The confound of hemodynamic response function variability in human resting-state functional MRI studies

Functional magnetic resonance imaging (fMRI) is an indirect measure of neural activity with the hemodynamic response function (HRF) coupling it with unmeasured neural activity. The HRF, modulated by several non-neural factors, is variable across brain regions, individuals and populations. Yet, a majority of human resting-state fMRI connectivity studies continue to assume a non-variable HRF. In this article, with supportive prior evidence, we argue that HRF variability cannot be ignored as it substantially confounds within-subject connectivity estimates and between-subjects connectivity group differences. We also discuss its clinical relevance with connectivity impairments confounded by HRF aberrations in several disorders. We present limited data on HRF differences between women and men, which resulted in a 15.4% median error in functional connectivity estimates in a group-level comparison. We also discuss the implications of HRF variability for fMRI studies in the spinal cord. There is a need for more dialogue within the community on the HRF confound, and we hope that our article is a catalyst in the process

Advanced Sensing and Image Processing Techniques for Healthcare Applications

This Special Issue aims to attract the latest research and findings in the design, development and experimentation of healthcare-related technologies. This includes, but is not limited to, using novel sensing, imaging, data processing, machine learning, and artificially intelligent devices and algorithms to assist/monitor the elderly, patients, and the disabled population

Improved decoding of neural activity from fMRI signals using non-separable spatiotemporal deconvolutions

The goal of most functional Magnetic Resonance Imaging (fMRI) analyses is to investigate neural activity. Many fMRI analysis methods assume that the temporal dynamics of the hemodynamic response function (HRF) to neural activation is separable from its spatial dynamics. Although there is empirical evidence that the HRF is more complex than suggested by space–time separable canonical HRF models, it is difficult to assess how much information about neural activity is lost when assuming space–time separability. In this study we directly test whether spatiotemporal variability in the HRF that is not captured by separable models contains information about neural signals. We predict intracranially measured neural activity from simultaneously recorded fMRI data using separable and non-separable spatiotemporal deconvolutions of voxel time series around the recording electrode. Our results show that abandoning the spatiotemporal separability assumption consistently improves the decoding accuracy of neural signals from fMRI data. We compare our findings with results from optical imaging and fMRI studies and discuss potential implications for classical fMRI analyses without invasive electrophysiological recordings

Note Taking in the Digital Age – Towards a Ubiquitous Pen Interface

The cultural technique of writing helped humans to express, communicate, think, and memorize throughout history. With the advent of human-computer-interfaces, pens as command input for digital systems became popular. While current applications allow carrying out complex tasks with digital pens, they lack the ubiquity and directness of pen and paper. This dissertation models the note taking process in the context of scholarly work, motivated by an understanding of note taking that surpasses mere storage of knowledge. The results, together with qualitative empirical findings about contemporary scholarly workflows that alternate between the analog and the digital world, inspire a novel pen interface concept. This concept proposes the use of an ordinary pen and unmodified writing surfaces for interacting with digital systems. A technological investigation into how a camera-based system can connect physical ink strokes with digital handwriting processing delivers artificial neural network-based building blocks towards that goal. Using these components, the technological feasibility of in-air pen gestures for command input is explored. A proof-of-concept implementation of a prototype system reaches real-time performance and demonstrates distributed computing strategies for realizing the interface concept in an end-user setting

Proceedings of the 19th Sound and Music Computing Conference

Proceedings of the 19th Sound and Music Computing Conference - June 5-12, 2022 - Saint-Étienne (France). https://smc22.grame.f