Total hip arthroplasty through the direct anterior approach for sequelae of Legg-Calvé-Perthes disease

INTRODUCTION Due to multiplanar deformities of the hip, total hip arthroplasty (THA) for sequelae of Legg-Calvé-Perthes disease (LCPD) is often technically demanding. This study aimed to compare the clinical and radiographic outcomes of patients with sequelae of LCPD undergoing THA through the direct anterior approach (DAA) and non-anterior approaches to the hip. METHODS All patients with sequelae of LCPD who underwent primary THA between 2004 and 2018 (minimum follow-up: 2 years) were evaluated and separated into two groups: THA through the DAA (Group AA), or THA through non-anterior approaches to the hip (Group non-AA). Furthermore, a consecutive control group of patients undergoing unilateral THA through the DAA for primary hip osteoarthritis (Group CC) was retrospectively reviewed for comparison. RESULTS Group AA comprises 14 hips, group non-AA 17 hips and group CC 30 hips. Mean follow-up was 8.6 (± 5.2; 2-15), 9.0 (± 4.6; 3-17) and 8.1 (± 2.2; 5-12) years, respectively. At latest follow-up, Harris Hip Score was 90 (± 20; 26-100), 84 (± 15; 57-100), and 95 (± 9; 63-100) points, respectively. Overall, 6 patients treated for LCPD (each 3 patient in the AA and non-AA group) developed postoperative sciatic nerve palsy, of which only one was permanent. Complication-related revision rate at the latest follow-up was 15% in the AA-group and 25% in the non-AA group, respectively. CONCLUSION THA through the DAA might be a credible option for the treatment of sequelae of LCPD with comparable complication rates and functional outcomes to non-anterior approaches

EmbraceNet for Activity: A Deep Multimodal Fusion Architecture for Activity Recognition

Human activity recognition using multiple sensors is a challenging but promising task in recent decades. In this paper, we propose a deep multimodal fusion model for activity recognition based on the recently proposed feature fusion architecture named EmbraceNet. Our model processes each sensor data independently, combines the features with the EmbraceNet architecture, and post-processes the fused feature to predict the activity. In addition, we propose additional processes to boost the performance of our model. We submit the results obtained from our proposed model to the SHL recognition challenge with the team name "Yonsei-MCML."Comment: Accepted in HASCA at ACM UbiComp/ISWC 2019, won the 2nd place in the SHL Recognition Challenge 201

A Feasibility Study on the Use of a Structured Light Depth-Camera for Three-Dimensional Body Measurements of Dairy Cows in Free-Stall Barns

Frequent checks on livestock\u2019s body growth can help reducing problems related to cow infertility or other welfare implications, and recognizing health\u2019s anomalies. In the last ten years, optical methods have been proposed to extract information on various parameters while avoiding direct contact with animals\u2019 body, generally causes stress. This research aims to evaluate a new monitoring system, which is suitable to frequently check calves and cow\u2019s growth through a three-dimensional analysis of their bodies\u2019 portions. The innovative system is based on multiple acquisitions from a low cost Structured Light Depth-Camera (Microsoft Kinect\u2122 v1). The metrological performance of the instrument is proved through an uncertainty analysis and a proper calibration procedure. The paper reports application of the depth camera for extraction of different body parameters. Expanded uncertainty ranging between 3 and 15 mm is reported in the case of ten repeated measurements. Coef\ufb01cients of determination R2> 0.84 and deviations lower than 6% from manual measurements where in general detected in the case of head size, hips distance, withers to tail length, chest girth, hips, and withers height. Conversely, lower performances where recognized in the case of animal depth (R2 = 0.74) and back slope (R2 = 0.12)

Human 3D cellular model of hypoxic brain injury of prematurity.

Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates1,2. After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and can develop a severe condition called encephalopathy of prematurity3. Over 80% of infants born before post-conception week 25 have moderate-to-severe long-term neurodevelopmental impairments4. The susceptible cell types in the cerebral cortex and the molecular mechanisms underlying associated gray-matter defects in premature infants remain unknown. Here we used human three-dimensional brain-region-specific organoids to study the effect of oxygen deprivation on corticogenesis. We identified specific defects in intermediate progenitors, a cortical cell type associated with the expansion of the human cerebral cortex, and showed that these are related to the unfolded protein response and changes. Moreover, we verified these findings in human primary cortical tissue and demonstrated that a small-molecule modulator of the unfolded protein response pathway can prevent the reduction in intermediate progenitors following hypoxia. We anticipate that this human cellular platform will be valuable for studying the environmental and genetic factors underlying injury in the developing human brain

Acoustic power absorption and enhancement generated by slow and fast MHD waves

We used long duration, high quality, unresolved (Sun-as-a star) observations collected by the ground based network BiSON and by the instruments GOLF and VIRGO on board the ESA/NASA SOHO satellite to search for solar-cycle-related changes in mode characteristics in velocity and continuum intensity for the frequency range between 2.5mHz < nu < 6.8mHz. Over the ascending phase of solar cycle 23 we found a suppression in the p-mode amplitudes both in the velocity and intensity data between 2.5mHz <nu< 4.5mHz with a maximum suppression for frequencies in the range between 2.5mHz <nu< 3.5mHz. The size of the amplitude suppression is 13+-2 per cent for the velocity and 9+-2 per cent for the intensity observations. Over the range 4.5mHz <nu< 5.5mHz the findings hint within the errors to a null change both in the velocity and intensity amplitudes. At still higher frequencies, in the so called High-frequency Interference Peaks (HIPs) between 5.8mHz <nu < 6.8mHz, we found an enhancement in the velocity amplitudes with the maximum 36+-7 per cent occurring for 6.3mHz <nu< 6.8mHz. However, in intensity observations we found a rather smaller enhancement of about 5+-2 per cent in the same interval. There is evidence that the frequency dependence of solar-cycle velocity amplitude changes is consistent with the theory behind the mode conversion of acoustic waves in a non-vertical magnetic field, but there are some problems with the intensity data, which may be due to the height in the solar atmosphere at which the VIRGO data are taken.Comment: Accepted for publication in A&A. 10 pages, 9 figures

An investigation into the impact of coaching strategies with respect to physical and performance characteristics of male youth of varying biological maturation

This thesis will be presented as two standalone experimental chapters which will culminate in a thesis discussion linking the two papers under the overarching concept of maturation in male youth. Chapter 2 is currently under review in ‘Cogent Medicine’, and the intention of Chapter 2 is to identify physical, injury and performance-based differences between maturational groups within a general school-based population of 8 youth. These observed differences within Chapter 2 will then inform the methodology and coaching strategies utilised within Chapter 3, which will investigate the effectiveness of various coaching methods in order to maximise adaptation, motor ability and injury prevention within each maturational group. The outcome of this thesis hopes to inform practitioners as to how they can best implement their training programmes to maximise learning and adaptation across a range of biological maturation levels. Rather than just knowing when training should occur which has been investigated previously, it is hoped this thesis will provide insight into how coaching should occur to maximise learning within this diverse adolescent population. Due to the layout of this thesis with the individual papers, there is an element of content repetition throughout Chapters 1,2,3 and 4 which needs to be acknowledged, although the various contexts provides uniqueness throughout

Outcomes of intra-articular corticosteroid injections for adolescents with hip pain.

Intra-articular injection of corticosteroid and anesthetic (CSI) is a useful diagnostic tool for hip pain secondary to labral tears or femoroacetabular impingement (FAI). However, the effectiveness of CSI as a stand-alone treatment for hip pain in adolescents is unknown. The purpose of this study is to evaluate the use of CSI for the treatment of hip pain and determine factors that may affect outcomes after injection. Retrospective analysis of 18 patients and 19 hips that underwent fluoroscopic guided hip injection for the treatment of pain at a single institution from 2012 to 2015 was carried out in this study. Mean age at the time of injection was 15.1 years (range 13-17) with mean follow-up of 29.4 months. Fifty-two percent (10/19 hips) went on to surgery after the injection. Average time to surgical conversion was 12.8 months after CSI. Cam or pincer morphologies were present in 90% (9/10 hips) of the operative group. Patients with FAI were more likely to need surgery than patients without bony abnormalities (RR= 10, 95% CI 1.6-64.2, P = 0.0001). There was no difference in the presence of labral tears in the operative and non-operative groups (100% versus 89%, P = 0.47). For adolescents without bony abnormalities, 90% improved with CSI alone and did not require further treatment within 2.4 years. Fluoroscopic guided corticosteroid hip injection may have limited efficacy for the treatment of hip pain secondary to FAI in adolescents. However, for patients without osseous deformity, CSI may offer prolonged improvement of symptoms even in the presence of labral tears