Pharmaceutical product modularization as a mass customization strategy to increase patient benefit cost-efficiently

Customized pharmaceutical products aim to comply with the individual needs of a patient to enhance the treatment outcome. The current pharmaceutical production paradigm is, however, dominated by mass production, where the pharmaceutical products embrace a one-size-fits-all design with a low possibility of treatment optimization to patient needs. This production paradigm is not designed or intended for customized pharmaceutical products and operating this production context for customized pharmaceutical products is argued to be cost-inefficient. To address this challenge of inefficient production of customized pharmaceutical products, this study proposes an approach to modular pharmaceutical product design. As a mass customization strategy, product modularization enables serving customers with customized products cost-efficiently. The proposed modular pharmaceutical products integrate three product design requirements originating from patient needs: a scalable dose strength, a flexible target release profile, and a scalable treatment size. An approach to assess the value of these product designs is presented, by means of proposing three benefit metrics complying with respective design requirements and a cost metric assessing the cost of producing these modular pharmaceutical product designs. Results suggest that pharmaceutical product modularization can, by keeping the number of produced components low, substantially increase the external product variety and, hence, enhance the treatment outcome of patients. Fur-thermore, results indicate that the achieved benefit for the patient through product modularization increases beyond additional costs arising during production. However, a careful modularization must be performed to optimize the tradeoff between the increased benefit and cost

30 Years of Software Refactoring Research: A Systematic Literature Review

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155872/4/30YRefactoring.pd

Model Transformation Languages with Modular Information Hiding

Model transformations, together with models, form the principal artifacts in model-driven software development. Industrial practitioners report that transformations on larger models quickly get sufficiently large and complex themselves. To alleviate entailed maintenance efforts, this thesis presents a modularity concept with explicit interfaces, complemented by software visualization and clustering techniques. All three approaches are tailored to the specific needs of the transformation domain

30 Years of Software Refactoring Research:A Systematic Literature Review

Due to the growing complexity of software systems, there has been a dramatic increase and industry demand for tools and techniques on software refactoring in the last ten years, defined traditionally as a set of program transformations intended to improve the system design while preserving the behavior. Refactoring studies are expanded beyond code-level restructuring to be applied at different levels (architecture, model, requirements, etc.), adopted in many domains beyond the object-oriented paradigm (cloud computing, mobile, web, etc.), used in industrial settings and considered objectives beyond improving the design to include other non-functional requirements (e.g., improve performance, security, etc.). Thus, challenges to be addressed by refactoring work are, nowadays, beyond code transformation to include, but not limited to, scheduling the opportune time to carry refactoring, recommendations of specific refactoring activities, detection of refactoring opportunities, and testing the correctness of applied refactorings. Therefore, the refactoring research efforts are fragmented over several research communities, various domains, and objectives. To structure the field and existing research results, this paper provides a systematic literature review and analyzes the results of 3183 research papers on refactoring covering the last three decades to offer the most scalable and comprehensive literature review of existing refactoring research studies. Based on this survey, we created a taxonomy to classify the existing research, identified research trends, and highlighted gaps in the literature and avenues for further research.Comment: 23 page

E valuating Support for Features in Advance d Modu larization Technologies

Abstract. A software product-line is a family of related programs. Each program is defined by a unique combination of features, where a feature is an increment in program functionality. Modularizing features is difficult, as feature-specific code often cuts across class boundaries. New modularization technologies have been proposed in recent years, but their support for feature modules has not been thoroughly examined. In this paper, we propose a variant of the expression problem as a canonical problem in product-line design. The problem reveals a set of technology-independent properties that feature modules should exhibit. We use these properties to evaluate five technologies: AspectJ, Hyper/J, Jiazzi, Scala, and AHEAD. The results suggest an abstract model of feature composition that is technology-independent and that relates compositional reasoning with algebraic reasoning 1

Application of service composition mechanisms to Future Networks architectures and Smart Grids

Aquesta tesi gira entorn de la hipòtesi de la metodologia i mecanismes de composició de serveis i com es poden aplicar a diferents camps d'aplicació per a orquestrar de manera eficient comunicacions i processos flexibles i sensibles al context. Més concretament, se centra en dos camps d'aplicació: la distribució eficient i sensible al context de contingut multimèdia i els serveis d'una xarxa elèctrica intel·ligent. En aquest últim camp es centra en la gestió de la infraestructura, cap a la definició d'una Software Defined Utility (SDU), que proposa una nova manera de gestionar la Smart Grid amb un enfocament basat en programari, que permeti un funcionament molt més flexible de la infraestructura de xarxa elèctrica. Per tant, revisa el context, els requisits i els reptes, així com els enfocaments de la composició de serveis per a aquests camps. Fa especial èmfasi en la combinació de la composició de serveis amb arquitectures Future Network (FN), presentant una proposta de FN orientada a serveis per crear comunicacions adaptades i sota demanda. També es presenten metodologies i mecanismes de composició de serveis per operar sobre aquesta arquitectura, i posteriorment, es proposa el seu ús (en conjunció o no amb l'arquitectura FN) en els dos camps d'estudi. Finalment, es presenta la investigació i desenvolupament realitzat en l'àmbit de les xarxes intel·ligents, proposant diverses parts de la infraestructura SDU amb exemples d'aplicació de composició de serveis per dissenyar seguretat dinàmica i flexible o l'orquestració i gestió de serveis i recursos dins la infraestructura de l'empresa elèctrica.Esta tesis gira en torno a la hipótesis de la metodología y mecanismos de composición de servicios y cómo se pueden aplicar a diferentes campos de aplicación para orquestar de manera eficiente comunicaciones y procesos flexibles y sensibles al contexto. Más concretamente, se centra en dos campos de aplicación: la distribución eficiente y sensible al contexto de contenido multimedia y los servicios de una red eléctrica inteligente. En este último campo se centra en la gestión de la infraestructura, hacia la definición de una Software Defined Utility (SDU), que propone una nueva forma de gestionar la Smart Grid con un enfoque basado en software, que permita un funcionamiento mucho más flexible de la infraestructura de red eléctrica. Por lo tanto, revisa el contexto, los requisitos y los retos, así como los enfoques de la composición de servicios para estos campos. Hace especial hincapié en la combinación de la composición de servicios con arquitecturas Future Network (FN), presentando una propuesta de FN orientada a servicios para crear comunicaciones adaptadas y bajo demanda. También se presentan metodologías y mecanismos de composición de servicios para operar sobre esta arquitectura, y posteriormente, se propone su uso (en conjunción o no con la arquitectura FN) en los dos campos de estudio. Por último, se presenta la investigación y desarrollo realizado en el ámbito de las redes inteligentes, proponiendo varias partes de la infraestructura SDU con ejemplos de aplicación de composición de servicios para diseñar seguridad dinámica y flexible o la orquestación y gestión de servicios y recursos dentro de la infraestructura de la empresa eléctrica.This thesis revolves around the hypothesis the service composition methodology and mechanisms and how they can be applied to different fields of application in order to efficiently orchestrate flexible and context-aware communications and processes. More concretely, it focuses on two fields of application that are the context-aware media distribution and smart grid services and infrastructure management, towards a definition of a Software-Defined Utility (SDU), which proposes a new way of managing the Smart Grid following a software-based approach that enable a much more flexible operation of the power infrastructure. Hence, it reviews the context, requirements and challenges of these fields, as well as the service composition approaches. It makes special emphasis on the combination of service composition with Future Network (FN) architectures, presenting a service-oriented FN proposal for creating context-aware on-demand communication services. Service composition methodology and mechanisms are also presented in order to operate over this architecture, and afterwards, proposed for their usage (in conjunction or not with the FN architecture) in the deployment of context-aware media distribution and Smart Grids. Finally, the research and development done in the field of Smart Grids is depicted, proposing several parts of the SDU infrastructure, with examples of service composition application for designing dynamic and flexible security for smart metering or the orchestration and management of services and data resources within the utility infrastructure

Model Transformation Languages with Modular Information Hiding

Model transformations, together with models, form the principal artifacts in model-driven software development. Industrial practitioners report that transformations on larger models quickly get sufficiently large and complex themselves. To alleviate entailed maintenance efforts, this thesis presents a modularity concept with explicit interfaces, complemented by software visualization and clustering techniques. All three approaches are tailored to the specific needs of the transformation domain

Project-Team RMoD (Analyses and Language Constructs for Object-Oriented Application Evolution) 2009 Activity Report

This is the yearly report of the RMOD team. A good way to understand what we are doing