Mindreading in individuals with an empathizing versus systemizing cognitive style An fMRI study

Our fMRI study compares the neural correlates of face-based mindreading in healthy individuals with an empathizing (n=12) versus systemizing cognitive style (n=12). The empathizing group consists of individuals that score high on empathizing and low on systemizing, while the systemizing group consists of individuals with an opposite cognitive pattern. We hypothesize that the empathizing group will show stronger simulation-type neural activity (e.g., in mirror neuron areas, medial prefrontal cortex, anterior cingulate cortex) or simulation-related neural activity (e.g., in areas involved in perspective taking and experiential processing) compared to the systemizing group. As hypothesized, our study reveals that the empathizing group shows significantly stronger activity in mirror neuron areas of the brain, such as the left inferior frontal gyrus and inferior parietal lobe, and in temporal areas involved in perspective taking and autobiographical memory. Moreover, the empathizing group, but not the systemizing group, shows activity in the medial prefrontal cortex and anterior cingulate cortex which have been related to simulation-type neural activity in the brain and are central to mindreading. Also, the systemizing group shows significantly stronger activity in the left parahippocampal gyrus. In conclusion, both the empathizing and systemizing individuals show simulation-type and simulation-related neural activity during face-based mindreading. However, more neural activity indicative of simulation-based processing is seen in the empathizing individuals, while more neural activity indicative of non-simulation-based processing is seen in the systemizing individuals

Information transmission in oscillatory neural activity

Periodic neural activity not locked to the stimulus or to motor responses is usually ignored. Here, we present new tools for modeling and quantifying the information transmission based on periodic neural activity that occurs with quasi-random phase relative to the stimulus. We propose a model to reproduce characteristic features of oscillatory spike trains, such as histograms of inter-spike intervals and phase locking of spikes to an oscillatory influence. The proposed model is based on an inhomogeneous Gamma process governed by a density function that is a product of the usual stimulus-dependent rate and a quasi-periodic function. Further, we present an analysis method generalizing the direct method (Rieke et al, 1999; Brenner et al, 2000) to assess the information content in such data. We demonstrate these tools on recordings from relay cells in the lateral geniculate nucleus of the cat.Comment: 18 pages, 8 figures, to appear in Biological Cybernetic

Large-scale multielectrode recording and stimulation of neural activity

Large circuits of neurons are employed by the brain to encode and process information. How this encoding and processing is carried out is one of the central questions in neuroscience. Since individual neurons communicate with each other through electrical signals (action potentials), the recording of neural activity with arrays of extracellular electrodes is uniquely suited for the investigation of this question. Such recordings provide the combination of the best spatial (individual neurons) and temporal (individual action-potentials) resolutions compared to other large-scale imaging methods. Electrical stimulation of neural activity in turn has two very important applications: it enhances our understanding of neural circuits by allowing active interactions with them, and it is a basis for a large variety of neural prosthetic devices. Until recently, the state-of-the-art in neural activity recording systems consisted of several dozen electrodes with inter-electrode spacing ranging from tens to hundreds of microns. Using silicon microstrip detector expertise acquired in the field of high-energy physics, we created a unique neural activity readout and stimulation framework that consists of high-density electrode arrays, multi-channel custom-designed integrated circuits, a data acquisition system, and data-processing software. Using this framework we developed a number of neural readout and stimulation systems: (1) a 512-electrode system for recording the simultaneous activity of as many as hundreds of neurons, (2) a 61-electrode system for electrical stimulation and readout of neural activity in retinas and brain-tissue slices, and (3) a system with telemetry capabilities for recording neural activity in the intact brain of awake, naturally behaving animals. We will report on these systems, their various applications to the field of neurobiology, and novel scientific results obtained with some of them. We will also outline future directions

Bootstrap testing for cross-correlation under low firing activity

A new cross-correlation synchrony index for neural activity is proposed. The index is based on the integration of the kernel estimation of the cross-correlation function. It is used to test for the dynamic synchronization levels of spontaneous neural activity under two induced brain states: sleep-like and awake-like. Two bootstrap resampling plans are proposed to approximate the distribution of the test statistics. The results of the first bootstrap method indicate that it is useful to discern significant differences in the synchronization dynamics of brain states characterized by a neural activity with low firing rate. The second bootstrap method is useful to unveil subtle differences in the synchronization levels of the awake-like state, depending on the activation pathway.Comment: 22 pages, 7 figure

Learning Hybrid System Models for Supervisory Decoding of Discrete State, with applications to the Parietal Reach Region

Based on Gibbs sampling, a novel method to identify mathematical models of neural activity in response to temporal changes of behavioral or cognitive state is presented. This work is motivated by the developing field of neural prosthetics, where a supervisory controller is required to classify activity of a brain region into suitable discrete modes. Here, neural activity in each discrete mode is modeled with nonstationary point processes, and transitions between modes are modeled as hidden Markov models. The effectiveness of this framework is first demonstrated on a simulated example. The identification algorithm is then applied to extracellular neural activity recorded from multi-electrode arrays in the parietal reach region of a rhesus monkey, and the results demonstrate the ability to decode discrete changes even from small data sets

Self-generated neural activity : models and perspective

Poster presentation: The brain is autonomously active and this self-sustained neural activity is in general modulated, but not driven, by the sensory input data stream [1,2]. Traditionally one has regarded this eigendynamics as resulting from inter-modular recurrent neural activity [3]. Understanding the basic modules for cognitive computation is, in this view, the primary focus of research and the overall neural dynamics would be determined by the the topology of the intermodular pathways. Here we examine an alternative point of view, asking whether certain aspects of the neural eigendynamics have a central functional role for overall cognitive computation [4,5]. Transiently stable neural activity is regularly observed on the cognitive time-scale of 80–100 ms, with indications that neural competition [6] plays an important role in the selection of the transiently stable neural ensembles [7], also denoted winning coalitions [8]. We report on a theory approach which implements these two principles, transient-state dynamics and neural competition, in terms of an associative neural network with clique encoding [9]. A cognitive system [10] with a non-trivial internal eigendynamics has two seemingly contrasting tasks to fulfill. The internal processes need to be regular and not chaotic on one side, but sensitive to the afferent sensory stimuli on the other side. We show, that these two contrasting demands can be reconciled within our approach based on competitive transient-state dynamics, when allowing the sensory stimuli to modulate the competition for the next winning coalition. By testing the system with the bars problem, we find an emerging cognitive capability. Only based on the two basic architectural principles, neural competition and transient-state dynamics, with no explicit algorithmic encoding, the system performs on its own a non-linear independent component analysis of input data stream. The system has rudimentary biological features. All learning is local Hebbian-style, unsupervised and online. It exhibits an ever-ongoing eigendynamics and at no time is the state or the value of synaptic strengths reset or the system restarted; there is no separation between training and performance. We believe that this kind of approach – cognitive computation with autonomously active neural networks – to be an emerging field, relevant both for system neuroscience and synthetic cognitive systems

Periodic Neural Activity Induced by Network Complexity

We study a model for neural activity on the small-world topology of Watts and Strogatz and on the scale-free topology of Barab\'asi and Albert. We find that the topology of the network connections may spontaneously induce periodic neural activity, contrasting with chaotic neural activities exhibited by regular topologies. Periodic activity exists only for relatively small networks and occurs with higher probability when the rewiring probability is larger. The average length of the periods increases with the square root of the network size.Comment: 4 pages, 5 figure

Neural correlates of consciousness are not pictorial representations

O'Regan & Noe (O&N) are pessimistic about the prospects for discovering the neural correlates of consciousness. They argue that there can be no one-to-one correspondence between awareness and patterns of neural activity in the brain, so a project attempting to identify the neural correlates of consciousness is doomed to failure. We believe that this degree of pessimism may be overstated; recent empirical data show some convergence in describing consistent patterns of neural activity associated with visual consciousness