Novel Image Representations and Learning Tasks

abstract: Computer Vision as a eld has gone through signicant changes in the last decade. The eld has seen tremendous success in designing learning systems with hand-crafted features and in using representation learning to extract better features. In this dissertation some novel approaches to representation learning and task learning are studied. Multiple-instance learning which is generalization of supervised learning, is one example of task learning that is discussed. In particular, a novel non-parametric k- NN-based multiple-instance learning is proposed, which is shown to outperform other existing approaches. This solution is applied to a diabetic retinopathy pathology detection problem eectively. In cases of representation learning, generality of neural features are investigated rst. This investigation leads to some critical understanding and results in feature generality among datasets. The possibility of learning from a mentor network instead of from labels is then investigated. Distillation of dark knowledge is used to eciently mentor a small network from a pre-trained large mentor network. These studies help in understanding representation learning with smaller and compressed networks.Dissertation/ThesisDoctoral Dissertation Computer Science 201

SSL-CPCD: Self-supervised learning with composite pretext-class discrimination for improved generalisability in endoscopic image analysis

Data-driven methods have shown tremendous progress in medical image analysis. In this context, deep learning-based supervised methods are widely popular. However, they require a large amount of training data and face issues in generalisability to unseen datasets that hinder clinical translation. Endoscopic imaging data incorporates large inter- and intra-patient variability that makes these models more challenging to learn representative features for downstream tasks. Thus, despite the publicly available datasets and datasets that can be generated within hospitals, most supervised models still underperform. While self-supervised learning has addressed this problem to some extent in natural scene data, there is a considerable performance gap in the medical image domain. In this paper, we propose to explore patch-level instance-group discrimination and penalisation of inter-class variation using additive angular margin within the cosine similarity metrics. Our novel approach enables models to learn to cluster similar representative patches, thereby improving their ability to provide better separation between different classes. Our results demonstrate significant improvement on all metrics over the state-of-the-art (SOTA) methods on the test set from the same and diverse datasets. We evaluated our approach for classification, detection, and segmentation. SSL-CPCD achieves 79.77% on Top 1 accuracy for ulcerative colitis classification, 88.62% on mAP for polyp detection, and 82.32% on dice similarity coefficient for segmentation tasks are nearly over 4%, 2%, and 3%, respectively, compared to the baseline architectures. We also demonstrate that our method generalises better than all SOTA methods to unseen datasets, reporting nearly 7% improvement in our generalisability assessment.Comment: 1

Deep learning to find colorectal polyps in colonoscopy: A systematic literature review

Colorectal cancer has a great incidence rate worldwide, but its early detection significantly increases the survival rate. Colonoscopy is the gold standard procedure for diagnosis and removal of colorectal lesions with potential to evolve into cancer and computer-aided detection systems can help gastroenterologists to increase the adenoma detection rate, one of the main indicators for colonoscopy quality and predictor for colorectal cancer prevention. The recent success of deep learning approaches in computer vision has also reached this field and has boosted the number of proposed methods for polyp detection, localization and segmentation. Through a systematic search, 35 works have been retrieved. The current systematic review provides an analysis of these methods, stating advantages and disadvantages for the different categories used; comments seven publicly available datasets of colonoscopy images; analyses the metrics used for reporting and identifies future challenges and recommendations. Convolutional neural networks are the most used architecture together with an important presence of data augmentation strategies, mainly based on image transformations and the use of patches. End-to-end methods are preferred over hybrid methods, with a rising tendency. As for detection and localization tasks, the most used metric for reporting is the recall, while Intersection over Union is highly used in segmentation. One of the major concerns is the difficulty for a fair comparison and reproducibility of methods. Even despite the organization of challenges, there is still a need for a common validation framework based on a large, annotated and publicly available database, which also includes the most convenient metrics to report results. Finally, it is also important to highlight that efforts should be focused in the future on proving the clinical value of the deep learning based methods, by increasing the adenoma detection rate.This work was partially supported by PICCOLO project. This project has received funding from the European Union's Horizon2020 Research and Innovation Programme under grant agreement No. 732111. The sole responsibility of this publication lies with the author. The European Union is not responsible for any use that may be made of the information contained therein. The authors would also like to thank Dr. Federico Soria for his support on this manuscript and Dr. José Carlos Marín, from Hospital 12 de Octubre, and Dr. Ángel Calderón and Dr. Francisco Polo, from Hospital de Basurto, for the images in Fig. 4

Artificial intelligence and automation in endoscopy and surgery

Modern endoscopy relies on digital technology, from high-resolution imaging sensors and displays to electronics connecting configurable illumination and actuation systems for robotic articulation. In addition to enabling more effective diagnostic and therapeutic interventions, the digitization of the procedural toolset enables video data capture of the internal human anatomy at unprecedented levels. Interventional video data encapsulate functional and structural information about a patient’s anatomy as well as events, activity and action logs about the surgical process. This detailed but difficult-to-interpret record from endoscopic procedures can be linked to preoperative and postoperative records or patient imaging information. Rapid advances in artificial intelligence, especially in supervised deep learning, can utilize data from endoscopic procedures to develop systems for assisting procedures leading to computer-assisted interventions that can enable better navigation during procedures, automation of image interpretation and robotically assisted tool manipulation. In this Perspective, we summarize state-of-the-art artificial intelligence for computer-assisted interventions in gastroenterology and surgery

A Robust and Fast System for CTC Computer-Aided Detection of Colorectal Lesions

We present a complete, end-to-end computer-aided detection (CAD) system for identifying lesions in the colon, imaged with computed tomography (CT). This system includes facilities for colon segmentation, candidate generation, feature analysis, and classification. The algorithms have been designed to offer robust performance to variation in image data and patient preparation. By utilizing efficient 2D and 3D processing, software optimizations, multi-threading, feature selection, and an optimized cascade classifier, the CAD system quickly determines a set of detection marks. The colon CAD system has been validated on the largest set of data to date, and demonstrates excellent performance, in terms of its high sensitivity, low false positive rate, and computational efficiency