Minimal long-term neurobehavioral impairments after endovascular perforation subarachnoid hemorrhage in mice

AbstractCognitive deficits are among the most severe and pervasive consequences of aneurysmal subarachnoid hemorrhage (SAH). A critical step in developing therapies targeting such outcomes is the characterization of experimentally-tractable pre-clinical models that exhibit multi-domain neurobehavioral deficits similar to those afflicting humans. We therefore searched for neurobehavioral abnormalities following endovascular perforation induction of SAH in mice, a heavily-utilized model. We instituted a functional screen to manage variability in injury severity, then assessed acute functional deficits, as well as activity, anxiety-related behavior, learning and memory, socialization, and depressive-like behavior at sub-acute and chronic time points (up to 1 month post-injury). Animals in which SAH was induced exhibited reduced acute functional capacity and reduced general activity to 1 month post-injury. Tests of anxiety-related behavior including central area time in the elevated plus maze and thigmotaxis in the open field test revealed increased anxiety-like behavior at subacute and chronic time-points, respectively. Effect sizes for subacute and chronic neurobehavioral endpoints in other domains, however, were small. In combination with persistent variability, this led to non-significant effects of injury on all remaining neurobehavioral outcomes. These results suggest that, with the exception of anxiety-related behavior, alternate mouse models are required to effectively analyze cognitive outcomes after SAH.</jats:p

Supporting Higher Education—Hospital Transition through Blended Learning

The purpose of this paper is to present two exploratory studies that have a potential for identifying research-based blended learning tools for CBME. The studies focus on the development of a group of medical students’ professional image (in Genova and Rome) during their hospital internship. The paper addresses three related questions: 1. How does their professional representation change in the transition from university to hospital? 2. Which competences emerge from the students’ reports? 3. Which competences are still under represented

The relation between patient discomfort and uncompensated forces of a patient support device for breast and regional lymph node radiotherapy

Although many authors stated that a user-centred design approach in medical device development has added values, the most common research approach within healthcare is evidence-based medicine, which tend to focus on functional data rather than patient wellbeing and comfort. End user comfort is well addressed in literature for commercial products such as seats and hand tools but no data was found for medical devices. A commercial patient support device for breast radiotherapy was analysed and a relation was found between discomfort and uncompensated internal body forces. Derived from CT-images, simplified patient free-body diagrams were analysed and pain and comfort evaluated. Subsequently, a new patient position was established and prototypes were developed. Patient comfort- and prototype optimization was done through iterative prototyping. With this approach, we were able to compensate all internal body forces and establish a force neutral patient free-body diagram. This resulted in comfortable patient positioning and favourable medical results

User-centered design in brain–computer interfaces — a case study

The array of available brain–computer interface (BCI) paradigms has continued to grow, and so has the corresponding set of machine learning methods which are at the core of BCI systems. The latter have evolved to provide more robust data analysis solutions, and as a consequence the proportion of healthy BCI users who can use a BCI successfully is growing. With this development the chances have increased that the needs and abilities of specific patients, the end-users, can be covered by an existing BCI approach. However, most end-users who have experienced the use of a BCI system at all have encountered a single paradigm only. This paradigm is typically the one that is being tested in the study that the end-user happens to be enrolled in, along with other end-users. Though this corresponds to the preferred study arrangement for basic research, it does not ensure that the end-user experiences a working BCI. In this study, a different approach was taken; that of a user-centered design. It is the prevailing process in traditional assistive technology. Given an individual user with a particular clinical profile, several available BCI approaches are tested and – if necessary – adapted to him/her until a suitable BCI system is found

"Silver" product design: Product innovation for older people

Aging populations challenge companies across different countries and industries to respond to the changing needs, demands and expectations of their growing shares of older customers. This opens room for improving or developing innovations - products as well as services - that correspond to the diverse expectations. New product development for older customers or 'Silver' product design is one way to approach the 'silver' market - without explicitly excluding younger customers. Research in this field is still in its infancy. Silver product design focuses on individual autonomy, representing an elementary aspect of good life, disappearing in a more or less continuous manner over the life cycle of a human being. Offering solutions that will allow people to maintain or recover autonomy and to use products and services in an independent manner therefore seems to be a promising avenue for companies innovating across different industries. The general concept of autonomy can be perceived as a boundary-spanning argument and a common denominator for starting development initiatives leading to innovations targeting the silver market. Cross-case analysis based on four different product innovations addressing typical needs of older people are used to present how firms in different industrial contexts and user-settings address such needs, which have their roots in a need to stay autonomous and independent. Technological, marketing and strategy-related observations as well as communalities and differences of the cases are being discussed and very first implications for managing the front end of silver product development sketched. --Demographic change,aging,older users,silver market,innovation management,silver product design,individual autonomy

Portable Tongue-Supported Human Computer Interaction System Design and Implementation

Tongue supported human-computer interaction (TSHCI) systems can help critically ill patients interact with both computers and people. These systems can be particularly useful for patients suffering injuries above C7 on their spinal vertebrae. Despite recent successes in their application, several limitations restrict performance of existing TSHCI systems and discourage their use in real life situations. This paper proposes a low-cost, less-intrusive, portable and easy to use design for implementing a TSHCI system. Two applications of the proposed system are reported. Design considerations and performance of the proposed system are also presented