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Strategies to achieve adequate vitamin A intake for young children: options for Cameroon.
Meeting children's vitamin A (VA) needs remains a policy priority. Doing so efficiently is a fiscal imperative and protecting at-risk children during policy transitions is a moral imperative. Using the Micronutrient Intervention Modeling tool and data for Cameroon, we predict the impacts and costs of alternative VA intervention programs, identify the least-cost strategy for meeting targets nationally, and compare it to a business-as-usual (BAU) strategy over 10 years. BAU programs effectively cover ∼12.8 million (m) child-years (CY) and cost ∼2.34 per CY effectively covered. Improving the VA-fortified oil program, implementing a VA-fortified bouillon cube program, and periodic VA supplements (VAS) in the North macroregion for 3 years effectively cover ∼13.1 m CY at a cost of ∼US0.71 per CY effectively covered. The tool then identifies a sequence of subnational policy choices leading from the BAU toward the more efficient strategy, while addressing VA-attributable mortality concerns. By year 4, fortification programs are predicted to eliminate inadequate VA intake in the South and Cities macroregions, but not the North, where VAS should continue until additional delivery platforms are implemented. This modeling approach offers a concrete example of the strategic use of data to follow the Global Alliance for VA framework and do so efficiently
The space of ultrametric phylogenetic trees
The reliability of a phylogenetic inference method from genomic sequence data
is ensured by its statistical consistency. Bayesian inference methods produce a
sample of phylogenetic trees from the posterior distribution given sequence
data. Hence the question of statistical consistency of such methods is
equivalent to the consistency of the summary of the sample. More generally,
statistical consistency is ensured by the tree space used to analyse the
sample.
In this paper, we consider two standard parameterisations of phylogenetic
time-trees used in evolutionary models: inter-coalescent interval lengths and
absolute times of divergence events. For each of these parameterisations we
introduce a natural metric space on ultrametric phylogenetic trees. We compare
the introduced spaces with existing models of tree space and formulate several
formal requirements that a metric space on phylogenetic trees must possess in
order to be a satisfactory space for statistical analysis, and justify them. We
show that only a few known constructions of the space of phylogenetic trees
satisfy these requirements. However, our results suggest that these basic
requirements are not enough to distinguish between the two metric spaces we
introduce and that the choice between metric spaces requires additional
properties to be considered. Particularly, that the summary tree minimising the
square distance to the trees from the sample might be different for different
parameterisations. This suggests that further fundamental insight is needed
into the problem of statistical consistency of phylogenetic inference methods.Comment: Minor changes. This version has been published in JTB. 27 pages, 9
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A Kosloff/Basal method, 3D migration program implemented on the CYBER 205 supercomputer
Conventional finite difference migration has relied on approximations to the acoustic wave equation which allow energy to propagate only downwards. Although generally reliable, such approaches usually do not yield an accurate migration for geological structures with strong lateral velocity variations or with steeply dipping reflectors. An earlier study by D. Kosloff and E. Baysal (Migration with the Full Acoustic Wave Equation) examined an alternative approach based on the full acoustic wave equation. The 2D, Fourier type algorithm which was developed was tested by Kosloff and Baysal against synthetic data and against physical model data. The results indicated that such a scheme gives accurate migration for complicated structures. This paper describes the development and testing of a vectorized, 3D migration program for the CYBER 205 using the Kosloff/Baysal method. The program can accept as many as 65,536 zero offset (stacked) traces
GOGMA: Globally-Optimal Gaussian Mixture Alignment
Gaussian mixture alignment is a family of approaches that are frequently used
for robustly solving the point-set registration problem. However, since they
use local optimisation, they are susceptible to local minima and can only
guarantee local optimality. Consequently, their accuracy is strongly dependent
on the quality of the initialisation. This paper presents the first
globally-optimal solution to the 3D rigid Gaussian mixture alignment problem
under the L2 distance between mixtures. The algorithm, named GOGMA, employs a
branch-and-bound approach to search the space of 3D rigid motions SE(3),
guaranteeing global optimality regardless of the initialisation. The geometry
of SE(3) was used to find novel upper and lower bounds for the objective
function and local optimisation was integrated into the scheme to accelerate
convergence without voiding the optimality guarantee. The evaluation
empirically supported the optimality proof and showed that the method performed
much more robustly on two challenging datasets than an existing
globally-optimal registration solution.Comment: Manuscript in press 2016 IEEE Conference on Computer Vision and
Pattern Recognitio
Clustering-Based Materialized View Selection in Data Warehouses
Materialized view selection is a non-trivial task. Hence, its complexity must
be reduced. A judicious choice of views must be cost-driven and influenced by
the workload experienced by the system. In this paper, we propose a framework
for materialized view selection that exploits a data mining technique
(clustering), in order to determine clusters of similar queries. We also
propose a view merging algorithm that builds a set of candidate views, as well
as a greedy process for selecting a set of views to materialize. This selection
is based on cost models that evaluate the cost of accessing data using views
and the cost of storing these views. To validate our strategy, we executed a
workload of decision-support queries on a test data warehouse, with and without
using our strategy. Our experimental results demonstrate its efficiency, even
when storage space is limited
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