25,109 research outputs found
Deep learning with convolutional neural networks for decoding and visualization of EEG pathology
We apply convolutional neural networks (ConvNets) to the task of
distinguishing pathological from normal EEG recordings in the Temple University
Hospital EEG Abnormal Corpus. We use two basic, shallow and deep ConvNet
architectures recently shown to decode task-related information from EEG at
least as well as established algorithms designed for this purpose. In decoding
EEG pathology, both ConvNets reached substantially better accuracies (about 6%
better, ~85% vs. ~79%) than the only published result for this dataset, and
were still better when using only 1 minute of each recording for training and
only six seconds of each recording for testing. We used automated methods to
optimize architectural hyperparameters and found intriguingly different ConvNet
architectures, e.g., with max pooling as the only nonlinearity. Visualizations
of the ConvNet decoding behavior showed that they used spectral power changes
in the delta (0-4 Hz) and theta (4-8 Hz) frequency range, possibly alongside
other features, consistent with expectations derived from spectral analysis of
the EEG data and from the textual medical reports. Analysis of the textual
medical reports also highlighted the potential for accuracy increases by
integrating contextual information, such as the age of subjects. In summary,
the ConvNets and visualization techniques used in this study constitute a next
step towards clinically useful automated EEG diagnosis and establish a new
baseline for future work on this topic.Comment: Published at IEEE SPMB 2017 https://www.ieeespmb.org/2017
An Automated System for Epilepsy Detection using EEG Brain Signals based on Deep Learning Approach
Epilepsy is a neurological disorder and for its detection, encephalography
(EEG) is a commonly used clinical approach. Manual inspection of EEG brain
signals is a time-consuming and laborious process, which puts heavy burden on
neurologists and affects their performance. Several automatic techniques have
been proposed using traditional approaches to assist neurologists in detecting
binary epilepsy scenarios e.g. seizure vs. non-seizure or normal vs. ictal.
These methods do not perform well when classifying ternary case e.g. ictal vs.
normal vs. inter-ictal; the maximum accuracy for this case by the
state-of-the-art-methods is 97+-1%. To overcome this problem, we propose a
system based on deep learning, which is an ensemble of pyramidal
one-dimensional convolutional neural network (P-1D-CNN) models. In a CNN model,
the bottleneck is the large number of learnable parameters. P-1D-CNN works on
the concept of refinement approach and it results in 60% fewer parameters
compared to traditional CNN models. Further to overcome the limitations of
small amount of data, we proposed augmentation schemes for learning P-1D-CNN
model. In almost all the cases concerning epilepsy detection, the proposed
system gives an accuracy of 99.1+-0.9% on the University of Bonn dataset.Comment: 18 page
Computational neurorehabilitation: modeling plasticity and learning to predict recovery
Despite progress in using computational approaches to inform medicine and neuroscience in the last 30 years, there have been few attempts to model the mechanisms underlying sensorimotor rehabilitation. We argue that a fundamental understanding of neurologic recovery, and as a result accurate predictions at the individual level, will be facilitated by developing computational models of the salient neural processes, including plasticity and learning systems of the brain, and integrating them into a context specific to rehabilitation. Here, we therefore discuss Computational Neurorehabilitation, a newly emerging field aimed at modeling plasticity and motor learning to understand and improve movement recovery of individuals with neurologic impairment. We first explain how the emergence of robotics and wearable sensors for rehabilitation is providing data that make development and testing of such models increasingly feasible. We then review key aspects of plasticity and motor learning that such models will incorporate. We proceed by discussing how computational neurorehabilitation models relate to the current benchmark in rehabilitation modeling – regression-based, prognostic modeling. We then critically discuss the first computational neurorehabilitation models, which have primarily focused on modeling rehabilitation of the upper extremity after stroke, and show how even simple models have produced novel ideas for future investigation. Finally, we conclude with key directions for future research, anticipating that soon we will see the emergence of mechanistic models of motor recovery that are informed by clinical imaging results and driven by the actual movement content of rehabilitation therapy as well as wearable sensor-based records of daily activity
Aberrant posterior cingulate connectivity classify first-episode schizophrenia from controls: A machine learning study
Background Posterior cingulate cortex (PCC) is a key aspect of the default mode network (DMN). Aberrant PCC functional connectivity (FC) is implicated in schizophrenia, but the potential for PCC related changes as biological classifier of schizophrenia has not yet been evaluated. Methods We conducted a data-driven approach using resting-state functional MRI data to explore differences in PCC-based region- and voxel-wise FC patterns, to distinguish between patients with first-episode schizophrenia (FES) and demographically matched healthy controls (HC). Discriminative PCC FCs were selected via false discovery rate estimation. A gradient boosting classifier was trained and validated based on 100 FES vs. 93 HC. Subsequently, classification models were tested in an independent dataset of 87 FES patients and 80 HC using resting-state data acquired on a different MRI scanner. Results Patients with FES had reduced connectivity between PCC and frontal areas, left parahippocampal regions, left anterior cingulate cortex, and right inferior parietal lobule, but hyperconnectivity with left lateral temporal regions. Predictive voxel-wise clusters were similar to region-wise selected brain areas functionally connected with PCC in relation to discriminating FES from HC subject categories. Region-wise analysis of FCs yielded a relatively high predictive level for schizophrenia, with an average accuracy of 72.28% in the independent samples, while selected voxel-wise connectivity yielded an accuracy of 68.72%. Conclusion FES exhibited a pattern of both increased and decreased PCC-based connectivity, but was related to predominant hypoconnectivity between PCC and brain areas associated with DMN, that may be a useful differential feature revealing underpinnings of neuropathophysiology for schizophrenia
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