Fast Detrending of Unevenly Sampled Series with Application to HRV

Abstract Detrending RR series is a common processing step prior to HRV analysis. In the classical approaches RR series, which are inherently unevenly sampled, are interpolated and uniformly resampled, thus introducing errors in subsequent HRV analysis. In this paper, we propose a novel approach to detrending unevenly sampled series and apply it to RR series. The approach is based on the notion of weighted quadratic variation, which is a suitable measure of variability for unevenly sampled series. Detrending is performed by solving a constrained convex optimization problem that exploits the weighted quadratic variation. Numerical results confirm the effectiveness of the approach. The algorithm is simple and favorable in terms of computational complexity, which is linear in the size of the series to detrend. This makes it suitable for long-term HRV analysis. To the best of the authors' knowledge, it is the fastest algorithm for detrending RR series

Design, Evaluation, and Application of Heart Rate Variability Analysis Software (HRVAS)

The analysis of heart rate variability (HRV) has become an increasingly popular and important tool for studying many disease pathologies in the past twenty years. HRV analyses are methods used to non-invasively quantify variability within heart rate. Purposes of this study were to design, evaluate, and apply an easy to use and open-source HRV analysis software package (HRVAS). HRVAS implements four major categories of HRV techniques: statistical and time-domain analysis, frequency-domain analysis, nonlinear analysis, and time-frequency analysis. Software evaluations were accomplished by performing HRV analysis on simulated and public congestive heart failure (CHF) data. Application of HRVAS included studying the effects of hyperaldosteronism on HRV in rats. Simulation and CHF results demonstrated that HRVAS was a dependable HRV analysis tool. Results from the rat hyperaldosteronism model showed that 5 of 26 HRV measures were statistically significant (p\u3c0.05). HRVAS provides a useful tool for HRV analysis to researchers

Estimating spectral HRV features with missing data

Abstract. Physiological signals, ECG signal, have been widely used for diagnosis, disease identification and nowadays for self-monitoring. Missing data represents the problem in spectral analysis. This study focuses on the HRV power spectral analysis in frequency-domain using three methods with simulated missing data in real RR interval tachograms. Actual missing ECG data are collected from the unconstrained measurement. Parametric, Non-parametric and uneven sampling approach were used for calculating the power spectral density (PSD), and cubic spline interpolation method was used for the non-parametric method. Based on this studies outcome, the effect of missing R-R interval data and optimal method was observed through the simulated real R-R interval tachograms for missing data. About 0 to 6 percentage data were removed according to the exponential Poisson distribution from the real R-R interval data for normal sinus rhythm, atrial fibrillation, tachycardia and bradycardia patient which data obtained from MIT-BIH Arrhythmia database to simulate real-world packet loss. For this analysis, 5 min duration data were used in all and 1000 Monte Carlo runs is performed for certain percentage missing data. Power spectral density (PSD) corresponding each frequency component was estimated as the frequency-domain parameters in each run and error power percentage based on each element difference between with and without the missing data duration were calculated. In addition, this study revealed that power spectral entropy measurement from power spectral density which differentiates between different arrhythmias

Application of the Lomb-Scargle Periodogram to Investigate Heart Rate Variability during Haemodialysis

Short-term cardiovascular compensatory responses to perturbations in the circulatory system caused by haemodialysis can be investigated by the spectral analysis of heart rate variability, thus providing an important variable for categorising individual patients' response, leading to a more personalised treatment. This is typically accomplished by resampling the irregular heart rate to generate an equidistant time series prior to spectral analysis, but resampling can further distort the data series whose interpretation can already be compromised by the presence of artefacts. The Lomb-Scargle periodogram provides a more direct method of spectral analysis as this method is specifically designed for large, irregularly sampled, and noisy datasets such as those obtained in clinical settings. However, guidelines for preprocessing patient data have been established in combination with equidistant time-series methods and their validity when used in combination with the Lomb-Scargle approach is missing from literature. This paper examines the effect of common preprocessing methods on the Lomb-Scargle power spectral density estimate using both real and synthetic heart rate data and will show that many common techniques for identifying and editing suspect data points, particularly interpolation and replacement, will distort the resulting power spectrum potentially misleading clinical interpretations of the results. Other methods are proposed and evaluated for use with the Lomb-Scargle approach leading to the main finding that suspicious data points should be excluded rather than edited, and where required, denoising of the heart rate signal can be reliably accomplished by empirical mode decomposition. Some additional methods were found to be particularly helpful when used in conjunction with the Lomb-Scargle periodogram, such as the use of a false alarm probability metric to establish whether spectral estimates are valid and help automate the assessment of valid heart rate records, potentially leading to greater use of this powerful technique in a clinical setting.The authors would like to thank Mel Morris and iTrend Medical Research Ltd. for funding the iTrend research programme

Validity of the Pneumonitor for RR intervals acquisition for short-term heart rate variability analysis extended with respiratory data in pediatric cardiac patients

BACKGROUND: Breathing pattern alterations change the variability and the spectral content of the RR intervals (RRi) from electrocardiogram (ECG). However, actually there is no solution on how to record and control participant’s breathing without influencing its natural rate and depth in heart rate variability (HRV) studies. AIM: The aim of the study was to assess the validity of the Pneumonitor for acquisition of short-term (5 min) RRi in comparison to the reference ECG method for analysis of heart rate (HR) and HRV parameters in the group of pediatric patients with cardiac disease. METHODS: Nineteen patients of both sexes participated in the study. ECG and Pneumonitor were used to record RRi from 5 min static rest conditions, the latter also to measure the relative tidal volume and respiratory rate. The validation comprised the Student’s t-test, Bland-Altman analysis, Intraclass Correlation Coefficient and Lin’s concordance correlation. The possible impact of the respiratory activity on the agreement between ECG and Pneumonitor was also assessed. RESULTS: Acceptable agreement for number of RRi, mean RR, HR and HRV measures calculated based on RRi acquired using ECG and Pneumonitor was presented. There was no association between breathing pattern and RRi agreement between devices. CONCLUSIONS: Pneumonitor might be considered appropriate for cardiorespiratory studies in the group of pediatric cardiac patients in rest condition

Influence of heart rate in non-linear HRV indices as a sampling rate effect evaluated on supine and standing

The purpose of this study is to characterize and attenuate the influence of mean heart rate (HR) on nonlinear heart rate variability (HRV) indices (correlation dimension, sample, and approximate entropy) as a consequence of being the HR the intrinsic sampling rate of HRV signal. This influence can notably alter nonlinear HRV indices and lead to biased information regarding autonomic nervous system (ANS) modulation. First, a simulation study was carried out to characterize the dependence of nonlinear HRV indices on HR assuming similar ANS modulation. Second, two HR-correction approaches were proposed: one based on regression formulas and another one based on interpolating RR time series. Finally, standard and HR-corrected HRV indices were studied in a body position change database. The simulation study showed the HR-dependence of non-linear indices as a sampling rate effect, as well as the ability of the proposed HR-corrections to attenuate mean HR influence. Analysis in a body position changes database shows that correlation dimension was reduced around 21% in median values in standing with respect to supine position (p < 0.05), concomitant with a 28% increase in mean HR (p < 0.05). After HR-correction, correlation dimension decreased around 18% in standing with respect to supine position, being the decrease still significant. Sample and approximate entropy showed similar trends. HR-corrected nonlinear HRV indices could represent an improvement in their applicability as markers of ANS modulation when mean HR changes

Relationship between metabolic and anthropometric maternal parameters and the fetal autonomic nervous system

Pre-pregnancy obesity, defined as a body mass index (BMI) greater than or equal to 30 kg/m2, can have adverse effects on the health of newborns and can also lead to metabolic, cardiovascular and neurological diseases in the offspring as they grow older. In the area of fetal origins and disease in adult life, a large number of studies have reported a critical role for maternal weight and metabolism before or during gestation in shaping the health of their offspring. Maternal obesity is recognised as a major modifiable contributor to obesity and metabolic syndrome in offspring, but the underlying factors remain unclear. The fetal autonomic nervous system (ANS) is subject to programming during developmental periods and is considered one of the processes by which early programming of disease can take place. The main goal of the present work was to use the fetal heart rate (HR) and heart rate variability (HRV) as proxies for the fetal ANS to study the effects of metabolic and anthropometric maternal (MAM) parameters before and during gestation on the fetuses of healthy, normoglycemic mothers. A total of 184 women in their second/third trimesters of uncomplicated pregnancies were included in this study. Pre-pregnancy BMI and maternal weight gain during pregnancy were recorded. In a subsample (n = 104), maternal insulin sensitivity was measured during an oral glucose tolerance test. Fetal HR and HRV were determined by magnetic recording in all subjects. The influence of pre-pregnancy BMI, maternal weight gain and maternal insulin sensitivity on fetal HR and HRV was evaluated. Associations between MAM parameters and maternal HR and HRV were also assessed. ANCOVA, partial correlation and mediation analysis were applied, all of which were adjusted for gestational age, gender and parity. A regression on fetal HR using a machine learning approach was tested to explore which maternal factor is the driving factor programming the fetal ANS. Four models were tested: Linear regression, Regression Tree, Support Vector Machine and Random Forest. The fetal HR was higher in fetuses of mothers with high pre-pregnancy BMI (overweight/obese) than in mothers with normal weight. The fetal HRV was lower in mothers with high weight gain than in mothers with normal weight gain. The fetal HR was negatively correlated with maternal weight gain and maternal insulin sensitivity. Pre-pregnancy BMI was positively correlated with fetal high frequency and negatively correlated with low frequency and the low to high frequency ratio. Maternal weight gain was associated indirectly with birth weight through fetal HR, while maternal insulin sensitivity was associated with fetal HR through fetal HRV. Separately, fetal HRV was associated with birth weight through the fetal HR. The Random Forest ensemble tree-based model outperformed linear regression as the fetal HR regression model. Fetal HR can be predicted using the following nine relevant variables (sorted from the most important to the least important): pre-pregnancy BMI, gender, maternal fasting insulin, maternal insulin sensitivity, gravidity, maternal age, maternal fasting glucose, gestational age and maternal weight gain. Pre-pregnancy BMI appeared to be the major factor predicting fetal HR. In conclusion, the fetal ANS is sensitive to maternal metabolic and anthropometric influences, and particularly maternal weight before pregnancy. These findings support the concept of the “Developmental Origin of Health and Disease” and increase our knowledge about the importance of the intrauterine environment in the programming of the ANS and the possible programming of disease in later life

Doctor of Philosophy

dissertationRecent theory and research on psychophysiological aspects of self-regulation emphasizes the central role of resting respiratory sinus arrhythmia (RSA), an index of parasympathetic nervous system functioning. Within the context of close relationships, resting RSA may index an individual's self-regulatory capacity to manage affect associated with interpersonal interactions. In the laboratory, RSA was measured during a 10-minute resting baseline and participants completed measures of relationship quality. Partners were emailed a link to complete an online measure of relationship quality. Following the laboratory sessions, participants were prompted (using experience sampling methodology) to provide ratings of their affect during interactions with a romantic partner throughout a day. Resting RSA was correlated with partner reports of conflict in the relationship but not participant ratings of relationship quality. Multilevel models revealed a positive association between resting RSA and reports of calm and relaxed affect during social interactions with a romantic partner. Resting RSA was negatively associated with upset and angry affect during interactions with a romantic partner. These findings suggest that resting RSA may influence affect regulation during social interactions with a romantic partner and may have implications for understanding processes key to self-regulation and health