38,191 research outputs found
Relaxing state-access constraints in stateful programmable data planes
Supporting the programming of stateful packet forwarding functions in
hardware has recently attracted the interest of the research community. When
designing such switching chips, the challenge is to guarantee the ability to
program functions that can read and modify data plane's state, while keeping
line rate performance and state consistency. Current state-of-the-art designs
are based on a very conservative all-or-nothing model: programmability is
limited only to those functions that are guaranteed to sustain line rate, with
any traffic workload. In effect, this limits the maximum time to execute state
update operations. In this paper, we explore possible options to relax these
constraints by using simulations on real traffic traces. We then propose a
model in which functions can be executed in a larger but bounded time, while
preventing data hazards with memory locking. We present results showing that
such flexibility can be supported with little or no throughput degradation.Comment: 6 page
cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission.
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at maturation are released into peripheral blood from where they are taken up during a mosquito blood meal. Release into the blood circulation is accompanied by an increase in GIE deformability that allows them to pass through the spleen. Here, we used a microsphere matrix to mimic splenic filtration and investigated the role of cAMP-signalling in regulating GIE deformability. We demonstrated that mature GIE deformability is dependent on reduced cAMP-signalling and on increased phosphodiesterase expression in stage V gametocytes, and that parasite cAMP-dependent kinase activity contributes to the stiffness of immature gametocytes. Importantly, pharmacological agents that raise cAMP levels in transmissible stage V gametocytes render them less deformable and hence less likely to circulate through the spleen. Therefore, phosphodiesterase inhibitors that raise cAMP levels in P. falciparum infected erythrocytes, such as sildenafil, represent new candidate drugs to block transmission of malaria parasites
Digital Switching in the Quantum Domain
In this paper, we present an architecture and implementation algorithm such
that digital data can be switched in the quantum domain. First we define the
connection digraph which can be used to describe the behavior of a switch at a
given time, then we show how a connection digraph can be implemented using
elementary quantum gates. The proposed mechanism supports unicasting as well as
multicasting, and is strict-sense non-blocking. It can be applied to perform
either circuit switching or packet switching. Compared with a traditional space
or time domain switch, the proposed switching mechanism is more scalable.
Assuming an n-by-n quantum switch, the space consumption grows linearly, i.e.
O(n), while the time complexity is O(1) for unicasting, and O(log n) for
multicasting. Based on these advantages, a high throughput switching device can
be built simply by increasing the number of I/O ports.Comment: 24 pages, 16 figures, LaTe
Novel Modifications of Parallel Jacobi Algorithms
We describe two main classes of one-sided trigonometric and hyperbolic
Jacobi-type algorithms for computing eigenvalues and eigenvectors of Hermitian
matrices. These types of algorithms exhibit significant advantages over many
other eigenvalue algorithms. If the matrices permit, both types of algorithms
compute the eigenvalues and eigenvectors with high relative accuracy.
We present novel parallelization techniques for both trigonometric and
hyperbolic classes of algorithms, as well as some new ideas on how pivoting in
each cycle of the algorithm can improve the speed of the parallel one-sided
algorithms. These parallelization approaches are applicable to both
distributed-memory and shared-memory machines.
The numerical testing performed indicates that the hyperbolic algorithms may
be superior to the trigonometric ones, although, in theory, the latter seem
more natural.Comment: Accepted for publication in Numerical Algorithm
A biophysical model explains the spontaneous bursting behavior in the developing retina
During early development, waves of activity propagate across the retina and
play a key role in the proper wiring of the early visual system. During the
stage II these waves are triggered by a transient network of neurons, called
Starburst Amacrine Cells (SACs), showing a bursting activity which disappears
upon further maturation. While several models have attempted to reproduce
retinal waves, none of them is able to mimic the rhythmic autonomous bursting
of individual SACs and reveal how these cells change their intrinsic properties
during development. Here, we introduce a mathematical model, grounded on
biophysics, which enables us to reproduce the bursting activity of SACs and to
propose a plausible, generic and robust, mechanism that generates it. The core
parameters controlling repetitive firing are fast depolarizing -gated
calcium channels and hyperpolarizing -gated potassium channels. The
quiescent phase of bursting is controlled by a slow after hyperpolarization
(sAHP), mediated by calcium-dependent potassium channels. Based on a
bifurcation analysis we show how biophysical parameters, regulating calcium and
potassium activity, control the spontaneously occurring fast oscillatory
activity followed by long refractory periods in individual SACs. We make a
testable experimental prediction on the role of voltage-dependent potassium
channels on the excitability properties of SACs and on the evolution of this
excitability along development. We also propose an explanation on how SACs can
exhibit a large variability in their bursting periods, as observed
experimentally within a SACs network as well as across different species, yet
based on a simple, unique, mechanism. As we discuss, these observations at the
cellular level have a deep impact on the retinal waves description.Comment: 25 pages, 13 figures, submitte
Lattice path counting and the theory of queues
In this paper we will show how recent advances in the combinatorics of lattice paths can be applied to solve interesting and nontrivial problems in the theory of queues. The problems we discuss range from classical ones like M^a/M^b/1 systems to open tandem systems with and without global blocking and to queueing models that are related to random walks in a quarter plane like the Flatto-Hahn model or systems with preemptive priorities. (authorÂŽs abstract)Series: Research Report Series / Department of Statistics and Mathematic
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