Secure Data Collection and Analysis in Smart Health Monitoring

Smart health monitoring uses real-time monitored data to support diagnosis, treatment, and health decision-making in modern smart healthcare systems and benefit our daily life. The accurate health monitoring and prompt transmission of health data are facilitated by the ever-evolving on-body sensors, wireless communication technologies, and wireless sensing techniques. Although the users have witnessed the convenience of smart health monitoring, severe privacy and security concerns on the valuable and sensitive collected data come along with the merit. The data collection, transmission, and analysis are vulnerable to various attacks, e.g., eavesdropping, due to the open nature of wireless media, the resource constraints of sensing devices, and the lack of security protocols. These deficiencies not only make conventional cryptographic methods not applicable in smart health monitoring but also put many obstacles in the path of designing privacy protection mechanisms. In this dissertation, we design dedicated schemes to achieve secure data collection and analysis in smart health monitoring. The first two works propose two robust and secure authentication schemes based on Electrocardiogram (ECG), which outperform traditional user identity authentication schemes in health monitoring, to restrict the access to collected data to legitimate users. To improve the practicality of ECG-based authentication, we address the nonuniformity and sensitivity of ECG signals, as well as the noise contamination issue. The next work investigates an extended authentication goal, denoted as wearable-user pair authentication. It simultaneously authenticates the user identity and device identity to provide further protection. We exploit the uniqueness of the interference between different wireless protocols, which is common in health monitoring due to devices\u27 varying sensing and transmission demands, and design a wearable-user pair authentication scheme based on the interference. However, the harm of this interference is also outstanding. Thus, in the fourth work, we use wireless human activity recognition in health monitoring as an example and analyze how this interference may jeopardize it. We identify a new attack that can produce false recognition result and discuss potential countermeasures against this attack. In the end, we move to a broader scenario and protect the statistics of distributed data reported in mobile crowd sensing, a common practice used in public health monitoring for data collection. We deploy differential privacy to enable the indistinguishability of workers\u27 locations and sensing data without the help of a trusted entity while meeting the accuracy demands of crowd sensing tasks

Explainable AI in medical imaging:An overview for clinical practitioners - Saliency-based XAI approaches

Since recent achievements of Artificial Intelligence (AI) have proven significant success and promising results throughout many fields of application during the last decade, AI has also become an essential part of medical research. The improving data availability, coupled with advances in high-performance computing and innovative algorithms, has increased AI's potential in various aspects. Because AI rapidly reshapes research and promotes the development of personalized clinical care, alongside its implementation arises an urgent need for a deep understanding of its inner workings, especially in high-stake domains. However, such systems can be highly complex and opaque, limiting the possibility of an immediate understanding of the system's decisions. Regarding the medical field, a high impact is attributed to these decisions as physicians and patients can only fully trust AI systems when reasonably communicating the origin of their results, simultaneously enabling the identification of errors and biases. Explainable AI (XAI), becoming an increasingly important field of research in recent years, promotes the formulation of explainability methods and provides a rationale allowing users to comprehend the results generated by AI systems. In this paper, we investigate the application of XAI in medical imaging, addressing a broad audience, especially healthcare professionals. The content focuses on definitions and taxonomies, standard methods and approaches, advantages, limitations, and examples representing the current state of research regarding XAI in medical imaging. This paper focuses on saliency-based XAI methods, where the explanation can be provided directly on the input data (image) and which naturally are of special importance in medical imaging.</p

Identification Of Metabolite Biomarkers In Epilepsy Using 1h Mrs

Epilepsy is a serious neurological disorder that affects 1% percent of the global population. Despite its status as one of the oldest neurological disorders known to man, its mechanisms remain poorly understood. Available medications are not curative but provide symptomatic management and do not work for well for more than 30 percent of patients. Because it is nearly impossible to predict on an individual level who will eventually develop epilepsy, it is also a disorder that can only be diagnosed after the patient has experienced established seizure activity, eliminating any possibility of stopping the disorder in its prodromal phase, before the patients are symptomatic. Availability of a reliable and non-invasive biomarker tool that can predict and identify the development of epilepsy would dramatically change how the disorder is detected, monitored, managed, and treated. In this project, we tested the potential of 1H MRS to provide metabolite biomarkers of epilepsy and epileptogenesis, both in human neocortical tissue obtained from intractable epilepsy patients who underwent resective surgery and also in a longitudinal rat model of epileptogenesis, using interictal epileptiform discharges as a surrogate indicator of disease progression. Using 1H MRS, we found unique metabolite differences that are highly predictive of epileptic and non-epileptic neocortex in humans that also partially overlaps with findings from our rat model. These findings provide evidence that 1H MRS is capable of identifying metabolite changes specific to epilepsy and may lead to reliable and non-invasive biomarkers of epilepsy and epileptogenesis in the future

Artificial intelligence within the interplay between natural and artificial computation:Advances in data science, trends and applications

Artificial intelligence and all its supporting tools, e.g. machine and deep learning in computational intelligence-based systems, are rebuilding our society (economy, education, life-style, etc.) and promising a new era for the social welfare state. In this paper we summarize recent advances in data science and artificial intelligence within the interplay between natural and artificial computation. A review of recent works published in the latter field and the state the art are summarized in a comprehensive and self-contained way to provide a baseline framework for the international community in artificial intelligence. Moreover, this paper aims to provide a complete analysis and some relevant discussions of the current trends and insights within several theoretical and application fields covered in the essay, from theoretical models in artificial intelligence and machine learning to the most prospective applications in robotics, neuroscience, brain computer interfaces, medicine and society, in general.BMS - Pfizer(U01 AG024904). Spanish Ministry of Science, projects: TIN2017-85827-P, RTI2018-098913-B-I00, PSI2015-65848-R, PGC2018-098813-B-C31, PGC2018-098813-B-C32, RTI2018-101114-B-I, TIN2017-90135-R, RTI2018-098743-B-I00 and RTI2018-094645-B-I00; the FPU program (FPU15/06512, FPU17/04154) and Juan de la Cierva (FJCI-2017–33022). Autonomous Government of Andalusia (Spain) projects: UMA18-FEDERJA-084. Consellería de Cultura, Educación e Ordenación Universitaria of Galicia: ED431C2017/12, accreditation 2016–2019, ED431G/08, ED431C2018/29, Comunidad de Madrid, Y2018/EMT-5062 and grant ED431F2018/02. PPMI – a public – private partnership – is funded by The Michael J. Fox Foundation for Parkinson’s Research and funding partners, including Abbott, Biogen Idec, F. Hoffman-La Roche Ltd., GE Healthcare, Genentech and Pfizer Inc

Learning from small and imbalanced dataset of images using generative adversarial neural networks.

The performance of deep learning models is unmatched by any other approach in supervised computer vision tasks such as image classification. However, training these models requires a lot of labeled data, which are not always available. Labelling a massive dataset is largely a manual and very demanding process. Thus, this problem has led to the development of techniques that bypass the need for labelling at scale. Despite this, existing techniques such as transfer learning, data augmentation and semi-supervised learning have not lived up to expectations. Some of these techniques do not account for other classification challenges, such as a class-imbalance problem. Thus, these techniques mostly underperform when compared with fully supervised approaches. In this thesis, we propose new methods to train a deep model on image classification with a limited number of labeled examples. This was achieved by extending state-of-the-art generative adversarial networks with multiple fake classes and network switchers. These new features enabled us to train a classifier using large unlabeled data, while generating class specific samples. The proposed model is label agnostic and is suitable for different classification scenarios, ranging from weakly supervised to fully supervised settings. This was used to address classification challenges with limited labeled data and a class-imbalance problem. Extensive experiments were carried out on different benchmark datasets. Firstly, the proposed approach was used to train a classification model and our findings indicated that the proposed approach achieved better classification accuracies, especially when the number of labeled samples is small. Secondly, the proposed approach was able to generate high-quality samples from class-imbalance datasets. The samples' quality is evident in improved classification performances when generated samples were used in neutralising class-imbalance. The results are thoroughly analyzed and, overall, our method showed superior performances over popular resampling technique and the AC-GAN model. Finally, we successfully applied the proposed approach as a new augmentation technique to two challenging real-world problems: face with attributes and legacy engineering drawings. The results obtained demonstrate that the proposed approach is effective even in extreme cases

State of the art of audio- and video based solutions for AAL

Working Group 3. Audio- and Video-based AAL ApplicationsIt is a matter of fact that Europe is facing more and more crucial challenges regarding health and social care due to the demographic change and the current economic context. The recent COVID-19 pandemic has stressed this situation even further, thus highlighting the need for taking action. Active and Assisted Living (AAL) technologies come as a viable approach to help facing these challenges, thanks to the high potential they have in enabling remote care and support. Broadly speaking, AAL can be referred to as the use of innovative and advanced Information and Communication Technologies to create supportive, inclusive and empowering applications and environments that enable older, impaired or frail people to live independently and stay active longer in society. AAL capitalizes on the growing pervasiveness and effectiveness of sensing and computing facilities to supply the persons in need with smart assistance, by responding to their necessities of autonomy, independence, comfort, security and safety. The application scenarios addressed by AAL are complex, due to the inherent heterogeneity of the end-user population, their living arrangements, and their physical conditions or impairment. Despite aiming at diverse goals, AAL systems should share some common characteristics. They are designed to provide support in daily life in an invisible, unobtrusive and user-friendly manner. Moreover, they are conceived to be intelligent, to be able to learn and adapt to the requirements and requests of the assisted people, and to synchronise with their specific needs. Nevertheless, to ensure the uptake of AAL in society, potential users must be willing to use AAL applications and to integrate them in their daily environments and lives. In this respect, video- and audio-based AAL applications have several advantages, in terms of unobtrusiveness and information richness. Indeed, cameras and microphones are far less obtrusive with respect to the hindrance other wearable sensors may cause to one’s activities. In addition, a single camera placed in a room can record most of the activities performed in the room, thus replacing many other non-visual sensors. Currently, video-based applications are effective in recognising and monitoring the activities, the movements, and the overall conditions of the assisted individuals as well as to assess their vital parameters (e.g., heart rate, respiratory rate). Similarly, audio sensors have the potential to become one of the most important modalities for interaction with AAL systems, as they can have a large range of sensing, do not require physical presence at a particular location and are physically intangible. Moreover, relevant information about individuals’ activities and health status can derive from processing audio signals (e.g., speech recordings). Nevertheless, as the other side of the coin, cameras and microphones are often perceived as the most intrusive technologies from the viewpoint of the privacy of the monitored individuals. This is due to the richness of the information these technologies convey and the intimate setting where they may be deployed. Solutions able to ensure privacy preservation by context and by design, as well as to ensure high legal and ethical standards are in high demand. After the review of the current state of play and the discussion in GoodBrother, we may claim that the first solutions in this direction are starting to appear in the literature. A multidisciplinary 4 debate among experts and stakeholders is paving the way towards AAL ensuring ergonomics, usability, acceptance and privacy preservation. The DIANA, PAAL, and VisuAAL projects are examples of this fresh approach. This report provides the reader with a review of the most recent advances in audio- and video-based monitoring technologies for AAL. It has been drafted as a collective effort of WG3 to supply an introduction to AAL, its evolution over time and its main functional and technological underpinnings. In this respect, the report contributes to the field with the outline of a new generation of ethical-aware AAL technologies and a proposal for a novel comprehensive taxonomy of AAL systems and applications. Moreover, the report allows non-technical readers to gather an overview of the main components of an AAL system and how these function and interact with the end-users. The report illustrates the state of the art of the most successful AAL applications and functions based on audio and video data, namely (i) lifelogging and self-monitoring, (ii) remote monitoring of vital signs, (iii) emotional state recognition, (iv) food intake monitoring, activity and behaviour recognition, (v) activity and personal assistance, (vi) gesture recognition, (vii) fall detection and prevention, (viii) mobility assessment and frailty recognition, and (ix) cognitive and motor rehabilitation. For these application scenarios, the report illustrates the state of play in terms of scientific advances, available products and research project. The open challenges are also highlighted. The report ends with an overview of the challenges, the hindrances and the opportunities posed by the uptake in real world settings of AAL technologies. In this respect, the report illustrates the current procedural and technological approaches to cope with acceptability, usability and trust in the AAL technology, by surveying strategies and approaches to co-design, to privacy preservation in video and audio data, to transparency and explainability in data processing, and to data transmission and communication. User acceptance and ethical considerations are also debated. Finally, the potentials coming from the silver economy are overviewed.publishedVersio

On the Recognition of Emotion from Physiological Data

This work encompasses several objectives, but is primarily concerned with an experiment where 33 participants were shown 32 slides in order to create ‗weakly induced emotions‘. Recordings of the participants‘ physiological state were taken as well as a self report of their emotional state. We then used an assortment of classifiers to predict emotional state from the recorded physiological signals, a process known as Physiological Pattern Recognition (PPR). We investigated techniques for recording, processing and extracting features from six different physiological signals: Electrocardiogram (ECG), Blood Volume Pulse (BVP), Galvanic Skin Response (GSR), Electromyography (EMG), for the corrugator muscle, skin temperature for the finger and respiratory rate. Improvements to the state of PPR emotion detection were made by allowing for 9 different weakly induced emotional states to be detected at nearly 65% accuracy. This is an improvement in the number of states readily detectable. The work presents many investigations into numerical feature extraction from physiological signals and has a chapter dedicated to collating and trialing facial electromyography techniques. There is also a hardware device we created to collect participant self reported emotional states which showed several improvements to experimental procedure