Cooperative resource pooling in multihomed mobile networks

The ubiquity of multihoming amongst mobile devices presents a unique opportunity for users to co-operate, sharing their available Internet connectivity, forming multihomed mobile networks on demand. This model provides users with vast potential to increase the quality of service they receive. Despite this, such mobile networks are typically underutilized and overly restrictive, as additional Internet connectivity options are predominantly ignored and selected gateways are both immutable and incapable of meeting the demand of the mobile network. This presents a number of research challenges, as users look to maximize their quality of experience, while balancing both the financial cost and power consumption associated with utilizing a diverse set of heterogeneous Internet connectivity options. In this thesis we present a novel architecture for mobile networks, the contribution of which is threefold. Firstly, we ensure the available Internet connectivity is appropriately advertised, building a routing overlay which allows mobile devices to access any available network resource. Secondly, we leverage the benefits of multipath communications, providing the mobile device with increased throughput, additional resilience and seamless mobility. Finally, we provide a multihomed framework, enabling policy driven network resource management and path selection on a per application basis. Policy driven resource management provides a rich and descriptive approach, allowing the context of the network and the device to be taken into account when making routing decisions at the edge of the Internet. The aim of this framework, is to provide an efficient and flexible approach to the allocation of applications to the optimal network resource, no matter where it resides in a mobile network. Furthermore, we investigate the benefits of path selection, facilitating the policy framework to choose the optimal network resource for specific applications. Through our evaluation, we prove that our approach to advertising Internet connectivity in a mobile network is both efficient and capable of increasing the utilization of the available network capacity. We then demonstrate that our policy driven approach to resource management and path selection can further improve the user’s quality of experience, by tailoring network resource usage to meet their specific needs

Control systems for function restoration, exercise, fitness and health in spinal cord injury

We describe original research contributions to the engineering development of systems which aim to restore function and enable effective exercise for people with spinal cord injury (SCI). Our work utilises functional electrical stimulation (FES) of paralysed muscle. Improving function and general health through participation in exercise is vital to the enhancement of quality of life, well-being and promotion of longevity. Crucial to the development of this research has been judicious use of advanced methods of feedback control engineering; this has been a key enabling factor in many of our original contributions. The consequences of a spinal cord injury can be severe. The primary effects may include; paralysis and loss of sensation in the legs, arms and trunk; disruption of bladder and bowel function; and disruption of the autonomic regulation of blood pressure, heart rate and lung function. If the abdominal and chest muscles are paralysed, breathing will be compromised, and patients with a high-level cervical injury may require mechanical ventilation. These primary effects of a spinal cord injury may, over time, lead to a range of debilitating secondary medical complications. These include reduced cardiovascular fitness, urinary tract infection and an associated risk of kidney disease, reduced bone mineral density, the possible development of pressure sores, and muscle spasticity. People with paralysed chest and abdominal muscles are at increased risk of respiratory infection. Consideration of these factors has led us to focus our research programme in this field on novel engineering solutions which have relevance to the secondary consequences of spinal cord injury, and which may help to alleviate some of their effects. In this thesis we describe our contributions in the following areas: 1. Control of Paraplegic Standing; This work concerns upright stance, and aims to provide; (i) automatic feedback control of balance during stance, with the arms free for functional tasks; (ii) methods and apparatus for dynamic standing therapy, which may help to enhance the individual's retained balance skills. This area of work has successfully demonstrated the automatic control of balance during quiet standing in paraplegic subjects. Further, we have established the feasibility of ankle stiffness control in paraplegic subjects using FES, and we have shown that this can be combined with volitional upper-body inputs to achieve stable, arm-free balance. 2. Lower-limb Cycling: Lower-limb cycling, achieved through electrical stimulation of paralysed leg-actuating muscles, is an effective exercise intervention. We have described refinements to the engineering design of an FES-cycling system, based upon the adaptation of commercially-available recumbent tricycles (of various designs), some of which are equipped with an auxiliary electric motor. We have contributed new methods of feedback control of key variables including cycle cadence and exercise workrate. These contributions have facilitated further detailed study of the effect of the exercise on cardiopulmonary fitness, bone integrity, spasticity, muscle condition, and factors relating to the likelihood of skin breakdown (i.e. the development of pressure sores). 3. Upper-limb Exercise in Tetraplegia; We have developed a new exercise modality for patients with a cervical-level injury and significant loss of arm function. The system allows effective arm ergometry by combining volitional motion with electrical stimulation of the paralysed upper-arm muscles. This work has developed new apparatus and exercise testing protocols, and has examined the effect of the exercise on cardiopulmonary fitness and muscle strength in experiments with tetraplegic subjects. 4. Modelling and Control of Stimulated Muscle; This fundamental area of research has investigated dynamic modelling and feedback control design approaches for electrically-stimulated muscle. This work has been applied in the three areas mentioned above. We identify promising areas for future research. These include extension of work on lower- limb cycling to patients with incomplete injuries, to those with cervical-level injuries, and to children with SCI. We wish to participate in a multi-centre clinical study of implanted nerve- root stimulation technology for restoration of bladder and bowel control, and for lower-limb exercise (including cycling). We have initiated a study of treadmill-based gait therapy for incomplete-lesion patients. The goals of this study are to develop test protocols for accurate characterisation of cardiopulmonary status, and to determine whether this form of cyclical lower-limb exercise has a positive impact on retained voluntary leg function. It is often the case that it is those people most severely affected by neurological impairment who stand to gain the most from these approaches (e.g. high-level tetraplegia, paediatric spinal cord injury, etc.). We must therefore continue to seek ways in which the work can be developed for the maximum benefit of these patients. In conclusion, this thesis has described original research contributions to the engineering development of systems which aim to restore important function and to enable effective exercise for people with spinal cord injury. An important facet of our work has been the application of feedback control methods; this has been an enabling factor in several areas of study. We have focused on areas which promise improved fitness and general health, and which may alleviate some of the secondary consequences of spinal cord injury. This work encompasses fundamental research, clinical studies, and the pursuit of technology transfer into clinical practice. Finally, we recognise the growing awareness of and interest in central nervous system plasticity, and in the broad field of central neural regeneration and repair. It is therefore timely to ask whether cyclical exercise interventions can lead to improvement of volitional function in patients with incomplete or discomplete lesions. Such improvements may, we speculate, result from the strengthening of muscles which retain at least partial volitional control, or from neural plasticity and re-organisation, or from regeneration effects (neurogenesis and functional connectivity). A key requirement in this line of investigation, and a major challenge, will be to develop or to utilise methods which can detect changes in a patient's volitional function and neurological status, and which can isolate the source of such changes. Should reliable methods become available, the way to the study of recovery of function through cyclical exercise would be opened. These considerations will remain, we propose, an indispensable complement to cell-based surgical interventions which may become available in the future

Internet of Things Applications - From Research and Innovation to Market Deployment

The book aims to provide a broad overview of various topics of Internet of Things from the research, innovation and development priorities to enabling technologies, nanoelectronics, cyber physical systems, architecture, interoperability and industrial applications. It is intended to be a standalone book in a series that covers the Internet of Things activities of the IERC – Internet of Things European Research Cluster from technology to international cooperation and the global "state of play".The book builds on the ideas put forward by the European research Cluster on the Internet of Things Strategic Research Agenda and presents global views and state of the art results on the challenges facing the research, development and deployment of IoT at the global level. Internet of Things is creating a revolutionary new paradigm, with opportunities in every industry from Health Care, Pharmaceuticals, Food and Beverage, Agriculture, Computer, Electronics Telecommunications, Automotive, Aeronautics, Transportation Energy and Retail to apply the massive potential of the IoT to achieving real-world solutions. The beneficiaries will include as well semiconductor companies, device and product companies, infrastructure software companies, application software companies, consulting companies, telecommunication and cloud service providers. IoT will create new revenues annually for these stakeholders, and potentially create substantial market share shakeups due to increased technology competition. The IoT will fuel technology innovation by creating the means for machines to communicate many different types of information with one another while contributing in the increased value of information created by the number of interconnections among things and the transformation of the processed information into knowledge shared into the Internet of Everything. The success of IoT depends strongly on enabling technology development, market acceptance and standardization, which provides interoperability, compatibility, reliability, and effective operations on a global scale. The connected devices are part of ecosystems connecting people, processes, data, and things which are communicating in the cloud using the increased storage and computing power and pushing for standardization of communication and metadata. In this context security, privacy, safety, trust have to be address by the product manufacturers through the life cycle of their products from design to the support processes. The IoT developments address the whole IoT spectrum - from devices at the edge to cloud and datacentres on the backend and everything in between, through ecosystems are created by industry, research and application stakeholders that enable real-world use cases to accelerate the Internet of Things and establish open interoperability standards and common architectures for IoT solutions. Enabling technologies such as nanoelectronics, sensors/actuators, cyber-physical systems, intelligent device management, smart gateways, telematics, smart network infrastructure, cloud computing and software technologies will create new products, new services, new interfaces by creating smart environments and smart spaces with applications ranging from Smart Cities, smart transport, buildings, energy, grid, to smart health and life. Technical topics discussed in the book include: • Introduction• Internet of Things Strategic Research and Innovation Agenda• Internet of Things in the industrial context: Time for deployment.• Integration of heterogeneous smart objects, applications and services• Evolution from device to semantic and business interoperability• Software define and virtualization of network resources• Innovation through interoperability and standardisation when everything is connected anytime at anyplace• Dynamic context-aware scalable and trust-based IoT Security, Privacy framework• Federated Cloud service management and the Internet of Things• Internet of Things Application

Proceedings of Abstracts 12th International Conference on Air Quality Science and Application

© 2020 The Author(s). This an open access work distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Final Published versio

Molecular genetic investigations of renal cell carcinoma predisposition

Renal Cell Carcinomas (RCC) are a diverse group of histologically and genetically distinct renal neoplasms accounting for 2.4% of all cancers worldwide. While a majority of RCC cases are sporadic in nature, a proportion are due to genetic predisposition caused by syndromic and non-syndromic conditions. Inherited renal cell carcinoma is associated with alterations in genes such as VHL, MET, FH, and FLCN and identification of these genes has been critical to understanding the molecular biology of both inherited and sporadic RCC, informing both clinical management and treatment. Despite the large number of known genes which are linked to RCC predisposition, most individuals with features of RCC predisposition do not harbour variants in known inherited RCC genes, suggesting additional unknown causes of heritability have yet to be uncovered. This study has utilised a range of genomic sequencing methodologies, scaling from single gene to whole genome sequencing, on individuals with features of renal cell carcinoma predisposition in order to identify novel causes of heritability associated with RCC. Multiple genomic sequencing approaches in these individuals has uncovered a range of potential genetic features that could be associated with predisposition to RCC, including genes not previously known to be associated with RCC, discovery of new molecular mechanisms of genetic inheritance for known RCC predisposition syndromes, and provided innovative methods for the identification and characterisation of molecular alterations in specific inherited RCC subtypes

Environmental Stewardship and the Virtuous Cycle: Pathways to Sustainability in a Coastal Context

Life on earth faces ongoing and growing anthropogenic threats. The need for sustainability through effective environmental stewardship is urgent, yet current concepts and frameworks are insufficient to achieve the sustainability agenda. Novel social-ecological research is required to better understand human-environment relationships, to balance the historic trend towards environmental pessimism with more positive opportunities for change, and to develop empirically grounded theories to inform real-world conservation outcomes. The aim of this thesis is to contribute new knowledge regarding effective environmental stewardship, the “virtuous cycle” of improving social and ecological outcomes, and sustainability. To achieve this, I investigated stewardship policies, actions, and their social and ecological outcomes in Australian coastal contexts. I gathered data over several years and four studies, spanning a range of scales from a single bioregion on the east coast of Australia to 56 sites over five States and 7000 km of coastline in southern Australia. My research questions explored the effectiveness of institutional stewardship policies in marine protected areas, the understanding and measurement of local environmental stewardship in people and places, and the depth of evidence to support (or not support) the virtuous cycle. I found empirical support for the virtuous cycle in the form of improving, mutually reinforcing social and ecological outcomes as a pathway to sustainability (Chapter 5 of this Thesis). These outcomes were driven by both institutional and local environmental stewardship, which operated separately but were strongest in combination. Institutional stewardship, in the form of marine protected areas, is effective under full protection but not partial protection (Chapter 4) and can work in small protected areas provided they are well-designed and managed and supported by the local community (Chapter 2). Local environmental stewardship comprises seven actions which can be quantified and is predicted by social-ecological factors such as attraction to wildlife and self-identification as local (Chapter 3). I conclude by presenting: (i) a new conceptual model - the Sustainability Spiral; (ii) policy and management implications including design guidelines for effective marine protected areas; (iii) strategies to increase local environmental stewardship; and (iv) general recommendations to enable the establishment of virtuous cycles for a sustainable future