Combined effect of neolamarckia cadamba leaves and electroporation method on hela cell anti- proliferation process

This study suggests that natural sources may become an important tool in treating cancer. Neolamarckia cadamba (NC) leaves also well-known as “Anthocephalus Cadamba”, is a precious plant in Ayurvedic medicine. HeLa cells are one of the examples of eukaryotic cells type. It is derived from human cervical cancer cells. This experiment is conducted in different concentrations of NC Leaves (1μg/ml, 5μg/ml, 10μg/ml, 20μg/ml, 30μg/ml, 40μg/ml, 50μg/ml, 60μg/ml, 70μg/ml, 80μg/ml, 90μg/ml and 100μg/ml) for 48 hours. This experiment’s result proves that the anti-cancer properties of the extract of NC leaves are by increasing the concentration of extract, the numbers of cell viability will decrease. For contribution, the process of NC leaves extract will be combined with the electroporation process to investigate the effect on HeLa cell. Electroporation parameters used for this study were (voltage 600v/cm, pulse duration 5ms, single pulse)

FPGA dynamic and partial reconfiguration : a survey of architectures, methods, and applications

Dynamic and partial reconfiguration are key differentiating capabilities of field programmable gate arrays (FPGAs). While they have been studied extensively in academic literature, they find limited use in deployed systems. We review FPGA reconfiguration, looking at architectures built for the purpose, and the properties of modern commercial architectures. We then investigate design flows, and identify the key challenges in making reconfigurable FPGA systems easier to design. Finally, we look at applications where reconfiguration has found use, as well as proposing new areas where this capability places FPGAs in a unique position for adoption

Dynamically Reconfigurable Systolic Array Accelerators: A Case Study with Extended Kalman Filter and Discrete Wavelet Transform Algorithms

Field programmable grid arrays (FPGA) are increasingly being adopted as the primary on-board computing system for autonomous deep space vehicles. There is a need to support several complex applications for navigation and image processing in a rapidly responsive on-board FPGA-based computer. This requires exploring and combining several design concepts such as systolic arrays, hardware-software partitioning, and partial dynamic reconfiguration. A microprocessor/co-processor design that can accelerate two single precision oating-point algorithms, extended Kalman lter and a discrete wavelet transform, is presented. This research makes three key contributions. (i) A polymorphic systolic array framework comprising of recofigurable partial region-based sockets to accelerate algorithms amenable to being mapped onto linear systolic arrays. When implemented on a low end Xilinx Virtex4 SX35 FPGA the design provides a speedup of at least 4.18x and 6.61x over a state of the art microprocessor used in spacecraft systems for the extended Kalman lter and discrete wavelet transform algorithms, respectively. (ii) Switchboxes to enable communication between static and partial reconfigurable regions and a simple protocol to enable schedule changes when a socket\u27s contents are dynamically reconfigured to alter the concurrency of the participating systolic arrays. (iii) A hybrid partial dynamic reconfiguration method that combines Xilinx early access partial reconfiguration, on-chip bitstream decompression, and bitstream relocation to enable fast scaling of systolic arrays on the PolySAF. This technique provided a 2.7x improvement in reconfiguration time compared to an o-chip partial reconfiguration technique that used a Flash card on the FPGA board, and a 44% improvement in BRAM usage compared to not using compression

Dynamic Partial Reconfiguration for Dependable Systems

Moore’s law has served as goal and motivation for consumer electronics manufacturers in the last decades. The results in terms of processing power increase in the consumer electronics devices have been mainly achieved due to cost reduction and technology shrinking. However, reducing physical geometries mainly affects the electronic devices’ dependability, making them more sensitive to soft-errors like Single Event Transient (SET) of Single Event Upset (SEU) and hard (permanent) faults, e.g. due to aging effects. Accordingly, safety critical systems often rely on the adoption of old technology nodes, even if they introduce longer design time w.r.t. consumer electronics. In fact, functional safety requirements are increasingly pushing industry in developing innovative methodologies to design high-dependable systems with the required diagnostic coverage. On the other hand commercial off-the-shelf (COTS) devices adoption began to be considered for safety-related systems due to real-time requirements, the need for the implementation of computationally hungry algorithms and lower design costs. In this field FPGA market share is constantly increased, thanks to their flexibility and low non-recurrent engineering costs, making them suitable for a set of safety critical applications with low production volumes. The works presented in this thesis tries to face new dependability issues in modern reconfigurable systems, exploiting their special features to take proper counteractions with low impacton performances, namely Dynamic Partial Reconfiguration

A Framework for the Design and Analysis of High-Performance Applications on FPGAs using Partial Reconfiguration

The field-programmable gate array (FPGA) is a dynamically reconfigurable digital logic chip used to implement custom hardware. The large densities of modern FPGAs and the capability of the on-thely reconfiguration has made the FPGA a viable alternative to fixed logic hardware chips such as the ASIC. In high-performance computing, FPGAs are used as co-processors to speed up computationally intensive processes or as autonomous systems that realize a complete hardware application. However, due to the limited capacity of FPGA logic resources, denser FPGAs must be purchased if more logic resources are required to realize all the functions of a complex application. Alternatively, partial reconfiguration (PR) can be used to swap, on demand, idle components of the application with active components. This research uses PR to swap components to improve the performance of the application given the limited logic resources available with smaller but economical FPGAs. The swap is called ”resource sharing PR”. In a pipelined design of multiple hardware modules (pipeline stages), resource sharing PR is a technique that uses PR to improve the performance of pipeline bottlenecks. This is done by reconfiguring other pipeline stages, typically those that are idle waiting for data from a bottleneck, into an additional parallel bottleneck module. The target pipeline of this research is a two-stage “slow-toast” pipeline where the flow of data traversing the pipeline transitions from a relatively slow, bottleneck stage to a fast stage. A two stage pipeline that combines FPGA-based hardware implementations of well-known Bioinformatics search algorithms, the X! Tandem algorithm and the Smith-Waterman algorithm, is implemented for this research; the implemented pipeline demonstrates that characteristics of these algorithm. The experimental results show that, in a database of unknown peptide spectra, when matching spectra with 388 peaks or greater, performing resource sharing PR to instantiate a parallel X! Tandem module is worth the cost for PR. In addition, from timings gathered during experiments, a general formula was derived for determining the value of performing PR upon a fast module

Dynamic partial reconfiguration for pipelined digital systems— A Case study using a color space conversion engine

In digital hardware design, reconfigurable devices such as Field Programmable Gate Arrays (FPGAs) allow for a unique feature called partial reconfiguration PR). This refers to the reprogramming of a subset of the reconfigurable logic during active operation. PR allows multiple hardware blocks to be consolidated into a single partition, which can be reprogrammed at run-time as desired. This may reduce the logic circuit (and silicon area) requirements and greatly extend functionality. Furthermore, dynamic partial reconfiguration (DPR) refers to PR that does not halt the system during reprogramming. This allows for configuration to overlap with normal processing, potentially achieving better system performance than a static(halting) PR implementation. This work has investigated the advantages and trade-offs of DPR as applied to an existing color space conversion(CSC) engine provided by Hewlett-Packard (HP). Two versions were created: a single-pipeline engine, which can only overlap tasks in specific sequences; and a dual-pipeline engine, which can overlap any consecutive tasks. These were implemented in a Virtex-6 FPGA. Data communication occurs over the PCI Express (PCIe) interface. Test results show improvements in execution speed and resource utilization, though some are minor due to intrinsic characteristics of the CSC engine pipeline. The dual-pipeline version outperformed the single-pipeline in most test cases. Therefore, future work will focus on multiple-pipeline architectures

Efficient reconfigurable architectures for 3D medical image compression

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Recently, the more widespread use of three-dimensional (3-D) imaging modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and ultrasound (US) have generated a massive amount of volumetric data. These have provided an impetus to the development of other applications, in particular telemedicine and teleradiology. In these fields, medical image compression is important since both efficient storage and transmission of data through high-bandwidth digital communication lines are of crucial importance. Despite their advantages, most 3-D medical imaging algorithms are computationally intensive with matrix transformation as the most fundamental operation involved in the transform-based methods. Therefore, there is a real need for high-performance systems, whilst keeping architectures exible to allow for quick upgradeability with real-time applications. Moreover, in order to obtain efficient solutions for large medical volumes data, an efficient implementation of these operations is of significant importance. Reconfigurable hardware, in the form of field programmable gate arrays (FPGAs) has been proposed as viable system building block in the construction of high-performance systems at an economical price. Consequently, FPGAs seem an ideal candidate to harness and exploit their inherent advantages such as massive parallelism capabilities, multimillion gate counts, and special low-power packages. The key achievements of the work presented in this thesis are summarised as follows. Two architectures for 3-D Haar wavelet transform (HWT) have been proposed based on transpose-based computation and partial reconfiguration suitable for 3-D medical imaging applications. These applications require continuous hardware servicing, and as a result dynamic partial reconfiguration (DPR) has been introduced. Comparative study for both non-partial and partial reconfiguration implementation has shown that DPR offers many advantages and leads to a compelling solution for implementing computationally intensive applications such as 3-D medical image compression. Using DPR, several large systems are mapped to small hardware resources, and the area, power consumption as well as maximum frequency are optimised and improved. Moreover, an FPGA-based architecture of the finite Radon transform (FRAT)with three design strategies has been proposed: direct implementation of pseudo-code with a sequential or pipelined description, and block random access memory (BRAM)- based method. An analysis with various medical imaging modalities has been carried out. Results obtained for image de-noising implementation using FRAT exhibits promising results in reducing Gaussian white noise in medical images. In terms of hardware implementation, promising trade-offs on maximum frequency, throughput and area are also achieved. Furthermore, a novel hardware implementation of 3-D medical image compression system with context-based adaptive variable length coding (CAVLC) has been proposed. An evaluation of the 3-D integer transform (IT) and the discrete wavelet transform (DWT) with lifting scheme (LS) for transform blocks reveal that 3-D IT demonstrates better computational complexity than the 3-D DWT, whilst the 3-D DWT with LS exhibits a lossless compression that is significantly useful for medical image compression. Additionally, an architecture of CAVLC that is capable of compressing high-definition (HD) images in real-time without any buffer between the quantiser and the entropy coder is proposed. Through a judicious parallelisation, promising results have been obtained with limited resources. In summary, this research is tackling the issues of massive 3-D medical volumes data that requires compression as well as hardware implementation to accelerate the slowest operations in the system. Results obtained also reveal a significant achievement in terms of the architecture efficiency and applications performance.Ministry of Higher Education Malaysia (MOHE), Universiti Tun Hussein Onn Malaysia (UTHM) and the British Counci

An fpga-based loco-ans implementation for lossless and near-lossless image compression using high-level synthesis

MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliationsIn this work, we present and evaluate a hardware architecture for the LOCO-ANS (Low Complexity Lossless Compression with Asymmetric Numeral Systems) lossless and near-lossless image compressor, which is based on JPEG-LS standard. The design is implemented in two FPGA generations, evaluating its performance for different codec configurations. The tests show that the design is capable of up to 40.5 MPixels/s and 124 MPixels/s per lane for Zynq 7020 and UltraScale+ FPGAs, respectively. Compared to the single thread LOCO-ANS software implementation running in a 1.2 GHz Raspberry Pi 3B, each hardware lane achieves 6.5 times higher throughput, even when implemented in an older and cost-optimized chip like the Zynq 7020. Results are also presented for a lossless only version, which achieves a lower footprint and approximately 50% higher performance than the version that supports both lossless and near-lossless. Interestingly, these great results were obtained applying High-Level Synthesis, describing the coder with C++ code, which tends to establish a trade-off between design time and quality of results. These results show that the algorithm is very suitable for hardware implementation. Moreover, the implemented system is faster and achieves higher compression than the best previously available near-lossless JPEG-LS hardware implementationThis research was funded in part by the Spanish Research Agency under the project AgileMon (AEI PID2019-104451RB-C21