Investigation of Intensity Correction in the Context of Image Registration

An image registration algorithm with intensity correction was developed. A particular goal was to apply intensity correction instead of using multimodal similarity measures. The algorithm utilises common Levenberg-Marquardt optimisation. The author has chosen two dimensional affine and one dimensional B-Spline model as spatial transformation, as well as intensity correction models specific to CT images. They are global non-linear mapping and smooth local affine correction. The algorithm was tested experimentally using a wide class of simulated images and a limited class of medical images. Affine registration works properly even for deformations which exceed typical deformation encountered in medical practice. B-Spline registration works properly for small deformations and requires further development to increase capture range. The idea of separating intensity correction mapping from similarity measure is shown to have advantages. Choosing intensity correction model can make the registration algorithm specific to the image class of interest

Medical image registration using Edgeworth-based approximation of Mutual Information

International audienceWe propose a new similarity measure for iconic medical image registration, an Edgeworth-based third order approximation of Mutual Information (MI) and named 3-EMI. Contrary to classical Edgeworth-based MI approximations, such as those proposed for inde- pendent component analysis, the 3-EMI measure is able to deal with potentially correlated variables. The performance of 3-EMI is then evaluated and compared with the Gaussian and B-Spline kernel-based estimates of MI, and the validation is leaded in three steps. First, we compare the intrinsic behavior of the measures as a function of the number of samples and the variance of an additive Gaussian noise. Then, they are evaluated in the context of multimodal rigid registration, using the RIRE data. We finally validate the use of our measure in the context of thoracic monomodal non-rigid registration, using the database proposed during the MICCAI EMPIRE10 challenge. The results show the wide range of clinical applications for which our measure can perform, including non-rigid registration which remains a challenging problem. They also demonstrate that 3-EMI outperforms classical estimates of MI for a low number of samples or a strong additive Gaussian noise. More generally, our measure gives competitive registration results, with a much lower numerical complexity compared to classical estimators such as the reference B-Spline kernel estimator, which makes 3-EMI a good candidate for fast and accurate registration tasks

Multispectral Palmprint Encoding and Recognition

Palmprints are emerging as a new entity in multi-modal biometrics for human identification and verification. Multispectral palmprint images captured in the visible and infrared spectrum not only contain the wrinkles and ridge structure of a palm, but also the underlying pattern of veins; making them a highly discriminating biometric identifier. In this paper, we propose a feature encoding scheme for robust and highly accurate representation and matching of multispectral palmprints. To facilitate compact storage of the feature, we design a binary hash table structure that allows for efficient matching in large databases. Comprehensive experiments for both identification and verification scenarios are performed on two public datasets -- one captured with a contact-based sensor (PolyU dataset), and the other with a contact-free sensor (CASIA dataset). Recognition results in various experimental setups show that the proposed method consistently outperforms existing state-of-the-art methods. Error rates achieved by our method (0.003% on PolyU and 0.2% on CASIA) are the lowest reported in literature on both dataset and clearly indicate the viability of palmprint as a reliable and promising biometric. All source codes are publicly available.Comment: Preliminary version of this manuscript was published in ICCV 2011. Z. Khan A. Mian and Y. Hu, "Contour Code: Robust and Efficient Multispectral Palmprint Encoding for Human Recognition", International Conference on Computer Vision, 2011. MATLAB Code available: https://sites.google.com/site/zohaibnet/Home/code

Image registration and visualization of in situ gene expression images.

In the age of high-throughput molecular biology techniques, scientists have incorporated the methodology of in-situ hybridization to map spatial patterns of gene expression. In order to compare expression patterns within a common tissue structure, these images need to be registered or organized into a common coordinate system for alignment to a reference or atlas images. We use three different image registration methodologies (manual; correlation based; mutual information based) to determine the common coordinate system for the reference and in-situ hybridization images. All three methodologies are incorporated into a Matlab tool to visualize the results in a user friendly way and save them for future work. Our results suggest that the user-defined landmark method is best when considering images from different modalities; automated landmark detection is best when the images are expected to have a high degree of consistency; and the mutual information methodology is useful when the images are from the same modality

Toward quantitative limited-angle ultrasound reflection tomography to inform abdominal HIFU treatment planning

High-Intensity Focused Ultrasound (HIFU) is a treatment modality for solid cancers of the liver and pancreas which is non-invasive and free from many of the side-effects of radiotherapy and chemotherapy. The safety and efficacy of abdominal HIFU treatment is dependent on the ability to bring the therapeutic sound waves to a small focal ”lesion” of known and controllable location within the patient anatomy. To achieve this, pre-treatment planning typically includes a numerical simulation of the therapeutic ultrasound beam, in which anatomical compartment locations are derived from computed tomography or magnetic resonance images. In such planning simulations, acoustic properties such as density and speed-of-sound are assumed for the relevant tissues which are rarely, if ever, determined specifically for the patient. These properties are known to vary between patients and disease states of tissues, and to influence the intensity and location of the HIFU lesion. The subject of this thesis is the problem of non-invasive patient-specific measurement of acoustic tissue properties. The appropriate method, also, of establishing spatial correspondence between physical ultrasound transducers and modeled (imaged) anatomy via multimodal image reg-istration is also investigated; this is of relevance both to acoustic tissue property estimation and to the guidance of HIFU delivery itself. First, the principle of a method is demonstrated with which acoustic properties can be recovered for several tissues simultaneously using reflection ultrasound, given accurate knowledge of the physical locations of tissue compartments. Second, the method is developed to allow for some inaccuracy in this knowledge commensurate with the inaccuracy typical in abdominal multimodal image registration. Third, several current multimodal image registration techniques, and two novel modifications, are compared for accuracy and robustness. In conclusion, relevant acoustic tissue properties can, in principle, be estimated using reflected ultrasound data that could be acquired using diagnostic imaging transducers in a clinical setting

Regularized Surface and Point Landmarks Based Efficient Non-Rigid Medical Image Registration

Medical image registration is one of the fundamental tasks in medical image processing. It has various applications in field of image guided surgery (IGS) and computer assisted diagnosis (CAD). A set of non-linear methods have been already developed for inter-subject and intra-subject 3D medical image registration. However, efficient registration in terms of accuracy and speed is one of the most demanded of today surgical navigation (SN) systems. This paper is a result of a series of experiments which utilizes Fast Radial Basis Function (RBF) technique to register one or more medical images non-rigidly. Initially, a set of curves are extracted using a combined watershed and active contours algorithm and then tiled and converted to a regular surface using a global parameterization algorithm. It is shown that the registration accuracy improves when higher number of salient features (i.e. anatomical point landmarks and surfaces) are used and it also has no impact on the speed of the algorithm. The results show that the target registration error is less than 2 mm and has sub-second performance on intra-subject registration of MR image real datasets. It is observed that the Fast RBF algorithm is relatively insensitive to the increasing number of point landmarks used as compared with the competing feature based algorithms

Exploiting Deep Matching and SAR Data for the Geo-Localization Accuracy Improvement of Optical Satellite Images

Improving the geo-localization of optical satellite images is an important pre-processing step for many remote sensing tasks like scene monitoring over time or the scene analysis after sudden events. These tasks often require the fusion of geo-referenced and precisely co-registered multi-sensor data. Images captured by high resolution synthetic aperture radar (SAR) satellites have an absolute geo-location accuracy within few decimeters. This renders SAR images interesting as a source for the geo-location improvement of optical images, whose geo-location accuracy is in the range of some meters. In this paper, we are investigating a deep learning based approach for the geo-localization accuracy improvement of optical satellite images through SAR reference data. Image registration between SAR and optical satellite images requires few but accurate and reliable matching points. To derive such matching points a neural network based on a Siamese network architecture was trained to learn the two dimensional spatial shift between optical and SAR image patches. The neural network was trained over TerraSAR-X and PRISM image pairs covering greater urban areas spread over Europe. The results of the proposed method confirm that accurate and reliable matching points are generated with a higher matching accuracy and precision than state-of-the-art approaches