DESIGN, DEVELOPMENT, AND EVALUATION OF A MRI-GUIDED NEUROSURGICAL INTRACRANIAL ROBOT

Brain tumors are among the most feared complications of cancer. Their treatment is challenging because of the lack of good imaging modality and the inability to remove the complete tumor. To overcome this limitation, we propose to develop a Magnetic Resonance Imaging (MRI)-compatible neurosurgical robot. The robot can be operated under continuous MRI, and the Magnetic Resonance (MR) images can be used to supplement physicians' visual capabilities, resulting in precise tumor removal. We have developed two prototypes of the Minimally Invasive Neurosurgical Intracranial Robot (MINIR) using MRI compatible materials and shape memory alloy (SMA) actuators. The major difference between the two robots is that one uses SMA wire actuators and the other uses SMA spring actuators combined with the tendon-sheath mechanism. Due to space limitation inside the robot body and the strong magnetic field in the MRI scanner, most sensors cannot be used inside the robot body. Hence, one possible approach is to rely on image feedback to control the motion of the robot. In this research, as a preliminary approach, we have relied on image feedback from a camera to control the motion of the robot. Since the image tracking algorithm may fail in some situations, we also developed a temperature feedback control scheme which served as a backup controller for the robot. Experimental results demonstrated that both image feedback and temperature feedback can be used reliably to control the joint motion of the robots. A series of MRI compatibility tests were performed to evaluate the MRI compatibility of the robots and to assess the degradation in image quality. The experimental results demonstrated that the robots are MRI compatible and created no significant image distortion in the MR images during actuation. The accomplishments presented in this dissertation represent a significant development of using SMA actuators to actuate MRI-compatible robots. It is anticipated that, in the future, continuous MR imaging would be used reliably to control the motion of the robot. It is aspired that the robot design and the control methods of SMA actuators developed in this research can be utilized in practical applications

Smart actuation and sensing for meso-scale surgical robotic systems

This dissertation presents the development of meso-scale surgical robotics based on smart actuation and sensing for minimally invasive surgery (MIS). By replacing conventional straight tools by steerable surgical robots, surgical outcomes can potentially be improved due to more precise, stable, and flexible manipulation. Since bending and torsion are the two fundamental motion forms required by surgical tools to complete general surgical procedures, compact torsion and bending modules, both integrated with intrinsic sensors for motion feedback, have been developed based on shape memory alloy (SMA). The developed actuation and sensing techniques have been applied on a robot for neurosurgical intracerebral hemorrhage evacuation (NICHE) and a steerable catheter for atrial fibrillation (AFib) treatment. The NICHE robot consists of a straight stem, an SMA torsion module, and an SMA bending module as a distal bending tip. By synchronizing the motion of the stem, the bending module, and the torsion module, the robot is capable of tip articulation within the brain to remove hemorrhage effectively through suction and electrocauterization. In addition, a skull-mounted robotic headframe has been developed based on a Stewart platform to manipulate the NICHE robot. The robotic catheter is developed by integrating multiple SMA bending modules with flexible braid reinforced tubing. Polymer 3D-printing is used to fabricate all the structural components due to its relatively low cost, short fabrication period, and capability of fabricating complicated structures with high accuracy. The developed surgical robotic systems have been thoroughly evaluated using phantom or cadaver models under computed tomography (CT) and/or magnetic resonance imaging (MRI) guidance. The imaging-guided experimental studies showed that the developed robotic systems consisting of smart actuation and sensing were compatible with CT and MR imaging.Ph.D

Utilizing Systematic Design and Shape Memory Alloys to Enhance Actuation of Modular High-Frequency Origami Robots

Shape memory alloys (SMAs) describe a group of smart metallic materials that can be deformed by external magnetic, thermal, or mechanical influence and then returned to a predetermined shape through the cycling of temperature or stress. They have several advantages, such as having excellent mechanical properties, being low cost, and being easily manufactured, while also providing a compact size, completely silent operation, high work density, and requiring less maintenance over time. SMAs can undergo sold-to-solid phase transformations, and it is because of these phase transformations that they can experience shape memory effect (SME); or the ability to recover from a deformed shape to an initially determined shape through the cycling of temperature. However, since SME requires the cycling of temperature to actuate SMAs, the actuation frequency of these materials has been slow for small-scale applications, as actuation speed is limited by the time it takes to transition from a higher temperature (actuated, pre-determined state) to a lower temperature (flexible, reconfigurable state). While SMAs are known to be highly advantageous, their main drawback is that they are one of the slowest actuation methods in the field of origami robotics. SMAs cannot actuate quickly enough cyclically due to the long cooling times required to get from their austenite (higher temperature, actuated, pre-determined state) phase to their martensite (lower temperature, flexible, reconfigurable state) phase. Researchers have attempted to achieve a higher actuation speed in previous projects by using active cooling agents. However, this study investigated the use of SMAs to initiate high-frequency cyclic movement through a small-scale origami fold without an active cooling source. This study used a combination of different system design parameters to mechanically hasten the actuation speed of a folding hinge with no cooling component present. Through only design and a complete understanding of the SMAs, this study achieved consistent and relatively high results (\u3e1.5 Hz) of an actuation speed for a system of this size. This study discovered knowledge regarding the composition, material properties, and actuation limits of SMAs, and a new systematic design method was proposed for creating origami robots

SMA-Based Muscle-Like Actuation in Biologically Inspired Robots: A State of the Art Review

New actuation technology in functional or "smart" materials has opened new horizons in robotics actuation systems. Materials such as piezo-electric fiber composites, electro-active polymers and shape memory alloys (SMA) are being investigated as promising alternatives to standard servomotor technology [52]. This paper focuses on the use of SMAs for building muscle-like actuators. SMAs are extremely cheap, easily available commercially and have the advantage of working at low voltages. The use of SMA provides a very interesting alternative to the mechanisms used by conventional actuators. SMAs allow to drastically reduce the size, weight and complexity of robotic systems. In fact, their large force-weight ratio, large life cycles, negligible volume, sensing capability and noise-free operation make possible the use of this technology for building a new class of actuation devices. Nonetheless, high power consumption and low bandwidth limit this technology for certain kind of applications. This presents a challenge that must be addressed from both materials and control perspectives in order to overcome these drawbacks. Here, the latter is tackled. It has been demonstrated that suitable control strategies and proper mechanical arrangements can dramatically improve on SMA performance, mostly in terms of actuation speed and limit cycles

Monolithic self-supportive bi-directional bending pneumatic bellows catheter

The minimally invasive surgery has proven to be advantageous over conventional open surgery in terms of reduction in recovery time, patient trauma, and overall cost of treatment. To perform a minimally invasive procedure, preliminary insertion of a flexible tube or catheter is crucial without sacrificing its ability to manoeuvre. Nevertheless, despite the vast amount of research reported on catheters, the ability to implement active catheters in the minimally invasive application is still limited. To date, active catheters are made of rigid structures constricted to the use of wires or on-board power supplies for actuation, which increases the risk of damaging the internal organs and tissues. To address this issue, an active catheter made of soft, flexible and biocompatible structure, driven via nonelectric stimulus is of utmost importance. This thesis presents the development of a novel monolithic self-supportive bi-directional bending pneumatic bellows catheter using a sacrificial molding technique. As a proof of concept, in order to understand the effects of structural parameters on the bending performance of a bellows-structured actuator, a single channel circular bellows pneumatic actuator was designed. The finite element analysis was performed in order to analyze the unidirectional bending performance, while the most optimal model was fabricated for experimental validation. Moreover, to attain biocompatibility and bidirectional bending, the novel monolithic polydimethylsiloxane (PDMS)-based dual-channel square bellows pneumatic actuator was proposed. The actuator was designed with an overall cross-sectional area of 5 x 5 mm2, while the input sequence and the number of bellows were characterized to identify their effects on the bending performance. A novel sacrificial molding technique was adopted for developing the monolithic-structured actuator, which enabled simple fabrication for complex designs. The experimental validation revealed that the actuator model with a size of5 x 5 x 68.4 mm3 i.e. having the highest number of bellows, attained optimal bi-directional bending with maximum angles of -65° and 75°, and force of 0.166 and 0.221 N under left and right channel actuation, respectively, at 100 kPa pressure. The bending performance characterization and thermal insusceptibility achieved by the developed pneumatic catheter presents a promising implementation of flexibility and thermal stability for various biomedical applications, such as dialysis and cardiac catheterization

New trends in 4D printing: A critical review

In a variety of industries, Additive Manufacturing has revolutionized the whole design-fabrication cycle. Traditional 3D printing is typically employed to produce static components, which are not able to fulfill the dynamic structures requirements and relevant applications such as soft grippers, self-assembly systems, and smart actuators. To address this limitation, an innovative technology has emerged and is called “4D printing”. It processes smart materials by using 3D printing for fabricating smart structures that can be reconfigured by applying different inputs such as heat, humidity, magnetic, electricity, light etc. At present, 4D printing is still a growing technology and it presents numerous challenges regarding materials, design, simulation, fabrication processes, applied strategies and reversibility. In this work a critical review about 4D printing technologies, materials and applications is discussed

A Novel Flexible and Steerable Probe for Minimally Invasive Soft Tissue Intervention

Current trends in surgical intervention favour a minimally invasive (MI) approach, in which complex procedures are performed through increasingly small incisions. Specifically, in neurosurgery, there is a need for minimally invasive keyhole access, which conflicts with the lack of maneuverability of conventional rigid instruments. In an attempt to address this fundamental shortcoming, this thesis describes the concept design, implementation and experimental validation of a novel flexible and steerable probe, named “STING” (Soft Tissue Intervention and Neurosurgical Guide), which is able to steer along curvilinear trajectories within a compliant medium. The underlying mechanism of motion of the flexible probe, based on the reciprocal movement of interlocked probe segments, is biologically inspired and was designed around the unique features of the ovipositor of certain parasitic wasps. Such insects are able to lay eggs by penetrating different kinds of “host” (e.g. wood, larva) with a very thin and flexible multi-part channel, thanks to a micro-toothed surface topography, coupled with a reciprocating “push and pull” motion of each segment. This thesis starts by exploring these foundations, where the “microtexturing” of the surface of a rigid probe prototype is shown to facilitate probe insertion into soft tissue (porcine brain), while gaining tissue purchase when the probe is tensioned outwards. Based on these findings, forward motion into soft tissue via a reciprocating mechanism is then demonstrated through a focused set of experimental trials in gelatine and agar gel. A flexible probe prototype (10 mm diameter), composed of four interconnected segments, is then presented and shown to be able to steer in a brain-like material along multiple curvilinear trajectories on a plane. The geometry and certain key features of the probe are optimised through finite element models, and a suitable actuation strategy is proposed, where the approach vector of the tip is found to be a function of the offset between interlocked segments. This concept of a “programmable bevel”, which enables the steering angle to be chosen with virtually infinite resolution, represents a world-first in percutaneous soft tissue surgery. The thesis concludes with a description of the integration and validation of a fully functional prototype within a larger neurosurgical robotic suite (EU FP7 ROBOCAST), which is followed by a summary of the corresponding implications for future work

Anthropomorphic surgical system for soft tissue robot-assisted surgery

Over the past century, abdominal surgery has seen a rapid transition from open procedures to less invasive methods such as laparoscopy and robot-assisted minimally invasive surgery (R-A MIS). These procedures have significantly decreased blood loss, postoperative morbidity and length of hospital stay in comparison with open surgery. R-A MIS has offered refined accuracy and more ergonomic instruments for surgeons, further minimising trauma to the patient.This thesis aims to investigate, design and prototype a novel system for R-A MIS that will provide more natural and intuitive manipulation of soft tissues and, at the same time, increase the surgeon's dexterity. The thesis reviews related work on surgical systems and discusses the requirements for designing surgical instrumentation. From the background research conducted in this thesis, it is clear that training surgeons in MIS procedures is becoming increasingly long and arduous. Furthermore, most available systems adopt a design similar to conventional laparoscopic instruments or focus on different techniques with debatable benefits. The system proposed in this thesis not only aims to reduce the training time for surgeons but also to improve the ergonomics of the procedure.In order to achieve this, a survey was conducted among surgeons, regarding their opinions on surgical training, surgical systems, how satisfied they are with them and how easy they are to use. A concept for MIS robotic instrumentation was then developed and a series of focus group meetings with surgeons were run to discuss it. The proposed system, named microAngelo, is an anthropomorphic master-slave system that comprises a three-digit miniature hand that can be controlled using the master, a three-digit sensory exoskeleton. While multi-fingered robotic hands have been developed for decades, none have been used for surgical operations. As the system has a human centred design, its relation to the human hand is discussed. Prototypes of both the master and the slave have been developed and their design and mechanisms is demonstrated. The accuracy and repeatability of the master as well as the accuracy and force capabilities of the slave are tested and discussed

経尿道的結石破砕術における精密レーザー照射のための形状記憶合金を用いた多方向屈曲デバイス

Tohoku University芳賀洋一課

Flexible robotic device for spinal surgery

Surgical robots have proliferated in recent years, with well-established benefits including: reduced patient trauma, shortened hospitalisation, and improved diagnostic accuracy and therapeutic outcome. Despite these benefits, many challenges in their development remain, including improved instrument control and ergonomics caused by rigid instrumentation and its associated fulcrum effect. Consequently, it is still extremely challenging to utilise such devices in cases that involve complex anatomical pathways such as the spinal column. The focus of this thesis is the development of a flexible robotic surgical cutting device capable of manoeuvring around the spinal column. The target application of the flexible surgical tool is the removal of cancerous tumours surrounding the spinal column, which cannot be excised completely using the straight surgical tools in use today; anterior and posterior sections of the spine must be accessible for complete tissue removal. A parallel robot platform with six degrees of freedom (6 DoFs) has been designed and fabricated to direct a flexible cutting tool to produce the necessary range of movements to reach anterior and posterior sections of the spinal column. A flexible water jet cutting system and a flexible mechanical drill, which may be assembled interchangeably with the flexible probe, have been developed and successfully tested experimentally. A model predicting the depth of cut by the water jet was developed and experimentally validated. A flexion probe that is able to guide the surgical cutting device around the spinal column has been fabricated and tested with human lumber model. Modelling and simulations show the capacity for the flexible surgical system to enable entering the posterior side of the human lumber model and bend around the vertebral body to reach the anterior side of the spinal column. A computer simulation with a full Graphical User Interface (GUI) was created and used to validate the system of inverse kinematic equations for the robot platform. The constraint controller and the inverse kinematics relations are both incorporated into the overall positional control structure of the robot, and have successfully established a haptic feedback controller for the 6 DoFs surgical probe, and effectively tested in vitro on spinal mock surgery. The flexible surgical system approached the surgery from the posterior side of the human lumber model and bend around the vertebral body to reach the anterior side of the spinal column. The flexible surgical robot removed 82% of mock cancerous tissue compared to 16% of tissue removed by the rigid tool.Open Acces