Programmability of Chemical Reaction Networks

Motivated by the intriguing complexity of biochemical circuitry within individual cells we study Stochastic Chemical Reaction Networks (SCRNs), a formal model that considers a set of chemical reactions acting on a finite number of molecules in a well-stirred solution according to standard chemical kinetics equations. SCRNs have been widely used for describing naturally occurring (bio)chemical systems, and with the advent of synthetic biology they become a promising language for the design of artificial biochemical circuits. Our interest here is the computational power of SCRNs and how they relate to more conventional models of computation. We survey known connections and give new connections between SCRNs and Boolean Logic Circuits, Vector Addition Systems, Petri Nets, Gate Implementability, Primitive Recursive Functions, Register Machines, Fractran, and Turing Machines. A theme to these investigations is the thin line between decidable and undecidable questions about SCRN behavior

Roadmap on semiconductor-cell biointerfaces.

This roadmap outlines the role semiconductor-based materials play in understanding the complex biophysical dynamics at multiple length scales, as well as the design and implementation of next-generation electronic, optoelectronic, and mechanical devices for biointerfaces. The roadmap emphasizes the advantages of semiconductor building blocks in interfacing, monitoring, and manipulating the activity of biological components, and discusses the possibility of using active semiconductor-cell interfaces for discovering new signaling processes in the biological world

1996 Laboratory directed research and development annual report

This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 1996. In addition to a programmatic and financial overview, the report includes progress reports from 259 individual R&D projects in seventeen categories. The general areas of research include: engineered processes and materials; computational and information sciences; microelectronics and photonics; engineering sciences; pulsed power; advanced manufacturing technologies; biomedical engineering; energy and environmental science and technology; advanced information technologies; counterproliferation; advanced transportation; national security technology; electronics technologies; idea exploration and exploitation; production; and science at the interfaces - engineering with atoms

Additive manufacturing of functional engineering components

Additive Manufacturing (AM) is a class of echnologies whereby components are made in an additive, layer-by-layer fashion enabling production of complex parts in which complexity has little or no effect on cost. However typical components roduced using these techniques are basic structural items with no major strength requirement and low geometric tolerances made from a single material. his thesis develops a low-cost Fused Filament abrication (FFF) based AM technique to produce functional parts. This is achieved by through esearching and implementing new materials in ombination and using precise control of infill tool paths for existing materials. Robocasting has previously been shown to be extremely versatile, however is known to offer poorer build quality relative to its ess-versatile counterparts. Research was ndertaken to enable Robocasting to be combined with FFF to enable the print quality and practical benefits of FFF with the material flexibility of Robocasting. This resulted in the manufacture of several multiple-material omponents using the technique to demonstrate its potential. In order to minimise the number of materials required to obtain desired properties, the effect of process parameters such as layer height, infill angle, and infill porosity were investigated. In total over an order of agnitude variation in Young’s modulus and tensile strength were achieved, enabling these properties to be actively controlled within the manufactured components. Finally a novel non-eutectic low melting point alloy was developed to be compatible with the FFF process. Its greater viscosity compared to traditional eutectics resulted in improved print quality and the reliable deposition of electrically conductive track 0.57x0.25mm in cross-section. In addition the material is approximately three orders of magnitude more conductive that typical printable organic inks. A micro-controller was produced using the technique in conjunction with traditional electronics components. This represents the first time a functional electrical circuitry, with sufficient conductivity for the majority of applications and interfacing directly with standard electrical components, has been produced using a very low-cost AM technique such as FFF. The research undertaken builds components with substantially improved functionality relative to traditional AM products, enabling electromechanical components with varying mechanical and electrical properties. It is anticipated that this could substantially reduce the part-count for many engineering assemblies and open up Additive Manufacturing to many new applications.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Development of a powertrain control algorithm for a compound-split diesel hybrid-electric vehicle

The goal of this research was to develop a unique powertrain control algorithm for a diesel-powered compound-split hybrid crossover utility vehicle (CUV) and evaluate the fuel consumption and greenhouse gas emissions benefits that can be realized compared to existing non-hybrid, gasoline-powered CUVs. This was achieved through the implementation of engine on/off functionality, regenerative braking, and electric-only drive. The research was conducted in conjunction with the university\u27s participation in EcoCAR: The NeXt Challenge, an inter-collegiate advanced vehicle engineering competition focused on developing alternatively powered vehicles in the interest of providing improved fuel efficiency and reduced tailpipe emissions while maintaining useful vehicle functionality. Prior to construction, the proposed vehicle was simulated for fuel efficiency and carbon dioxide emissions using the Powertrain System Analysis Toolkit. Initial simulation results indicated that the proposed compound-split hybrid vehicle would achieve 35 mpgge combined fuel economy and produce carbon dioxide at a rate of 242 g/mi. A 2009 Saturn Vue was modified to accept the proposed hybrid powertrain consisting of a 1.3 liter diesel engine, 2-mode compound-split transaxle, and lithium-ion high-voltage battery system. This vehicle served as the platform for the development and validation of the powertrain control algorithm. Using the vehicle\u27s CAN communication capabilities, auxiliary control units were integrated to manage the new powertrain components and implement the control strategy. The project vehicle and control algorithm were validated and tested on-road for fuel efficiency and performance. The final powertrain control algorithm developed through this research included automatic engine start/stop, regenerative braking, and full-electric driving capability at speeds up to 25 mph. In its final configuration, the WVU 2-mode hybrid-electric vehicle achieved city/highway fuel economy of 24.5/31.5 mpgge. Compared to the base vehicle, the project vehicle achieved a 28.9% improvement in city fuel economy, a 21.2% improvement in highway fuel economy, and a 20% reduction of in-use CO2 emissions

NASA Technology Applications Team: Commercial applications of aerospace technology

The Research Triangle Institute (RTI) Team has maintained its focus on helping NASA establish partnerships with U.S. industry for dual use development and technology commercialization. Our emphasis has been on outcomes, such as licenses, industry partnerships and commercialization of technologies, that are important to NASA in its mission of contributing to the improved competitive position of U.S. industry. The RTI Team has been successful in the development of NASA/industry partnerships and commercialization of NASA technologies. RTI ongoing commitment to quality and customer responsiveness has driven our staff to continuously improve our technology transfer methodologies to meet NASA's requirements. For example, RTI has emphasized the following areas: (1) Methodology For Technology Assessment and Marketing: RTI has developed and implemented effective processes for assessing the commercial potential of NASA technologies. These processes resulted from an RTI study of best practices, hands-on experience, and extensive interaction with the NASA Field Centers to adapt to their specific needs. (2) Effective Marketing Strategies: RTI surveyed industry technology managers to determine effective marketing tools and strategies. The Technology Opportunity Announcement format and content were developed as a result of this industry input. For technologies with a dynamic visual impact, RTI has developed a stand-alone demonstration diskette that was successful in developing industry interest in licensing the technology. And (3) Responsiveness to NASA Requirements: RTI listened to our customer (NASA) and designed our processes to conform with the internal procedures and resources at each NASA Field Center and the direction provided by NASA's Agenda for Change. This report covers the activities of the Research Triangle Institute Technology Applications Team for the period 1 October 1993 through 31 December 1994

NASA Technology Applications Team: Commercial applications of aerospace technology

The Research Triangle Institute (RTI) is pleased to report the results of NASA contract NASW-4367, 'Operation of a Technology Applications Team'. Through a period of significant change within NASA, the RTI Team has maintained its focus on helping NASA establish partnerships with U.S. industry for dual use development and technology commercialization. Our emphasis has been on outcomes, such as licenses, industry partnerships and commercialization of technologies that are important to NASA in its mission of contributing to the improved competitive position of U.S. industry. RTI's ongoing commitment to quality and customer responsiveness has driven our staff to continuously improve our technology transfer methodologies to meet NASA's requirements. For example, RTI has emphasized the following areas: (1) Methodology For Technology Assessment and Marketing: RTI has developed an implemented effective processes for assessing the commercial potential of NASA technologies. These processes resulted from an RTI study of best practices, hands-on experience, and extensive interaction with the NASA Field Centers to adapt to their specific needs; (2) Effective Marketing Strategies: RTI surveyed industry technology managers to determine effective marketing tools and strategies. The Technology Opportunity Announcement format and content were developed as a result of this industry input. For technologies with a dynamic visual impact, RTI has developed a stand-alone demonstration diskette that was successful in developing industry interest in licensing the technology; and (3) Responsiveness to NASA Requirements: RTI listened to our customer (NASA) and designed our processes to conform with the internal procedures and resources at each NASA Field Center and the direction provided by NASA's Agenda for Change. This report covers the activities of the Research Triangle Institute Technology Applications Team for the period 1 October 1993 through 31 December 1994

Dual-Use Space Technology Transfer Conference and Exhibition

This document contains papers presented at the Dual-Use Space Technology Transfer Conference and Exhibition held at the Johnson Space Center February 1-3, 1994. Possible technology transfers covered during the conference were in the areas of information access; innovative microwave and optical applications; materials and structures; marketing and barriers; intelligent systems; human factors and habitation; communications and data systems; business process and technology transfer; software engineering; biotechnology and advanced bioinstrumentation; communications signal processing and analysis; new ways of doing business; medical care; applications derived from control center data systems; human performance evaluation; technology transfer methods; mathematics, modeling, and simulation; propulsion; software analysis and decision tools systems/processes in human support technology; networks, control centers, and distributed systems; power; rapid development perception and vision technologies; integrated vehicle health management; automation technologies; advanced avionics; ans robotics technologies. More than 77 papers, 20 presentations, and 20 exhibits covering various disciplines were presented b experts from NASA, universities, and industry