How Fair Is IS Research?

While both information systems and machine learning are not neutral, the identification of discrimination is more difficult if a system learns from data and discrimination can be introduced at several stages. Therefore, this article investigates if IS Research has taken up with this topic. A literature analysis is conducted and its discussion shows that technology, organization, and human aspects have to be considered, making it a topic not only for data scientist or computer scientist, but for information systems researchers as well

Rule Mining and Sequential Pattern Based Predictive Modeling with EMR Data

Electronic medical record (EMR) data is collected on a daily basis at hospitals and other healthcare facilities to track patients’ health situations including conditions, treatments (medications, procedures), diagnostics (labs) and associated healthcare operations. Besides being useful for individual patient care and hospital operations (e.g., billing, triaging), EMRs can also be exploited for secondary data analyses to glean discriminative patterns that hold across patient cohorts for different phenotypes. These patterns in turn can yield high level insights into disease progression with interventional potential. In this dissertation, using a large scale realistic EMR dataset of over one million patients visiting University of Kentucky healthcare facilities, we explore data mining and machine learning methods for association rule (AR) mining and predictive modeling with mood and anxiety disorders as use-cases. Our first work involves analysis of existing quantitative measures of rule interestingness to assess how they align with a practicing psychiatrist’s sense of novelty/surprise corresponding to ARs identified from EMRs. Our second effort involves mining causal ARs with depression and anxiety disorders as target conditions through matching methods accounting for computationally identified confounding attributes. Our final effort involves efficient implementation (via GPUs) and application of contrast pattern mining to predictive modeling for mental conditions using various representational methods and recurrent neural networks. Overall, we demonstrate the effectiveness of rule mining methods in secondary analyses of EMR data for identifying causal associations and building predictive models for diseases

Deep Learning for Genomics: A Concise Overview

Advancements in genomic research such as high-throughput sequencing techniques have driven modern genomic studies into "big data" disciplines. This data explosion is constantly challenging conventional methods used in genomics. In parallel with the urgent demand for robust algorithms, deep learning has succeeded in a variety of fields such as vision, speech, and text processing. Yet genomics entails unique challenges to deep learning since we are expecting from deep learning a superhuman intelligence that explores beyond our knowledge to interpret the genome. A powerful deep learning model should rely on insightful utilization of task-specific knowledge. In this paper, we briefly discuss the strengths of different deep learning models from a genomic perspective so as to fit each particular task with a proper deep architecture, and remark on practical considerations of developing modern deep learning architectures for genomics. We also provide a concise review of deep learning applications in various aspects of genomic research, as well as pointing out potential opportunities and obstacles for future genomics applications.Comment: Invited chapter for Springer Book: Handbook of Deep Learning Application

Open Data

Open data is freely usable, reusable, or redistributable by anybody, provided there are safeguards in place that protect the data’s integrity and transparency. This book describes how data retrieved from public open data repositories can improve the learning qualities of digital networking, particularly performance and reliability. Chapters address such topics as knowledge extraction, Open Government Data (OGD), public dashboards, intrusion detection, and artificial intelligence in healthcare

A survey on bias in machine learning research

Current research on bias in machine learning often focuses on fairness, while overlooking the roots or causes of bias. However, bias was originally defined as a "systematic error," often caused by humans at different stages of the research process. This article aims to bridge the gap between past literature on bias in research by providing taxonomy for potential sources of bias and errors in data and models. The paper focus on bias in machine learning pipelines. Survey analyses over forty potential sources of bias in the machine learning (ML) pipeline, providing clear examples for each. By understanding the sources and consequences of bias in machine learning, better methods can be developed for its detecting and mitigating, leading to fairer, more transparent, and more accurate ML models.Comment: Submitted to journal. arXiv admin note: substantial text overlap with arXiv:2308.0946

A Review of the Role of Causality in Developing Trustworthy AI Systems

State-of-the-art AI models largely lack an understanding of the cause-effect relationship that governs human understanding of the real world. Consequently, these models do not generalize to unseen data, often produce unfair results, and are difficult to interpret. This has led to efforts to improve the trustworthiness aspects of AI models. Recently, causal modeling and inference methods have emerged as powerful tools. This review aims to provide the reader with an overview of causal methods that have been developed to improve the trustworthiness of AI models. We hope that our contribution will motivate future research on causality-based solutions for trustworthy AI.Comment: 55 pages, 8 figures. Under revie

Artificial Intelligence and Cardiovascular Genetics

Polygenic diseases, which are genetic disorders caused by the combined action of multiple genes, pose unique and significant challenges for the diagnosis and management of affected patients. A major goal of cardiovascular medicine has been to understand how genetic variation leads to the clinical heterogeneity seen in polygenic cardiovascular diseases (CVDs). Recent advances and emerging technologies in artificial intelligence (AI), coupled with the ever-increasing availability of next generation sequencing (NGS) technologies, now provide researchers with unprecedented possibilities for dynamic and complex biological genomic analyses. Combining these technologies may lead to a deeper understanding of heterogeneous polygenic CVDs, better prognostic guidance, and, ultimately, greater personalized medicine. Advances will likely be achieved through increasingly frequent and robust genomic characterization of patients, as well the integration of genomic data with other clinical data, such as cardiac imaging, coronary angiography, and clinical biomarkers. This review discusses the current opportunities and limitations of genomics; provides a brief overview of AI; and identifies the current applications, limitations, and future directions of AI in genomics.</jats:p

Gaining Insight into Determinants of Physical Activity using Bayesian Network Learning

Contains fulltext : 228326pre.pdf (preprint version ) (Open Access) Contains fulltext : 228326pub.pdf (publisher's version ) (Open Access)BNAIC/BeneLearn 202