Computational modelling of neural mechanisms underlying natural speech perception

Humans are highly skilled at the analysis of complex auditory scenes. In particular, the human auditory system is characterized by incredible robustness to noise and can nearly effortlessly isolate the voice of a specific talker from even the busiest of mixtures. However, neural mechanisms underlying these remarkable properties remain poorly understood. This is mainly due to the inherent complexity of speech signals and multi-stage, intricate processing performed in the human auditory system. Understanding these neural mechanisms underlying speech perception is of interest for clinical practice, brain-computer interfacing and automatic speech processing systems. In this thesis, we developed computational models characterizing neural speech processing across different stages of the human auditory pathways. In particular, we studied the active role of slow cortical oscillations in speech-in-noise comprehension through a spiking neural network model for encoding spoken sentences. The neural dynamics of the model during noisy speech encoding reflected speech comprehension of young, normal-hearing adults. The proposed theoretical model was validated by predicting the effects of non-invasive brain stimulation on speech comprehension in an experimental study involving a cohort of volunteers. Moreover, we developed a modelling framework for detecting the early, high-frequency neural response to the uninterrupted speech in non-invasive neural recordings. We applied the method to investigate top-down modulation of this response by the listener's selective attention and linguistic properties of different words from a spoken narrative. We found that in both cases, the detected responses of predominantly subcortical origin were significantly modulated, which supports the functional role of feedback, between higher- and lower levels stages of the auditory pathways, in speech perception. The proposed computational models shed light on some of the poorly understood neural mechanisms underlying speech perception. The developed methods can be readily employed in future studies involving a range of experimental paradigms beyond these considered in this thesis.Open Acces

Complex network modeling of EEG band coupling in dyslexia: An exploratory analysis of auditory processing and diagnosis

Complex network analysis has an increasing relevance in the study of neurological disorders, enhancing the knowledge of brain’s structural and functional organization. Network structure and efficiency reveal different brain states along with different ways of processing the information. This work is structured around the exploratory analysis of the brain processes involved in low-level auditory processing. A complex network analysis was performed on the basis of brain coupling obtained from electroencephalography (EEG) data, while different auditory stimuli were presented to the subjects. This coupling is inferred from the Phase-Amplitude coupling (PAC) from different EEG electrodes to explore differences between control and dyslexic subjects. Coupling data allows the construction of a graph, and then, graph theory is used to study the characteristics of the complex networks throughout time for control and dyslexic subjects. This results in a set of metrics including clustering coefficient, path length and small-worldness. From this, different characteristics linked to the temporal evolution of networks and coupling are pointed out for dyslexics. Our study revealed patterns related to Dyslexia as losing the small-world topology. Finally, these graph-based features are used to classify between control and dyslexic subjects by means of a Support Vector Machine (SVM).Spanish Government PGC2018-098813-B-C32Junta de Andalucia UMA20-FEDERJA-086European CommissionNVIDIA CorporationMinistry of Science and Innovation, Spain (MICINN) Spanish GovernmentEuropean CommissionUniversidad de Malaga/CBU

Complex network modelling of EEG band coupling in dyslexia: An exploratory analysis of auditory processing and diagnosis

Complex network analysis has an increasing relevance in the study of neurological disorders, enhancing the knowledge of brain’s structural and functional organization. Network structure and efficiency reveal different brain states along with different ways of processing the informa- tion. This work is structured around the exploratory analysis of the brain processes involved in low-level auditory processing. A complex network analysis was performed on the basis of brain coupling obtained from electroencephalography (EEG) data, while different auditory stim- uli were presented to the subjects. This coupling is inferred from the Phase-Amplitude coupling (PAC) from different EEG electrodes to explore differences between control and dyslexic sub- jects. Coupling data allows the construction of a graph, and then, graph theory is used to study the characteristics of the complex networks throughout time for control and dyslexic subjects. This results in a set of metrics including clustering coefficient, path length and small-worldness. From this, different characteristics linked to the temporal evolution of networks and coupling are pointed out for dyslexics. Our study revealed patterns related to Dyslexia as losing the small- world topology. Finally, these graph-based features are used to classify between control and dyslexic subjects by means of a Support Vector Machine (SVM).This work was supported by projects PGC2018-098813-B-C32 (Spanish “Ministerio de Cien- cia, Innovación y Universidades”), UMA20-FEDERJA-086 (Consejería de econnomía y conocimiento, Junta de Andalucía) and by European Regional Development Funds (ERDF). We gratefully ac- knowledge the support of NVIDIA Corporation with the donation of one of the GPUs used for this research. Work by F.J.M.M. was supported by the MICINN “Juan de la Cierva - Incorpo- ración” Fellowship. We also thank the Leeduca research group and Junta de Andalucía for the data supplied and the support. Funding for open access charge: Universidad de Málaga / CBU

Noise processing in the auditory system with applications in speech enhancement

Abstract: The auditory system is extremely efficient in extracting auditory information in the presence of background noise. However, speech enhancement algorithms, aimed at removing the background noise from a degraded speech signal, are not achieving results that are near the efficacy of the auditory system. The purpose of this study is thus to first investigate how noise affects the spiking activity of neurons in the auditory system and then use the brain activity in the presence of noise to design better speech enhancement algorithms. In order to investigate how noise affects the spiking activity of neurons, we first design a generalized linear model that relates the spiking activity of neurons to intrinsic and extrinsic covariates that can affect their activity, such as noise. From this model, we extract two metrics, one that shows the effects of noise on the spiking activity and another the relative effects of vocalization compared to noise. We use these metrics to analyze neural data, recorded from a structure of the auditory system named the inferior colliculus (IC), while presenting noisy vocalizations. We studied the effect of different kinds of noises (non-stationary, white and natural stationary), different vocalizations, different input sound levels and signal-to-noise ratios (SNR). We found that the presence of non-stationary noise increases the spiking activity of neurons, regardless of the SNR, input level or vocalization type. The presence of white or natural stationary noises however causes a great diversity of responses where the activity of sites could increase, decrease or remain unchanged. This shows that the noise invariance previously reported in the IC depends on the noisy conditions, which had not been observed before. We then address the problem of speech enhancement using information from the brain's processing in the presence of noise. It has been shown before that the brain waves of a listener strongly correlates with the speaker to which the listener attends. Given this, we design two speech enhancement algorithms with a denoising autoencoder structure, namely the Brain Enhanced Speech Denoiser (BESD) and U-shaped Brain Enhanced Speech Denoiser (U-BESD). These algorithms take advantage of the attended auditory information present in the brain activity of the listener to denoise a multi-talker speech. The U-BESD is built upon the BESD with the addition of skip connections and dilated convolutions. Compared to previously proposed approaches, BESD and U-BESD are trained in a single neural architecture, lowering the complexity of the algorithm. We investigate two experimental settings. In the first one, the attended speaker is known, referred to as the speaker-specific setting, and in the second one no prior information is available about the attended speaker, referred to as the speaker-independent setting. In the speaker-specific setting, we show that both the BESD and U-BESD algorithms surpass a similar denoising autoencoder. Moreover, we also show that in the speaker-independent setting, U-BESD surpasses the performance of the only known approach that also uses the brain's activity.Le système auditif est extrêmement efficace pour extraire de l’information pertinente en présence d’un bruit de fond. Par contre, les algorithmes de rehaussement de la parole, visant à supprimer le bruit d’un signal de parole bruité, n’atteignent pas des résultats proches de l’efficacité du système auditif. Le but de cette étude est donc d’abord d’étudier comment le bruit affecte l’activité neuronale dans le système auditif, puis d’utiliser l’activité cérébrale en présence de bruit pour concevoir de meilleurs algorithmes de rehaussement. Afin d’étudier comment le bruit peut affecter l’activité des neurones, nous concevons d’abord un modèle linéaire généralisé qui relie l’activité des neurones aux covariables intrinsèques et extrinsèques qui peuvent affecter leur activité, comme le bruit. De ce modèle, nous extrayons deux métriques, l’une qui permet d’étudier les effets du bruit sur l’activité neuronale et l’autre les effets relatifs sur cette activité de la vocalisation par rapport au bruit. Nous utilisons ces métriques pour analyser l’activité neuronale d’une structure du système auditif, nomée le colliculus inférieur (IC), enregistrée lors de la présentation de vocalisations bruitées. Nous avons étudié l’effet de différents types de bruits, différentes vocalisations, différents niveaux sonores d’entrée et différents rapports signal sur bruit (SNR). Nous avons constaté que la présence de bruit non stationnaire augmente l’activité des neurones, quel que soit le SNR, le niveau d’entrée ou le type de vocalisation. La présence de bruits stationnaires blancs ou naturels provoque cependant une grande diversité de réponses où l’activité des sites d’enregistrement pouvait augmenter, diminuer ou rester inchangée. Cela montre que l’invariance du bruit précédemment signalée dans l’IC dépend des conditions de bruit, ce qui n’avait pas été observé auparavant. Nous abordons ensuite le problème du rehaussement de la parole en utilisant de l’information provenant du cerveau. Il a été démontré auparavant que les ondes cérébrales d’un auditeur sont fortement corrélées avec le locuteur auquel l’auditeur porte attention. Compte tenu de cette corrélation, nous concevons deux algorithmes de rehaussement de la parole, le Brain Enhanced Speech Denoiser (BESD) et le U-shaped Brain Enhanced Speech Denoiser (U-BESD), qui tirent parti de l’information présente dans l’activité cérébrale de l’auditeur pour débruiter un signal de parole multi-locuteurs. L’U-BESD est construit à partir du BESD avec l’ajout de sauts de connexions (skip connections) et de convolutions dilatées. De plus, BESD et U-BESD sont constitués respectivement d’un seul réseau qui nécessite un seul entraînement, ce qui réduit la complexité de l’algorithme en comparaison avec les approches existantes. Nous étudions deux conditions expérimentales. Dans la première, le locuteur auquel l’auditeur porte attention est connu, et dans la seconde, ce locuteur n’est pas connu. Dans le cadre du locuteur connu, nous montrons que les algorithmes BESD et U-BESD surpassent un autoencodeur similaire. De plus, nous montrons également que dans le cadre du locuteur inconnu, le U-BESD surpasse les performances de la seule approche existante connue qui utilise également l’activité cérébrale