for combining online and face-to-face environments and offer possibilities for the expanded use of blogs in pre-service teacher education