Multipass communication systems for tiled processor architectures

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.Includes bibliographical references (p. 191-202).Multipass communication systems utilize multiple sets of parallel baseband receiver functions to balance communication data rates and available computation capabilities. This is achieved by spatially pipelining baseband functions across parallel resources to perform multiple processing passes on the same set of received values, thus allowing the system to simultaneously convey multiple sequences of data using a single wireless link. The use of multiple passes mitigates the effects of data rate on receiver processing bottlenecks, making the use of general-purpose processing elements for high data rate communication functions viable. The flexibility of general-purpose processing, in turn, allows the receiver composition to trade-off resource usage and required processing rate. For instance, a communication system could be distributed across 2 passes using 2x the overall area, but reducing the data rate for each pass and the resultant overall required processing rate, and hence clock speed, by 1/2. Lowering the clock speed can also be leveraged to reduce power through voltage scaling and/or the use of higher Vt devices. The characteristics of general-purpose parallel processors for communications processing are explored, as well as the applicability of specific parallel designs to communications processing.(Cont.) In particular, an in depth look is taken of the Raw processor's tiled architecture as a general-purpose parallel processor particularly well suited to portable communications processing. An example of a multipass system, based on the 802.11a baseband, implemented on the Raw processor along with the accompanying hardware implementation is presented as both a proof-of-concept, as well as a means to explore some of the advantages and trade-offs of such a system. A bit-error rate study is presented which shows this multipass system to be within a small fraction of dB of the performance of an equivalent data rate single pass system, thus demonstrating the viability of the multipass algorithm. In addition, the capability of tiled processors to maximize processing capabilities at the system block level, as well as the system architectural level, is shown. Parallel implementations of two processing intensive functions: the FFT and the Viterbi decoder are shown. A parallelized assembly language FFT utilizing 16 tiles is shown to have a 1,000x improvement , and a parallelized 48-tile assembly language Viterbi decoder is shown to have a 10, 000x improvement over corresponding serial C implementations.by Nathan Robert Shnidman.Ph.D

Theater Ballistic Missile Defense From the Sea

A sense of urgency informs Theater Ballistic Missile Defense from the Sea: Issues for the Maritime Component Commander. Theater ballistic missiles armed with chemical, biological, or nuclear Weapons of Mass Destruction (WMD) will be acquired and deployed by hostile forces in the developing world, posing an imminent threat to the us. and coalition forces that must operate in that world. The gravity of this evolving threat is recognized in our national military strategy.https://digital-commons.usnwc.edu/usnwc-newport-papers/1012/thumbnail.jp

Cell-free expression and molecular modeling of the γ-secretase complex and G-protein-coupled receptors

Alzheimer’s disease (AD), which was first reported more than a century ago by Alhzeimer, is one of the commonest forms of dementia which affects >30 million people globally (>8 million in Europe). The origin and pathogenesis of AD is poorly understood and there is no cure available for the disease. AD is characterized by the accumulation of senile plaques composed of amyloid beta peptides (Ab 37-43) which is formed by the gamma secretase (GS) complex by cleaving amyloid precursor protein. Therefore GS can be an attractive drug target. Since GS processes several other substrates like Notch, CD44 and Cadherins, nonspecific inhibition of GS has many side effects. Due to the lack of crystal structure of GS, which is attributed to the extreme difficulties in purifying it, molecular modeling can be useful to understand its architecture. So far only low resolution cryoEM structures of the complex has been solved which only provides a rough structure of the complex at low 12-15 A resolution Furthermore the activity of GS in vitro can be achieved by means of cell-free (CF) expression. GS comprises catalytic subunits namely presenilins and supporting elements containing Pen-2, Aph-1 and Nicastrin. The origin of AD is hidden in the regulated intramembrnae proteolysis (RIP) which is involved in various physiological processes and also in leukemia. So far growth factors, cytokines, receptors, viral proteins, cell adhesion proteins, signal peptides and GS has been shown to undergo RIP. During RIP, the target proteins undergo extracellular shredding and intramembrane proteolysis. This thesis is based on molecular modeling, molecular dynamics (MD) simulations, cell-free (CF) expression, mass spectrometry, NMR, crystallization, activity assay etc of the components of GS complex and G-protein coupled receptors (GPCRs). First I validated the NMR structure of PS1 CTF in detergent micelles and lipid bilayers using coarse-grained MD simulations using MARTINI forcefield implemented in Gromacs. CTF was simulated in DPC micelles, DPPC and DLPC lipid bilayer. Starting from random configuration of detergent and lipids, micelle and lipid bilyer were formed respectively in presence of CTF and it was oriented properly to the micelle and bilyer during the simulation. Around DPC molecules formed micelle around CTF in agreement of the experimental results in which 80-85 DPC molecules are required to form micelles. The structure obtained in DPC was similar to that of NMR structure but differed in bilayer simulations showed the possibility of substrate docking in the conserved PAL motif. Simulations of CTF in implicit membrane (IMM1) in CHAMM yielded similar structure to that from coarse grained MD. I performed cell-free expression optimization, crystallization and NMR spectroscopy of Pen-2 in various detergent micelles. Additionally Pen-2 was modeled by a combination of rosetta membrane ab-initio method, HHPred distant homology modeling and incorporating NMR constraints. The models were validated by all atom and coarse grained MD simulations both in detergent micelles and POPC/DPPC lipid bilayers using MARTINI forcefield. GS operon consisting of all four subunits was co-expressed in CF and purified. The presence of of GS subunits after pull-down with Aph-1 was determined by western blotting (Pen-2) and mass spectrometry (Presenilin-1 and Aph-1). I also studied interactions of especially PS1 CTF, APP and NTF by docking and MD. I also made models and interfaces of Pen-2 with PS1 NTF and checked their stability by MD simulations and compared with experimental results. The goal is to model the interfaces between GS subunits using molecular modeling approaches based on available experimental data like cross-linking, mutations and NMR structure of C-terminal fragment of PS1 and transmembrane part of APP. The obtained interfaces of GS subunits may explain its catalysis mechanism which can be exploited for novel lead design. Due to lack of crystal/NMR structure of the GS subunits except the PS1 CTF, it is not possible to predict the effect of mutations in terms of APP cleavage. So I also developed a sequence based approach based on machine learning using support vector machine to predict the effect of PS1 CTF L383 mutations in terms of Aβ40/Aβ42 ratio with 88% accuracy. Mutational data derived from the Molgen database of Presenilin 1 mutations was using for training. GPCRs (also called 7TM receptors) form a large superfamily of membrane proteins, which can be activated by small molecules, lipids, hormones, peptides, light, pain, taste and smell etc. Although 50% of the drugs in market target GPCRs , only few are targeted therapeutically. Such wide range of targets is due to involvement of GPCRs in signaling pathways related to many diseases i.e. dementia (like Alzheimer's disease), metabolic (like diabetes) including endocrinological disorders, immunological including viral infections, cardiovascular, inflammatory, senses disorders, pain and cancer. Cannabinoid and adrenergic receptors belong to the class A (similar to rhodopsin) GPCRs. Docking of agonists and antagonists to CB1 and CB2 cannabinoid receptors revealed the importance of a centrally located rotamer toggle switch, and its possible role in the mechanism of agonist/antagonist recognition. The switch is composed of two residues, F3.36 and W6.48, located on opposite transmembrane helices TM3 and TM6 in the central part of the membranous domain of cannabinoid receptors. The CB1 and CB2 receptor models were constructed based on the adenosine A2A receptor template. The two best scored conformations of each receptor were used for the docking procedure. In all poses (ligand-receptor conformations) characterized by the lowest ligand-receptor intermolecular energy and free energy of binding the ligand type matched the state of the rotamer toggle switch: antagonists maintained an inactive state of the switch, whereas agonists changed it. In case of agonists of β2AR, the (R,R) and (S,S) stereoisomers of fenoterol, the molecular dynamics simulations provided evidence of different binding modes while preserving the same average position of ligands in the binding site. The (S,S) isomer was much more labile in the binding site and only one stable hydrogen bond was created. Such dynamical binding modes may also be valid for ligands of cannabinoid receptors because of the hydrophobic nature of their ligand-receptor interactions. However, only very long molecular dynamics simulations could verify the validity of such binding modes and how they affect the process of activation. Human N-formyl peptide receptors (FPRs) are G protein-coupled receptors (GPCRs) involved in many physiological processes, including host defense against bacterial infection and resolving inflammation. The three human FPRs (FPR1, FPR2 and FPR3) share significant sequence homology and perform their action via coupling to Gi protein. Activation of FPRs induces a variety of responses, which are dependent on the agonist, cell type, receptor subtype, and also species involved. FPRs are expressed mainly by phagocytic leukocytes. Together, these receptors bind a large number of structurally diverse groups of agonistic ligands, including N-formyl and nonformyl peptides of different composition, that chemoattract and activate phagocytes. For example, N-formyl-Met-Leu-Phe (fMLF), an FPR1 agonist, activates human phagocyte inflammatory responses, such as intracellular calcium mobilization, production of cytokines, generation of reactive oxygen species, and chemotaxis. This ligand can efficiently activate the major bactericidal neutrophil functions and it was one of the first characterized bacterial chemotactic peptides. Whereas fMLF is by far the most frequently used chemotactic peptide in studies of neutrophil functions, atomistic descriptions for fMLF-FPR1 binding mode are still scarce mainly because of the absence of a crystal structure of this receptor. Elucidating the binding modes may contribute to designing novel and more efficient non-peptide FPR1 drug candidates. Molecular modeling of FPR1, on the other hand, can provide an efficient way to reveal details of ligand binding and activation of the receptor. However, recent modelings of FPRs were confined only to bovine rhodopsin as a template. To locate specific ligand-receptor interactions based on a more appropriate template than rhodopsin we generated the homology models of FPR1 using the crystal structure of the chemokine receptor CXCR4, which shares over 30% sequence identity with FPR1 and is located in the same γ branch of phylogenetic tree of GPCRs (rhodopsin is located in α branch). Docking and model refinement procedures were pursued afterward. Finally, 40 ns full-atom MD simulations were conducted for the Apo form as well as for complexes of fMLF (agonist) and tBocMLF (antagonist) with FPR1 in the membrane. Based on locations of the N- and C-termini of the ligand the FPR1 extracellular pocket can be divided into two zones, namely, the anchor and activation regions. The formylated M1 residue of fMLF bound to the activation region led to a series of conformational changes of conserved residues. Internal water molecules participating in extended hydrogen bond networks were found to play a crucial role in transmitting the agonist-receptor interactions. A mechanism of initial steps of the activation concurrent with ligand binding is proposed. I accurately predicted the structure and ligand binding pose of dopamine receptor 3 (RMSD to the crystal structure: 2.13 Å) and chemokine receptor 4 (CXCR4, RMSD to the crystal structure 3.21 Å) in GPCR-Dock 2010 competition. The homology model of the dopamine receptor 3 was 8 th best overall in the competition

Application of ”ART SIMULATOR” for Manufacturing Similarity Identification in Group Technology Design - Chapter 10

This chapter 10 carried out the exceptional implementation of ART-1 neural network in the analysis of the manufacturing similarity of the cylindrical parts within the group technology design. Established concept of the group technology design begins from the complex part of the group or the group representative. Group representative has all the geometrical elements of the parts in group, and manufacturing procedure may be applied to the machining of any part in the group. The complex part may be realistic or a hypothetical one. The ART-1 artificial neural network provided manufacturing classification according to the geometrical similarities of work-pieces for the group of cylindrical parts. For the manufacturing similarity identification within the group technology design, software package "ART Simulator" is developed and presented in this chapter

Innovative Techniques for the Retrieval of Earth’s Surface and Atmosphere Geophysical Parameters: Spaceborne Infrared/Microwave Combined Analyses

With the advent of the first satellites for Earth Observation: Landsat-1 in July 1972 and ERS-1 in May 1991, the discipline of environmental remote sensing has become, over time, increasingly fundamental for the study of phenomena characterizing the planet Earth. The goal of environmental remote sensing is to perform detailed analyses and to monitor the temporal evolution of different physical phenomena, exploiting the mechanisms of interaction between the objects that are present in an observed scene and the electromagnetic radiation detected by sensors, placed at a distance from the scene, operating at different frequencies. The analyzed physical phenomena are those related to climate change, weather forecasts, global ocean circulation, greenhouse gas profiling, earthquakes, volcanic eruptions, soil subsidence, and the effects of rapid urbanization processes. Generally, remote sensing sensors are of two primary types: active and passive. Active sensors use their own source of electromagnetic radiation to illuminate and analyze an area of interest. An active sensor emits radiation in the direction of the area to be investigated and then detects and measures the radiation that is backscattered from the objects contained in that area. Passive sensors, on the other hand, detect natural electromagnetic radiation (e.g., from the Sun in the visible band and the Earth in the infrared and microwave bands) emitted or reflected by the object contained in the observed scene. The scientific community has dedicated many resources to developing techniques to estimate, study and analyze Earth’s geophysical parameters. These techniques differ for active and passive sensors because they depend strictly on the type of the measured physical quantity. In my P.h.D. work, inversion techniques for estimating Earth’s surface and atmosphere geophysical parameters will be addressed, emphasizing methods based on machine learning (ML). In particular, the study of cloud microphysics and the characterization of Earth’s surface changes phenomenon are the critical points of this work

Sustainable Supply Chain Management

The book is a collection of studies dedicated to different perspectives of three dimensions or pillars of the sustainability of supply chain and supply chain management - economic, environmental, and social - and other aspects related to performance evaluation, optimization, and modelling of and for sustainable supply chain management, and thus presents another valuable contribution to sustainable development and sustainable way of life

Optimization of Machining Parameters in Turning Operation Using PSO and AIS Algorithms: A Survey

In recent manufacturing, the optimization of turning processes is one of important problems which aim to increase competitiveness and product quality. However, the choice of optimal machining parameters is difficult and complex. Traditionally, the selections is heavily relies on trial and error methods which is tedious and unreliable. Metaheuristics methods have been proposed over the last decade to overcome these problems. This paper presents a survey for optimizing the parameters of turning operation using Particle Swarm Optimization (PSO) and Artificial Immune System (AIS). This study deals with different machining performance in turning operation like surface roughness, material removal rate , tool wear , tool life, production cost, machining time and cutting temperature. Most papers in the field of turning parameters optimization are based on (PSO) algorithms, but only a few efforts that are using (AIS) algorithms. In addition, there is a gap of several machining operation parameters especially for cutting temperature optimization in turning operation using PSO and AIS

Control of Energy Storage

Energy storage can provide numerous beneficial services and cost savings within the electricity grid, especially when facing future challenges like renewable and electric vehicle (EV) integration. Public bodies, private companies and individuals are deploying storage facilities for several purposes, including arbitrage, grid support, renewable generation, and demand-side management. Storage deployment can therefore yield benefits like reduced frequency fluctuation, better asset utilisation and more predictable power profiles. Such uses of energy storage can reduce the cost of energy, reduce the strain on the grid, reduce the environmental impact of energy use, and prepare the network for future challenges. This Special Issue of Energies explore the latest developments in the control of energy storage in support of the wider energy network, and focus on the control of storage rather than the storage technology itself

Resilience-Building Technologies: State of Knowledge -- ReSIST NoE Deliverable D12

This document is the first product of work package WP2, "Resilience-building and -scaling technologies", in the programme of jointly executed research (JER) of the ReSIST Network of Excellenc