Characterization of structural bone properties through portable single-sided nmr devices: State of the art and future perspectives

Nuclear Magnetic Resonance (NMR) is a well-suited methodology to study bone composition and structural properties. This is because the NMR parameters, such as the T2 relaxation time, are sensitive to the chemical and physical environment of the1H nuclei. Although magnetic resonance imaging (MRI) allows bone structure assessment in vivo, its cost limits the suitability of conventional MRI for routine bone screening. With difficulty accessing clinically suitable exams, the diagnosis of bone diseases, such as osteoporosis, and the associated fracture risk estimation is based on the assessment of bone mineral density (BMD), obtained by the dual-energy X-ray absorptiometry (DXA). However, integrating the information about the structure of the bone with the bone mineral density has been shown to improve fracture risk estimation related to osteoporosis. Portable NMR, based on low-field single-sided NMR devices, is a promising and appealing approach to assess NMR properties of biological tissues with the aim of medical applications. Since these scanners detect the signal from a sensitive volume external to the magnet, they can be used to perform NMR measurement without the need to fit a sample inside a bore of a magnet, allowing, in principle, in vivo application. Techniques based on NMR single-sided devices have the potential to provide a high impact on the clinical routine because of low purchasing and running costs and low maintenance of such scanners. In this review, the development of new methodologies to investigate structural properties of trabecular bone exploiting single-sided NMR devices is reviewed, and current limitations and future perspectives are discussed

Integrated Analysis and Synthesis of the Dynamic Behaviour of a Carbonate Field

Imperial Users onl

Integrating New Zealand census mortality study and New Zealand longitudinal census: privacy impact assessment

This paper outlines the processes for managing the privacy risks raised by integrating two particular census datasets. Overview Integrating New Zealand Census Mortality Study and New Zealand Longitudinal Census: Privacy impact assessment provides a systematic evaluation of the privacy risks associated with integrating datasets from the New Zealand Census Mortality Study (NZCMS) and the New Zealand Longitudinal Census (NZLC). It outlines the processes for managing these risks. The NZCMS comprise datasets of mortality records linked to the 1981–2006 Censuses and the NZLC datasets comprise linked census pairs covering the same period

VR-PMS: a new approach for performance measurement and management of industrial systems

A new performance measurement and management framework based on value and risk is proposed. The proposed framework is applied to the modelling and evaluation of the a priori performance evaluation of manufacturing processes and to deciding on their alternatives. For this reason, it consistently integrates concepts relevant to objectives, activity, and risk in a single framework comprising a conceptual value/risk model, and it conceptualises the idea of value- and risk based performance management in a process context. In addition, a methodological framework is developed to provide guidelines for the decision-makers or performance evaluators of the processes. To facilitate the performance measurement and management process, this latter framework is organized in four phases: context establishment, performance modelling, performance assessment, and decision-making. Each phase of the framework is then instrumented with state of-the-art quantitative analysis tools and methods. For process design and evaluation, the deliverable of the value- and risk-based performance measurement and management system (VR-PMS) is a set of ranked solutions (i.e. alternative business processes) evaluated against the developed value and risk indicators. The proposed VR-PMS is illustrated with a case study from discrete parts manufacturing but is indeed applicable to a wide range of processes or systems

The valuation tool user guide: monetizing Cradle to Cradle®

This User Guide outlines the object, scope and expected deliverables from the Valuation Tool component of the Cradle to Cradle ® C2C BIZZ project. It describes the compendium of subtools that have been developed comprising: i) overview of funding tools; ii) C2C investment appraisal tool; and iii) C2C value indexing tool. The underpinning methodologies, as well as their inherent strengths and limitations are also described. The C2C BIZZ project as a whole aims specifically to promote and enhance the implementation of C2C methods in business site development within North Western Europe (NWE) (PAD, p.14). It is intended to infuse C2C notions into conventional site development, restructuring and management. The primary focus of the project is on planning, building and managing of business sites with C2C credentials (PAD, p.18) using sites in Lille Metropole (La Lainiere), London (London Sustainable Industries Park) and Luxemburg (Ecoparc Windhof) as experimental fields. C2C BIZZ is not concerned with the internal operations and activities of occupiers or users of the developed site. Accordingly, the scope of the valuation tool is confined to the planning, building and management of C2C sites. The deliverable from this component is a compendium of subtools (see Figure 1 below) that may be used to analyse the financial performance of C2C credentials in business sites to aid the making of a business case for such developments and evaluating the financial incentives for particular C2C site development projects. This entire work is premised on the argument that the wider adoption of C2C principles within the built environment depends on the rate of uptake by the private sector. The private sector, being profit driven, are likely to engage in C2C site development if they are convinced of its capacity to contribute to their business goals which ultimately is a return on their investment. The tool development described in this document attempts to provide a framework for collating an evidence base that can assist in articulating the business case for C2C in business site developments

Impacts of Weather and Time Horizon Selection on Crop Insurance Ratemaking: A Conditional Distribution Approach

An important issue in the agricultural actuarial literature is the extent to which sample period selection affects the accuracy of insurance rating. A conditional Weibull distribution approach is developed which explicitly models the interaction of weather, technology, and other variables on probabilistic yield outcomes to address this issue. Results from an application with an extensive producer-level yield dataset representing commercial-scale Illinois firms suggest that the impact of weather heterogeneity on risk estimation across reasonable samples is likely not as great as is often claimed. The results also suggest that yield risk is decreasing significantly through time, and indicate the presence of trend acceleration. A rating analysis indicates that violations in the risk evolution assumptions of the rating approaches used in the Federal Crop Insurance Program—which implicitly assume increasing yield risk through time when yields trend—result in severely biased rates, with typical overstatements of 200% to 400% for Midwest corn.Conditional Weibull Distribution, Conditional Production Function, Catastrophic Risk Modeling, Sample Selection, Yield Risk, Crop Insurance, Ratemaking, Crop Production/Industries, Risk and Uncertainty,

Risk and Business Goal Based Security Requirement and Countermeasure Prioritization

Companies are under pressure to be in control of their assets but at the same time they must operate as efficiently as possible. This means that they aim to implement “good-enough security” but need to be able to justify their security investment plans. Currently companies achieve this by means of checklist-based security assessments, but these methods are a way to achieve consensus without being able to provide justifications of countermeasures in terms of business goals. But such justifications are needed to operate securely and effectively in networked businesses. In this paper, we first compare a Risk-Based Requirements Prioritization method (RiskREP) with some requirements engineering and risk assessment methods based on their requirements elicitation and prioritization properties. RiskREP extends misuse case-based requirements engineering methods with IT architecture-based risk assessment and countermeasure definition and prioritization. Then, we present how RiskREP prioritizes countermeasures by linking business goals to countermeasure specification. Prioritizing countermeasures based on business goals is especially important to provide the stakeholders with structured arguments for choosing a set of countermeasures to implement. We illustrate RiskREP and how it prioritizes the countermeasures it elicits by an application to an action case