Recent development of respiratory rate measurement technologies

Respiratory rate (RR) is an important physiological parameter whose abnormity has been regarded as an important indicator of serious illness. In order to make RR monitoring simple to do, reliable and accurate, many different methods have been proposed for such automatic monitoring. According to the theory of respiratory rate extraction, methods are categorized into three modalities: extracting RR from other physiological signals, RR measurement based on respiratory movements, and RR measurement based on airflow. The merits and limitations of each method are highlighted and discussed. In addition, current works are summarized to suggest key directions for the development of future RR monitoring methodologies

DICOM for EIT

With EIT starting to be used in routine clinical practice [1], it important that the clinically relevant information is portable between hospital data management systems. DICOM formats are widely used clinically and cover many imaging modalities, though not specifically EIT. We describe how existing DICOM specifications, can be repurposed as an interim solution, and basis from which a consensus EIT DICOM ‘Supplement’ (an extension to the standard) can be writte

Estimation of thorax shape for forward modelling in lungs EIT

The thorax models for pre-term babies are developed based on the CT scans from new-borns and their effect on image reconstruction is evaluated in comparison with other available models

Rapid generation of subject-specific thorax forward models

For real-time monitoring of lung function using accurate patient geometry, shape information needs to be acquired and a forward model generated rapidly. This paper shows that warping a cylindrical model to an acquired shape results in meshes of acceptable mesh quality, in terms of stretch and aspect ratio

Torso shape detection to improve lung monitoring

Two methodologies are proposed to detect the patient-specific boundary of the chest, aiming to produce a more accurate forward model for EIT analysis. Thus, a passive resistive and an inertial prototypes were prepared to characterize and reconstruct the shape of multiple phantoms. Preliminary results show how the passive device generates a minimum scatter between the reconstructed image and the actual shap

Nanoparticle electrical impedance tomography

We have developed a new approach to imaging with electrical impedance tomography (EIT) using gold nanoparticles (AuNPs) to enhance impedance changes at targeted tissue sites. This is achieved using radio frequency (RF) to heat nanoparticles while applying EIT imaging. The initial results using 5-nm citrate coated AuNPs show that heating can enhance the impedance in a solution containing AuNPs due to the application of an RF field at 2.60 GHz

Development of Triboelectric Devices for Self-powered Sensing And Energy Harvesting Applications

Due to the bulky size and limited lifespan of batteries, remote charging and energy har- vesting from the environment are becoming two trends to power miniaturized electronics. Tri- boelectric nanogenerator (TENG) is an emerging technology to convert mechanical energy to electricitical energy by the coupling of triboelectrification and electrostatic induction. It has been widely applied to self-powered sensing and energy generation by virtue of the simpler device configuration and broader material choices compared to conventional energy conversion technologies, such as electromagnetic and piezoelectric energy harvesters. In this thesis, it is the first time to presented a self-powered on-line ion concentration monitoring system based on the impedance matching effect of TENG. Other than handcrafted TENGs, the rotary disc-shaped TENG (RD-TENG) was fabricated by the industrial printed circuit board (PCB) technology, which could realize sophisticated design and low-cost fabrica- tion. Flowing water, as the energy source, in the pipeline was utilized to drive the RD-TENG and generate an open-circuit voltage (VOC) of ∼210 VP−P. The impedance matching effect of TENG as the sensing mechanism was studied thoroughly. Based on the impedance matching effect, an alarm circuit was designed for the demonstration and the alarm LED can be success- fully lit up by the change of NaCl concentration with only 1×10−5 mol/L, which showed a high sensitivity. Compared to environmental monitoring, healthcare monitoring requires further miniatur- ized size and better compatibility with electronics. To satisfy the demands, a novel micro tri- boelectric energy harvester (μTEH) was developed. Based on the μTEH, a propotyped acoustic energy transfer system was built via an ultrasound link. For the very first time, TENG was fab- ricated by Micro-electro-mechanical systems (MEMS) technologies in batch process, giving better integrated circuit (IC) integration. More importantly, it is also the first time that the size of TENG is brought into microscale. We demonstrated a prototyped acoustic energy transfer system for implanted devices that could generate 50 nW power on load resistor under 1 MHz, 132 mW/cm2 incident acoustic power. The μTEH also achieved a signal-to-ratio (SNR) of 20.54 dB and exhibited promising potential for wireless communication by modulating the in- cident ultrasound. Finally, detailed optimization methods were proposed to improve the output power of the μTEHs in the future

A contribution to unobtrusive video-based measurement of respiratory signals

Due to the growing popularity of video-based methods for physiological signal measurement, and taking into account the technological advancements of these type of devices, this work proposes a series of new novel methods to obtain the respiratory signal from a distance, based on video analysis. This thesis aims to improve the state of the art video methods for respiratory measurement, more specifically, by presenting methods that can be used to obtain respiratory variability or perform respiratory rhythm measurements. Moreover, this thesis also aims to present a new implementation of a time-frequency signal processing technique, to improve its computational efficiency when applied to the respiratory signals. In this document a first approach to video-based methods for respiratory signal measurement is performed, to assert the feasibility of using a consumer-grade camera, not only to measure the mean respiratory rate or frequency, but to assert if this hardware could be used to acquire the raw respiratory signal and the respiratory rhythm as well. In this regard a new video-based method was introduced that measures the respiratory signal of a subject at a distance, with the aid of a custom pattern placed on the thorax of the subject. Given the results from the first video-based method, a more broad approach was taken by comparing three different types of video hardware, with the aim to characterise if they could be used for respiratory signal acquisition and respiratory variability measurements. The comparative analysis was performed in terms of instantaneous frequency, as it allowed to characterise the methods in terms of respiratory variability and to compare them in the same terms with the reference method. Subsequently, and due to the previous obtained results, a new method was proposed using a stereo depth camera with the aim to tackle the limitations of the previous study. The proposed method uses an hybrid architecture were the synchronized infrared frame and depth point-cloud from the same camera are acquired. The infrared frame is used to detect the movements of the subject inside the scene, and to recompute on demand a region of interest to obtain the respiratory signal from the depth point-cloud. Furthermore, in this study an opportunistic approach is taken in order to process all the obtained data, as it is also the aim of this study to verify if using a more realistic approach to respiratory signal analysis in real-life conditions, would influence the respiratory rhythm measurement. Even though the depth camera method proved reliable in terms of respiratory rhythm measurement, the opportunistic approach relied on visual inspection of the obtained respiratory signal to properly define each piece. For this reason, a quality indicator had to be proposed that could objectively identify whenever a respiratory signal contained errors. Furthermore, from the idea to characterise the movements of a subject, and by changing the measuring point from a frontal to a lateral perspective to avoid most of the occlusions, a new method based on obtaining the movement of the thoraco-abdominal region using dense optical flow was proposed. This method makes us of the phase of the optical flow to obtain the respiratory signal of the subject, while using the modulus to compute a quality index. Finally, regarding the different signal processing methods used in this thesis to obtain the instantaneous frequency, there were none that could perform in real-time, making the analysis of the respiratory variability not possible in real-life systems where the signals have to be processed in a sample by sample basis. For this reason, as a final chapter a new implementation of the synchrosqueezing transform for time-frequency analysis in real-time is proposed, with the aim to provide a new tool for non-contact methods to obtain the variability of the respiratory signal in real-time.A causa de la creixent popularitat en la mesura de senyals fisiològics amb mètodes de vídeo, i tenint en compte els avenços tecnològics d'aquests dispositius, aquesta tesi proposa una sèrie de nous mètodes per tal d'obtenir la respiració a distància mitjançant l'anàlisi de vídeo. Aquesta tesi té com a objectiu millorar l'estat de l'art referent a la mesura de senyal respiratòria mitjançant els mètodes que en ella es descriuen, així com presentar mètodes que puguin ser usats per obtenir la variabilitat o el ritme respiratori. A més, aquesta tesi té com a objectiu presentar una nova implementació d'un mètode de processat de senyal temps-freqüencial, per tal de millorar-ne l'eficiència computacional quant s’aplica a senyals respiratoris. En aquest document, es realitza una primera aproximació a la mesura de senyal respiratòria mitjançant mètodes de vídeo per tal de verificar si és factible utilitzar una càmera de consum, no només per mesurar el senyal respiratori, sinó verificar si aquest tipus de hardware també pot ser emprat per obtenir el ritme respiratori. En aquest sentit, es presenta en aquest document un nou mètode d'adquisició de senyal respiratòria a distància basat en vídeo, el qual fa ús d'un patró ubicat al tòrax del subjecte per tal d'obtenir-ne la respiració. Un cop obtinguts els resultats del primers resultats, s'han analitzat tres tipus diferents de càmeres, amb la finalitat de caracteritzar-ne la viabilitat d'obtenir el senyal respiratori i la seva variabilitat. L'estudi comparatiu s'ha realitzat en termes de freqüència instantània, donat que permet caracteritzar els mètodes en termes de variabilitat respiratòria i comparar-los, en les mateixes condicions, amb el mètode de referencia. A continuació, s'ha presentat un nou mètode basat en una càmera de profunditat estèreo amb la finalitat de millorar i corregir les limitacions anteriors. El nou mètode proposat es basa en una arquitectura hibrida la qual utilitza els canals de vídeo infraroig i de profunditat de forma sincronitzada. El canal infraroig s'utilitza per detectar els moviments del subjecte dins l'escena i calcular, sota demanda, una regió d'interès que s'utilitza posteriorment en el canal de profunditat per extreure el senyal respiratori. A més a més, en aquest estudi s'ha utilitzat una aproximació oportunista en el processat del senyal respiratori, donat que també és un dels objectius d'aquest estudi, verificar si el fet d'utilitzar una aproximació més realista en l'adquisició de senyal, pot influir en la mesura del ritme respiratori. Tot i que el mètode anterior es mostra fiable en termes de mesura del ritme respiratori, la selecció oportunista del senyal necessita d’inspecció visual per tal de definir correctament cada fragment. Per aquest motiu, era necessari definir un índex de qualitat el qual permetés identificar de forma objectiva cada tram de senyal, així com detectar si el senyal conté errors. Partint de la idea de caracteritzar el moviment del subjecte de l'estudi anterior, i modificant el punt de mesura frontal cap a un de lateral per tal d'evitar oclusions, es proposa un nou mètode basat en l'obtenció del moviment toràcic-abdominal a partir del flux òptic del senyal de vídeo. Aquest mètode recupera el senyal respiratori del subjecte a partir de la fase del flux òptic, tot calculant un índex de qualitat a partir del mòdul. Finalment, i tenint en compte els diferents mètodes de processat utilitzats en aquesta tesi per tal de obtenir la freqüència instantània, es pot apreciar que cap d'ells és capaç de funcionar en temps real, fent inviable l'anàlisi de la variabilitat respiratòria en sistemes reals amb processat mostra a mostra. Per aquest motiu, en el capítol final d'aquesta tesi, s'ha proposat una nova implementació de la transformació "synchrosqueezing" per tal de realitzar l’anàlisi temporal-freqüencial en temps real, i proveir d'una nova eina per tal d'obtenir la variabilitat respiratòria en temps real, amb mètodes sense contacte

Development of a Novel Dataset and Tools for Non-Invasive Fetal Electrocardiography Research

This PhD thesis presents the development of a novel open multi-modal dataset for advanced studies on fetal cardiological assessment, along with a set of signal processing tools for its exploitation. The Non-Invasive Fetal Electrocardiography (ECG) Analysis (NInFEA) dataset features multi-channel electrophysiological recordings characterized by high sampling frequency and digital resolution, maternal respiration signal, synchronized fetal trans-abdominal pulsed-wave Doppler (PWD) recordings and clinical annotations provided by expert clinicians at the time of the signal collection. To the best of our knowledge, there are no similar dataset available. The signal processing tools targeted both the PWD and the non-invasive fetal ECG, exploiting the recorded dataset. About the former, the study focuses on the processing aimed at the preparation of the signal for the automatic measurement of relevant morphological features, already adopted in the clinical practice for cardiac assessment. To this aim, a relevant step is the automatic identification of the complete and measurable cardiac cycles in the PWD videos: a rigorous methodology was deployed for the analysis of the different processing steps involved in the automatic delineation of the PWD envelope, then implementing different approaches for the supervised classification of the cardiac cycles, discriminating between complete and measurable vs. malformed or incomplete ones. Finally, preliminary measurement algorithms were also developed in order to extract clinically relevant parameters from the PWD. About the fetal ECG, this thesis concentrated on the systematic analysis of the adaptive filters performance for non-invasive fetal ECG extraction processing, identified as the reference tool throughout the thesis. Then, two studies are reported: one on the wavelet-based denoising of the extracted fetal ECG and another one on the fetal ECG quality assessment from the analysis of the raw abdominal recordings. Overall, the thesis represents an important milestone in the field, by promoting the open-data approach and introducing automated analysis tools that could be easily integrated in future medical devices