Gestalt Theory in Visual Screen Design — A New Look at an old subject

Although often presented as a single basis for educational visual screen design, Gestalt theory is not a single small set of visual principles uniformly applied by all designers. In fact, it appears that instructional visual design literature often deals with only a small set of Gestalt laws. In this project Gestalt literature was consulted to distil the most relevant Gestalt laws for educational visual screen design. Eleven laws were identified. They deal with balance/symmetry, continuation, closure, figure-ground, focal point, isomorphic correspondence, prŠgnanz, proximity, similarity, simplicity, and unity/harmony. To test the usefulness of these laws in visual screen design they were applied to the redesign of an instructional multimedia application, 'WoundCare', designed to teach nursing students wound management. The basic text-based screens in the original WoundCare application were replaced with graphical user interface screens, that were designed according to these principles. The new screen designs were then evaluated by asking students and others to compare the designs. The viewers were also asked to rate directly the value of using the eleven Gestalt design principles in the redesign, both for improving the product's appearance and improving its value for learning. The evaluation results were overwhelmingly positive. Both the new design and the value of applying the eleven Gestalt laws to improve learning were strongly supported by the students' opinions. However, some differences in the value of applying particular Gestalt laws to the interface design were identified and this forms a useful direction for future research

Hyperbolic Organizational Identity and Identity of Digital Artifacts: A Comparative Study of Healthcare Innovations

As digital technologies move toward the core of an organization’s offerings, the identity of many contemporary organizations is now born in association with the digital technology that characterizes them. Entrepreneurs largely rely on setting up high expectations to attract initial resources to materialize the idea for their digital innovation. However, such a tactic may be problematic when their eventual digital artifact contradicts their core organizational identity, leading to their legitimacy loss. In this ongoing study, we explore a novel phenomenon of hyperbolic organizational identity. Drawing on longitudinal archival sources, we conduct a comparative case study of IBM Watson and DeepMind, whose identities both became hyperbolic, yet experienced different outcomes in their healthcare innovations. From our findings to date, a preliminary dialectical process model is presented that depicts the interplay between organizational and technical identities of the digital artifact in leading to the formation and change in hyperbolic organizational identity

Fast sensing of double-dot charge arrangement and spin state with an rf sensor quantum dot

Single-shot measurement of the charge arrangement and spin state of a double quantum dot are reported, with measurement times down to ~ 100 ns. Sensing uses radio-frequency reflectometry of a proximal quantum dot in the Coulomb blockade regime. The sensor quantum dot is up to 30 times more sensitive than a comparable quantum point contact sensor, and yields three times greater signal to noise in rf single-shot measurements. Numerical modeling is qualitatively consistent with experiment and shows that the improved sensitivity of the sensor quantum dot results from reduced screening and lifetime broadening.Comment: related papers at http://marcuslab.harvard.ed

Evidence of topological superconductivity in planar Josephson junctions

Majorana zero modes are quasiparticle states localized at the boundaries of topological superconductors that are expected to be ideal building blocks for fault-tolerant quantum computing. Several observations of zero-bias conductance peaks measured in tunneling spectroscopy above a critical magnetic field have been reported as experimental indications of Majorana zero modes in superconductor/semiconductor nanowires. On the other hand, two dimensional systems offer the alternative approach to confine Ma jorana channels within planar Josephson junctions, in which the phase difference {\phi} between the superconducting leads represents an additional tuning knob predicted to drive the system into the topological phase at lower magnetic fields. Here, we report the observation of phase-dependent zero-bias conductance peaks measured by tunneling spectroscopy at the end of Josephson junctions realized on a InAs/Al heterostructure. Biasing the junction to {\phi} ~ {\pi} significantly reduces the critical field at which the zero-bias peak appears, with respect to {\phi} = 0. The phase and magnetic field dependence of the zero-energy states is consistent with a model of Majorana zero modes in finite-size Josephson junctions. Besides providing experimental evidence of phase-tuned topological superconductivity, our devices are compatible with superconducting quantum electrodynamics architectures and scalable to complex geometries needed for topological quantum computing.Comment: main text and extended dat

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation

Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely unknown. Here, we performed a novel approach to characterize the transcriptome of IECs from IBD patients using a genome wide approach. We observed disease-specific alterations in IECs with markedly impaired Rho-A signaling in active IBD patients. Localization of epithelial Rho-A was shifted to the cytosol in IBD where Rho-A activation was suppressed due to reduced expression of the Rho-A prenylation enzyme GGTase-I. The functional relevance of this pathway was highlighted by studies in mice with conditional gene targeting in which deletion of RhoA or GGTase-I in IECs caused spontaneous chronic intestinal inflammation with accumulation of granulocytes and CD4+ T cells. This phenotype was associated with cytoskeleton rearrangement and aberrant cell shedding ultimately leading to loss of epithelial integrity and subsequent inflammation. These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis of IBD. As therapeutic triggering of Rho-A signaling suppressed intestinal inflammation in mice with GGTase-I deficient IECs, our findings open new avenues for treatment of epithelial injury and mucosal inflammation in IBD patients

Simulating galaxy Clusters -II: global star formation histories and galaxy populations

Cosmological (LambdaCDM) TreeSPH simulations of the formation and evolution of galaxy groups and clusters have been performed. The simulations invoke star formation, chemical evolution with non-instantaneous recycling, metal dependent radiative cooling, strong star burst and (optionally) AGN driven galactic super winds, effects of a meta-galactic UV field and thermal conduction. The properties of the galaxy populations in two clusters, one Virgo-like (T~3 keV) and one (sub) Coma-like (T~6 keV), are discussed. The global star formation rates of the cluster galaxies are found to decrease very significantly with time from redshift z=2 to 0, in agreement with observations. The total K-band luminosity of the cluster galaxies correlates tightly with total cluster mass, and for models without additional AGN feedback, the zero point of the relation matches the observed one fairly well. The match to observed galaxy luminosity functions is reasonable, except for a deficiency of bright galaxies (M_B < -20), which becomes increasingly significant with super-wind strength. Results of a high resolution test indicate that this deficiency is not due to ``over--merging''. The redshift evolution of the luminosity functions from z=1 to 0 is mainly driven by luminosity evolution, but also by merging of bright galaxies with the cD. The colour--magnitude relation of the cluster galaxies matches the observed "red sequence" very well and, on average, galaxy metallicity increases with luminosity. As the brighter galaxies are essentially coeval, the colour--magnitude relation results from metallicity rather than age effects, as observed.Comment: 15 pages, 10 figures. Final version accepted by MNRAS, presenting new simulations and major changes. Printing in colour recommende