5,524 research outputs found
Ontology of core data mining entities
In this article, we present OntoDM-core, an ontology of core data mining
entities. OntoDM-core defines themost essential datamining entities in a three-layered
ontological structure comprising of a specification, an implementation and an application
layer. It provides a representational framework for the description of mining
structured data, and in addition provides taxonomies of datasets, data mining tasks,
generalizations, data mining algorithms and constraints, based on the type of data.
OntoDM-core is designed to support a wide range of applications/use cases, such as
semantic annotation of data mining algorithms, datasets and results; annotation of
QSAR studies in the context of drug discovery investigations; and disambiguation of
terms in text mining. The ontology has been thoroughly assessed following the practices
in ontology engineering, is fully interoperable with many domain resources and
is easy to extend
Conceptual graph-based knowledge representation for supporting reasoning in African traditional medicine
Although African patients use both conventional or modern and traditional healthcare simultaneously, it has been proven that 80% of people rely on African traditional medicine (ATM). ATM includes medical activities stemming from practices, customs and traditions which were integral to the distinctive African cultures. It is based mainly on the oral transfer of knowledge, with the risk of losing critical knowledge. Moreover, practices differ according to the regions and the availability of medicinal plants. Therefore, it is necessary to compile tacit, disseminated and complex knowledge from various Tradi-Practitioners (TP) in order to determine interesting patterns for treating a given disease. Knowledge engineering methods for traditional medicine are useful to model suitably complex information needs, formalize knowledge of domain experts and highlight the effective practices for their integration to conventional medicine. The work described in this paper presents an approach which addresses two issues. First it aims at proposing a formal representation model of ATM knowledge and practices to facilitate their sharing and reusing. Then, it aims at providing a visual reasoning mechanism for selecting best available procedures and medicinal plants to treat diseases. The approach is based on the use of the Delphi method for capturing knowledge from various experts which necessitate reaching a consensus. Conceptual graph formalism is used to model ATM knowledge with visual reasoning capabilities and processes. The nested conceptual graphs are used to visually express the semantic meaning of Computational Tree Logic (CTL) constructs that are useful for formal specification of temporal properties of ATM domain knowledge. Our approach presents the advantage of mitigating knowledge loss with conceptual development assistance to improve the quality of ATM care (medical diagnosis and therapeutics), but also patient safety (drug monitoring)
RegenBase: a knowledge base of spinal cord injury biology for translational research.
Spinal cord injury (SCI) research is a data-rich field that aims to identify the biological mechanisms resulting in loss of function and mobility after SCI, as well as develop therapies that promote recovery after injury. SCI experimental methods, data and domain knowledge are locked in the largely unstructured text of scientific publications, making large scale integration with existing bioinformatics resources and subsequent analysis infeasible. The lack of standard reporting for experiment variables and results also makes experiment replicability a significant challenge. To address these challenges, we have developed RegenBase, a knowledge base of SCI biology. RegenBase integrates curated literature-sourced facts and experimental details, raw assay data profiling the effect of compounds on enzyme activity and cell growth, and structured SCI domain knowledge in the form of the first ontology for SCI, using Semantic Web representation languages and frameworks. RegenBase uses consistent identifier schemes and data representations that enable automated linking among RegenBase statements and also to other biological databases and electronic resources. By querying RegenBase, we have identified novel biological hypotheses linking the effects of perturbagens to observed behavioral outcomes after SCI. RegenBase is publicly available for browsing, querying and download.Database URL:http://regenbase.org
The OBO Foundry: Coordinated Evolution of Ontologies to Support Biomedical Data Integration
The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or ‘ontologies’. Unfortunately, the very success of this approach has led to a proliferation of ontologies, which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium has set in train a strategy to overcome this problem. Existing OBO ontologies, including the Gene Ontology, are undergoing a process of coordinated reform, and new ontologies being created, on the basis of an evolving set of shared principles governing ontology development. The result is an expanding family of ontologies designed to be interoperable, logically well-formed, and to incorporate accurate representations of biological reality. We describe the OBO Foundry initiative, and provide guidelines for those who might wish to become involved in the future
PAV ontology: provenance, authoring and versioning
Provenance is a critical ingredient for establishing trust of published
scientific content. This is true whether we are considering a data set, a
computational workflow, a peer-reviewed publication or a simple scientific
claim with supportive evidence. Existing vocabularies such as DC Terms and the
W3C PROV-O are domain-independent and general-purpose and they allow and
encourage for extensions to cover more specific needs. We identify the specific
need for identifying or distinguishing between the various roles assumed by
agents manipulating digital artifacts, such as author, contributor and curator.
We present the Provenance, Authoring and Versioning ontology (PAV): a
lightweight ontology for capturing just enough descriptions essential for
tracking the provenance, authoring and versioning of web resources. We argue
that such descriptions are essential for digital scientific content. PAV
distinguishes between contributors, authors and curators of content and
creators of representations in addition to the provenance of originating
resources that have been accessed, transformed and consumed. We explore five
projects (and communities) that have adopted PAV illustrating their usage
through concrete examples. Moreover, we present mappings that show how PAV
extends the PROV-O ontology to support broader interoperability.
The authors strived to keep PAV lightweight and compact by including only
those terms that have demonstrated to be pragmatically useful in existing
applications, and by recommending terms from existing ontologies when
plausible.
We analyze and compare PAV with related approaches, namely Provenance
Vocabulary, DC Terms and BIBFRAME. We identify similarities and analyze their
differences with PAV, outlining strengths and weaknesses of our proposed model.
We specify SKOS mappings that align PAV with DC Terms.Comment: 22 pages (incl 5 tables and 19 figures). Submitted to Journal of
Biomedical Semantics 2013-04-26 (#1858276535979415). Revised article
submitted 2013-08-30. Second revised article submitted 2013-10-06. Accepted
2013-10-07. Author proofs sent 2013-10-09 and 2013-10-16. Published
2013-11-22. Final version 2013-12-06.
http://www.jbiomedsem.com/content/4/1/3
The development of non-coding RNA ontology
Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of large amounts of ncRNA biological and clinical data
On Reasoning with RDF Statements about Statements using Singleton Property Triples
The Singleton Property (SP) approach has been proposed for representing and
querying metadata about RDF triples such as provenance, time, location, and
evidence. In this approach, one singleton property is created to uniquely
represent a relationship in a particular context, and in general, generates a
large property hierarchy in the schema. It has become the subject of important
questions from Semantic Web practitioners. Can an existing reasoner recognize
the singleton property triples? And how? If the singleton property triples
describe a data triple, then how can a reasoner infer this data triple from the
singleton property triples? Or would the large property hierarchy affect the
reasoners in some way? We address these questions in this paper and present our
study about the reasoning aspects of the singleton properties. We propose a
simple mechanism to enable existing reasoners to recognize the singleton
property triples, as well as to infer the data triples described by the
singleton property triples. We evaluate the effect of the singleton property
triples in the reasoning processes by comparing the performance on RDF datasets
with and without singleton properties. Our evaluation uses as benchmark the
LUBM datasets and the LUBM-SP datasets derived from LUBM with temporal
information added through singleton properties
Knowledge-based Biomedical Data Science 2019
Knowledge-based biomedical data science (KBDS) involves the design and
implementation of computer systems that act as if they knew about biomedicine.
Such systems depend on formally represented knowledge in computer systems,
often in the form of knowledge graphs. Here we survey the progress in the last
year in systems that use formally represented knowledge to address data science
problems in both clinical and biological domains, as well as on approaches for
creating knowledge graphs. Major themes include the relationships between
knowledge graphs and machine learning, the use of natural language processing,
and the expansion of knowledge-based approaches to novel domains, such as
Chinese Traditional Medicine and biodiversity.Comment: Manuscript 43 pages with 3 tables; Supplemental material 43 pages
with 3 table
Ontologies in medicinal chemistry: current status and future challenges
[Abstract] Recent years have seen a dramatic increase in the amount and availability of data in the diverse areas of medicinal chemistry, making it possible to achieve significant advances in fields such as the design, synthesis and biological evaluation of compounds. However, with this data explosion, the storage, management and analysis of available data to extract relevant information has become even a more complex task that offers challenging research issues to Artificial Intelligence (AI) scientists. Ontologies have emerged in AI as a key tool to formally represent and semantically organize aspects of the real world. Beyond glossaries or thesauri, ontologies facilitate communication between experts and allow the application of computational techniques to extract useful information from available data. In medicinal chemistry, multiple ontologies have been developed during the last years which contain knowledge about chemical compounds and processes of synthesis of pharmaceutical products. This article reviews the principal standards and ontologies in medicinal chemistry, analyzes their main applications and suggests future directions.Instituto de Salud Carlos III; FIS-PI10/02180Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo; 209RT0366Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; CN2012/217Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; CN2011/034Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; CN2012/21
- …