Breast cancer diagnosis: a survey of pre-processing, segmentation, feature extraction and classification

Machine learning methods have been an interesting method in the field of medical for many years, and they have achieved successful results in various fields of medical science. This paper examines the effects of using machine learning algorithms in the diagnosis and classification of breast cancer from mammography imaging data. Cancer diagnosis is the identification of images as cancer or non-cancer, and this involves image preprocessing, feature extraction, classification, and performance analysis. This article studied 93 different references mentioned in the previous years in the field of processing and tries to find an effective way to diagnose and classify breast cancer. Based on the results of this research, it can be concluded that most of today’s successful methods focus on the use of deep learning methods. Finding a new method requires an overview of existing methods in the field of deep learning methods in order to make a comparison and case study

DEEP LEARNING BASED SEGMENTATION AND CLASSIFICATION FOR IMPROVED BREAST CANCER DETECTION

Breast Cancer is a leading killer of women globally. It is a serious health concern caused by calcifications or abnormal tissue growth in the breast. Doing a screening and identifying the nature of the tumor as benign or malignant is important to facilitate early intervention, which drastically decreases the mortality rate. Usually, it uses ultrasound images, since they are easily accessible to most people and have no drawbacks as such, unlike in the other most famous screening technique of mammograms where in some cases you may not get a clear scan. In this thesis, the approach to this problem is to build a stacked model which makes predictions on the basis of the shape, pattern, and spread of the tumor. To achieve this, typical steps are pre-processing of images followed by segmentation of the image and classification. For pre-processing, the proposed approach in this thesis uses histogram equalization that helps in improving the contrast of the image, making the tumor stand out from its surroundings, and making it easier for the segmentation step. Through segmentation, the approach uses UNet architecture with a ResNet backbone. The UNet architecture is made specifically for biomedical imaging. The aim of segmentation is to separate the tumor from the ultrasound image so that the classification model can make its predictions from this mask. The metric result of the F1-score for the segmentation model turned out to be 97.30%. For classification, the CNN base model is used for feature extraction from provided masks. These are then fed into a network and the predictions are done. The base CNN model used is ResNet50 and the neural network used for the output layer is a simple 8-layer network with ReLU activation in the hidden layers and softmax in the final decision-making layer. The ResNet weights are initialized from training on ImageNet. The ResNet50 returns 2048 features from each mask. These are then fed into the network for decision-making. The hidden layers of the neural network have 1024, 512, 256, 128, 64, 32, and 10 neurons respectively. The classification accuracy achieved for the proposed model was 98.61% with an F1 score of 98.41%. The detailed experimental results are presented along with comparative data

Hybrid ACO and SVM algorithm for pattern classification

Ant Colony Optimization (ACO) is a metaheuristic algorithm that can be used to solve a variety of combinatorial optimization problems. A new direction for ACO is to optimize continuous and mixed (discrete and continuous) variables. Support Vector Machine (SVM) is a pattern classification approach originated from statistical approaches. However, SVM suffers two main problems which include feature subset selection and parameter tuning. Most approaches related to tuning SVM parameters discretize the continuous value of the parameters which will give a negative effect on the classification performance. This study presents four algorithms for tuning the SVM parameters and selecting feature subset which improved SVM classification accuracy with smaller size of feature subset. This is achieved by performing the SVM parameters’ tuning and feature subset selection processes simultaneously. Hybridization algorithms between ACO and SVM techniques were proposed. The first two algorithms, ACOR-SVM and IACOR-SVM, tune the SVM parameters while the second two algorithms, ACOMV-R-SVM and IACOMV-R-SVM, tune the SVM parameters and select the feature subset simultaneously. Ten benchmark datasets from University of California, Irvine, were used in the experiments to validate the performance of the proposed algorithms. Experimental results obtained from the proposed algorithms are better when compared with other approaches in terms of classification accuracy and size of the feature subset. The average classification accuracies for the ACOR-SVM, IACOR-SVM, ACOMV-R and IACOMV-R algorithms are 94.73%, 95.86%, 97.37% and 98.1% respectively. The average size of feature subset is eight for the ACOR-SVM and IACOR-SVM algorithms and four for the ACOMV-R and IACOMV-R algorithms. This study contributes to a new direction for ACO that can deal with continuous and mixed-variable ACO

Image processing and machine learning techniques used in computer-aided detection system for mammogram screening - a review

This paper aims to review the previously developed Computer-aided detection (CAD) systems for mammogram screening because increasing death rate in women due to breast cancer is a global medical issue and it can be controlled only by early detection with regular screening. Till now mammography is the widely used breast imaging modality. CAD systems have been adopted by the radiologists to increase the accuracy of the breast cancer diagnosis by avoiding human errors and experience related issues. This study reveals that in spite of the higher accuracy obtained by the earlier proposed CAD systems for breast cancer diagnosis, they are not fully automated. Moreover, the false-positive mammogram screening cases are high in number and over-diagnosis of breast cancer exposes a patient towards harmful overtreatment for which a huge amount of money is being wasted. In addition, it is also reported that the mammogram screening result with and without CAD systems does not have noticeable difference, whereas the undetected cancer cases by CAD system are increasing. Thus, future research is required to improve the performance of CAD system for mammogram screening and make it completely automated

Survey analysis for optimization algorithms applied to electroencephalogram

This paper presents a survey for optimization approaches that analyze and classify Electroencephalogram (EEG) signals. The automatic analysis of EEG presents a significant challenge due to the high-dimensional data volume. Optimization algorithms seek to achieve better accuracy by selecting practical features and reducing unwanted features. Forty-seven reputable research papers are provided in this work, emphasizing the developed and executed techniques divided into seven groups based on the applied optimization algorithm particle swarm optimization (PSO), ant colony optimization (ACO), artificial bee colony (ABC), grey wolf optimizer (GWO), Bat, Firefly, and other optimizer approaches). The main measures to analyze this paper are accuracy, precision, recall, and F1-score assessment. Several datasets have been utilized in the included papers like EEG Bonn University, CHB-MIT, electrocardiography (ECG) dataset, and other datasets. The results have proven that the PSO and GWO algorithms have achieved the highest accuracy rate of around 99% compared with other techniques

Implementing decision tree-based algorithms in medical diagnostic decision support systems

As a branch of healthcare, medical diagnosis can be defined as finding the disease based on the signs and symptoms of the patient. To this end, the required information is gathered from different sources like physical examination, medical history and general information of the patient. Development of smart classification models for medical diagnosis is of great interest amongst the researchers. This is mainly owing to the fact that the machine learning and data mining algorithms are capable of detecting the hidden trends between features of a database. Hence, classifying the medical datasets using smart techniques paves the way to design more efficient medical diagnostic decision support systems. Several databases have been provided in the literature to investigate different aspects of diseases. As an alternative to the available diagnosis tools/methods, this research involves machine learning algorithms called Classification and Regression Tree (CART), Random Forest (RF) and Extremely Randomized Trees or Extra Trees (ET) for the development of classification models that can be implemented in computer-aided diagnosis systems. As a decision tree (DT), CART is fast to create, and it applies to both the quantitative and qualitative data. For classification problems, RF and ET employ a number of weak learners like CART to develop models for classification tasks. We employed Wisconsin Breast Cancer Database (WBCD), Z-Alizadeh Sani dataset for coronary artery disease (CAD) and the databanks gathered in Ghaem Hospital’s dermatology clinic for the response of patients having common and/or plantar warts to the cryotherapy and/or immunotherapy methods. To classify the breast cancer type based on the WBCD, the RF and ET methods were employed. It was found that the developed RF and ET models forecast the WBCD type with 100% accuracy in all cases. To choose the proper treatment approach for warts as well as the CAD diagnosis, the CART methodology was employed. The findings of the error analysis revealed that the proposed CART models for the applications of interest attain the highest precision and no literature model can rival it. The outcome of this study supports the idea that methods like CART, RF and ET not only improve the diagnosis precision, but also reduce the time and expense needed to reach a diagnosis. However, since these strategies are highly sensitive to the quality and quantity of the introduced data, more extensive databases with a greater number of independent parameters might be required for further practical implications of the developed models

IMCAD: Computer Aided System for Breast Masses Detection based on Immune Recognition

Computer Aided Detection (CAD) systems are very important tools which help radiologists as a second reader in detecting early breast cancer in an efficient way, specially on screening mammograms. One of the challenging problems is the detection of masses, which are powerful signs of cancer, because of their poor apperance on mammograms. This paper investigates an automatic CAD for detection of breast masses in screening mammograms based on fuzzy segmentation and a bio-inspired method for pattern recognition: Artificial Immune Recognition System. The proposed approach is applied to real clinical images from the full field digital mammographic database: Inbreast. In order to validate our proposition, we propose the Receiver Operating Characteristic Curve as an analyzer of our IMCAD classifier system, which achieves a good area under curve, with a sensitivity of 100% and a specificity of 95%. The recognition system based on artificial immunity has shown its efficiency on recognizing masses from a very restricted set of training regions