Functional interpretation of single cell similarity maps.

We present Vision, a tool for annotating the sources of variation in single cell RNA-seq data in an automated and scalable manner. Vision operates directly on the manifold of cell-cell similarity and employs a flexible annotation approach that can operate either with or without preconceived stratification of the cells into groups or along a continuum. We demonstrate the utility of Vision in several case studies and show that it can derive important sources of cellular variation and link them to experimental meta-data even with relatively homogeneous sets of cells. Vision produces an interactive, low latency and feature rich web-based report that can be easily shared among researchers, thus facilitating data dissemination and collaboration

Proceedings ICPW'07: 2nd International Conference on the Pragmatic Web, 22-23 Oct. 2007, Tilburg: NL

Proceedings ICPW'07: 2nd International Conference on the Pragmatic Web, 22-23 Oct. 2007, Tilburg: N

The interplay between cognitive, conative, and affective constructs along the entrepreneurial learning process

Purpose: Although the role of reflections in entrepreneurship education is undeniable, the research has focused mainly on their advantages and consequences for learning process, whereas their dynamics and interrelations with other mental processes remain unexplored. The purpose of this paper is to better understand how personality and intelligence constructs: cognition, conation, and affection evolve and change along the learning process during entrepreneurship education. Design/methodology/approach: To better understand reflective processes in entrepreneurial learning this paper adopts the tripartite constructs of personality and intelligence. By employing longitudinal explorative research approach and self-organizing map (SOM) algorithm, the authors follow students’ reflections during their two-year learning processes. First, the authors try to identify how the interplay between the cognitive, conative, and affective aspects emerges in students’ reflections. Then, the authors investigate how this interplay evolves during the individual learning process and finally, by looking for similarities in these learning pathways, the authors aim to identify patterns of students’ reflective learning process. Findings: All constructs are present during the learning process and all are prone to change. The individual constructs alone shed no light on the interplay between different constructs, but rather that the interplay between sub-constructs should be taken into consideration as well. This seems to be particularly true for cognition, as procedural and declarative knowledge have very different profiles. Procedural knowledge emerges together with emotions, motivation, and volition, whereas the profile of declarative knowledge is individual. The unique profile of declarative knowledge in students’ reflections is an important finding as declarative knowledge is regarded as the center of current pedagogic practices. Research limitations/implications The study broadens the understanding of reflective practices in the entrepreneurial learning process and the interplay between affective, cognitive, and conative sub-constructs and reflective practices in entrepreneurship education. The findings clearly indicate the need for further research on the interplay between sub-constructs and students’ reflection profiles. The authors see the study as an attempt to apply an exploratory statistical method for the problem in question. Practical implications: The results are able to advise pedagogy. Practical implications concern the need to develop reflective practises in entrepreneurial learning interventions to enhance all three meta-competencies, even though there are so far no irrefutable findings to indicate that some types of reflection may be better than others. Originality/value: The results of the analysis indicate that it is possible to study the complex and dynamic interplay between sub-constructs of cognitive, conative and affective constructs. Moreover, the research succeeded in identifying both individual variations and general reflection patterns and changes in these during the learning process. This was possible by adopting a longitudinal explorative research approach with SOM analyses.Peer reviewe

Data Representation Methods For Environmentally Conscious Product Design

The challenge of holistically integrating environmental sustainability considerations with design decision-making requires novel representations for design and sustainability-related data that allow designers to understand correlations among them. Challenges such as (1) lack of suitable data & information models, (2) methods that simultaneously consider environmental sustainability as well as design constraints, and (3) uncertainty models for characterizing subjectivity in environmental sustainability-based decision making, pose serious impediments towards this goal

Exploring student perceptions about the use of visual programming environments, their relation to student learning styles and their impact on student motivation in undergraduate introductory programming modules

My research aims to explore how students perceive the usability and enjoyment of visual/block-based programming environments (VPEs), to what extent their learning styles relate to these perceptions and finally to what extent these tools facilitate student understanding of basic programming constructs and impact their motivation to learn programming