1,058 research outputs found
Predicting respiratory motion for real-time tumour tracking in radiotherapy
Purpose. Radiation therapy is a local treatment aimed at cells in and around
a tumor. The goal of this study is to develop an algorithmic solution for
predicting the position of a target in 3D in real time, aiming for the short
fixed calibration time for each patient at the beginning of the procedure.
Accurate predictions of lung tumor motion are expected to improve the precision
of radiation treatment by controlling the position of a couch or a beam in
order to compensate for respiratory motion during radiation treatment.
Methods. For developing the algorithmic solution, data mining techniques are
used. A model form from the family of exponential smoothing is assumed, and the
model parameters are fitted by minimizing the absolute disposition error, and
the fluctuations of the prediction signal (jitter). The predictive performance
is evaluated retrospectively on clinical datasets capturing different behavior
(being quiet, talking, laughing), and validated in real-time on a prototype
system with respiratory motion imitation.
Results. An algorithmic solution for respiratory motion prediction (called
ExSmi) is designed. ExSmi achieves good accuracy of prediction (error
mm/s) with acceptable jitter values (5-7 mm/s), as tested on out-of-sample
data. The datasets, the code for algorithms and the experiments are openly
available for research purposes on a dedicated website.
Conclusions. The developed algorithmic solution performs well to be
prototyped and deployed in applications of radiotherapy
Couch-based motion compensation: modelling, simulation and real-time experiments
Abstract
The paper presents a couch-based active motion compensation strategy evaluated in simulation and validated experimentally using both a research and a clinical Elekta Precise Tableā¢. The control strategy combines a Kalman filter to predict the surrogate motion used as a reference by a linear model predictive controller with the control action calculation based on estimated position and velocity feedback provided by an observer as well as predicted couch position and velocity using a linearized state space model. An inversion technique isāused to compensate for the dead-zone nonlinearity. New generic couch models are presented and applied to model the Elekta Precise Tableā¢ dynamics and nonlinearities including dead zone. Couch deflection was measured for different manufacturers and found to be up to 25Ā mm. A feed-forward approach is proposed to compensate for such couch deflection. Simultaneous motion compensation for longitudinal, lateral and vertical motions was evaluated using arbitrary trajectories generated from sensors or loaded from files. Tracking errors were between 0.5 and 2Ā mm RMS. A dosimetric evaluation of the motion compensation was done using a sinusoidal waveform. No notable differences were observed between films obtained for a fixed- or motion-compensated target. Further dosimetric improvement could be made by combining gating, based on tracking error together with beam on/off time, and PSS compensation.</jats:p
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Optimization based trajectory planning for real-time 6DoF robotic patient motion compensation systems
Purpose: Robotic stabilization of a therapeutic radiation beam with respect to a dynamically moving tumor target can be accomplished either by moving the radiation source, the patient, or both. As the treatment beam is on during this process, the primary goal is to minimize exposure of normal tissue to radiation as much as possible when moving the target back to the desired position. Due to the complex mechanical structure of 6 degree-of-freedom (6DoF) robots, it is not intuitive as to what 6 dimensional (6D) correction trajectory is optimal in achieving such a goal. With proportional-integrative-derivative (PID) and other controls, the potential exists that the controller may generate a trajectory that is highly curved, slow, or suboptimal in that it leads to unnecessary exposure of healthy tissue to radiation. This work investigates a novel feedback planning method that takes into account a robotās mechanical joint structure, patient safety tolerances, and other system constraints, and performs real-time optimization to search the entire 6D trajectory space in each time cycle so it can respond with an optimal 6D correction trajectory. Methods: Computer simulations were created for two 6DoF robotic patient support systems: a Stewart-Gough platform for moving a patientās head in frameless maskless stereotactic radiosurgery, and a linear accelerator treatment table for moving a patient in prostate cancer radiation therapy. Motion planning was formulated as an optimization problem and solved at real-time speeds using the L-BFGS algorithm. Three planning methods were investigated, moving the platform as fast as possible (platform-D), moving the target along a straight-line (target-S), and moving the target based on the fastest descent of position error (target-D). Both synthetic motion and prior recorded human motion were used as input data and output results were analyzed. Results: For randomly generated 6D step-like and sinusoidal synthetic input motion, target-D planning demonstrated the smallest net trajectory error in all cases. On average, optimal planning was found to have a 45% smaller target trajectory error than platform-D control, and a 44% smaller target trajectory error than target-S planning. For patient head motion compensation, only target-D planning was able to maintain a ā¤0.5mm and ā¤0.5deg clinical tolerance objective for 100% of the treatment time. For prostate motion, both target-S planning and target-D planning outperformed platform-D control. Conclusions: A general 6D target trajectory optimization framework for robotic patient motion compensation systems was investigated. The method was found to be flexible as it allows control over various performance requirements such as mechanical limits, velocities, acceleration, or other system control objectives.</p
PREDICTION OF RESPIRATORY MOTION
Radiation therapy is a cancer treatment method that employs high-energy radiation beams to destroy cancer cells by damaging the ability of these cells to reproduce. Thoracic and abdominal tumors may change their positions during respiration by as much as three centimeters during radiation treatment. The prediction of respiratory motion has become an important research area because respiratory motion severely affects precise radiation dose delivery. This study describes recent radiotherapy technologies including tools for measuring target position during radiotherapy and tracking-based delivery systems. In the first part of our study we review three prediction approaches of respiratory motion, i.e., model-based methods, model-free heuristic learning algorithms, and hybrid methods. In the second part of our work we propose respiratory motion estimation with hybrid implementation of extended Kalman filter. The proposed method uses the recurrent neural network as the role of the predictor and the extended Kalman filter as the role of the corrector. In the third part of our work we further extend our research work to present customized prediction of respiratory motion with clustering from multiple patient interactions. For the customized prediction we construct the clustering based on breathing patterns of multiple patients using the feature selection metrics that are composed of a variety of breathing features. In the fourth part of our work we retrospectively categorize breathing data into several classes and propose a new approach to detect irregular breathing patterns using neural networks. We have evaluated the proposed new algorithm by comparing the prediction overshoot and the tracking estimation value. The experimental results of 448 patientsā breathing patterns validated the proposed irregular breathing classifier
Application of a spring-dashpot system to clinical lung tumor motion data
A spring-dashpot system based on the Voigt model was developed to model the
correlation between abdominal respiratory motion and tumor motion during lung
radiotherapy. The model was applied to clinical data comprising 52 treatment
beams from 10 patients, treated on the Mitsubishi Real-Time Radiation Therapy
system, Sapporo, Japan. In Stage 1, model parameters were optimized for
individual patients and beams to determine reference values and to investigate
how well the model can describe the data. In Stage 2, for each patient the
optimal parameters determined for a single beam were applied to data from other
beams to investigate whether a beam-specific set of model parameters is
sufficient to model tumor motion over a course of treatment.
In Stage 1 the baseline root mean square (RMS) residual error for all
individually-optimized beam data was 0.90 plus or minus 0.40 mm. In Stage 2,
patient-specific model parameters based on a single beam were found to model
the tumor position closely, even for irregular beam data, with a mean increase
with respect to Stage 1 values in RMS error of 0.37 mm. On average the obtained
model output for the tumor position was 95% of the time within an absolute
bound of 2.0 mm and 2.6 mm in Stage 1 and 2, respectively.
The model was capable of dealing with baseline, amplitude and frequency
variations of the input data, as well as phase shifts between the input tumor
and output abdominal signals. These results indicate that it may be feasible to
collect patient-specific model parameters during or prior to the first
treatment, and then retain these for the rest of the treatment period. The
model has potential for clinical application during radiotherapy treatment of
lung tumors
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