Medical and biological physics

ФИЗИКАБИОФИЗИКАФИЗИКА МЕДИЦИНСКАЯПОСОБИЯЛЕКЦИИЛекции по медицинской и биологической физике содержат текстовый материал, формулы и диаграммы

Imaging the injured beating heart intravitally and the vasculoprotection afforded by haematopoietic stem cells in myocardial ischaemia/reperfusion injury

Myocardial ischaemia/reperfusion (IR) injury is a major contributor to the clinical mortality and morbidity in patients who have suffered a myocardial infarction (MI). Although stem cell (SC)-based therapy for MI holds promise, clinical success has been poor. This may be due to a lack of knowledge of whether systemically infused SCs efficiently home and adhere within the injured heart and whether therapeutic mechanisms involve SCs conferring vasculoprotection in damaged coronary microvessels. Indeed, the microcirculatory perturbations that occur during myocardial IR injury itself are not well understood, as pre-clinical research has been incapable of routinely and reliably directly imaging the beating heart in vivo. This study has presented a novel technique for visualising these disturbances through the use of intravital microscopy (IVM) alongside ventricular blood flow assessment. Laser speckle contrast imaging (LSCI) showed a sustained hyperaemic ventricular response during reperfusion that was not transmitted downstream, as IVM of the coronary microcirculation showed heterogenic flow with patchy, disorganised reperfusion and reduced functional capillary density. This was accompanied by a thrombo-inflammatory response leading to aggregates of microthrombi that occluded coronary capillaries. There was a significant and rapid increase in adherent platelets, neutrophils and monocytes in the IR injured heart. HSC therapy produced a remarkable reverse in these phenomena in IR injured hearts, alleviating the thrombo-inflammatory response and restoring the microcirculation to an organised state. Surprisingly, this was achieved without the need for HSCs to home to the injured heart. This suggest an important paracrine role in HSC therapy that confers vasculoprotection to the microvessels of the heart, likely through a reduction in oxidative stress-induced endothelial cell damage, which was characterised by a reduction in levels of 8-OHdG (a marker for oxidative damage) and endothelial adhesion molecules (ICAM-1 & VCAM-1). This is also the first study to show the pro-inflammatory effects of topical application of IL-36 isoforms on the beating heart, with promising potential for the IL-36 receptor antagonist to reduce the inflammatory infiltration observed in IR injured hearts

The 26th Annual Boston University Undergraduate Research (UROP) Abstracts

The file is available to be viewed by anyone in the BU community. To view the file, click on "Login" or the Person icon top-right with your BU Kerberos password. You will then be able to see an option to View.Abstracts for the 2023 UROP Symposium, held at Boston University on October 20, 2023 at GSU Metcalf Ballroom. Cover and logo design by Morgan Danna. Booklet compiled by Molly Power

Applied Measurement Systems

Measurement is a multidisciplinary experimental science. Measurement systems synergistically blend science, engineering and statistical methods to provide fundamental data for research, design and development, control of processes and operations, and facilitate safe and economic performance of systems. In recent years, measuring techniques have expanded rapidly and gained maturity, through extensive research activities and hardware advancements. With individual chapters authored by eminent professionals in their respective topics, Applied Measurement Systems attempts to provide a comprehensive presentation and in-depth guidance on some of the key applied and advanced topics in measurements for scientists, engineers and educators

Libro de actas. XXXV Congreso Anual de la Sociedad Española de Ingeniería Biomédica

596 p.CASEIB2017 vuelve a ser el foro de referencia a nivel nacional para el intercambio científico de conocimiento, experiencias y promoción de la I D i en Ingeniería Biomédica. Un punto de encuentro de científicos, profesionales de la industria, ingenieros biomédicos y profesionales clínicos interesados en las últimas novedades en investigación, educación y aplicación industrial y clínica de la ingeniería biomédica. En la presente edición, más de 160 trabajos de alto nivel científico serán presentados en áreas relevantes de la ingeniería biomédica, tales como: procesado de señal e imagen, instrumentación biomédica, telemedicina, modelado de sistemas biomédicos, sistemas inteligentes y sensores, robótica, planificación y simulación quirúrgica, biofotónica y biomateriales. Cabe destacar las sesiones dedicadas a la competición por el Premio José María Ferrero Corral, y la sesión de competición de alumnos de Grado en Ingeniería biomédica, que persiguen fomentar la participación de jóvenes estudiantes e investigadores

Treatment of Later Humoral Rejection with Anti-CD20 Monoclonal Antibody Rituximab: A Single Centre Experience

Humoral or vascular rejection is a B cell-mediated production of immunoglobulin (Ig) G antibody against a transplanted organ that results in immune complex deposition on the vascular endothelium, activation of the complement cascade, production of endothelial dysfunction and regional ischaemic injury

IC 077 Guide to Texas Medical Center Historical Resources Project Records

The Medical World News Photograph Collection (IC 077) predominantly consists of photographic prints, negatives, and transparencies that document the production of a premiere medical news magazine. The collection contains most of the images published in the magazine from 1967-1985. See more at https://archives.library.tmc.edu/ic-077