Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning

The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the number of total and mature dendritic spines in DH. Intra-basolateral amygdala (BLA) infusion of midazolam prior to stress prevented both the enhancement of fear retention and an increase in the density of total and mature dendritic spines in DH. These findings emphasize the role of the stress-induced attenuation of GABAergic neurotransmission in BLA in the promoting influence of stress on fear memory and on synaptic remodeling in DH. In conclusion, the structural remodeling in DH accompanied the facilitated fear memory following a combination of fear conditioning and stressful stimulation.Fil: Giachero, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Calfa, Gaston Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentin

O(N)-Space Spatiotemporal Filter for Reducing Noise in Neuromorphic Vision Sensors

Neuromorphic vision sensors are an emerging technology inspired by how retina processing images. A neuromorphic vision sensor only reports when a pixel value changes rather than continuously outputting the value every frame as is done in an 'ordinary' Active Pixel Sensor (ASP). This move from a continuously sampled system to an asynchronous event driven one effectively allows for much faster sampling rates; it also fundamentally changes the sensor interface. In particular, these sensors are highly sensitive to noise, as any additional event reduces the bandwidth, and thus effectively lowers the sampling rate. In this work we introduce a novel spatiotemporal filter with O(N)O(N) memory complexity for reducing background activity noise in neuromorphic vision sensors. Our design consumes 10× less memory and has 100× reduction in error compared to previous designs. Our filter is also capable of recovering real events and can pass up to 180 percent more real events

The ACS Virgo Cluster Survey. XVII. The Spatial Alignment of Globular Cluster Systems With Early-Type Host Galaxies

We study the azimuthal distribution of globular clusters (GCs) in early-type galaxies and compare them to their host galaxies using data from the ACS Virgo Cluster Survey. We find that in host galaxies with visible elongation (epsilon > 0.2) and intermediate to high luminosities (M_z<-19), the GCs are preferentially aligned along the major axis of the stellar light. The red (metal-rich) GC subpopulations show strong alignment with the major axis of the host galaxy, which supports the notion that these GCs are associated with metal-rich field stars. The metal-rich GCs in lenticular galaxies show signs of being more strongly associated with disks rather than bulges. Surprisingly, we find that the blue (metal-poor) GCs can also show the same correlation. If the metal-poor GCs are part of the early formation of the halo and built up through mergers, then our results support a picture where halo formation and merging occur anisotropically, and where the present day major axis is an indicator of the preferred merging axis.Comment: 8 pages, 7 figures, accepted for publication in The Astrophysical Journa

Comparison of transabdominal ultrasound and electromagnetic transponders for prostate localization.

The aim of this study is to compare two methodologies of prostate localization in a large cohort of patients. Daily prostate localization using B-mode ultrasound has been performed at the Nebraska Medical Center since 2000. More recently, a technology using electromagnetic transponders implanted within the prostate was introduced into our clinic (Calypso(R)). With each technology, patients were localized initially using skin marks. Localization error distributions were determined from offsets between the initial setup positions and those determined by ultrasound or Calypso. Ultrasound localization data was summarized from 16619 imaging sessions spanning 7 years; Calypso localization data consists of 1524 fractions in 41 prostate patients treated in the course of a clinical trial at five institutions and 640 localizations from the first 16 patients treated with our clinical system. Ultrasound and Calypso patients treated between March and September 2007 at the Nebraska Medical Center were analyzed and compared, allowing a single institutional comparison of the two technologies. In this group of patients, the isocenter determined by ultrasound-based localization is on average 5.3 mm posterior to that determined by Calypso, while the systematic and random errors and PTV margins calculated from the ultrasound localizations were 3 - 4 times smaller than those calculated from the Calypso localizations. Our study finds that there are systematic differences between Calypso and ultrasound for prostate localization

Statistical Characterization of Temperature Patterns in Anisotropic Cosmologies

We consider the issue of characterizing the coherent large-scale patterns from CMB temperature maps in globally anisotropic cosmologies. The methods we investigate are reasonably general; the particular models we test them on are the homogeneous but anisotropic relativistic cosmologies described by the Bianchi classification. Although the temperature variations produced in these models are not stochastic, they give rise to a "non-Gaussian" distribution of temperature fluctuations over the sky that is a partial diagnostic of the model. We explore two methods for quantifying non-Gaussian and/or non-stationary fluctuation fields in order to see how they respond to the Bianchi models.We first investigate the behavior of phase correlations between the spherical harmonic modes of the maps. Then we examine the behavior of the multipole vectors of the temperature distribution which, though defined in harmonic space, can indicate the presence of a preferred direction in real space, i.e. on the 2-sphere. These methods give extremely clear signals of the presence of anisotropy when applied to the models we discuss, suggesting that they have some promise as diagnostics of the presence of global asymmetry in the Universe.Comment: 14 pages, 10 figures, 4 tables, accepted by MNRA