Data Hiding and Its Applications

Data hiding techniques have been widely used to provide copyright protection, data integrity, covert communication, non-repudiation, and authentication, among other applications. In the context of the increased dissemination and distribution of multimedia content over the internet, data hiding methods, such as digital watermarking and steganography, are becoming increasingly relevant in providing multimedia security. The goal of this book is to focus on the improvement of data hiding algorithms and their different applications (both traditional and emerging), bringing together researchers and practitioners from different research fields, including data hiding, signal processing, cryptography, and information theory, among others

Complexity in Developmental Systems: Toward an Integrated Understanding of Organ Formation

During animal development, embryonic cells assemble into intricately structured organs by working together in organized groups capable of implementing tightly coordinated collective behaviors, including patterning, morphogenesis and migration. Although many of the molecular components and basic mechanisms underlying such collective phenomena are known, the complexity emerging from their interplay still represents a major challenge for developmental biology. Here, we first clarify the nature of this challenge and outline three key strategies for addressing it: precision perturbation, synthetic developmental biology, and data-driven inference. We then present the results of our effort to develop a set of tools rooted in two of these strategies and to apply them to uncover new mechanisms and principles underlying the coordination of collective cell behaviors during organogenesis, using the zebrafish posterior lateral line primordium as a model system. To enable precision perturbation of migration and morphogenesis, we sought to adapt optogenetic tools to control chemokine and actin signaling. This endeavor proved far from trivial and we were ultimately unable to derive functional optogenetic constructs. However, our work toward this goal led to a useful new way of perturbing cortical contractility, which in turn revealed a potential role for cell surface tension in lateral line organogenesis. Independently, we hypothesized that the lateral line primordium might employ plithotaxis to coordinate organ formation with collective migration. We tested this hypothesis using a novel optical tool that allows targeted arrest of cell migration, finding that contrary to previous assumptions plithotaxis does not substantially contribute to primordium guidance. Finally, we developed a computational framework for automated single-cell segmentation, latent feature extraction and quantitative analysis of cellular architecture. We identified the key factors defining shape heterogeneity across primordium cells and went on to use this shape space as a reference for mapping the results of multiple experiments into a quantitative atlas of primordium cell architecture. We also propose a number of data-driven approaches to help bridge the gap from big data to mechanistic models. Overall, this study presents several conceptual and methodological advances toward an integrated understanding of complex multi-cellular systems

Study of fibroblasts activation kinetics and identification of fibroblast subpopulations in physiological and pathological situations

Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2022-2023. Tutor/Director: Gavara i Casas, NúriaFibroblasts undergo significant morphological and functional changes in response to specific environmental cues and functional changes. In wound healing processes and cancerous environments, fibroblasts undergo transformative activation adopting novel phenotype. The aim of this project was to understand the changes in cell morphology and cytoskeletal reorganization that occur for both normal-associated fibroblasts (NAFs) and cancer-associated fibroblasts (CAFs) activation. To achieve this, we used an innovative approach using biophysical biomarkers derived from epifluorescence imaging of the cell's cytoskeleton, employing CSKmorphometrics. Clustering algorithms have been applied to do a preliminarily identification of CAFs subpopulations. Our findings confirm that cytoskeletal reorganization occurs during both physiological and pathological activation. Non-tumoral fibroblasts experience larger morphological changes characterized by an increase in area and cell convexity, as well as changes in the total fluorescence of F-actin fibers during the 24 hours posterior to the administration of TGF-β. On the contrary CAFs exhibited sustained larger areas throughout the process regardless of TGF-β administration. They underwent most drastic changes in fiber length and showed a significant increase in nuclear volume. The application of logistic regression algorithms has allowed for a classification with 81% accuracy to differentiate between CAFs and NAFs, highlighting the differences in the cytoskeleton of these cell types in both study contexts. On the other hand, the intragroup analysis provided by clustering has enabled the identification of 5 clusters for non-activated CAFs, which converge at 72 hours into two larger clusters with significant differences. This study enhances understanding of the changes occurring in CAFs and NAFs during activation from a cytoskeletal point of view and remarks the need for a study of fibroblasts subpopulations as well as the need for novel biomarkers

Key Topics in Deep Geological Disposal : Conference Report (KIT Scientific Reports ; 7696)

The current state of knowledge of central aspects of radioactive waste repository research was presented in the course of the DAEF conference "Key topics in deep geological disposal". For the first time socio-economic and socio-technical issues played an important role within a conference focusing on the disposal of radioactive waste. Scientists from about 16 different countries presented their scientific work in 8 sessions and during a poster session

Development of sensors and non-destructive techniques to determine the performance of coatings in construction

The primary objective of this work was to examine and develop techniques for monitoring the degradation of Organically Coated Steel (OCS) in-situ. This included the detection of changes associated with the weathering to both the organic coating and metallic substrate. Initially, a review of current promising techniques was carried out however many were found to be unsuitable for this application and the adaptation of current techniques and the development of new techniques was considered. A brief concept investigation, based on initial testing and considerations, was used to determine a number of sensing techniques to examine. These included embedded, Resonant Frequency Identification (RFID), Magnetic Flux Leakage (MFL) and dielectric sensing. Each of these techniques were assessed for the application, prototyped, and tested against a range of samples to determine the accuracy and sensitivity of degradation detection provided. A range of poorly and highly durable coated samples were used in conjunction with accelerated weathering testing for this aim. Track based electronic printed sensors were presented as both a cut edge corrosion tracking and coating capacitance measurement method. While suffering somewhat from electrical paint compatibility issues both concepts showed merit in initial trials however the capacitive sensor ultimately proved insufficiently responsive to coating changes. The embedded, progressive failure-based, cut edge corrosion sensor was produced and tested in modern coating systems with moderate success. Novel applications of RFID and MLF techniques were considered and proved capable of detecting large changes in substrate condition due to significant corrosion. However, there was a lack of sufficient sensitivity when considering early-stage corrosion of durable modern OCS products. Finally, it was shown that a chipless antenna could be designed and optimised for novelly monitoring the changes to the dielectric properties of a paint layer due to degradation. However, ultimately this test, due to equipment requirements, lent itself more to lab testing than in-situ. Due to some of these limitations a different approach was considered in which the environmental factors influencing degradation were examined with the aim of relating these to performance across a building. It was observed that a combination of high humidity and the build-up of aggressive natural deposits contributed to high degradation rates in sheltered regions, such as building eaves, where microclimates were created. The build-up of deposits and their effect was presented as a key degradation accelerant during in-use service. A unique numerical simulation approach was developed to predict the natural washing, via rain impact and characteristics of the building analysed. This approach showed promise for determining areas unlikely to be naturally washed, and therefore subjected to a degradation accelerating, build-up of deposits. Given these understandings coated wetness sensors were considered as a realistic live-monitoring device capable of determining deposit build up and ultimately OCS lifetime

Cyber Security

This open access book constitutes the refereed proceedings of the 17th International Annual Conference on Cyber Security, CNCERT 2021, held in Beijing, China, in AJuly 2021. The 14 papers presented were carefully reviewed and selected from 51 submissions. The papers are organized according to the following topical sections: ​data security; privacy protection; anomaly detection; traffic analysis; social network security; vulnerability detection; text classification