18,236 research outputs found
Manifold Learning in MR spectroscopy using nonlinear dimensionality reduction and unsupervised clustering
Purpose To investigate whether nonlinear dimensionality reduction improves unsupervised classification of 1H MRS brain tumor data compared with a linear method. Methods In vivo single-voxel 1H magnetic resonance spectroscopy (55 patients) and 1H magnetic resonance spectroscopy imaging (MRSI) (29 patients) data were acquired from histopathologically diagnosed gliomas. Data reduction using Laplacian eigenmaps (LE) or independent component analysis (ICA) was followed by k-means clustering or agglomerative hierarchical clustering (AHC) for unsupervised learning to assess tumor grade and for tissue type segmentation of MRSI data. Results An accuracy of 93% in classification of glioma grade II and grade IV, with 100% accuracy in distinguishing tumor and normal spectra, was obtained by LE with unsupervised clustering, but not with the combination of k-means and ICA. With 1H MRSI data, LE provided a more linear distribution of data for cluster analysis and better cluster stability than ICA. LE combined with k-means or AHC provided 91% accuracy for classifying tumor grade and 100% accuracy for identifying normal tissue voxels. Color-coded visualization of normal brain, tumor core, and infiltration regions was achieved with LE combined with AHC. Conclusion Purpose To investigate whether nonlinear dimensionality reduction improves unsupervised classification of 1H MRS brain tumor data compared with a linear method. Methods In vivo single-voxel 1H magnetic resonance spectroscopy (55 patients) and 1H magnetic resonance spectroscopy imaging (MRSI) (29 patients) data were acquired from histopathologically diagnosed gliomas. Data reduction using Laplacian eigenmaps (LE) or independent component analysis (ICA) was followed by k-means clustering or agglomerative hierarchical clustering (AHC) for unsupervised learning to assess tumor grade and for tissue type segmentation of MRSI data. Results An accuracy of 93% in classification of glioma grade II and grade IV, with 100% accuracy in distinguishing tumor and normal spectra, was obtained by LE with unsupervised clustering, but not with the combination of k-means and ICA. With 1H MRSI data, LE provided a more linear distribution of data for cluster analysis and better cluster stability than ICA. LE combined with k-means or AHC provided 91% accuracy for classifying tumor grade and 100% accuracy for identifying normal tissue voxels. Color-coded visualization of normal brain, tumor core, and infiltration regions was achieved with LE combined with AHC. Conclusion The LE method is promising for unsupervised clustering to separate brain and tumor tissue with automated color-coding for visualization of 1H MRSI data after cluster analysis
Anomalous Normal-State Properties of High-T Superconductors -- Intrinsic Properties of Strongly Correlated Electron Systems?
A systematic study of optical and transport properties of the Hubbard model,
based on Metzner and Vollhardt's dynamical mean-field approximation, is
reviewed. This model shows interesting anomalous properties that are, in our
opinion, ubiquitous to single-band strongly correlated systems (for all spatial
dimensions greater than one), and also compare qualitatively with many
anomalous transport features of the high-T cuprates. This anomalous
behavior of the normal-state properties is traced to a ``collective single-band
Kondo effect,'' in which a quasiparticle resonance forms at the Fermi level as
the temperature is lowered, ultimately yielding a strongly renormalized Fermi
liquid at zero temperature.Comment: 27 pages, latex, 13 figures, Invited for publication in Advances in
Physic
Orbital order and fluctuations in Mott insulators
Basic mechanisms controlling orbital order and orbital fluctuations in
transition metal oxides are discussed. The lattice driven classical orbital
picture, e.g. like in manganites LaMnO, is contrasted to the quantum
behavior of orbitals in frustrated superexchange models as realised in
pseudocubic titanites ATiO and vanadates AVO. In YVO, the lattice
and superexchange effects strongly compete -- this explains the extreme
sensitivity of magnetic states to temperature and doping. Lifting the
orbital degeneracy by a relativistic spin-orbital coupling is considered on
example of the layered cobaltates. We find that the spin-orbital mixing of
low-energy states leads to unusual magnetic correlations in a triangular
lattice of the CoO parent compound. Finally, the magnetism of sodium-rich
compounds NaCoO is discussed in terms of a spin/orbital polaronic
liquid.Comment: 48 pages, 5 figures; typos corrected, journal reference adde
The metaRbolomics Toolbox in Bioconductor and beyond
Metabolomics aims to measure and characterise the complex composition of metabolites in a biological system. Metabolomics studies involve sophisticated analytical techniques such as mass spectrometry and nuclear magnetic resonance spectroscopy, and generate large amounts of high-dimensional and complex experimental data. Open source processing and analysis tools are of major interest in light of innovative, open and reproducible science. The scientific community has developed a wide range of open source software, providing freely available advanced processing and analysis approaches. The programming and statistics environment R has emerged as one of the most popular environments to process and analyse Metabolomics datasets. A major benefit of such an environment is the possibility of connecting different tools into more complex workflows. Combining reusable data processing R scripts with the experimental data thus allows for open, reproducible research. This review provides an extensive overview of existing packages in R for different steps in a typical computational metabolomics workflow, including data processing, biostatistics, metabolite annotation and identification, and biochemical network and pathway analysis. Multifunctional workflows, possible user interfaces and integration into workflow management systems are also reviewed. In total, this review summarises more than two hundred metabolomics specific packages primarily available on CRAN, Bioconductor and GitHub
Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis
Peer reviewedPublisher PD
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