1,084 research outputs found
Quasi-static imaged-based immersed boundary-finite element model of human left ventricle in diastole
SUMMARY:
Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient-specific models of the left ventricle using an immersed boundary (IB) method with a finite element (FE) structural mechanics model. We use a structure-based hyperelastic strain-energy function to describe the passive mechanics of the ventricular myocardium, a realistic anatomical geometry reconstructed from clinical magnetic resonance images of a healthy human heart, and a rule-based fiber architecture. Numerical predictions of this IB/FE model are compared with results obtained by a commercial FE solver. We demonstrate that the IB/FE model yields results that are in good agreement with those of the conventional FE model under diastolic loading conditions, and the predictions of the LV model using either numerical method are shown to be consistent with previous computational and experimental data. These results are among the first to analyze the stress and strain predictions of IB models of ventricular mechanics, and they serve both to verify the IB/FE simulation framework and to validate the IB/FE model. Moreover, this work represents an important step toward using such models for fully dynamic fluid–structure interaction simulations of the heart
Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method
Detailed models of the biomechanics of the heart are important both for developing improved interventions for patients with heart disease and also for patient risk stratification and treatment planning. For instance, stress distributions in the heart affect cardiac remodelling, but such distributions are not presently accessible in patients. Biomechanical models of the heart offer detailed three-dimensional deformation, stress and strain fields that can supplement conventional clinical data. In this work, we introduce dynamic computational models of the human left ventricle (LV) that are derived from clinical imaging data obtained from a healthy subject and from a patient with a myocardial infarction (MI). Both models incorporate a detailed invariant-based orthotropic description of the passive elasticity of the ventricular myocardium along with a detailed biophysical model of active tension generation in the ventricular muscle. These constitutive models are employed within a dynamic simulation framework that accounts for the inertia of the ventricular muscle and the blood that is based on an immersed boundary (IB) method with a finite element description of the structural mechanics. The geometry of the models is based on data obtained non-invasively by cardiac magnetic resonance (CMR). CMR imaging data are also used to estimate the parameters of the passive and active constitutive models, which are determined so that the simulated end-diastolic and end-systolic volumes agree with the corresponding volumes determined from the CMR imaging studies. Using these models, we simulate LV dynamics from end-diastole to end-systole. The results of our simulations are shown to be in good agreement with subject-specific CMR-derived strain measurements and also with earlier clinical studies on human LV strain distributions
A finite strain nonlinear human mitral valve model with fluid structure interaction
A simulated human mitral valve under a physiological pressure loading is developed using a hybrid finite element immersed boundary method, which incorporates experimentally based constitutive laws in a three-dimensional fluid-structure interaction framework. A transversely isotropic material constitutive model is used for characterizing the mechanical behaviour of the mitral valve tissue based on recent mechanical tests of healthy human mitral leaflets. Our results show good agreement, in terms of the flow rate and the closing and opening configurations, with the measurements from the magnetic resonance images. The stresses in the anterior leaflet are found to be higher than those in the posterior leaflet, and concentrated around the annulus trigons and free edges of the valve leaflets. Those areas are located where the leaflet has the highest curvature. Effects of the chordae tendineae in the material model are studied and the results show that these chordae play an important role in providing a secondary orifice for the flow when valve opens. Although there are some discrepancies to be overcome in future works, our simulations show that the developed computational model is promising in mimicking the in vivo mitral valve dynamics and providing important information that are not obtainable by in vivo measurements. This article is protected by copyright. All rights reserved
Modelling mitral valvular dynamics–current trend and future directions
Dysfunction of mitral valve causes morbidity and premature mortality and remains a leading medical problem worldwide. Computational modelling aims to understand the biomechanics of human mitral valve and could lead to the development of new treatment, prevention and diagnosis of mitral valve diseases. Compared with the aortic valve, the mitral valve has been much less studied owing to its highly complex structure and strong interaction with the blood flow and the ventricles. However, the interest in mitral valve modelling is growing, and the sophistication level is increasing with the advanced development of computational technology and imaging tools. This review summarises the state-of-the-art modelling of the mitral valve, including static and dynamics models, models with fluid-structure interaction, and models with the left ventricle interaction. Challenges and future directions are also discussed
A parallel interaction potential approach coupled with the immersed boundary method for fully resolved simulations of deformable interfaces and membranes
In this paper we show and discuss the use of a versatile interaction
potential approach coupled with an immersed boundary method to simulate a
variety of flows involving deformable bodies. In particular, we focus on two
kinds of problems, namely (i) deformation of liquid-liquid interfaces and (ii)
flow in the left ventricle of the heart with either a mechanical or a natural
valve. Both examples have in common the two-way interaction of the flow with a
deformable interface or a membrane. The interaction potential approach (de
Tullio & Pascazio, Jou. Comp. Phys., 2016; Tanaka, Wada and Nakamura,
Computational Biomechanics, 2016) with minor modifications can be used to
capture the deformation dynamics in both classes of problems. We show that the
approach can be used to replicate the deformation dynamics of liquid-liquid
interfaces through the use of ad-hoc elastic constants. The results from our
simulations agree very well with previous studies on the deformation of drops
in standard flow configurations such as deforming drop in a shear flow or a
cross flow. We show that the same potential approach can also be used to study
the flow in the left ventricle of the heart. The flow imposed into the
ventricle interacts dynamically with the mitral valve (mechanical or natural)
and the ventricle which are simulated using the same model. Results from these
simulations are compared with ad- hoc in-house experimental measurements.
Finally, a parallelisation scheme is presented, as parallelisation is
unavoidable when studying large scale problems involving several thousands of
simultaneously deforming bodies on hundreds of distributed memory computing
processors
Left Ventricular Fluid Mechanics: the long way from theoretical models to clinical applications
\u2014The flow inside the left ventricle is characterized
by the formation of vortices that smoothly accompany blood
from the mitral inlet to the aortic outlet. Computational fluid
dynamics permitted to shed some light on the fundamental
processes involved with vortex motion. More recently,
patient-specific numerical simulations are becoming an
increasingly feasible tool that can be integrated with the
developing imaging technologies. The existing computational
methods are reviewed in the perspective of their potential role
as a novel aid for advanced clinical analysis. The current
results obtained by simulation methods either alone or in
combination with medical imaging are summarized. Open
problems are highlighted and perspective clinical applications
are discussed
Multi-scale modelling of the human left ventricle
In this paper, a multi-scale computational frame is proposed to simulate dynamics of the human left ventricle. First of all, a modified Level Set method is used to segment the cardiac magnetic resonance imaging and then reconstruct the 3D computational domain of the left ventricle. The Holzapfel-Ogden's nonlinear and anisotropic model is imposed to calculate the passive elastic response. The Fenton-Karma model with stimulus current is optimized to produce the reasonable membrane potential and intracellular calcium concentration. Based on the obtained calcium concentration, the active tension is calculated. Finally, the passive elastic response and the active tension of the left ventricle are coupled with the blood and the obtained fluid structure interaction is solved by the immersed boundary method. Our numerical results at end-diastole and end-systole are generally in good agreement with the clinical measurement and the earlier studies, which verifies the efficiency of the method
Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities
The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in a patient-specific environment. Given the recent advances in medical imaging, computational power and mathematical algorithms, patient-specific cardiac models can be produced from cardiac images faster, and more efficiently than ever before. The emergence of patient-specific computational fluid dynamics (CFD) has paved the way for the new field of computer-aided diagnostics. This article provides a review of CFD methods, challenges and opportunities in coronary and intra-cardiac flow simulations. It includes a review of market products and clinical trials. Key components of patient-specific CFD are covered briefly which include image segmentation, geometry reconstruction, mesh generation, fluid-structure interaction, and solver techniques
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