Multi-Population Differential Evolution for Retinal Blood Vessel Segmentation

The retinal blood vessel segmentation plays a significant role in the automatic or computer-assisted diagnosis of retinopathy. Manual blood vessel segmentation is very time-consuming and requires a great amount of domain knowledge. In addition, the blood vessels are only a few pixels wide and cover the entire fundus image. This further hinders the recent systems from automating the retinal blood vessel segmentation efficiently. In this paper, we propose a modified differential evolution (DE) algorithm to carry out automatic retinal blood vessel segmentation. The modified DE employs cross-communication among multiple populations to select three types of features i.e. thick blood vessels, thin blood vessels and non-blood vessels. Multiple classifiers such as neural networks (NN), Support vector machines (SVM), NN based and SVM based ensembles are used to further measure the performance of segmentation. The proposed algorithm is evaluated on three publicly available retinal image datasets like DRIVE, STARE and HRF. It outperformed the state-of-the-art with a high average accuracy of 98.5% along with high sensitivity and specificity

Improved modelling of the human cerebral vasculature

Ph.DDOCTOR OF PHILOSOPH

Retinal Vessels Segmentation Techniques and Algorithms: A Survey

Retinal vessels identification and localization aim to separate the different retinal vasculature structure tissues, either wide or narrow ones, from the fundus image background and other retinal anatomical structures such as optic disc, macula, and abnormal lesions. Retinal vessels identification studies are attracting more and more attention in recent years due to non-invasive fundus imaging and the crucial information contained in vasculature structure which is helpful for the detection and diagnosis of a variety of retinal pathologies included but not limited to: Diabetic Retinopathy (DR), glaucoma, hypertension, and Age-related Macular Degeneration (AMD). With the development of almost two decades, the innovative approaches applying computer-aided techniques for segmenting retinal vessels are becoming more and more crucial and coming closer to routine clinical applications. The purpose of this paper is to provide a comprehensive overview for retinal vessels segmentation techniques. Firstly, a brief introduction to retinal fundus photography and imaging modalities of retinal images is given. Then, the preprocessing operations and the state of the art methods of retinal vessels identification are introduced. Moreover, the evaluation and validation of the results of retinal vessels segmentation are discussed. Finally, an objective assessment is presented and future developments and trends are addressed for retinal vessels identification techniques.https://doi.org/10.3390/app802015

A Multi-Anatomical Retinal Structure Segmentation System For Automatic Eye Screening Using Morphological Adaptive Fuzzy Thresholding

Eye exam can be as efficacious as physical one in determining health concerns. Retina screening can be the very first clue to detecting a variety of hidden health issues including pre-diabetes and diabetes. Through the process of clinical diagnosis and prognosis; ophthalmologists rely heavily on the binary segmented version of retina fundus image; where the accuracy of segmented vessels, optic disc and abnormal lesions extremely affects the diagnosis accuracy which in turn affect the subsequent clinical treatment steps. This thesis proposes an automated retinal fundus image segmentation system composed of three segmentation subsystems follow same core segmentation algorithm. Despite of broad difference in features and characteristics; retinal vessels, optic disc and exudate lesions are extracted by each subsystem without the need for texture analysis or synthesis. For sake of compact diagnosis and complete clinical insight, our proposed system can detect these anatomical structures in one session with high accuracy even in pathological retina images. The proposed system uses a robust hybrid segmentation algorithm combines adaptive fuzzy thresholding and mathematical morphology. The proposed system is validated using four benchmark datasets: DRIVE and STARE (vessels), DRISHTI-GS (optic disc), and DIARETDB1 (exudates lesions). Competitive segmentation performance is achieved, outperforming a variety of up-to-date systems and demonstrating the capacity to deal with other heterogenous anatomical structures

AUTOMATED ANALYSIS OF NEURONAL MORPHOLOGY: DETECTION, MODELING AND RECONSTRUCTION

Ph.DDOCTOR OF PHILOSOPH