Medical Data Visual Synchronization and Information interaction Using Internet-based Graphics Rendering and Message-oriented Streaming

The rapid technology advances in medical devices make possible the generation of vast amounts of data, which contain massive quantities of diagnostic information. Interactively accessing and sharing the acquired data on the Internet is critically important in telemedicine. However, due to the lack of efficient algorithms and high computational cost, collaborative medical data exploration on the Internet is still a challenging task in clinical settings. Therefore, we develop a web-based medical image rendering and visual synchronization software platform, in which novel algorithms are created for parallel data computing and image feature enhancement, where Node.js and Socket.IO libraries are utilized to establish bidirectional connections between server and clients in real time. In addition, we design a new methodology to stream medical information among all connected users, whose identities and input messages can be automatically stored in database and extracted in web browsers. The presented software framework will provide multiple medical practitioners with immediate visual feedback and interactive information in applications such as collaborative therapy planning, distributed treatment, and remote clinical health care

Path tracing for direct volume rendering with web technologies

Rendering of volumetric data is of great significance in numerous fields of science and technology, although it is far from being a trivial task. Interactive and real-time rendering is even more difficult to achieve. Majority of applications nowadays employ primitive methods to reach high execution speeds, and furthermore, they are often accessible only on specific platforms. The web revolution in recent years enabled us to use web browsers to access powerful graphics hardware and in turn build modern graphical application in a platform-agnostic manner. Therefore, in this work we combine state-of-the-art web technology with the latest advancements in volume rendering in a proof-of-concept web application for interactive, real-time and physically correct rendering of volumetric data of arbitrary origin that runs on a wide variety of desktop and mobile devices. The methods used are as general as possible so as to not impose any restrictions on interaction, scene, camera and lighting. With extensibility of the implementation in mind we propose a new pipeline model with a direct support for stochastic methods, which allows for simple extension of existing and fast testing of new rendering methods. With this work we bridge the currently ubiquitous gap between theory and practice in a wide range of use cases

Real-time quality visualization of medical models on commodity and mobile devices

This thesis concerns the specific field of visualization of medical models using commodity and mobile devices. Mechanisms for medical imaging acquisition such as MRI, CT, and micro-CT scanners are continuously evolving, up to the point of obtaining volume datasets of large resolutions (> 512^3). As these datasets grow in resolution, its treatment and visualization become more and more expensive due to their computational requirements. For this reason, special techniques such as data pre-processing (filtering, construction of multi-resolution structures, etc.) and sophisticated algorithms have to be introduced in different points of the visualization pipeline to achieve the best visual quality without compromising performance times. The problem of managing big datasets comes from the fact that we have limited computational resources. Not long ago, the only physicians that were rendering volumes were radiologists. Nowadays, the outcome of diagnosis is the data itself, and medical doctors need to render them in commodity PCs (even patients may want to render the data, and the DVDs are commonly accompanied with a DICOM viewer software). Furthermore, with the increasing use of technology in daily clinical tasks, small devices such as mobile phones and tablets can fit the needs of medical doctors in some specific areas. Visualizing diagnosis images of patients becomes more challenging when it comes to using these devices instead of desktop computers, as they generally have more restrictive hardware specifications. The goal of this Ph.D. thesis is the real-time, quality visualization of medium to large medical volume datasets (resolutions >= 512^3 voxels) on mobile phones and commodity devices. To address this problem, we use multiresolution techniques that apply downsampling techniques on the full resolution datasets to produce coarser representations which are easier to handle. We have focused our efforts on the application of Volume Visualization in the clinical practice, so we have a particular interest in creating solutions that require short pre-processing times that quickly provide the specialists with the data outcome, maximize the preservation of features and the visual quality of the final images, achieve high frame rates that allow interactive visualizations, and make efficient use of the computational resources. The contributions achieved during this thesis comprise improvements in several stages of the visualization pipeline. The techniques we propose are located in the stages of multi-resolution generation, transfer function design and the GPU ray casting algorithm itself.Esta tesis se centra en la visualización de modelos médicos de volumen en dispositivos móviles y de bajas prestaciones. Los sistemas médicos de captación tales como escáners MRI, CT y micro-CT, están en constante evolución, hasta el punto de obtener modelos de volumen de gran resolución (> 512^3). A medida que estos datos crecen en resolución, su manejo y visualización se vuelve más y más costoso debido a sus requisitos computacionales. Por este motivo, técnicas especiales como el pre-proceso de datos (filtrado, construcción de estructuras multiresolución, etc.) y algoritmos específicos se tienen que introducir en diferentes puntos de la pipeline de visualización para conseguir la mejor calidad visual posible sin comprometer el rendimiento. El problema que supone manejar grandes volumenes de datos es debido a que tenemos recursos computacionales limitados. Hace no mucho, las únicas personas en el ámbito médico que visualizaban datos de volumen eran los radiólogos. Hoy en día, el resultado de la diagnosis son los datos en sí, y los médicos necesitan renderizar estos datos en PCs de características modestas (incluso los pacientes pueden querer visualizar estos datos, pues los DVDs con los resultados suelen venir acompañados de un visor de imágenes DICOM). Además, con el reciente aumento del uso de las tecnologías en la clínica práctica habitual, dispositivos pequeños como teléfonos móviles o tablets son los más convenientes en algunos casos. La visualización de volumen es más difícil en este tipo de dispositivos que en equipos de sobremesa, pues las limitaciones de su hardware son superiores. El objetivo de esta tesis doctoral es la visualización de calidad en tiempo real de modelos grandes de volumen (resoluciones >= 512^3 voxels) en teléfonos móviles y dispositivos de bajas prestaciones. Para enfrentarnos a este problema, utilizamos técnicas multiresolución que aplican técnicas de reducción de datos a los modelos en resolución original, para así obtener modelos de menor resolución. Hemos centrado nuestros esfuerzos en la aplicación de la visualización de volumen en la práctica clínica, así que tenemos especial interés en diseñar soluciones que requieran cortos tiempos de pre-proceso para que los especialistas tengan rápidamente los resultados a su disposición. También, queremos maximizar la conservación de detalles de interés y la calidad de las imágenes finales, conseguir frame rates altos que faciliten visualizaciones interactivas y que hagan un uso eficiente de los recursos computacionales. Las contribuciones aportadas por esta tesis són mejoras en varias etapas de la pipeline de visualización. Las técnicas que proponemos se situan en las etapas de generación de la estructura multiresolución, el diseño de la función de transferencia y el algoritmo de ray casting en la GPU.Postprint (published version

Real-time quality visualization of medical models on commodity and mobile devices

This thesis concerns the specific field of visualization of medical models using commodity and mobile devices. Mechanisms for medical imaging acquisition such as MRI, CT, and micro-CT scanners are continuously evolving, up to the point of obtaining volume datasets of large resolutions (> 512^3). As these datasets grow in resolution, its treatment and visualization become more and more expensive due to their computational requirements. For this reason, special techniques such as data pre-processing (filtering, construction of multi-resolution structures, etc.) and sophisticated algorithms have to be introduced in different points of the visualization pipeline to achieve the best visual quality without compromising performance times. The problem of managing big datasets comes from the fact that we have limited computational resources. Not long ago, the only physicians that were rendering volumes were radiologists. Nowadays, the outcome of diagnosis is the data itself, and medical doctors need to render them in commodity PCs (even patients may want to render the data, and the DVDs are commonly accompanied with a DICOM viewer software). Furthermore, with the increasing use of technology in daily clinical tasks, small devices such as mobile phones and tablets can fit the needs of medical doctors in some specific areas. Visualizing diagnosis images of patients becomes more challenging when it comes to using these devices instead of desktop computers, as they generally have more restrictive hardware specifications. The goal of this Ph.D. thesis is the real-time, quality visualization of medium to large medical volume datasets (resolutions >= 512^3 voxels) on mobile phones and commodity devices. To address this problem, we use multiresolution techniques that apply downsampling techniques on the full resolution datasets to produce coarser representations which are easier to handle. We have focused our efforts on the application of Volume Visualization in the clinical practice, so we have a particular interest in creating solutions that require short pre-processing times that quickly provide the specialists with the data outcome, maximize the preservation of features and the visual quality of the final images, achieve high frame rates that allow interactive visualizations, and make efficient use of the computational resources. The contributions achieved during this thesis comprise improvements in several stages of the visualization pipeline. The techniques we propose are located in the stages of multi-resolution generation, transfer function design and the GPU ray casting algorithm itself.Esta tesis se centra en la visualización de modelos médicos de volumen en dispositivos móviles y de bajas prestaciones. Los sistemas médicos de captación tales como escáners MRI, CT y micro-CT, están en constante evolución, hasta el punto de obtener modelos de volumen de gran resolución (> 512^3). A medida que estos datos crecen en resolución, su manejo y visualización se vuelve más y más costoso debido a sus requisitos computacionales. Por este motivo, técnicas especiales como el pre-proceso de datos (filtrado, construcción de estructuras multiresolución, etc.) y algoritmos específicos se tienen que introducir en diferentes puntos de la pipeline de visualización para conseguir la mejor calidad visual posible sin comprometer el rendimiento. El problema que supone manejar grandes volumenes de datos es debido a que tenemos recursos computacionales limitados. Hace no mucho, las únicas personas en el ámbito médico que visualizaban datos de volumen eran los radiólogos. Hoy en día, el resultado de la diagnosis son los datos en sí, y los médicos necesitan renderizar estos datos en PCs de características modestas (incluso los pacientes pueden querer visualizar estos datos, pues los DVDs con los resultados suelen venir acompañados de un visor de imágenes DICOM). Además, con el reciente aumento del uso de las tecnologías en la clínica práctica habitual, dispositivos pequeños como teléfonos móviles o tablets son los más convenientes en algunos casos. La visualización de volumen es más difícil en este tipo de dispositivos que en equipos de sobremesa, pues las limitaciones de su hardware son superiores. El objetivo de esta tesis doctoral es la visualización de calidad en tiempo real de modelos grandes de volumen (resoluciones >= 512^3 voxels) en teléfonos móviles y dispositivos de bajas prestaciones. Para enfrentarnos a este problema, utilizamos técnicas multiresolución que aplican técnicas de reducción de datos a los modelos en resolución original, para así obtener modelos de menor resolución. Hemos centrado nuestros esfuerzos en la aplicación de la visualización de volumen en la práctica clínica, así que tenemos especial interés en diseñar soluciones que requieran cortos tiempos de pre-proceso para que los especialistas tengan rápidamente los resultados a su disposición. También, queremos maximizar la conservación de detalles de interés y la calidad de las imágenes finales, conseguir frame rates altos que faciliten visualizaciones interactivas y que hagan un uso eficiente de los recursos computacionales. Las contribuciones aportadas por esta tesis són mejoras en varias etapas de la pipeline de visualización. Las técnicas que proponemos se situan en las etapas de generación de la estructura multiresolución, el diseño de la función de transferencia y el algoritmo de ray casting en la GPU

Ubiquitous volume rendering in the web platform

176 p.The main thesis hypothesis is that ubiquitous volume rendering can be achieved using WebGL. The thesis enumerates the challenges that should be met to achieve that goal. The results allow web content developers the integration of interactive volume rendering within standard HTML5 web pages. Content developers only need to declare the X3D nodes that provide the rendering characteristics they desire. In contrast to the systems that provide specific GPU programs, the presented architecture creates automatically the GPU code required by the WebGL graphics pipeline. This code is generated directly from the X3D nodes declared in the virtual scene. Therefore, content developers do not need to know about the GPU.The thesis extends previous research on web compatible volume data structures for WebGL, ray-casting hybrid surface and volumetric rendering, progressive volume rendering and some specific problems related to the visualization of medical datasets. Finally, the thesis contributes to the X3D standard with some proposals to extend and improve the volume rendering component. The proposals are in an advance stage towards their acceptance by the Web3D Consortium

High-performance volume rendering on the ubiquitous webGL platform

We have invented a high-performance GPU based volume rendering algorithm on the ubiquitous WebGL platform. As WebGL is emerging as a standard platform for web applications on mobile devices, a remarkable advantage of our approach is that the advanced volume rendering algorithms can run directly on mobile devices such as smart phones and tablets in which GPU is embedded, anywhere and anytime. Technically, we deployed a novel single-pass rendering pipeline, in contrast to the other WebGL volume rendering systems using the multi-pass approach. We extended the pseudo-color shading and ray function blending by using a custom transfer function widget in the web browser, which enables interactive feature enhancement in rendering. And lastly, to get rid of the limitation in the loop iteration for dynamic loops on the current mobile platforms, we devised a WebGL compliant 3D texture slicer as an alternative solution to rendering of large datasets. Extensive experimental results and performance assessments are reported in the paper

Interactive web-based visualization

The visualization of large amounts of data, which cannot be easily copied for processing on a user’s local machine, is not yet a fully solved problem. Remote visualization represents one possible solution approach to the problem, and has long been an important research topic. Depending on the device used, modern hardware, such as high-performance GPUs, is sometimes not available. This is another reason for the use of remote visualization. Additionally, due to the growing global networking and collaboration among research groups, collaborative remote visualization solutions are becoming more important. The additional use of collaborative visualization solutions is eventually due to the growing global networking and collaboration among research groups. The attractiveness of web-based remote visualization is greatly increased by the wide availability of web browsers on almost all devices; these are available today on all systems - from desktop computers to smartphones. In order to ensure interactivity, network bandwidth and latency are the biggest challenges that web-based visualization algorithms have to solve. Despite the steady improvements in available bandwidth, these improvements are still significantly slower than, for example, processor performance, resulting in increasing the impact of this bottleneck. For example, visualization of large dynamic data in low-bandwidth environments can be challenging because it requires continuous data transfer. However, bandwidth improvement alone cannot improve the latency because it is also affected by factors such as the distance between server and client and network utilization. To overcome these challenges, a combination of techniques is needed to customize the individual processing steps of the visualization pipeline, from efficient data representation to hardware-accelerated rendering on the client side. This thesis first deals with related work in the field of remote visualization with a particular focus on interactive web-based visualization and then presents techniques for interactive visualization in the browser using modern web standards such as WebGL and HTML5. These techniques enable the visualization of dynamic molecular data sets with more than one million atoms at interactive frame rates using GPU-based ray casting. Due to the limitations which exist in a browser-based environment, the concrete implementation of the GPU-based ray casting had to be customized. Evaluation of the resulting performance shows that GPU-based techniques enable the interactive rendering of large data sets and achieve higher image quality compared to polygon-based techniques. In order to reduce data transfer times and network latency, and improve rendering speed, efficient approaches for data representation and transmission are used. Furthermore, this thesis introduces a GPU-based volume-ray marching technique based on WebGL 2.0, which uses progressive brick-wise data transfer, as well as multiple levels of detail in order to achieve interactive volume rendering of datasets stored on a server. The concepts and results presented in this thesis contribute to the further spread of interactive web-based visualization. The algorithmic and technological advances that have been achieved form a basis for further development of interactive browser-based visualization applications. At the same time, this approach has the potential for enabling future collaborative visualization in the cloud.Die Visualisierung großer Datenmengen, welche nicht ohne Weiteres zur Verarbeitung auf den lokalen Rechner des Anwenders kopiert werden können, ist ein bisher nicht zufriedenstellend gelöstes Problem. Remote-Visualisierung stellt einen möglichen Lösungsansatz dar und ist deshalb seit langem ein relevantes Forschungsthema. Abhängig vom verwendeten Endgerät ist moderne Hardware, wie etwa performante GPUs, teilweise nicht verfügbar. Dies ist ein weiterer Grund für den Einsatz von Remote-Visualisierung. Durch die zunehmende globale Vernetzung und Kollaboration von Forschungsgruppen gewinnt kollaborative Remote-Visualisierung zusätzlich an Bedeutung. Die Attraktivität web-basierter Remote-Visualisierung wird durch die weitreichende Verfügbarkeit von Web-Browsern auf nahezu allen Endgeräten enorm gesteigert; diese sind heutzutage auf allen Systemen - vom Desktop-Computer bis zum Smartphone - vorhanden. Bei der Gewährleistung der Interaktivität sind Bandbreite und Latenz der Netzwerkverbindung die größten Herausforderungen, welche von web-basierten Visualisierungs-Algorithmen gelöst werden müssen. Trotz der stetigen Verbesserungen hinsichtlich der verfügbaren Bandbreite steigt diese signifikant langsamer als beispielsweise die Prozessorleistung, wodurch sich die Auswirkung dieses Flaschenhalses immer weiter verstärkt. So kann beispielsweise die Visualisierung großer dynamischer Daten in Umgebungen mit geringer Bandbreite eine Herausforderung darstellen, da kontinuierlicher Datentransfer benötigt wird. Dennoch kann die alleinige Verbesserung der Bandbreite keine entsprechende Verbesserung der Latenz bewirken, da diese zudem von Faktoren wie der Distanz zwischen Server und Client sowie der Netzwerkauslastung beeinflusst wird. Um diese Herausforderungen zu bewältigen, wird eine Kombination verschiedener Techniken für die Anpassung der einzelnen Verarbeitungsschritte der Visualisierungspipeline benötigt, angefangen bei effizienter Datenrepräsentation bis hin zu hardware-beschleunigtem Rendering auf der Client-Seite. Diese Doktorarbeit befasst sich zunächst mit verwandten Arbeiten auf dem Gebiet der Remote-Visualisierung mit besonderem Fokus auf interaktiver web-basierter Visualisierung und präsentiert danach Techniken für die interaktive Visualisierung im Browser mit Hilfe moderner Web-Standards wie WebGL und HTML5. Diese Techniken ermöglichen die Visualisierung dynamischer molekularer Datensätze mit mehr als einer Million Atomen bei interaktiven Frameraten durch die Verwendung GPU-basierten Raycastings. Aufgrund der Einschränkungen, welche in einer Browser-basierten Umgebung vorliegen, musste die konkrete Implementierung des GPU-basierten Raycastings angepasst werden. Die Evaluation der daraus resultierenden Performanz zeigt, dass GPU-basierte Techniken das interaktive Rendering von großen Datensätzen ermöglichen und eine im Vergleich zu Polygon-basierten Techniken höhere Bildqualität erreichen. Zur Verringerung der Übertragungszeiten, Reduktion der Latenz und Verbesserung der Darstellungsgeschwindigkeit werden effiziente Ansätze zur Datenrepräsentation und übertragung verwendet. Des Weiteren wird in dieser Doktorarbeit eine GPU-basierte Volumen-Ray-Marching-Technik auf Basis von WebGL 2.0 eingeführt, welche progressive blockweise Datenübertragung verwendet, sowie verschiedene Detailgrade, um ein interaktives Volumenrendering von auf dem Server gespeicherten Datensätzen zu erreichen. Die in dieser Doktorarbeit präsentierten Konzepte und Resultate tragen zur weiteren Verbreitung von interaktiver web-basierter Visualisierung bei. Die erzielten algorithmischen und technologischen Fortschritte bilden eine Grundlage für weiterführende Entwicklungen von interaktiven Visualisierungsanwendungen auf Browser-Basis. Gleichzeitig hat dieser Ansatz das Potential, zukünftig kollaborative Visualisierung in der Cloud zu ermöglichen