Deep Lesion Graphs in the Wild: Relationship Learning and Organization of Significant Radiology Image Findings in a Diverse Large-scale Lesion Database

Radiologists in their daily work routinely find and annotate significant abnormalities on a large number of radiology images. Such abnormalities, or lesions, have collected over years and stored in hospitals' picture archiving and communication systems. However, they are basically unsorted and lack semantic annotations like type and location. In this paper, we aim to organize and explore them by learning a deep feature representation for each lesion. A large-scale and comprehensive dataset, DeepLesion, is introduced for this task. DeepLesion contains bounding boxes and size measurements of over 32K lesions. To model their similarity relationship, we leverage multiple supervision information including types, self-supervised location coordinates and sizes. They require little manual annotation effort but describe useful attributes of the lesions. Then, a triplet network is utilized to learn lesion embeddings with a sequential sampling strategy to depict their hierarchical similarity structure. Experiments show promising qualitative and quantitative results on lesion retrieval, clustering, and classification. The learned embeddings can be further employed to build a lesion graph for various clinically useful applications. We propose algorithms for intra-patient lesion matching and missing annotation mining. Experimental results validate their effectiveness.Comment: Accepted by CVPR2018. DeepLesion url adde

3D hand tracking.

The hand is often considered as one of the most natural and intuitive interaction modalities for human-to-human interaction. In human-computer interaction (HCI), proper 3D hand tracking is the first step in developing a more intuitive HCI system which can be used in applications such as gesture recognition, virtual object manipulation and gaming. However, accurate 3D hand tracking, remains a challenging problem due to the hand’s deformation, appearance similarity, high inter-finger occlusion and complex articulated motion. Further, 3D hand tracking is also interesting from a theoretical point of view as it deals with three major areas of computer vision- segmentation (of hand), detection (of hand parts), and tracking (of hand). This thesis proposes a region-based skin color detection technique, a model-based and an appearance-based 3D hand tracking techniques to bring the human-computer interaction applications one step closer. All techniques are briefly described below. Skin color provides a powerful cue for complex computer vision applications. Although skin color detection has been an active research area for decades, the mainstream technology is based on individual pixels. This thesis presents a new region-based technique for skin color detection which outperforms the current state-of-the-art pixel-based skin color detection technique on the popular Compaq dataset (Jones & Rehg 2002). The proposed technique achieves 91.17% true positive rate with 13.12% false negative rate on the Compaq dataset tested over approximately 14,000 web images. Hand tracking is not a trivial task as it requires tracking of 27 degreesof- freedom of hand. Hand deformation, self occlusion, appearance similarity and irregular motion are major problems that make 3D hand tracking a very challenging task. This thesis proposes a model-based 3D hand tracking technique, which is improved by using proposed depth-foreground-background ii feature, palm deformation module and context cue. However, the major problem of model-based techniques is, they are computationally expensive. This can be overcome by discriminative techniques as described below. Discriminative techniques (for example random forest) are good for hand part detection, however they fail due to sensor noise and high interfinger occlusion. Additionally, these techniques have difficulties in modelling kinematic or temporal constraints. Although model-based descriptive (for example Markov Random Field) or generative (for example Hidden Markov Model) techniques utilize kinematic and temporal constraints well, they are computationally expensive and hardly recover from tracking failure. This thesis presents a unified framework for 3D hand tracking, using the best of both methodologies, which out performs the current state-of-the-art 3D hand tracking techniques. The proposed 3D hand tracking techniques in this thesis can be used to extract accurate hand movement features and enable complex human machine interaction such as gaming and virtual object manipulation

Co-Fusion: Real-time Segmentation, Tracking and Fusion of Multiple Objects

In this paper we introduce Co-Fusion, a dense SLAM system that takes a live stream of RGB-D images as input and segments the scene into different objects (using either motion or semantic cues) while simultaneously tracking and reconstructing their 3D shape in real time. We use a multiple model fitting approach where each object can move independently from the background and still be effectively tracked and its shape fused over time using only the information from pixels associated with that object label. Previous attempts to deal with dynamic scenes have typically considered moving regions as outliers, and consequently do not model their shape or track their motion over time. In contrast, we enable the robot to maintain 3D models for each of the segmented objects and to improve them over time through fusion. As a result, our system can enable a robot to maintain a scene description at the object level which has the potential to allow interactions with its working environment; even in the case of dynamic scenes.Comment: International Conference on Robotics and Automation (ICRA) 2017, http://visual.cs.ucl.ac.uk/pubs/cofusion, https://github.com/martinruenz/co-fusio

Human Pose Tracking from Monocular Image Sequences

This thesis proposes various novel approaches for improving the performance of automatic 2D human pose tracking system including multi-scale strategy, mid-level spatial dependencies to constrain more relations of multiple body parts, additional constraints between symmetric body parts and the left/right confusion correction by a head orientation estimator. These proposed approaches are employed to develop a complete human pose tracking system. The experimental results demonstrate significant improvements of all the proposed approaches towards accuracy and efficiency

Stratified decision forests for accurate anatomical landmark localization in cardiac images

Accurate localization of anatomical landmarks is an important step in medical imaging, as it provides useful prior information for subsequent image analysis and acquisition methods. It is particularly useful for initialization of automatic image analysis tools (e.g. segmentation and registration) and detection of scan planes for automated image acquisition. Landmark localization has been commonly performed using learning based approaches, such as classifier and/or regressor models. However, trained models may not generalize well in heterogeneous datasets when the images contain large differences due to size, pose and shape variations of organs. To learn more data-adaptive and patient specific models, we propose a novel stratification based training model, and demonstrate its use in a decision forest. The proposed approach does not require any additional training information compared to the standard model training procedure and can be easily integrated into any decision tree framework. The proposed method is evaluated on 1080 3D highresolution and 90 multi-stack 2D cardiac cine MR images. The experiments show that the proposed method achieves state-of-theart landmark localization accuracy and outperforms standard regression and classification based approaches. Additionally, the proposed method is used in a multi-atlas segmentation to create a fully automatic segmentation pipeline, and the results show that it achieves state-of-the-art segmentation accuracy

Computer vision in target pursuit using a UAV

Research in target pursuit using Unmanned Aerial Vehicle (UAV) has gained attention in recent years, this is primarily due to decrease in cost and increase in demand of small UAVs in many sectors. In computer vision, target pursuit is a complex problem as it involves the solving of many sub-problems which are typically concerned with the detection, tracking and following of the object of interest. At present, the majority of related existing methods are developed using computer simulation with the assumption of ideal environmental factors, while the remaining few practical methods are mainly developed to track and follow simple objects that contain monochromatic colours with very little texture variances. Current research in this topic is lacking of practical vision based approaches. Thus the aim of this research is to fill the gap by developing a real-time algorithm capable of following a person continuously given only a photo input. As this research considers the whole procedure as an autonomous system, therefore the drone is activated automatically upon receiving a photo of a person through Wi-Fi. This means that the whole system can be triggered by simply emailing a single photo from any device anywhere. This is done by first implementing image fetching to automatically connect to WIFI, download the image and decode it. Then, human detection is performed to extract the template from the upper body of the person, the intended target is acquired using both human detection and template matching. Finally, target pursuit is achieved by tracking the template continuously while sending the motion commands to the drone. In the target pursuit system, the detection is mainly accomplished using a proposed human detection method that is capable of detecting, extracting and segmenting the human body figure robustly from the background without prior training. This involves detecting face, head and shoulder separately, mainly using gradient maps. While the tracking is mainly accomplished using a proposed generic and non-learning template matching method, this involves combining intensity template matching with colour histogram model and employing a three-tier system for template management. A flight controller is also developed, it supports three types of controls: keyboard, mouse and text messages. Furthermore, the drone is programmed with three different modes: standby, sentry and search. To improve the detection and tracking of colour objects, this research has also proposed several colour related methods. One of them is a colour model for colour detection which consists of three colour components: hue, purity and brightness. Hue represents the colour angle, purity represents the colourfulness and brightness represents intensity. It can be represented in three different geometric shapes: sphere, hemisphere and cylinder, each of these shapes also contains two variations. Experimental results have shown that the target pursuit algorithm is capable of identifying and following the target person robustly given only a photo input. This can be evidenced by the live tracking and mapping of the intended targets with different clothing in both indoor and outdoor environments. Additionally, the various methods developed in this research could enhance the performance of practical vision based applications especially in detecting and tracking of objects

Visual Analysis of Extremely Dense Crowded Scenes

Visual analysis of dense crowds is particularly challenging due to large number of individuals, occlusions, clutter, and fewer pixels per person which rarely occur in ordinary surveillance scenarios. This dissertation aims to address these challenges in images and videos of extremely dense crowds containing hundreds to thousands of humans. The goal is to tackle the fundamental problems of counting, detecting and tracking people in such images and videos using visual and contextual cues that are automatically derived from the crowded scenes. For counting in an image of extremely dense crowd, we propose to leverage multiple sources of information to compute an estimate of the number of individuals present in the image. Our approach relies on sources such as low confidence head detections, repetition of texture elements (using SIFT), and frequency-domain analysis to estimate counts, along with confidence associated with observing individuals, in an image region. Furthermore, we employ a global consistency constraint on counts using Markov Random Field which caters for disparity in counts in local neighborhoods and across scales. We tested this approach on crowd images with the head counts ranging from 94 to 4543 and obtained encouraging results. Through this approach, we are able to count people in images of high-density crowds unlike previous methods which are only applicable to videos of low to medium density crowded scenes. However, the counting procedure just outputs a single number for a large patch or an entire image. With just the counts, it becomes difficult to measure the counting error for a query image with unknown number of people. For this, we propose to localize humans by finding repetitive patterns in the crowd image. Starting with detections from an underlying head detector, we correlate them within the image after their selection through several criteria: in a pre-defined grid, locally, or at multiple scales by automatically finding the patches that are most representative of recurring patterns in the crowd image. Finally, the set of generated hypotheses is selected using binary integer quadratic programming with Special Ordered Set (SOS) Type 1 constraints. Human Detection is another important problem in the analysis of crowded scenes where the goal is to place a bounding box on visible parts of individuals. Primarily applicable to images depicting medium to high density crowds containing several hundred humans, it is a crucial pre-requisite for many other visual tasks, such as tracking, action recognition or detection of anomalous behaviors, exhibited by individuals in a dense crowd. For detecting humans, we explore context in dense crowds in the form of locally-consistent scale prior which captures the similarity in scale in local neighborhoods with smooth variation over the image. Using the scale and confidence of detections obtained from an underlying human detector, we infer scale and confidence priors using Markov Random Field. In an iterative mechanism, the confidences of detections are modified to reflect consistency with the inferred priors, and the priors are updated based on the new detections. The final set of detections obtained are then reasoned for occlusion using Binary Integer Programming where overlaps and relations between parts of individuals are encoded as linear constraints. Both human detection and occlusion reasoning in this approach are solved with local neighbor-dependent constraints, thereby respecting the inter-dependence between individuals characteristic to dense crowd analysis. In addition, we propose a mechanism to detect different combinations of body parts without requiring annotations for individual combinations. Once human detection and localization is performed, we then use it for tracking people in dense crowds. Similar to the use of context as scale prior for human detection, we exploit it in the form of motion concurrence for tracking individuals in dense crowds. The proposed method for tracking provides an alternative and complementary approach to methods that require modeling of crowd flow. Simultaneously, it is less likely to fail in the case of dynamic crowd flows and anomalies by minimally relying on previous frames. The approach begins with the automatic identification of prominent individuals from the crowd that are easy to track. Then, we use Neighborhood Motion Concurrence to model the behavior of individuals in a dense crowd, this predicts the position of an individual based on the motion of its neighbors. When the individual moves with the crowd flow, we use Neighborhood Motion Concurrence to predict motion while leveraging five-frame instantaneous flow in case of dynamically changing flow and anomalies. All these aspects are then embedded in a framework which imposes hierarchy on the order in which positions of individuals are updated. The results are reported on eight sequences of medium to high density crowds and our approach performs on par with existing approaches without learning or modeling patterns of crowd flow. We experimentally demonstrate the efficacy and reliability of our algorithms by quantifying the performance of counting, localization, as well as human detection and tracking on new and challenging datasets containing hundreds to thousands of humans in a given scene

Robust and real-time hand detection and tracking in monocular video

In recent years, personal computing devices such as laptops, tablets and smartphones have become ubiquitous. Moreover, intelligent sensors are being integrated into many consumer devices such as eyeglasses, wristwatches and smart televisions. With the advent of touchscreen technology, a new human-computer interaction (HCI) paradigm arose that allows users to interface with their device in an intuitive manner. Using simple gestures, such as swipe or pinch movements, a touchscreen can be used to directly interact with a virtual environment. Nevertheless, touchscreens still form a physical barrier between the virtual interface and the real world. An increasingly popular field of research that tries to overcome this limitation, is video based gesture recognition, hand detection and hand tracking. Gesture based interaction allows the user to directly interact with the computer in a natural manner by exploring a virtual reality using nothing but his own body language. In this dissertation, we investigate how robust hand detection and tracking can be accomplished under real-time constraints. In the context of human-computer interaction, real-time is defined as both low latency and low complexity, such that a complete video frame can be processed before the next one becomes available. Furthermore, for practical applications, the algorithms should be robust to illumination changes, camera motion, and cluttered backgrounds in the scene. Finally, the system should be able to initialize automatically, and to detect and recover from tracking failure. We study a wide variety of existing algorithms, and propose significant improvements and novel methods to build a complete detection and tracking system that meets these requirements. Hand detection, hand tracking and hand segmentation are related yet technically different challenges. Whereas detection deals with finding an object in a static image, tracking considers temporal information and is used to track the position of an object over time, throughout a video sequence. Hand segmentation is the task of estimating the hand contour, thereby separating the object from its background. Detection of hands in individual video frames allows us to automatically initialize our tracking algorithm, and to detect and recover from tracking failure. Human hands are highly articulated objects, consisting of finger parts that are connected with joints. As a result, the appearance of a hand can vary greatly, depending on the assumed hand pose. Traditional detection algorithms often assume that the appearance of the object of interest can be described using a rigid model and therefore can not be used to robustly detect human hands. Therefore, we developed an algorithm that detects hands by exploiting their articulated nature. Instead of resorting to a template based approach, we probabilistically model the spatial relations between different hand parts, and the centroid of the hand. Detecting hand parts, such as fingertips, is much easier than detecting a complete hand. Based on our model of the spatial configuration of hand parts, the detected parts can be used to obtain an estimate of the complete hand's position. To comply with the real-time constraints, we developed techniques to speed-up the process by efficiently discarding unimportant information in the image. Experimental results show that our method is competitive with the state-of-the-art in object detection while providing a reduction in computational complexity with a factor 1 000. Furthermore, we showed that our algorithm can also be used to detect other articulated objects such as persons or animals and is therefore not restricted to the task of hand detection. Once a hand has been detected, a tracking algorithm can be used to continuously track its position in time. We developed a probabilistic tracking method that can cope with uncertainty caused by image noise, incorrect detections, changing illumination, and camera motion. Furthermore, our tracking system automatically determines the number of hands in the scene, and can cope with hands entering or leaving the video canvas. We introduced several novel techniques that greatly increase tracking robustness, and that can also be applied in other domains than hand tracking. To achieve real-time processing, we investigated several techniques to reduce the search space of the problem, and deliberately employ methods that are easily parallelized on modern hardware. Experimental results indicate that our methods outperform the state-of-the-art in hand tracking, while providing a much lower computational complexity. One of the methods used by our probabilistic tracking algorithm, is optical flow estimation. Optical flow is defined as a 2D vector field describing the apparent velocities of objects in a 3D scene, projected onto the image plane. Optical flow is known to be used by many insects and birds to visually track objects and to estimate their ego-motion. However, most optical flow estimation methods described in literature are either too slow to be used in real-time applications, or are not robust to illumination changes and fast motion. We therefore developed an optical flow algorithm that can cope with large displacements, and that is illumination independent. Furthermore, we introduce a regularization technique that ensures a smooth flow-field. This regularization scheme effectively reduces the number of noisy and incorrect flow-vector estimates, while maintaining the ability to handle motion discontinuities caused by object boundaries in the scene. The above methods are combined into a hand tracking framework which can be used for interactive applications in unconstrained environments. To demonstrate the possibilities of gesture based human-computer interaction, we developed a new type of computer display. This display is completely transparent, allowing multiple users to perform collaborative tasks while maintaining eye contact. Furthermore, our display produces an image that seems to float in thin air, such that users can touch the virtual image with their hands. This floating imaging display has been showcased on several national and international events and tradeshows. The research that is described in this dissertation has been evaluated thoroughly by comparing detection and tracking results with those obtained by state-of-the-art algorithms. These comparisons show that the proposed methods outperform most algorithms in terms of accuracy, while achieving a much lower computational complexity, resulting in a real-time implementation. Results are discussed in depth at the end of each chapter. This research further resulted in an international journal publication; a second journal paper that has been submitted and is under review at the time of writing this dissertation; nine international conference publications; a national conference publication; a commercial license agreement concerning the research results; two hardware prototypes of a new type of computer display; and a software demonstrator