One frame and several new infinite families of Z-cyclic whist designs

AbstractIn 2001, Ge and Zhu published a frame construction which they utilized to construct a large class of Z-cyclic triplewhist designs. In this study the power and elegance of their methodology is illustrated in a rather dramatic fashion. Primarily due to the discovery of a single new frame it is possible to combine their techniques with the product theorems of Anderson, Finizio and Leonard along with a few new specific designs to obtain several new infinite classes of Z-cyclic whist designs. A sampling of the new results contained herein is as follows: (1) Z-cyclic Wh(33p+1), p a prime of the form 4t+1; (2) Z-cyclic Wh(32n+1s+1), for all n⩾1, s=5,13,17; (3) Z-cyclic Wh(32ns+1), for all n⩾1, s=35,55,91; (4) Z-cyclic Wh(32n+1s), for all n⩾1, and for all s for which there exist a Z-cyclic Wh(3s) and a homogeneous (s,4,1)-DM; and (5) Z-cyclic Wh(32ns) for all n⩾1, s=5,13. Many other results are also obtained. In particular, there exist Z-cyclic Wh(33v+1) where v is any number for which Ge and Zhu obtained Z-cyclic TWh(3v+1)

Further combinatorial constructions for optimal frequency-hopping sequences

AbstractFrequency-hopping multiple-access (FHMA) spread-spectrum communication systems employing multiple frequency shift keying as data modulation technique were investigated by Fuji-Hara, Miao and Mishima [R. Fuji-Hara, Y. Miao, M. Mishima, Optimal frequency hopping sequences: A combinatorial approach, IEEE Trans. Inform. Theory 50 (2004) 2408–2420] from a combinatorial approach, where a correspondence between frequency-hopping (FH) sequences and partition-type cyclic difference packings was established, and several combinatorial constructions were provided for FHMA systems with a single optimal FH sequence. In this paper, by means of this correspondence, we describe more combinatorial constructions for such optimal FH sequences. As a consequence, more new infinite series of optimal FH sequences are obtained

Some difference matrix constructions and an almost completion for the existence of triplewhist tournaments TWh(v)

AbstractA necessary condition for the existence of a triplewhist tournament TWh(v) is v≡0 or 1(mod4); this condition is known to be sufficient except for v=5,9,12,13 and possibly v=17,57,65,69,77,85,93,117,129,153. In this paper, we remove all the possible exceptions except v=17. This provides an almost complete solution for the more than 100 year old problem on the existence of triplewhist tournaments TWh(v). By applying frame constructions and product constructions, several new infinite classes of Z-cyclic triplewhist tournaments are also obtained. A couple of new cyclic difference matrices are also obtained

Design and semantics of form and movement : DeSForM 2007

A strong theme that has emerged in our previous two conferences in the importance of narrative to the process of generating, developing and communicating new modalities of interaction between people, things and environments. Our researches have identified aspects of importance in the design and have begun to establish orders of, priority of approach and representation for these aspects as components of interaction. We have begun to grapple with the growth in the complexity of the interaction design process for truly ‘animated’ functionality in products, especially where this manifests itself as apparent behavioural characteristics resident in or portrayed by products. The findings and experience of researchers is that this increase in complexity is likely to be exponential compared to the rigours relating to the resolution of static physical product configuration or even system operated product with screen based interfaces. The emerging sense is that narrative in the process is essential to bring meaning and to ‘touch’ our humanity or connect with human experience. ‘The science of the artificial in conversation with the poetics of human experience’! Through this conference we will once again engage in presentations, debate and demonstrations on these issues. In this respect we, the conference co-chairs, have sought to bring together researchers from academia, industry and professional design practice and related disciplines connected with interactive product service and system development to share our latest thinking in the field, to asses its outcomes and to identify further research questions, opportunities and territories for future investigation and exploration

Design and semantics of form and movement : DeSForM 2007

A strong theme that has emerged in our previous two conferences in the importance of narrative to the process of generating, developing and communicating new modalities of interaction between people, things and environments. Our researches have identified aspects of importance in the design and have begun to establish orders of, priority of approach and representation for these aspects as components of interaction. We have begun to grapple with the growth in the complexity of the interaction design process for truly ‘animated’ functionality in products, especially where this manifests itself as apparent behavioural characteristics resident in or portrayed by products. The findings and experience of researchers is that this increase in complexity is likely to be exponential compared to the rigours relating to the resolution of static physical product configuration or even system operated product with screen based interfaces. The emerging sense is that narrative in the process is essential to bring meaning and to ‘touch’ our humanity or connect with human experience. ‘The science of the artificial in conversation with the poetics of human experience’! Through this conference we will once again engage in presentations, debate and demonstrations on these issues. In this respect we, the conference co-chairs, have sought to bring together researchers from academia, industry and professional design practice and related disciplines connected with interactive product service and system development to share our latest thinking in the field, to asses its outcomes and to identify further research questions, opportunities and territories for future investigation and exploration

The generative, analytic and instructional capacities of sound in architecture : fundamentals, tools and evaluation of a design methodology

Premi extraordinari doctorat UPC curs 2017-2018, Àmbit d’Arquitectura, Urbanisme i EdificacióThe disciplines of space and time form two domains to which it is daring to compare, since it is obvious that they are of a different nature. Music happens in time, while architecture happens in space. However, from the first treatises on both architecture and music, repeated calls for comparison, complementarity and influence of both disciplines can be read, at least to the observation of certain common orders between the two domains. In this doctoral thesis we do not question this whole theoretical corpus that has been enriching the relationship between both disciplines. We received it and joined that stream of knowledge. What we do notice, however, is the almost impertinent question that follows: can sound help the architect in his daily tasks? And, therefore, what are the contributions of sound to the architect? To do this we must seek the connection in the principles of both arts, where we can detach ourselves from time and space, and approach the most universal of art forms. The architect, in his daily work, is faced with three particular tasks: the architectural project, the architectural analysis and the teaching of architecture. Each of the three tasks is connected with the other two tasks: the project is carried out again with the analysis and transmitted to the new architect; the analysis supports the project decisions and gives tools to the disciple; and the teaching has the project as its purpose and the analysis as its method. The thesis presented here shows what sound offers to the task of the project, to that of analysis and to that of teaching. These three tasks are approached from three premises: theoretical foundations, tools and evaluation. The interaction of the three tasks with the three premises gives rise to nine lines of work that articulate the chapters of the thesis. The first, fourth and seventh chapters approach the three tasks from the premise of theoretical foundations, foundations that perhaps because they are obvious, have been ignored or overlooked but which constitute the nature of both disciplines. The first shows, by the hand of two 20th century authors - the architect Dom Hans van der Laan and the composer Olivier Messiaen - that creation in both disciplines is of a systematic nature. The fourth one revaluates the analytical systems of representation of form both in architecture and in music which, starting with the basic characteristics of its elements, lead to a symbolic notation and a tool for the analysis of the work: the plan and the score. The seventh introduces the student of architecture to the growing separation between music and architecture that has been accentuated to this day. The second, fifth and eighth chapters approach the three particular tasks from the premise of tools, working tools that help to understand more directly the influence of architecture on sound. The second places virtual reality and auralization techniques at the service of the architectural and urban planning project, enhancing the sound experience in these projects. The fifth deals with the acoustic analysis of exterior spaces and their relationship with the urban configuration of these spaces. The eighth section presents the study of acoustic heritage as an educational tool. The third, sixth and ninth chapters deal with the three tasks from the premise of evaluation, a check that ensures the influence of sound on them through teaching experiments. The third argues and exemplifies that a sound landscape can be the engine and generator of an architectural design. The sixth one reviews the methods for evaluating the subjective and objective parameters of architectural acoustics. The ninth shows that in teaching sound to architects, "learning by listening" should be given priority over "passive learning".Las disciplinas del espacio y del tiempo forman dos dominios a los que resulta atrevido comparar, pues es obvio que son de naturaleza distinta. La música ocurre en el tiempo, mientras que la arquitectura en el espacio. No obstante, desde los primeros tratados tanto de arquitectura como de música, se pueden leer repetidas llamadas a la comparación, al complemento y a la influencia de ambas disciplinas, cuanto menos a la constatación de ciertos órdenes comunes entre ambos dominios. En esta tesis doctoral no ponemos en cuestión todo este corpus teórico que ha venido enriqueciendo la relación entre ambas disciplinas. La recibimos y nos unimos a esa corriente de conocimiento. En lo que sí reparamos, en cambio, es en la pregunta casi impertinente que surge seguidamente: ¿puede el sonido ayudar al arquitecto en sus tareas diarias? Y, por tanto, ¿cuáles son las contribuciones del sonido para el arquitecto? Para ello debemos buscar la conexión en los principios de ambas artes, allí donde podemos despegarnos del tiempo y del espacio, y acercarnos a la más universal de las formas de arte. El arquitecto, en su tarea diaria, se enfrenta a tres tareas particulares: el proyecto arquitectónico, el análisis arquitectónico y la enseñanza de la arquitectura. Cada una de las tres tareas está conectada con las otras dos: el proyecto se reconduce con el análisis y se transmite al nuevo arquitecto; el análisis soporta las decisiones de proyecto y da herramientas al discípulo; y la enseñanza tiene como fin el proyecto y como método el análisis. La tesis aquí presentada pone de manifiesto lo que el sonido ofrece a la tarea del proyecto, a la del análisis y a la de la enseñanza. Estas tres tareas son abordadas desde tres premisas: los fundamentos teóricos, las herramientas y la evaluación. La interacción de las tres tareas con las tres premisas da lugar a nueve líneas de trabajo que articulan los capítulos de la tesis. Los capítulos primero, cuarto y séptimo abordan las tres tareas desde la premisa de los fundamentos teóricos, fundamentos que quizá por ser obvios, se han obviado o pasado por alto pero que constituyen la naturaleza de ambas disciplinas. El primero muestra, de la mano de dos autores del siglo XX -el arquitecto Dom Hans van der Laan y el compositor Olivier Messiaen- que la creación en ambas disciplinas es de naturaleza sistemática. El cuarto revaloriza los sistemas analíticos de representación de la forma tanto en arquitectura como en música que, empezando por las características básicas de sus elementos, conducen a una notación simbólica y una herramienta de análisis de la obra: el plano y la partitura. El séptimo presenta al estudiante de arquitectura la creciente separación entre la música y la arquitectura que se ha venido acentuando hasta nuestros días. Los capítulos segundo, quinto y octavo abordan las tres tareas particulares desde la premisa de las herramientas, útiles de trabajo que ayudan a comprender de modo más directo la influencia de la arquitectura en el sonido. El segundo sitúa la realidad virtual y las técnicas de auralización al servicio del proyecto de arquitectura y urbanismo, potenciando la experiencia sonora en estos proyectos. El quinto aborda el análisis acústico de espacios exteriores y su relación con la configuración urbana de estos espacios. El octavo presenta el estudio del patrimonio acústico como herramienta pedagógica. Los capítulos tercero, sexto y noveno abordan las tres tareas desde la premisa de la evaluación, comprobación que asegura mediante experimentos docentes la influencia del sonido en ellas. El tercero argumenta y ejemplifica que un paisaje sonoro puede ser el motor y generador de un diseño arquitectónico. El sexto realiza una revisión de los métodos de evaluación de los parámetros subjetivos y objetivos de la acústica arquitectónica. El noveno muestra que en la enseñanza del sonido para los arquitectos debe priorizarse "aprender escuchando" antes que el "aprendizaje pasivo".Award-winningPostprint (published version

The generative, analytic and instructional capacities of sound in architecture : fundamentals, tools and evaluation of a design methodology

The disciplines of space and time form two domains to which it is daring to compare, since it is obvious that they are of a different nature. Music happens in time, while architecture happens in space. However, from the first treatises on both architecture and music, repeated calls for comparison, complementarity and influence of both disciplines can be read, at least to the observation of certain common orders between the two domains. In this doctoral thesis we do not question this whole theoretical corpus that has been enriching the relationship between both disciplines. We received it and joined that stream of knowledge. What we do notice, however, is the almost impertinent question that follows: can sound help the architect in his daily tasks? And, therefore, what are the contributions of sound to the architect? To do this we must seek the connection in the principles of both arts, where we can detach ourselves from time and space, and approach the most universal of art forms. The architect, in his daily work, is faced with three particular tasks: the architectural project, the architectural analysis and the teaching of architecture. Each of the three tasks is connected with the other two tasks: the project is carried out again with the analysis and transmitted to the new architect; the analysis supports the project decisions and gives tools to the disciple; and the teaching has the project as its purpose and the analysis as its method. The thesis presented here shows what sound offers to the task of the project, to that of analysis and to that of teaching. These three tasks are approached from three premises: theoretical foundations, tools and evaluation. The interaction of the three tasks with the three premises gives rise to nine lines of work that articulate the chapters of the thesis. The first, fourth and seventh chapters approach the three tasks from the premise of theoretical foundations, foundations that perhaps because they are obvious, have been ignored or overlooked but which constitute the nature of both disciplines. The first shows, by the hand of two 20th century authors - the architect Dom Hans van der Laan and the composer Olivier Messiaen - that creation in both disciplines is of a systematic nature. The fourth one revaluates the analytical systems of representation of form both in architecture and in music which, starting with the basic characteristics of its elements, lead to a symbolic notation and a tool for the analysis of the work: the plan and the score. The seventh introduces the student of architecture to the growing separation between music and architecture that has been accentuated to this day. The second, fifth and eighth chapters approach the three particular tasks from the premise of tools, working tools that help to understand more directly the influence of architecture on sound. The second places virtual reality and auralization techniques at the service of the architectural and urban planning project, enhancing the sound experience in these projects. The fifth deals with the acoustic analysis of exterior spaces and their relationship with the urban configuration of these spaces. The eighth section presents the study of acoustic heritage as an educational tool. The third, sixth and ninth chapters deal with the three tasks from the premise of evaluation, a check that ensures the influence of sound on them through teaching experiments. The third argues and exemplifies that a sound landscape can be the engine and generator of an architectural design. The sixth one reviews the methods for evaluating the subjective and objective parameters of architectural acoustics. The ninth shows that in teaching sound to architects, "learning by listening" should be given priority over "passive learning".Las disciplinas del espacio y del tiempo forman dos dominios a los que resulta atrevido comparar, pues es obvio que son de naturaleza distinta. La música ocurre en el tiempo, mientras que la arquitectura en el espacio. No obstante, desde los primeros tratados tanto de arquitectura como de música, se pueden leer repetidas llamadas a la comparación, al complemento y a la influencia de ambas disciplinas, cuanto menos a la constatación de ciertos órdenes comunes entre ambos dominios. En esta tesis doctoral no ponemos en cuestión todo este corpus teórico que ha venido enriqueciendo la relación entre ambas disciplinas. La recibimos y nos unimos a esa corriente de conocimiento. En lo que sí reparamos, en cambio, es en la pregunta casi impertinente que surge seguidamente: ¿puede el sonido ayudar al arquitecto en sus tareas diarias? Y, por tanto, ¿cuáles son las contribuciones del sonido para el arquitecto? Para ello debemos buscar la conexión en los principios de ambas artes, allí donde podemos despegarnos del tiempo y del espacio, y acercarnos a la más universal de las formas de arte. El arquitecto, en su tarea diaria, se enfrenta a tres tareas particulares: el proyecto arquitectónico, el análisis arquitectónico y la enseñanza de la arquitectura. Cada una de las tres tareas está conectada con las otras dos: el proyecto se reconduce con el análisis y se transmite al nuevo arquitecto; el análisis soporta las decisiones de proyecto y da herramientas al discípulo; y la enseñanza tiene como fin el proyecto y como método el análisis. La tesis aquí presentada pone de manifiesto lo que el sonido ofrece a la tarea del proyecto, a la del análisis y a la de la enseñanza. Estas tres tareas son abordadas desde tres premisas: los fundamentos teóricos, las herramientas y la evaluación. La interacción de las tres tareas con las tres premisas da lugar a nueve líneas de trabajo que articulan los capítulos de la tesis. Los capítulos primero, cuarto y séptimo abordan las tres tareas desde la premisa de los fundamentos teóricos, fundamentos que quizá por ser obvios, se han obviado o pasado por alto pero que constituyen la naturaleza de ambas disciplinas. El primero muestra, de la mano de dos autores del siglo XX ?el arquitecto Dom Hans van der Laan y el compositor Olivier Messiaen- que la creación en ambas disciplinas es de naturaleza sistemática. El cuarto revaloriza los sistemas analíticos de representación de la forma tanto en arquitectura como en música que, empezando por las características básicas de sus elementos, conducen a una notación simbólica y una herramienta de análisis de la obra: el plano y la partitura. El séptimo presenta al estudiante de arquitectura la creciente separación entre la música y la arquitectura que se ha venido acentuando hasta nuestros días. Los capítulos segundo, quinto y octavo abordan las tres tareas particulares desde la premisa de las herramientas, útiles de trabajo que ayudan a comprender de modo más directo la influencia de la arquitectura en el sonido. El segundo sitúa la realidad virtual y las técnicas de auralización al servicio del proyecto de arquitectura y urbanismo, potenciando la experiencia sonora en estos proyectos. El quinto aborda el análisis acústico de espacios exteriores y su relación con la configuración urbana de estos espacios. El octavo presenta el estudio del patrimonio acústico como herramienta pedagógica. Los capítulos tercero, sexto y noveno abordan las tres tareas desde la premisa de la evaluación, comprobación que asegura mediante experimentos docentes la influencia del sonido en ellas. El tercero argumenta y ejemplifica que un paisaje sonoro puede ser el motor y generador de un diseño arquitectónico. El sexto realiza una revisión de los métodos de evaluación de los parámetros subjetivos y objetivos de la acústica arquitectónica. El noveno muestra que en la enseñanza del sonido para los arquitectos debe priorizarse "aprender escuchando" antes que el "aprendizaje pasivo"

Studies within Fragment-Based Drug Discovery: Library Synthesis and Hit-to-Lead Optimisation

This thesis reports two projects aimed at addressing challenges within fragment-based drug discovery. The first project describes efforts towards utilising synthetic methodology to address deficiencies within fragment screening collections. This involved the development of a modular, robust and scalable route to access α,α-disubstituted amino ester building blocks, which in turn were derivatised to allow the rapid assembly of five (a total of eight in collaboration) spirocyclic scaffolds. Importantly, this library was structurally diverse, comprising three (a total of six in collaboration) pharmacophore-like heterocycles and carbocycles. Moreover, numerous three-dimensional exit vectors were incorporated within each core spirocycle, and the ability of these handles to effect a diverse set of chemical modifications was exemplified through the generation of 16 (a total of 21 in collaboration) examples. Computational studies highlighted the excellent physicochemical and 3D properties of the library, as well as the broad coverage of underexplored chemical space that was achieved. This library was also screened for antibacterial activity in a phenotypic assay against the clinically relevant bacterial strains, Pseudomonas aeruginosa and Staphylococcus aureus. The second project examined the inhibition of propionate detoxification mechanisms in bacteria as an attractive strategy for the development of antibacterial agents. A fragment screening campaign against 2-methylcitrate synthase (PrpC) from Pseudomonas aeruginosa identified several hit compounds based on an indole unit. Synthetic efforts were undertaken to elaborate these fragment hits to increase potency. The adopted strategy focused on growing the indole fragment towards the nearby oxaloacetate binding pocket and occupying it with a fragment mimicking its natural substrate. This approach yielded a compound with an in vitro half maximal inhibitory concentration of 130 µM against the enzymatic activity of PrpC