Near-complete external difference families

We introduce and explore near-complete external difference families, a partitioning of the nonidentity elements of a group so that each nonidentity element is expressible as a difference of elements from distinct subsets a fixed number of times. We show that the existence of such an object implies the existence of a near-resolvable design. We provide examples and general constructions of these objects, some of which lead to new parameter families of near-resolvable designs on a non-prime-power number of points. Our constructions employ cyclotomy, partial difference sets, and Galois rings.PostprintPeer reviewe

Existence and non-existence results for Strong External Difference Families

We consider strong external difference families (SEDFs); these are external difference families satisfying additional conditions on the patterns of external differences that occur, and were first defined in the context of classifying optimal strong algebraic manipulation detection codes. We establish new necessary conditions for the existence of (n, m, k, �)-SEDFs; in particular giving a near-complete treatment of the � = 2 case. For the case m = 2, we obtain a structural characterization for partition type SEDFs (of maximum possible k and �), showing that these correspond to Paley partial difference sets. We also prove a version of our main result for generalized SEDFs, establishing non-trivial necessary conditions for their existence

Existence and non-existence results for strong external difference families

The first author is supported by a Research Incentive Grant from The Carnegie Trust for the Universities of Scotland (Grant No. 70582).We consider strong external difference families (SEDFs); these are external difference families satisfying additional conditions on the patterns of external differences that occur, and were first defined in the context of classifying optimal strong algebraic manipulation detection codes. We establish new necessary conditions for the existence of (n , m , k , λ) -SEDFs; in particular giving a near-complete treatment of the λ = 2 case. For the case m = 2 , we obtain a structural characterization for partition type SEDFs (of maximum possible k and λ), showing that these correspond to Paley partial difference sets. We also prove a version of our main result for generalized SEDFs, establishing non-trivial necessary conditions for their existence.PostprintPeer reviewe

Weighted external difference families and R-optimal AMD codes

In this paper, we provide a mathematical framework for characterizing AMD codes that are R-optimal. We introduce a new combinatorial object, the reciprocally-weighted external difference family (RWEDF), which corresponds precisely to an R-optimal weak AMD code. This definition subsumes known examples of existing optimal codes, and also encompasses combinatorial objects not covered by previous definitions in the literature. By developing structural group-theoretic characterizations, we exhibit infinite families of new RWEDFs, and new construction methods for known objects such as near-complete EDFs. Examples of RWEDFs in non-abelian groups are also discussed

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates.

Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigrees suggests that, in such families, large-effect inherited variants might play a greater role. To identify roles of rare and common variants on BP, we conducted genetic analyses in 26 Colombia and Costa Rica pedigrees ascertained for bipolar disorder 1 (BP1), the most severe and heritable form of BP. In these pedigrees, we performed microarray SNP genotyping of 838 individuals and high-coverage whole-genome sequencing of 449 individuals. We compared polygenic risk scores (PRS), estimated using the latest BP1 genome-wide association study (GWAS) summary statistics, between BP1 individuals and related controls. We also evaluated whether BP1 individuals had a higher burden of rare deleterious single-nucleotide variants (SNVs) and rare copy number variants (CNVs) in a set of genes related to BP1. We found that compared with unaffected relatives, BP1 individuals had higher PRS estimated from BP1 GWAS statistics (P = 0.001 ~ 0.007) and displayed modest increase in burdens of rare deleterious SNVs (P = 0.047) and rare CNVs (P = 0.002 ~ 0.033) in genes related to BP1. We did not observe rare variants segregating in the pedigrees. These results suggest that small-to-moderate effect rare and common variants are more likely to contribute to BP1 risk in these extended pedigrees than a few large-effect rare variants

Phase diagram and magnetic properties of La1−x_{1-x}Cax_xMnO3_3 compound for 0≤x≤0.230\leq x \leq 0.23

In this article a detailed study of La$_{1-x}$Ca$_x$MnO$_3$ ($0\leq x \leq 0.23$) phase diagram using powder x-ray diffraction and magnetization measurements is presented. Unfortunately, in the related literature no properly characterized samples have been used, with consequence the smearing of the real physics in this complicated system. As the present results reveal, there are two families of samples. The first family concerns samples prepared in atmosphere ($P({\rm O}_2)=0.2$ Atm) which are all ferromagnetic with Curie temperature rising with $x$. The second family concerns samples, where a post annealing in nearly zero oxygen partial pressure is applied. These samples show a canted antiferromagnetic structure for $0\leq x \leq 0.1$ below $T_N$, while for $0.125\leq x <0.23$ an unconventional ferromagnetic insulated phase is present below $T_c$. The most important difference between nonstoichiometric and stoichiometric samples concerning the magnetic behavior, is the anisotropy in the exchange interactions, in the stoichiometric samples putting forward the idea that a new orbital ordered phase is responsible for the ferromagnetic insulating regime in the La$_{1-x}$Ca$_x$MnO$_3$ compound