33,113 research outputs found
Bumps and rings in a two-dimensional neural field: splitting and rotational instabilities
In this paper we consider instabilities of localised solutions in planar neural field firing rate models of Wilson-Cowan or Amari type. Importantly we show that angular perturbations can destabilise spatially localised solutions. For a scalar model with Heaviside firing rate function we calculate symmetric one-bump and ring solutions explicitly and use an Evans function approach to predict the point of instability and the shapes of the dominant growing modes. Our predictions are shown to be in excellent agreement with direct numerical simulations. Moreover, beyond the instability our simulations demonstrate the emergence of multi-bump and labyrinthine patterns.
With the addition of spike-frequency adaptation, numerical simulations of the resulting vector model show that it is possible for structures without rotational symmetry, and in particular multi-bumps, to undergo an instability to a rotating wave. We use a general argument, valid for smooth firing rate functions, to establish the conditions necessary to generate such a rotational instability. Numerical continuation of the rotating wave is used to quantify the emergent angular velocity as a bifurcation parameter is varied. Wave stability is found via the numerical evaluation of an associated eigenvalue problem
Nonlinear physics of electrical wave propagation in the heart: a review
The beating of the heart is a synchronized contraction of muscle cells
(myocytes) that are triggered by a periodic sequence of electrical waves (action
potentials) originating in the sino-atrial node and propagating over the atria and
the ventricles. Cardiac arrhythmias like atrial and ventricular fibrillation (AF,VF)
or ventricular tachycardia (VT) are caused by disruptions and instabilities of these
electrical excitations, that lead to the emergence of rotating waves (VT) and turbulent
wave patterns (AF,VF). Numerous simulation and experimental studies during the
last 20 years have addressed these topics. In this review we focus on the nonlinear
dynamics of wave propagation in the heart with an emphasis on the theory of pulses,
spirals and scroll waves and their instabilities in excitable media and their application
to cardiac modeling. After an introduction into electrophysiological models for action
potential propagation, the modeling and analysis of spatiotemporal alternans, spiral
and scroll meandering, spiral breakup and scroll wave instabilities like negative line
tension and sproing are reviewed in depth and discussed with emphasis on their impact
in cardiac arrhythmias.Peer ReviewedPreprin
Development and applications of a model for cellular response to multiple chemotactic cues
The chemotactic response of a cell population to a single chemical species has been characterized experimentally for many cell types and has been extensively studied from a theoretical standpoint. However, cells frequently have multiple receptor types and can detect and respond chemotactically to more than one chemical. How these signals are integrated within the cell is not known, and we therefore adopt a macroscopic phenomenological approach to this problem. In this paper we derive and analyze chemotactic models based on partial differential (chemotaxis) equations for cell movement in response to multiple chemotactic cues. Our derivation generalizes the approach of Othmer and Stevens [29], who have recently developed a modeling framework for studying different chemotactic responses to a single chemical species. The importance of such a generalization is illustrated by the effect of multiple chemical cues on the chemotactic sensitivity and the spatial pattern of cell densities in several examples. We demonstrate that the model can generate the complex patterns observed on the skin of certain animal species and we indicate how the chemotactic response can be viewed as a form of positional indicator
Order out of Randomness : Self-Organization Processes in Astrophysics
Self-organization is a property of dissipative nonlinear processes that are
governed by an internal driver and a positive feedback mechanism, which creates
regular geometric and/or temporal patterns and decreases the entropy, in
contrast to random processes. Here we investigate for the first time a
comprehensive number of 16 self-organization processes that operate in
planetary physics, solar physics, stellar physics, galactic physics, and
cosmology. Self-organizing systems create spontaneous {\sl order out of chaos},
during the evolution from an initially disordered system to an ordered
stationary system, via quasi-periodic limit-cycle dynamics, harmonic mechanical
resonances, or gyromagnetic resonances. The internal driver can be gravity,
rotation, thermal pressure, or acceleration of nonthermal particles, while the
positive feedback mechanism is often an instability, such as the
magneto-rotational instability, the Rayleigh-B\'enard convection instability,
turbulence, vortex attraction, magnetic reconnection, plasma condensation, or
loss-cone instability. Physical models of astrophysical self-organization
processes involve hydrodynamic, MHD, and N-body formulations of Lotka-Volterra
equation systems.Comment: 61 pages, 38 Figure
Local and global dynamics of warped astrophysical discs
Astrophysical discs are warped whenever a misalignment is present in the
system, or when a flat disc is made unstable by external forces. The evolution
of the shape and mass distribution of a warped disc is driven not only by
external influences but also by an internal torque, which transports angular
momentum through the disc. This torque depends on internal flows driven by the
oscillating pressure gradient associated with the warp, and on physical
processes operating on smaller scales, which may include instability and
turbulence. We introduce a local model for the detailed study of warped discs.
Starting from the shearing sheet of Goldreich & Lynden-Bell, we impose the
oscillating geometry of the orbital plane by means of a coordinate
transformation. This warped shearing sheet (or box) is suitable for analytical
and computational treatments of fluid dynamics, magnetohydrodynamics, etc., and
it can be used to compute the internal torque that drives the large-scale
evolution of the disc. The simplest hydrodynamic states in the local model are
horizontally uniform laminar flows that oscillate at the orbital frequency.
These correspond to the nonlinear solutions for warped discs found in previous
work by Ogilvie, and we present an alternative derivation and generalization of
that theory. In a companion paper we show that these laminar flows are often
linearly unstable, especially if the disc is nearly Keplerian and of low
viscosity. The local model can be used in future work to determine the
nonlinear outcome of the hydrodynamic instability of warped discs, and its
interaction with others such as the magnetorotational instability.Comment: 17 pages, 10 figures, revised version, to be published in MNRA
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