A self-adaptive multimeme memetic algorithm co-evolving utility scores to control genetic operators and their parameter settings

Memetic algorithms are a class of well-studied metaheuristics which combine evolutionary algorithms and local search techniques. A meme represents contagious piece of information in an adaptive information sharing system. The canonical memetic algorithm uses a fixed meme, denoting a hill climbing operator, to improve each solution in a population during the evolutionary search process. Given global parameters and multiple parametrised operators, adaptation often becomes a crucial constituent in the design of MAs. In this study, a self-adaptive self-configuring steady-state multimeme memetic algorithm (SSMMA) variant is proposed. Along with the individuals (solutions), SSMMA co-evolves memes, encoding the utility score for each algorithmic component choice and relevant parameter setting option. An individual uses tournament selection to decide which operator and parameter setting to employ at a given step. The performance of the proposed algorithm is evaluated on six combinatorial optimisation problems from a cross-domain heuristic search benchmark. The results indicate the success of SSMMA when compared to the static Mas as well as widely used self-adaptive Multimeme Memetic Algorithm from the scientific literature

Coevolving memetic algorithms: A review and progress report

Coevolving memetic algorithms are a family of metaheuristic search algorithms in which a rule-based representation of local search (LS) is coadapted alongside candidate solutions within a hybrid evolutionary system. Simple versions of these systems have been shown to outperform other nonadaptive memetic and evolutionary algorithms on a range of problems. This paper presents a rationale for such systems and places them in the context of other recent work on adaptive memetic algorithms. It then proposes a general structure within which a population of LS algorithms can be evolved in tandem with the solutions to which they are applied. Previous research started with a simple self-adaptive system before moving on to more complex models. Results showed that the algorithm was able to discover and exploit certain forms of structure and regularities within the problems. This "metalearning" of problem features provided a means of creating highly scalable algorithms. This work is briefly reviewed to highlight some of the important findings and behaviors exhibited. Based on this analysis, new results are then presented from systems with more flexible representations, which, again, show significant improvements. Finally, the current state of, and future directions for, research in this area is discussed. © 2007 IEEE

On the role of metaheuristic optimization in bioinformatics

Metaheuristic algorithms are employed to solve complex and large-scale optimization problems in many different fields, from transportation and smart cities to finance. This paper discusses how metaheuristic algorithms are being applied to solve different optimization problems in the area of bioinformatics. While the text provides references to many optimization problems in the area, it focuses on those that have attracted more interest from the optimization community. Among the problems analyzed, the paper discusses in more detail the molecular docking problem, the protein structure prediction, phylogenetic inference, and different string problems. In addition, references to other relevant optimization problems are also given, including those related to medical imaging or gene selection for classification. From the previous analysis, the paper generates insights on research opportunities for the Operations Research and Computer Science communities in the field of bioinformatics

Active modules identification in multilayer intracellular networks

The network analysis has become a basic tool to gain insights on evolution and organization of living organisms in computational system biology. Since a group of genes may get involved into a biological process other than act alone, identifying modules from biological networks has been a central challenge to this field in the past decade. Several representative methods have been proposed to search such important modules using different intuitions while no unified framework exists yet, especially for multilayer networks, which can model gene expression dynamics and species conservation. This thesis provides a comprehensive study on active modules identification in multilayer intracellular networks, with the following main contributions: - An improvement on a heuristic method for identifying active modules from protein-protein interaction (PPI) networks. - A new objective of active modules to incorporate the topological structure and active property on the single layer and multilayer dynamic PPI network, and a convex optimization algorithm to solve it. - A new definition for active modules in single layer and multilayer gene co-expression networks and a novel algorithm which achieves the state-of-the-art performance. - A framework to conduct networks comparison via modules differentiation analysis, which can find condition-specific modules as well as conserved modules

Knowledge management overview of feature selection problem in high-dimensional financial data: Cooperative co-evolution and Map Reduce perspectives

The term big data characterizes the massive amounts of data generation by the advanced technologies in different domains using 4Vs volume, velocity, variety, and veracity-to indicate the amount of data that can only be processed via computationally intensive analysis, the speed of their creation, the different types of data, and their accuracy. High-dimensional financial data, such as time-series and space-Time data, contain a large number of features (variables) while having a small number of samples, which are used to measure various real-Time business situations for financial organizations. Such datasets are normally noisy, and complex correlations may exist between their features, and many domains, including financial, lack the al analytic tools to mine the data for knowledge discovery because of the high-dimensionality. Feature selection is an optimization problem to find a minimal subset of relevant features that maximizes the classification accuracy and reduces the computations. Traditional statistical-based feature selection approaches are not adequate to deal with the curse of dimensionality associated with big data. Cooperative co-evolution, a meta-heuristic algorithm and a divide-And-conquer approach, decomposes high-dimensional problems into smaller sub-problems. Further, MapReduce, a programming model, offers a ready-To-use distributed, scalable, and fault-Tolerant infrastructure for parallelizing the developed algorithm. This article presents a knowledge management overview of evolutionary feature selection approaches, state-of-The-Art cooperative co-evolution and MapReduce-based feature selection techniques, and future research directions

DISCOVERING DRIVER MUTATIONS IN BIOLOGICAL DATA

Background Somatic mutations accumulate in human cells throughout life. Some may have no adverse consequences, but some of them may lead to cancer. A cancer genome is typically unstable, and thus more mutations can accumulate in the DNA of cancer cells. An ongoing problem is to figure out which mutations are drivers - play a role in oncogenesis, and which are passengers - do not play a role. One way of addressing this question is through inspection of somatic mutations in DNA of cancer samples from a cohort of patients and detection of patterns that differentiate driver from passenger mutations. Results We propose QuaDMutEx an QuadMutNetEx, a method that incorporates three novel elements: a new gene set penalty that includes non-linear penalization of multiple mutations in putative sets of driver genes, an ability to adjust the method to handle slow- and fast-evolving tumors, and a computationally efficient method for finding gene sets that minimize the penalty, through a combination of heuristic Monte Carlo optimization and exact binary quadratic programming. QuaDMutNetEx is our proposed method that combines protein-protein interaction networks to the method elements of QuaDMutEx. In particular, QuaDMutEx incorporates three novel elements: a non-linear penalization of multiple mutations in putative sets of driver genes, an ability to adjust the method to handle slow- and fast-evolving tumors, and a computationally efficient method for finding gene sets that minimize the penalty. In the new method, we incorporated a new quadratic rewarding term that prefers gene solution set that is connected with respect to protein-protein interaction networks. Compared to existing methods, the proposed algorithm finds sets of putative driver genes that show higher coverage and lower excess coverage in eight sets of cancer samples coming from brain, ovarian, lung, and breast tumors. Conclusions Superior ability to improve on both coverage and excess coverage on different types of cancer shows that QuaDMutEx and QuaDMutNetEx are tools that should be part of a state-of-the-art toolbox in the driver gene discovery pipeline. It can detect genes harboring rare driver mutations that may be missed by existing methods

Hyper‐Heuristics and Metaheuristics for Selected Bio‐Inspired Combinatorial Optimization Problems

Many decision and optimization problems arising in bioinformatics field are time demanding, and several algorithms are designed to solve these problems or to improve their current best solution approach. Modeling and implementing a new heuristic algorithm may be time‐consuming but has strong motivations: on the one hand, even a small improvement of the new solution may be worth the long time spent on the construction of a new method; on the other hand, there are problems for which good‐enough solutions are acceptable which could be achieved at a much lower computational cost. In the first case, specially designed heuristics or metaheuristics are needed, while the latter hyper‐heuristics can be proposed. The paper will describe both approaches in different domain problems

Advances in Evolutionary Algorithms

With the recent trends towards massive data sets and significant computational power, combined with evolutionary algorithmic advances evolutionary computation is becoming much more relevant to practice. Aim of the book is to present recent improvements, innovative ideas and concepts in a part of a huge EA field

Distributed and Lightweight Meta-heuristic Optimization method for Complex Problems

The world is becoming more prominent and more complex every day. The resources are limited and efficiently use them is one of the most requirement. Finding an Efficient and optimal solution in complex problems needs to practical methods. During the last decades, several optimization approaches have been presented that they can apply to different optimization problems, and they can achieve different performance on various problems. Different parameters can have a significant effect on the results, such as the type of search spaces. Between the main categories of optimization methods (deterministic and stochastic methods), stochastic optimization methods work more efficient on big complex problems than deterministic methods. But in highly complex problems, stochastic optimization methods also have some issues, such as execution time, convergence to local optimum, incompatible with distributed systems, and dependence on the type of search spaces. Therefore this thesis presents a distributed and lightweight metaheuristic optimization method (MICGA) for complex problems focusing on four main tracks. 1) The primary goal is to improve the execution time by MICGA. 2) The proposed method increases the stability and reliability of the results by using the multi-population strategy in the second track. 3) MICGA is compatible with distributed systems. 4) Finally, MICGA is applied to the different type of optimization problems with other kinds of search spaces (continuous, discrete and order based optimization problems). MICGA has been compared with other efficient optimization approaches. The results show the proposed work has been achieved enough improvement on the main issues of the stochastic methods that are mentioned before.Maailmasta on päivä päivältä tulossa yhä monimutkaisempi. Resurssit ovat rajalliset, ja siksi niiden tehokas käyttö on erittäin tärkeää. Tehokkaan ja optimaalisen ratkaisun löytäminen monimutkaisiin ongelmiin vaatii tehokkaita käytännön menetelmiä. Viime vuosikymmenien aikana on ehdotettu useita optimointimenetelmiä, joilla jokaisella on vahvuutensa ja heikkoutensa suorituskyvyn ja tarkkuuden suhteen erityyppisten ongelmien ratkaisemisessa. Parametreilla, kuten hakuavaruuden tyypillä, voi olla merkittävä vaikutus tuloksiin. Optimointimenetelmien pääryhmistä (deterministiset ja stokastiset menetelmät) stokastinen optimointi toimii suurissa monimutkaisissa ongelmissa tehokkaammin kuin deterministinen optimointi. Erittäin monimutkaisissa ongelmissa stokastisilla optimointimenetelmillä on kuitenkin myös joitain ongelmia, kuten korkeat suoritusajat, päätyminen paikallisiin optimipisteisiin, yhteensopimattomuus hajautetun toteutuksen kanssa ja riippuvuus hakuavaruuden tyypistä. Tämä opinnäytetyö esittelee hajautetun ja kevyen metaheuristisen optimointimenetelmän (MICGA) monimutkaisille ongelmille keskittyen neljään päätavoitteeseen: 1) Ensisijaisena tavoitteena on pienentää suoritusaikaa MICGA:n avulla. 2) Lisäksi ehdotettu menetelmä lisää tulosten vakautta ja luotettavuutta käyttämällä monipopulaatiostrategiaa. 3) MICGA tukee hajautettua toteutusta. 4) Lopuksi MICGA-menetelmää sovelletaan erilaisiin optimointiongelmiin, jotka edustavat erityyppisiä hakuavaruuksia (jatkuvat, diskreetit ja järjestykseen perustuvat optimointiongelmat). Työssä MICGA-menetelmää verrataan muihin tehokkaisiin optimointimenetelmiin. Tulokset osoittavat, että ehdotetulla menetelmällä saavutetaan selkeitä parannuksia yllä mainittuihin stokastisten menetelmien pääongelmiin liittyen