The two-component model of memory development, and its potential implications for educational settings

We recently introduced a two-component model of the mechanisms underlying age differences in memory functioning across the lifespan. According to this model, memory performance is based on associative and strategic components. The associative component is relatively mature by middle childhood, whereas the strategic component shows a maturational lag and continues to develop until young adulthood. Focusing on work from our own lab, we review studies from the domains of episodic and working memory informed by this model, and discuss their potential implications for educational settings. The episodic memory studies uncover the latent potential of the associative component in childhood by documenting children's ability to greatly improve their memory performance following mnemonic instruction and training. The studies on working memory also point to an immature strategic component in children whose operation is enhanced under supportive conditions. Educational settings may aim at fostering the interplay between associative and strategic components. We explore possible routes towards this goal by linking our findings to recent trends in research on instructional design

Age-related changes to the neural correlates of working memory which emerge after midlife

Previous research has indicated that the neural processes which underlie working memory change with age. Both age-related increases and decreases to cortical activity have been reported. This study investigated which stages of working memory are most vulnerable to age-related changes after midlife. To do this we examined age-differences in the 13 Hz steady state visually evoked potential (SSVEP) associated with a spatial working memory delayed response task. Participants were 130 healthy adults separated into a midlife (40-60 years) and an older group (61-82 years). Relative to the midlife group, older adults demonstrated greater bilateral frontal activity during encoding and this pattern of activity was related to better working memory performance. In contrast, evidence of age-related under activation was identified over left frontal regions during retrieval. Findings from this study suggest that after midlife, under-activation of frontal regions during retrieval contributes to age-related decline in working memory performance. © 2014 Macpherson, White, Ellis, Stough, Camfield, Silberstein and Pipingas

Neural dynamics of selective attention to speech in noise

This thesis investigates how the neural system instantiates selective attention to speech in challenging acoustic conditions, such as spectral degradation and the presence of background noise. Four studies using behavioural measures, magneto- and electroencephalography (M/EEG) recordings were conducted in younger (20–30 years) and older participants (60–80 years). The overall results can be summarized as follows. An EEG experiment demonstrated that slow negative potentials reflect participants’ enhanced allocation of attention when they are faced with more degraded acoustics. This basic mechanism of attention allocation was preserved at an older age. A follow-up experiment in younger listeners indicated that attention allocation can be further enhanced in a context of increased task-relevance through monetary incentives. A subsequent study focused on brain oscillatory dynamics in a demanding speech comprehension task. The power of neural alpha oscillations (~10 Hz) reflected a decrease in demands on attention with increasing acoustic detail and critically also with increasing predictiveness of the upcoming speech content. Older listeners’ behavioural responses and alpha power dynamics were stronger affected by acoustic detail compared with younger listeners, indicating that selective attention at an older age is particularly dependent on the sensory input signal. An additional analysis of listeners’ neural phase-locking to the temporal envelopes of attended speech and unattended background speech revealed that younger and older listeners show a similar segregation of attended and unattended speech on a neural level. A dichotic listening experiment in the MEG aimed at investigating how neural alpha oscillations support selective attention to speech. Lateralized alpha power modulations in parietal and auditory cortex regions predicted listeners’ focus of attention (i.e., left vs right). This suggests that alpha oscillations implement an attentional filter mechanism to enhance the signal and to suppress noise. A final behavioural study asked whether acoustic and semantic aspects of task-irrelevant speech determine how much it interferes with attention to task-relevant speech. Results demonstrated that younger and older adults were more distracted when acoustic detail of irrelevant speech was enhanced, whereas predictiveness of irrelevant speech had no effect. All findings of this thesis are integrated in an initial framework for the role of attention for speech comprehension under demanding acoustic conditions

A comparison of visual working memory and episodic memory performance in younger and older adults

Item does not contain fulltextWorking memory and episodic memory decline with age.  However, as they are typically studied separately, it is largely unknown whether age-associated differences are similar. A task design was developed in which visual working memory and episodic memory performances were measured using the same stimuli, with both tasks involving context binding. A 2-back working memory task was followed by a surprise subsequent recognition memory task that assessed incidental encoding of object locations of the 2-back task. The study compared performance of younger (N=30; Mage=23.5, SDage=2.9, range=20-29) and older adults (N=29; Mage=72.1, SDage=6.8, range=62-90). Older adults performed worse than younger adults, without an interaction effect. In younger, but not in older adults, performance on the two tasks was related. We conclude that although age differences (Young>Older) are similar in the working memory and incidental associative memory tasks, the relationship between the two memory systems differs as a function of age group.20 p

Cortical and subcortical speech-evoked responses in young and older adults: Effects of background noise, arousal states, and neural excitability

This thesis investigated how the brain processes speech signals in human adults across a wide age-range in the sensory auditory systems using electroencephalography (EEG). Two types of speech-evoked phase-locked responses were focused on: (i) cortical responses (theta-band phase-locked responses) that reflect processing of low-frequency slowly-varying envelopes of speech; (ii) subcortical/peripheral responses (frequency-following responses; FFRs) that reflect encoding of speech periodicity and temporal fine structure information. The aims are to elucidate how these neural activities are affected by different internal (aging, hearing loss, level of arousal and neural excitability) and external (background noise) factors during our daily life through three studies. Study 1 investigated theta-band phase-locking and FFRs in noisy environments in young and older adults. It investigated how aging and hearing loss affect these activities under quiet and noisy environments, and how these activities are associated with speech-in-noise perception. The results showed that ageing and hearing loss affect speech-evoked phase-locked responses through different mechanisms, and the effects of aging on cortical and subcortical activities take different roles in speech-in-noise perception. Study 2 investigated how level of arousal, or consciousness, affects phase-locked responses in young and older adults. The results showed that both theta-band phase-locking and FFRs decreases following decreases in the level of arousal. It was further found that neuro-regulatory role of sleep spindles on theta-band phase-locking is distinct between young and older adults, indicating that the mechanisms of neuro-regulation for phase-locked responses in different arousal states are age-dependent. Study 3 established a causal relationship between the auditory cortical excitability and FFRs using combined transcranial direct current stimulation (tDCS) and EEG. FFRs were measured before and after tDCS was applied over the auditory cortices. The results showed that changes in neural excitability of the right auditory cortex can alter FFR magnitudes along the contralateral pathway. This shows important theoretical and clinical implications that causally link functions of auditory cortex with neural encoding of speech periodicity. Taken together, findings of this thesis will advance our understanding of how speech signals are processed via neural phase-locking in our everyday life across the lifespan

Investigating the neural mechanisms underlying auditory and audio-visual perception in younger and older adults

This thesis aimed to address questions in two distinct areas of research in ageing and cognitive neuroscience. Firstly, given that the pre-stimulus state of cortical oscillations had been shown to predict behavioural and neural responses, we addressed the question of whether pre-stimulus oscillatory mechanisms change or remain consistent in the ageing brain. Secondly, previous research had shown that Audio-visual (AV) speech influences the amplitude and latency of evoked activity. Our research addressed the questions of whether/how AV enhancement and visual predictability of AV speech is represented in evoked activity in noisy listening conditions, and whether such Electroencephalographic (EEG) signatures remain stable with age. In Chapter 3 we investigated the consistency of how pre-stimulus activity influences auditory frequency discrimination performance in young and older participants. In both groups the power of pre-stimulus activity influenced the encoding of sensory evidence reflected by early evoked components, while the phase influenced choice formation in later-activated EEG components. Importantly, for the early EEG components we did not find evidence for a systematic difference in the time scales of the perceptually relevant pre-stimulus activity. In the later-activated EEG component we found a trend for perceptually relevant rhythmic activity to arise from slower frequencies in the ageing brain. At the same time our data replicate previous findings of a significant age-related slowing of Auditory Evoked Potential (AEP) latency, modulations of AEP amplitudes, and a flattening of the spectral profile of EEG activity. In Chapter 4, we investigated the consistency of behaviour and evoked activity underlying AV speech integration in a speech-in-noise discrimination task in younger and older adults. Behaviourally, younger and older adults performed comparably. Performance was greater for Audio-visually informative (AVinf) speech compared to Auditory-only informative (AOinf) speech across groups and noise levels, and was poorer at low noise levels. AV enhancement was greater in high noise levels, across all participants, and older adults derived greater AV enhancement compared to younger adults (an effect that was consistent across noise levels). In terms of visual predictability, we found that word discrimination performance was greater for target words with non-labial initial phonemes (assumed least visually predictive), compared to labial initial phonemes (assumed most visually predictive). Furthermore, we found that AV enhancement was greater for labial initial phonemes, compared to non-labial initial phonemes, and this was consistent across age groups.Neurally, we found that AV enhancement is represented by a centro-parietal P3-like activity in older adults and an N4-like fronto-central activity in younger adults, but found that this activity did not correlate with behavioural AV enhancement. Our results point to distinct patterns of late evoked activity underlying AV enhancement between younger and older adults, possibly representing distinct cognitive (memory) strategies in predicting upcoming target stimuli. At the same time our data replicate previous findings of a significant age-related slowing of AEP latency, modulations of AEP amplitudes, and a flattening of the spectral profile of EEG activity. In Chapter 5 we investigated the consistency of evoked activity underlying the visual predictability of AV speech. We found that visual predictability was reflected by late fronto-central negativity in older adults, but not in younger adults. However, we did not find evidence of an interaction between visual predictability and AV enhancement in terms of evoked activity, raising further questions about how visual predictability of speech is represented the brain’s electrophysiology. Our results point to distinct patterns of late evoked activity underlying visual predictability of visual speech, again possibly reflecting differential strategies in predictive coding. In summary, the results of this thesis demonstrate that pre-stimulus mechanisms in auditory pitch perception remain consistent in the younger and older adult brain, while spectral dynamics change with age. Our results also replicate previous work demonstrating age-related delays in peak latency, and changes in peak amplitude, of early auditory evoked activity. And lastly, we demonstrate that differences in the EEG signatures of AV enhancement between younger and older adults emerge in late evoked activity, and that visual predictability of speech is represented in late evoked activity only in older adults

Brain maturation throughout adolescence : an EEG study

Objective: Adolescence is characterised by a genuine interest in new experiences and an increased sense of responsibility. The aim of this study was to investigate changes in brain maturation that underlie task-relevant behaviour and the relation of these changes to novel impressions during the transition from childhood into adolescence and then young adulthood. We hypothesized that, with development, improved target detection abilities and reduced distractibility will be characterised by an increased involvement of frontal brain regions within the fronto-parietal brain network during novel processing and target detection. Methods: In a cross-sectional study, a classical visual oddball task (n = 159) and a novelty visual oddball task (n = 84) were utilized in combination with EEG measurements to investigate brain maturation between late childhood and young adulthood (8 to 30 years of age). Developmental changes of late ERP components and concurrent delta (0.5 - 4 Hz) and theta (4 - 7 Hz) oscillations were analysed using regression models. Pre-stimulus amplitude and post-stimulus amplitude modulation, inter-trial phase coherence of local maxima and inter-electrode spatial phase coherence were assessed. Results and Discussion: A general decline in reaction time and late ERP latency (novelty N2, P3a and P3b) with age was observed and may depend on task performance. The frontal novelty N2 amplitude decreased while the P3a amplitude increased with age. This opposing developmental trend may relate to a compensatory mechanism for immature P3a-related cognitive functions, such as attention control. The pre-stimulus amplitudes of delta and theta oscillations decreased while post-stimulus amplitude enhancements and inter-trial phase coherence increased with age. Both effects seem to underlie maturation of the P3b amplitude, even though this cannot be observed directly in ERP amplitude measurements. Post-stimulus theta inter-electrode spatial phase coherence originating from frontal electrode sites increased with age during novel and target stimulus processing, indicating prolonged maturation of the fronto-parietal network that underlies target detection and novel processing. Conclusion: Functional brain networks involving the frontal cortex, such as the fronto-parietal network, mature until young adulthood, thereby affecting slow-wave oscillations on a local and global scale alongside late frontal ERP components. Brain maturation during adolescence may lead to a reduction of spontaneous slow-wave oscillations and an enhancement of amplitude modulation and regional and inter-regional precision of timing of event-related oscillations within the P3 time-window. Thus, brain maturation underlying task-related behaviour and reduced distractibility is versatile. Significance: Combined analysis of developmental trajectories of late ERPs, concurrent changes in spontaneous and task-modulated brain oscillations and their embedding within functional brain networks (e.g., the fronto-parietal network) is important to estimate how brain maturation relates to abilities of cognitive control during the transition into adolescence and young adulthood. It is critical to extend our understanding of healthy brain maturation as excessive brain plasticity during adolescence raises the sensitivity to the environment and learning experiences, and its outcome may have long-term positive or negative impact on personal opportunities in life and mental health

Change blindness: eradication of gestalt strategies

Arrays of eight, texture-defined rectangles were used as stimuli in a one-shot change blindness (CB) task where there was a 50% chance that one rectangle would change orientation between two successive presentations separated by an interval. CB was eliminated by cueing the target rectangle in the first stimulus, reduced by cueing in the interval and unaffected by cueing in the second presentation. This supports the idea that a representation was formed that persisted through the interval before being 'overwritten' by the second presentation (Landman et al, 2003 Vision Research 43149–164]. Another possibility is that participants used some kind of grouping or Gestalt strategy. To test this we changed the spatial position of the rectangles in the second presentation by shifting them along imaginary spokes (by ±1 degree) emanating from the central fixation point. There was no significant difference seen in performance between this and the standard task [F(1,4)=2.565, p=0.185]. This may suggest two things: (i) Gestalt grouping is not used as a strategy in these tasks, and (ii) it gives further weight to the argument that objects may be stored and retrieved from a pre-attentional store during this task