A Parallel Genetic Algorithm for Optimizing Multicellular Models Applied to Biofilm Wrinkling

Multiscale computational models integrating sub-cellular, cellular, and multicellular levels can be powerful tools that help researchers replicate, understand, and predict multicellular biological phenomena. To leverage their potential, these models need correct parameter values, which specify cellular physiology and affect multicellular outcomes. This work presents a robust parameter optimization method, utilizing a parallel and distributed genetic-algorithm software package. A genetic algorithm was chosen because of its superiority in fitting complex functions for which mathematical techniques are less suited. Searching for optimal parameters proceeds by comparing the multicellular behavior of a simulated system to that of a real biological system on the basis of features extracted from each which capture high-level, emergent multicellular outcomes. The goal is to find the set of parameters which minimizes discrepancy between the two sets of features. The method is first validated by demonstrating its effectiveness on synthetic data, then it is applied to calibrating a simple mechanical model of biofilm wrinkling, a common type of morphology observed in biofilms. Spatiotemporal convergence of cellular movement derived from experimental observations of different strains of Bacillus subtilis colonies is used as the basis of comparison

Proceedings of the XIII Global Optimization Workshop: GOW'16

[Excerpt] Preface: Past Global Optimization Workshop shave been held in Sopron (1985 and 1990), Szeged (WGO, 1995), Florence (GO’99, 1999), Hanmer Springs (Let’s GO, 2001), Santorini (Frontiers in GO, 2003), San José (Go’05, 2005), Mykonos (AGO’07, 2007), Skukuza (SAGO’08, 2008), Toulouse (TOGO’10, 2010), Natal (NAGO’12, 2012) and Málaga (MAGO’14, 2014) with the aim of stimulating discussion between senior and junior researchers on the topic of Global Optimization. In 2016, the XIII Global Optimization Workshop (GOW’16) takes place in Braga and is organized by three researchers from the University of Minho. Two of them belong to the Systems Engineering and Operational Research Group from the Algoritmi Research Centre and the other to the Statistics, Applied Probability and Operational Research Group from the Centre of Mathematics. The event received more than 50 submissions from 15 countries from Europe, South America and North America. We want to express our gratitude to the invited speaker Panos Pardalos for accepting the invitation and sharing his expertise, helping us to meet the workshop objectives. GOW’16 would not have been possible without the valuable contribution from the authors and the International Scientific Committee members. We thank you all. This proceedings book intends to present an overview of the topics that will be addressed in the workshop with the goal of contributing to interesting and fruitful discussions between the authors and participants. After the event, high quality papers can be submitted to a special issue of the Journal of Global Optimization dedicated to the workshop. [...

Faster Evolutionary Multi-Objective Optimization via GALE, the Geometric Active Learner

Goal optimization has long been a topic of great interest in computer science. The literature contains many thousands of papers that discuss methods for the search of optimal solutions to complex problems. In the case of multi-objective optimization, such a search yields iteratively improved approximations to the Pareto frontier, i.e. the set of best solutions contained along a trade-off curve of competing objectives.;To approximate the Pareto frontier, one method that is ubiquitous throughout the field of optimization is stochastic search. Stochastic search engines explore solution spaces by randomly mutating candidate guesses to generate new solutions. This mutation policy is employed by the most commonly used tools (e.g. NSGA-II, SPEA2, etc.), with the goal of a) avoiding local optima, and b) expand upon diversity in the set of generated approximations. Such blind mutation policies explore many sub-optimal solutions that are discarded when better solutions are found. Hence, this approach has two problems. Firstly, stochastic search can be unnecessarily computationally expensive due to evaluating an overwhelming number of candidates. Secondly, the generated approximations to the Pareto frontier are usually very large, and can be difficult to understand.;To solve these two problems, a more-directed, less-stochastic approach than standard search tools is necessary. This thesis presents GALE (Geometric Active Learning). GALE is an active learner that finds approximations to the Pareto frontier by spectrally clustering candidates using a near-linear time recursive descent algorithm that iteratively divides candidates into halves (called leaves at the bottom level). Active learning in GALE selects a minimally most-informative subset of candidates by only evaluating the two-most different candidates during each descending split; hence, GALE only requires at most, 2Log2(N) evaluations per generation. The candidates of each leaf are thereafter non-stochastically mutated in the most promising directions along each piece. Those leafs are piece-wise approximations to the Pareto frontier.;The experiments of this thesis lead to the following conclusion: a near-linear time recursive binary division of the decision space of candidates in a multi-objective optimization algorithm can find useful directions to mutate instances and find quality solutions much faster than traditional randomization approaches. Specifically, in comparative studies with standard methods (NSGA-II and SPEA2) applied to a variety of models, GALE required orders of magnitude fewer evaluations to find solutions. As a result, GALE can perform dramatically faster than the other methods, especially for realistic models

International Conference on Continuous Optimization (ICCOPT) 2019 Conference Book

The Sixth International Conference on Continuous Optimization took place on the campus of the Technical University of Berlin, August 3-8, 2019. The ICCOPT is a flagship conference of the Mathematical Optimization Society (MOS), organized every three years. ICCOPT 2019 was hosted by the Weierstrass Institute for Applied Analysis and Stochastics (WIAS) Berlin. It included a Summer School and a Conference with a series of plenary and semi-plenary talks, organized and contributed sessions, and poster sessions. This book comprises the full conference program. It contains, in particular, the scientific program in survey style as well as with all details, and information on the social program, the venue, special meetings, and more

逐次探索による多目的最適化および宇宙往還機の複合領域概念設計への応用

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 土屋 武司, 東京大学教授 鈴木 真二, 東京大学教授 鈴木 宏二郎, 東京大学准教授 今村 太郎, 防衛大学校准教授 横山 信宏University of Tokyo(東京大学

Evolutionary approaches for portfolio optimization

Portfolio optimization involves the optimal assignment of limited capital to different available financial assets to achieve a reasonable trade-off between profit and risk objectives. Markowitz’s mean variance (MV) model is widely regarded as the foundation of modern portfolio theory and provides a quantitative framework for portfolio optimization problems. In real market, investors commonly face real-world trading restrictions and it requires that the constructed portfolios have to meet trading constraints. When additional constraints are added to the basic MV model, the problem thus becomes more complex and the exact optimization approaches run into difficulties to deliver solutions within reasonable time for large problem size. By introducing the cardinality constraint alone already transformed the classic quadratic optimization model into a mixed-integer quadratic programming problem which is an NP-hard problem. Evolutionary algorithms, a class of metaheuristics, are one of the known alternatives for optimization problems that are too complex to be solved using deterministic techniques. This thesis focuses on single-period portfolio optimization problems with practical trading constraints and two different risk measures. Four hybrid evolutionary algorithms are presented to efficiently solve these problems with gradually more complex real world constraints. In the first part of the thesis, the mean variance portfolio model is investigated by taking into account real-world constraints. A hybrid evolutionary algorithm (PBILDE) for portfolio optimization with cardinality and quantity constraints is presented. The proposed PBILDE is able to achieve a strong synergetic effect through hybridization of PBIL and DE. A partially guided mutation and an elitist update strategy are proposed in order to promote the efficient convergence of PBILDE. Its effectiveness is evaluated and compared with other existing algorithms over a number of datasets. A multi-objective scatter search with archive (MOSSwA) algorithm for portfolio optimization with cardinality, quantity and pre-assignment constraints is then presented. New subset generations and solution combination methods are proposed to generate efficient and diverse portfolios. A learning-guided multi-objective evolutionary (MODEwAwL) algorithm for the portfolio optimization problems with cardinality, quantity, pre-assignment and round lot constraints is presented. A learning mechanism is introduced in order to extract important features from the set of elite solutions. Problem-specific selection heuristics are introduced in order to identify high-quality solutions with a reduced computational cost. An efficient and effective candidate generation scheme utilizing a learning mechanism, problem specific heuristics and effective direction-based search methods is proposed to guide the search towards the promising regions of the search space. In the second part of the thesis, an alternative risk measure, VaR, is considered. A non-parametric mean-VaR model with six practical trading constraints is investigated. A multi-objective evolutionary algorithm with guided learning (MODE-GL) is presented for the mean-VaR model. Two different variants of DE mutation schemes in the solution generation scheme are proposed in order to promote the exploration of the search towards the least crowded region of the solution space. Experimental results using historical daily financial market data from S &P 100 and S & P 500 indices are presented. When the cardinality constraints are considered, incorporating a learning mechanism significantly promotes the efficient convergence of the search

Humanoid Robots

For many years, the human being has been trying, in all ways, to recreate the complex mechanisms that form the human body. Such task is extremely complicated and the results are not totally satisfactory. However, with increasing technological advances based on theoretical and experimental researches, man gets, in a way, to copy or to imitate some systems of the human body. These researches not only intended to create humanoid robots, great part of them constituting autonomous systems, but also, in some way, to offer a higher knowledge of the systems that form the human body, objectifying possible applications in the technology of rehabilitation of human beings, gathering in a whole studies related not only to Robotics, but also to Biomechanics, Biomimmetics, Cybernetics, among other areas. This book presents a series of researches inspired by this ideal, carried through by various researchers worldwide, looking for to analyze and to discuss diverse subjects related to humanoid robots. The presented contributions explore aspects about robotic hands, learning, language, vision and locomotion

Evolutionary approaches for portfolio optimization

Portfolio optimization involves the optimal assignment of limited capital to different available financial assets to achieve a reasonable trade-off between profit and risk objectives. Markowitz’s mean variance (MV) model is widely regarded as the foundation of modern portfolio theory and provides a quantitative framework for portfolio optimization problems. In real market, investors commonly face real-world trading restrictions and it requires that the constructed portfolios have to meet trading constraints. When additional constraints are added to the basic MV model, the problem thus becomes more complex and the exact optimization approaches run into difficulties to deliver solutions within reasonable time for large problem size. By introducing the cardinality constraint alone already transformed the classic quadratic optimization model into a mixed-integer quadratic programming problem which is an NP-hard problem. Evolutionary algorithms, a class of metaheuristics, are one of the known alternatives for optimization problems that are too complex to be solved using deterministic techniques. This thesis focuses on single-period portfolio optimization problems with practical trading constraints and two different risk measures. Four hybrid evolutionary algorithms are presented to efficiently solve these problems with gradually more complex real world constraints. In the first part of the thesis, the mean variance portfolio model is investigated by taking into account real-world constraints. A hybrid evolutionary algorithm (PBILDE) for portfolio optimization with cardinality and quantity constraints is presented. The proposed PBILDE is able to achieve a strong synergetic effect through hybridization of PBIL and DE. A partially guided mutation and an elitist update strategy are proposed in order to promote the efficient convergence of PBILDE. Its effectiveness is evaluated and compared with other existing algorithms over a number of datasets. A multi-objective scatter search with archive (MOSSwA) algorithm for portfolio optimization with cardinality, quantity and pre-assignment constraints is then presented. New subset generations and solution combination methods are proposed to generate efficient and diverse portfolios. A learning-guided multi-objective evolutionary (MODEwAwL) algorithm for the portfolio optimization problems with cardinality, quantity, pre-assignment and round lot constraints is presented. A learning mechanism is introduced in order to extract important features from the set of elite solutions. Problem-specific selection heuristics are introduced in order to identify high-quality solutions with a reduced computational cost. An efficient and effective candidate generation scheme utilizing a learning mechanism, problem specific heuristics and effective direction-based search methods is proposed to guide the search towards the promising regions of the search space. In the second part of the thesis, an alternative risk measure, VaR, is considered. A non-parametric mean-VaR model with six practical trading constraints is investigated. A multi-objective evolutionary algorithm with guided learning (MODE-GL) is presented for the mean-VaR model. Two different variants of DE mutation schemes in the solution generation scheme are proposed in order to promote the exploration of the search towards the least crowded region of the solution space. Experimental results using historical daily financial market data from S &P 100 and S & P 500 indices are presented. When the cardinality constraints are considered, incorporating a learning mechanism significantly promotes the efficient convergence of the search

Particle Swarm Optimization

Particle swarm optimization (PSO) is a population based stochastic optimization technique influenced by the social behavior of bird flocking or fish schooling.PSO shares many similarities with evolutionary computation techniques such as Genetic Algorithms (GA). The system is initialized with a population of random solutions and searches for optima by updating generations. However, unlike GA, PSO has no evolution operators such as crossover and mutation. In PSO, the potential solutions, called particles, fly through the problem space by following the current optimum particles. This book represents the contributions of the top researchers in this field and will serve as a valuable tool for professionals in this interdisciplinary field

An Approach Based on Particle Swarm Optimization for Inspection of Spacecraft Hulls by a Swarm of Miniaturized Robots

The remoteness and hazards that are inherent to the operating environments of space infrastructures promote their need for automated robotic inspection. In particular, micrometeoroid and orbital debris impact and structural fatigue are common sources of damage to spacecraft hulls. Vibration sensing has been used to detect structural damage in spacecraft hulls as well as in structural health monitoring practices in industry by deploying static sensors. In this paper, we propose using a swarm of miniaturized vibration-sensing mobile robots realizing a network of mobile sensors. We present a distributed inspection algorithm based on the bio-inspired particle swarm optimization and evolutionary algorithm niching techniques to deliver the task of enumeration and localization of an a priori unknown number of vibration sources on a simplified 2.5D spacecraft surface. Our algorithm is deployed on a swarm of simulated cm-scale wheeled robots. These are guided in their inspection task by sensing vibrations arising from failure points on the surface which are detected by on-board accelerometers. We study three performance metrics: (1) proximity of the localized sources to the ground truth locations, (2) time to localize each source, and (3) time to finish the inspection task given a 75% inspection coverage threshold. We find that our swarm is able to successfully localize the present so