Reconciling the influence of task-set switching and motor inhibition processes on stop signal after-effects.

Executive response functions can be affected by preceding events, even if they are no longer associated with the current task at hand. For example, studies utilizing the stop signal task have reported slower response times to "GO" stimuli when the preceding trial involved the presentation of a "STOP" signal. However, the neural mechanisms that underlie this behavioral after-effect are unclear. To address this, behavioral and electroencephalography (EEG) measures were examined in 18 young adults (18-30 years) on "GO" trials following a previously "Successful Inhibition" trial (pSI), a previously "Failed Inhibition" trial (pFI), and a previous "GO" trial (pGO). Like previous research, slower response times were observed during both pSI and pFI trials (i.e., "GO" trials that were preceded by a successful and unsuccessful inhibition trial, respectively) compared to pGO trials (i.e., "GO" trials that were preceded by another "GO" trial). Interestingly, response time slowing was greater during pSI trials compared to pFI trials, suggesting executive control is influenced by both task set switching and persisting motor inhibition processes. Follow-up behavioral analyses indicated that these effects resulted from between-trial control adjustments rather than repetition priming effects. Analyses of inter-electrode coherence (IEC) and inter-trial coherence (ITC) indicated that both pSI and pFI trials showed greater phase synchrony during the inter-trial interval compared to pGO trials. Unlike the IEC findings, differential ITC was present within the beta and alpha frequency bands in line with the observed behavior (pSI > pFI > pGO), suggestive of more consistent phase synchrony involving motor inhibition processes during the ITI at a regional level. These findings suggest that between-trial control adjustments involved with task-set switching and motor inhibition processes influence subsequent performance, providing new insights into the dynamic nature of executive control

The International Trade Commission's Assessment of the Trans-Pacific Partnership: Main Findings and Implications

In May of 2016 the United States International Trade Commission (ITC) issued its assessment of the impact of the Trans-Pacific Partnership (TPP). This paper highlights the main findings of the ITC report and explains their derivation and implications. It also examines several issues that were explicitly excluded from analysis in the ITC report

TIGER Capacity Building Facility - Phase 1, lessons learnt

The TIGER Capacity Building Facility focused on closing the technological gap between the users and the earth observation community within the TIGER programme. Thirteen projects participated in different aspects of the capacity building facility: 1. - Basic education, provided via distance learning. 2. - Tailored short courses, selected according to the research interest and technical background of the participants. 3. - Research topic oriented supervision, provided by specialists of the research fields of the participants. 4. - Advanced short courses focusing on selected earth observation techniques. Distance education turned to be efficient and cost effective in the programme - but only for those, who followed the courses completely. There was a relatively large percentage that could not complete the studies. The second and the third type of education were carried out in ITC, in the Netherlands. The participants evaluated the courses and the supervision very effective and adequate. Nevertheless, the follow-up was not always possible. Two advanced short courses were held in Africa (Cape Town and Nairobi). One of them addressed the 'scientific elite' of the EO community, whilst the second focused on the users of this technology

The International Trade Commission: Potential Bias, Hold-Up, and the Need for Reform

The International Trade Commission (ITC) is an alternate venue for holders of U.S. patents to pursue litigation against infringing products produced abroad and imported to the United States. Because the ITC may only grant injunctive relief, it has awarded injunctions in situations where there may have been better and more efficient remedies to the infringement available through litigation in federal district court. The increased likelihood of injunctive relief bolsters the position of patent holders against a wide range of producers in royalty negotiations and can harm the end consumers through a process known as patent hold-up. There are currently sweeping and aggressive proposed reforms to reduce this harm to consumers. This iBrief suggests that the optimal reforms would not change the overall structure or scope of the ITC or its jurisdiction. Rather it would harmonize the substantive law, available defenses for respondents, and requirements for injunctive relief between ITC proceedings and litigation in federal district court

Conformational and thermodynamic hallmarks of DNA operator site specificity in the copper sensitive operon repressor from Streptomyces lividans

Metal ion homeostasis in bacteria relies on metalloregulatory proteins to upregulate metal resistance genes and enable the organism to preclude metal toxicity. The copper sensitive operon repressor (CsoR) family is widely distributed in bacteria and controls the expression of copper efflux systems. CsoR operator sites consist of G-tract containing pseudopalindromes of which the mechanism of operator binding is poorly understood. Here, we use a structurally characterized CsoR from Streptomyces lividans (CsoRSl) together with three specific operator targets to reveal the salient features pertaining to the mechanism of DNA binding. We reveal that CsoRSl binds to its operator site through a 2-fold axis of symmetry centred on a conserved 5′-TAC/GTA-3′ inverted repeat. Operator recognition is stringently dependent not only on electropositive residues but also on a conserved polar glutamine residue. Thermodynamic and circular dichroic signatures of the CsoRSl-DNA interaction suggest selectivity towards the A-DNA-like topology of the G-tracts at the operator site. Such properties are enhanced on protein binding thus enabling the symmetrical binding of two CsoRSl tetramers. Finally, differential binding modes may exist in operator sites having more than one 5′-TAC/GTA-3′ inverted repeat with implications in vivo for a mechanism of modular control. © 2013 The Author(s)

Trans-Pacific Partnership (TPP) Countries: Comparative Trade and Economic Analysis

[Excerpt] This report focuses primarily on U.S. economic interests in the TPP agreement. It provides acomparative economic analysis of the countries currently negotiating the TPP and describes the U.S. trade flows with these countries at the bilateral level and in relation to the countries’ economic linkages with the rest of the world. It also provides information on the existing trade agreements of TPP countries. As such, this report aims to serve as an introduction to the economic relationship these countries have, both individually and collectively, with the United States

Automatically detecting neighbourhood constraint interactions using Comet

Local Search has been shown to be capable of producing high quality solutions in a variety of hard constraint and optimisation problems. Typically implementing a Local Search algorithm is done in a problem specic manner. In the last few years a variety of approaches have emerged focussed on easing the implementation and creating a clean separation between the algorithm and problem. We present a system which can deduce information about the interactions between problem constraints and the search neighbourhoods whilst maintaining a loose coupling between these components. We apply this technique to the International Timetabling Competition instances and show an implementation expressed in Comet

Antidumping and Market Power in the Agriculture Sector, with a Special Case Study of the Fresh Tomato Industry

In this article we highlight the anticompetitive nature of antidumping (AD) legislation. Antidumping legislation was set up to protect domestic firms from predatory pricing by foreign firms. We argue that protecting highly concentrated industries drastically reduces competition at home. In cases where the industry consists only of one or two firms, import restriction may breed monopolies at the expense of domestic consumers. This article looks at cases filed by the agriculture sector, and at the market concentration of industries in this sector, to illustrate the above possibility. We study the case of fresh tomatoes in detail to further demonstrate the anticompetitive nature of AD legislation. We show the effect of AD legislation on imports, as well as the change in the Lerner index in the fresh tomato industry.agriculture, antidumping legislation, competition, fresh tomato industry, Crop Production/Industries, International Relations/Trade,

Determinants for Labour Contract Length: A French Microeconometric Study

Two types of analyses are conducted to explain the determinants of labour contracts length. The first analysis emphasizes on the contracting costs and the level of uncertainty. The second analysis focuses on the incentive and selection effect of the contract length. This paper test the determinants for contract duration by means of econometric duration models. The estimates are carried out from French data (TDE). An econometric treatment of the endogeneity of the labour contract status and unobservable heterogeneity is carried out. Our results show that wages positively affect employment duration. This confirms the positive effect of contracting costs reported.contract length ; duration model ; selection bias ; unobservable heterogeneity