Desynchronization: Synthesis of asynchronous circuits from synchronous specifications

Asynchronous implementation techniques, which measure logic delays at run time and activate registers accordingly, are inherently more robust than their synchronous counterparts, which estimate worst-case delays at design time, and constrain the clock cycle accordingly. De-synchronization is a new paradigm to automate the design of asynchronous circuits from synchronous specifications, thus permitting widespread adoption of asynchronicity, without requiring special design skills or tools. In this paper, we first of all study different protocols for de-synchronization and formally prove their correctness, using techniques originally developed for distributed deployment of synchronous language specifications. We also provide a taxonomy of existing protocols for asynchronous latch controllers, covering in particular the four-phase handshake protocols devised in the literature for micro-pipelines. We then propose a new controller which exhibits provably maximal concurrency, and analyze the performance of desynchronized circuits with respect to the original synchronous optimized implementation. We finally prove the feasibility and effectiveness of our approach, by showing its application to a set of real designs, including a complete implementation of the DLX microprocessor architectur

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner. While most studies focus on its role in the TNF-receptor complex, we here identify a novel component in the A20-mediated decision between life and death. Loss of A20 in NK cells led to spontaneous NK cell death and severe NK cell lymphopenia. The few remaining NK cells showed an immature, hyperactivated phenotype, hallmarked by the basal release of cytokines and cytotoxic molecules. NK-A20(-/-) cells were hypersensitive to TNF-induced cell death and could be rescued, at least partially, by a combined deficiency with TNF. Unexpectedly, rapamycin, a well-established inhibitor of mTOR, also strongly protected NK-A20(-/-) cells from death, and further studies revealed that A20 restricts mTOR activation in NK cells. This study therefore maps A20 as a crucial regulator of mTOR signaling and underscores the need for a tightly balanced mTOR pathway in NK cell homeostasis

Derivation of the Cubic Non-linear Schr\"odinger Equation from Quantum Dynamics of Many-Body Systems

We prove rigorously that the one-particle density matrix of three dimensional interacting Bose systems with a short-scale repulsive pair interaction converges to the solution of the cubic non-linear Schr\"odinger equation in a suitable scaling limit. The result is extended to $k$-particle density matrices for all positive integer $k$.Comment: 72 pages, 17 figures. Final versio

Modeling and optimum time performance for concurrent processing

The development of a new graph theoretic model for describing the relation between a decomposed algorithm and its execution in a data flow environment is presented. Called ATAMM, the model consists of a set of Petri net marked graphs useful for representing decision-free algorithms having large-grained, computationally complex primitive operations. Performance time measures which determine computing speed and throughput capacity are defined, and the ATAMM model is used to develop lower bounds for these times. A concurrent processing operating strategy for achieving optimum time performance is presented and illustrated by example

Heap Abstractions for Static Analysis

Heap data is potentially unbounded and seemingly arbitrary. As a consequence, unlike stack and static memory, heap memory cannot be abstracted directly in terms of a fixed set of source variable names appearing in the program being analysed. This makes it an interesting topic of study and there is an abundance of literature employing heap abstractions. Although most studies have addressed similar concerns, their formulations and formalisms often seem dissimilar and some times even unrelated. Thus, the insights gained in one description of heap abstraction may not directly carry over to some other description. This survey is a result of our quest for a unifying theme in the existing descriptions of heap abstractions. In particular, our interest lies in the abstractions and not in the algorithms that construct them. In our search of a unified theme, we view a heap abstraction as consisting of two features: a heap model to represent the heap memory and a summarization technique for bounding the heap representation. We classify the models as storeless, store based, and hybrid. We describe various summarization techniques based on k-limiting, allocation sites, patterns, variables, other generic instrumentation predicates, and higher-order logics. This approach allows us to compare the insights of a large number of seemingly dissimilar heap abstractions and also paves way for creating new abstractions by mix-and-match of models and summarization techniques.Comment: 49 pages, 20 figure

A Reference Interpreter for the Graph Programming Language GP 2

GP 2 is an experimental programming language for computing by graph transformation. An initial interpreter for GP 2, written in the functional language Haskell, provides a concise and simply structured reference implementation. Despite its simplicity, the performance of the interpreter is sufficient for the comparative investigation of a range of test programs. It also provides a platform for the development of more sophisticated implementations.Comment: In Proceedings GaM 2015, arXiv:1504.0244

Petri nets for systems and synthetic biology

We give a description of a Petri net-based framework for modelling and analysing biochemical pathways, which uni¯es the qualita- tive, stochastic and continuous paradigms. Each perspective adds its con- tribution to the understanding of the system, thus the three approaches do not compete, but complement each other. We illustrate our approach by applying it to an extended model of the three stage cascade, which forms the core of the ERK signal transduction pathway. Consequently our focus is on transient behaviour analysis. We demonstrate how quali- tative descriptions are abstractions over stochastic or continuous descrip- tions, and show that the stochastic and continuous models approximate each other. Although our framework is based on Petri nets, it can be applied more widely to other formalisms which are used to model and analyse biochemical networks

Reliability models for dataflow computer systems

The demands for concurrent operation within a computer system and the representation of parallelism in programming languages have yielded a new form of program representation known as data flow (DENN 74, DENN 75, TREL 82a). A new model based on data flow principles for parallel computations and parallel computer systems is presented. Necessary conditions for liveness and deadlock freeness in data flow graphs are derived. The data flow graph is used as a model to represent asynchronous concurrent computer architectures including data flow computers