Wavelet feature extraction and genetic algorithm for biomarker detection in colorectal cancer data

Biomarkers which predict patient’s survival can play an important role in medical diagnosis and treatment. How to select the significant biomarkers from hundreds of protein markers is a key step in survival analysis. In this paper a novel method is proposed to detect the prognostic biomarkers ofsurvival in colorectal cancer patients using wavelet analysis, genetic algorithm, and Bayes classifier. One dimensional discrete wavelet transform (DWT) is normally used to reduce the dimensionality of biomedical data. In this study one dimensional continuous wavelet transform (CWT) was proposed to extract the features of colorectal cancer data. One dimensional CWT has no ability to reduce dimensionality of data, but captures the missing features of DWT, and is complementary part of DWT. Genetic algorithm was performed on extracted wavelet coefficients to select the optimized features, using Bayes classifier to build its fitness function. The corresponding protein markers were located based on the position of optimized features. Kaplan-Meier curve and Cox regression model 2 were used to evaluate the performance of selected biomarkers. Experiments were conducted on colorectal cancer dataset and several significant biomarkers were detected. A new protein biomarker CD46 was found to significantly associate with survival time

SciTech News Volume 71, No. 2 (2017)

Columns and Reports From the Editor 3 Division News Science-Technology Division 5 Chemistry Division 8 Engineering Division 9 Aerospace Section of the Engineering Division 12 Architecture, Building Engineering, Construction and Design Section of the Engineering Division 14 Reviews Sci-Tech Book News Reviews 16 Advertisements IEEE

Optimal management of bio-based energy supply chains under parametric uncertainty through a data-driven decision-support framework

This paper addresses the optimal management of a multi-objective bio-based energy supply chain network subjected to multiple sources of uncertainty. The complexity to obtain an optimal solution using traditional uncertainty management methods dramatically increases with the number of uncertain factors considered. Such a complexity produces that, if tractable, the problem is solved after a large computational effort. Therefore, in this work a data-driven decision-making framework is proposed to address this issue. Such a framework exploits machine learning techniques to efficiently approximate the optimal management decisions considering a set of uncertain parameters that continuously influence the process behavior as an input. A design of computer experiments technique is used in order to combine these parameters and produce a matrix of representative information. These data are used to optimize the deterministic multi-objective bio-based energy network problem through conventional optimization methods, leading to a detailed (but elementary) map of the optimal management decisions based on the uncertain parameters. Afterwards, the detailed data-driven relations are described/identified using an Ordinary Kriging meta-model. The result exhibits a very high accuracy of the parametric meta-models for predicting the optimal decision variables in comparison with the traditional stochastic approach. Besides, and more importantly, a dramatic reduction of the computational effort required to obtain these optimal values in response to the change of the uncertain parameters is achieved. Thus the use of the proposed data-driven decision tool promotes a time-effective optimal decision making, which represents a step forward to use data-driven strategy in large-scale/complex industrial problems.Peer ReviewedPostprint (published version

Assessing the current landscape of AI and sustainability literature:Identifying key trends, addressing gaps and challenges

The United Nations’ 17 Sustainable Development Goals stress the importance of global and local efforts to address inequalities and implement sustainability. Addressing complex, interconnected sustainability challenges requires a systematic, interdisciplinary approach, where technology, AI, and data-driven methods offer potential solutions for optimizing resources, integrating different aspects of sustainability, and informed decision-making. Sustainability research surrounds various local, regional, and global challenges, emphasizing the need to identify emerging areas and gaps where AI and data-driven models play a crucial role. The study performs a comprehensive literature survey and scientometric and semantic analyses, categorizes data-driven methods for sustainability problems, and discusses the sustainable use of AI and big data. The outcomes of the analyses highlight the importance of collaborative and inclusive research that bridges regional differences, the interconnection of AI, technology, and sustainability topics, and the major research themes related to sustainability. It further emphasizes the significance of developing hybrid approaches combining AI, data-driven techniques, and expert knowledge for multi-level, multi-dimensional decision-making. Furthermore, the study recognizes the necessity of addressing ethical concerns and ensuring the sustainable use of AI and big data in sustainability research.</p

Absorptive capacity and the growth and investment effects of regional transfers : a regression discontinuity design with heterogeneous treatment effects

Researchers often estimate average treatment effects of programs without investigating heterogeneity across units. Yet, individuals, firms, regions, or countries vary in their ability, e.g., to utilize transfers. We analyze Objective 1 Structural Funds transfers of the European Commission to regions of EU member states below a certain income level by way of a regression discontinuity design with systematically heterogeneous treatment effects. Only about 30% and 21% of the regions - those with sufficient human capital and good-enough institutions - are able to turn transfers into faster per-capita income growth and per-capita investment. In general, the variance of the treatment effect is much bigger than its mean

The state of the art development of AHP (1979-2017): A literature review with a social network analysis

Although many papers describe the evolution of the analytic hierarchy process (AHP), most adopt a subjective approach. This paper examines the pattern of development of the AHP research field using social network analysis and scientometrics, and identifies its intellectual structure. The objectives are: (i) to trace the pattern of development of AHP research; (ii) to identify the patterns of collaboration among authors; (iii) to identify the most important papers underpinning the development of AHP; and (iv) to discover recent areas of interest. We analyse two types of networks: social networks, that is, co-authorship networks, and cognitive mapping or the network of disciplines affected by AHP. Our analyses are based on 8441 papers published between 1979 and 2017, retrieved from the ISI Web of Science database. To provide a longitudinal perspective on the pattern of evolution of AHP, we analyse these two types of networks during the three periods 1979?1990, 1991?2001 and 2002?2017. We provide some basic statistics on AHP journals and researchers, review the main topics and applications of integrated AHPs and provide direction for future research by highlighting some open questions

AN INTEGRATED FRAMEWORK FOR QUALITY EVALUATION OF FRUITS AND VEGETABLE STORE LOCATED IN THE SUPERMARKET UNDER UTOPIAN ENVIRONMENT

Customer satisfaction depends on the availability of different varieties of fruits and vegetables in a supermarket store as well as the quality of this supermarket store for fruits and vegetables. The store may contain different variety of fruits and vegetables in a utopian environment. Apart from this, there are several quality parameters of a fruits and vegetable store. The quality evaluation of fruits and vegetable stores located in a supermarket is a big challenge for managerial personnel. Here, a quality evaluation framework is proposed for the fruits and vegetable store. The committee of experts identifies and finalizes the quality evaluation parameters through a brainstorming session. Fuzzy AHP is used to calculate the weights of evaluation parameters. A fuzzy TOPSIS generally ranks for the alternative stores. An improved fuzzy TOPSIS, which is named fuzzy k-TOPSIS, is proposed here to evaluate the quality of fruits and vegetable stores located in a supermarket. The fuzzy k-TOPSIS will provide rank as well as classification of the alternatives. A numerical example is demonstrated for a better understanding of the proposed framework

マーカーレス腫瘍位置決めを目的とした深層学習に基づく患者固有標的輪郭予測モデルの開発

京都大学新制・課程博士博士(人間健康科学)甲第24542号人健博第113号新制||人健||8(附属図書館)京都大学大学院医学研究科人間健康科学系専攻(主査)教授 中尾 恵, 教授 杉本 直三, 教授 黒田 知宏学位規則第4条第1項該当Doctor of Human Health SciencesKyoto UniversityDFA

The state of the art development of AHP (1979-2017): a literature review with a social network analysis

Although many papers describe the evolution of the analytic hierarchy process (AHP), most adopt a subjective approach. This paper examines the pattern of development of the AHP research field using social network analysis and scientometrics, and identifies its intellectual structure. The objectives are: (i) to trace the pattern of development of AHP research; (ii) to identify the patterns of collaboration among authors; (iii) to identify the most important papers underpinning the development of AHP; and (iv) to discover recent areas of interest. We analyse two types of networks: social networks, that is, co-authorship networks, and cognitive mapping or the network of disciplines affected by AHP. Our analyses are based on 8441 papers published between 1979 and 2017, retrieved from the ISI Web of Science database. To provide a longitudinal perspective on the pattern of evolution of AHP, we analyse these two types of networks during the three periods 1979–1990, 1991–2001 and 2002–2017. We provide some basic statistics on AHP journals and researchers, review the main topics and applications of integrated AHPs and provide direction for future research by highlighting some open questions