15,851 research outputs found
Nonlinear analyses of composite aerospace structures in sonic fatigue
This report summarizes the semiannual research progress, accomplishments, and future plans performed under the NASA Langley Research Center Grant No. NAG-1-1358. The primary research effort of this project is the development of analytical methods for the prediction of nonlinear random response of composite aerospace structures subjected to combined acoustic and thermal loads. The progress, accomplishments, and future plates on four sonic fatigue research topics are described. The sonic fatigue design and passive control of random response of shape memory alloy hybrid composites presented in section 4, which is suited especially for HSCT, is a new initiative
Multi-step self-guided pathways for shape-changing metamaterials
Multi-step pathways, constituted of a sequence of reconfigurations, are
central to a wide variety of natural and man-made systems. Such pathways
autonomously execute in self-guided processes such as protein folding and
self-assembly, but require external control in macroscopic mechanical systems,
provided by, e.g., actuators in robotics or manual folding in origami. Here we
introduce shape-changing mechanical metamaterials, that exhibit self-guided
multi-step pathways in response to global uniform compression. Their design
combines strongly nonlinear mechanical elements with a multimodal architecture
that allows for a sequence of topological reconfigurations, i.e., modifications
of the topology caused by the formation of internal self-contacts. We realized
such metamaterials by digital manufacturing, and show that the pathway and
final configuration can be controlled by rational design of the nonlinear
mechanical elements. We furthermore demonstrate that self-contacts suppress
pathway errors. Finally, we demonstrate how hierarchical architectures allow to
extend the number of distinct reconfiguration steps. Our work establishes
general principles for designing mechanical pathways, opening new avenues for
self-folding media, pluripotent materials, and pliable devices in, e.g.,
stretchable electronics and soft robotics.Comment: 16 pages, 3 main figures, 10 extended data figures. See
https://youtu.be/8m1QfkMFL0I for an explanatory vide
Subtle pH differences trigger single residue motions for moderating conformations of calmodulin
This study reveals the essence of ligand recognition mechanisms by which calmodulin (CaM) controls a variety of Ca2+ signaling processes. We study eight forms of calcium-loaded CaM each with distinct conformational states. Reducing the structure to two degrees of freedom conveniently describes main features of the conformational changes of CaM via simultaneous twist-bend motions of the two lobes. We utilize perturbation-response scanning (PRS) technique, coupled with molecular dynamics simulations. PRS is based on linear response theory, comprising sequential application of directed forces on selected residues followed by recording the resulting protein coordinates. We analyze directional preferences of the perturbations and resulting conformational changes. Manipulation of a single residue reproduces the structural change more effectively than that of single/pairs/triplets of collective modes of motion. Our findings also give information on how the flexible linker acts as a transducer of binding information to distant parts of the protein. Furthermore, by perturbing residue E31 located in one of the EF hand motifs in a specific direction, it is possible to induce conformational change relevant to five target structures. Independently, using four different pKa calculation strategies, we find this particular residue to be the charged residue (out of a total of 52), whose ionization state is most sensitive to subtle pH variations in the physiological range. It is plausible that at relatively low pH, CaM structure is less flexible. By gaining charged states at specific sites at a pH value around 7, such as E31 found in the present study, local conformational changes in the protein will lead to shifts in the energy landscape, paving the way to other conformational states. These findings are in accordance with Fluorescence Resonance Energy Transfer (FRET) measured shifts in conformational distributions towards more compact forms with decreased pH. They also corroborate mutational studies and proteolysis results which point to the significant role of E31 in CaM dynamics
Beyond backscattering: Optical neuroimaging by BRAD
Optical coherence tomography (OCT) is a powerful technology for rapid
volumetric imaging in biomedicine. The bright field imaging approach of
conventional OCT systems is based on the detection of directly backscattered
light, thereby waiving the wealth of information contained in the angular
scattering distribution. Here we demonstrate that the unique features of
few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging
for OCT. As backscattered light is picked up by the different modes of a FMF
depending upon the angular scattering pattern, we obtain access to the
directional scattering signatures of different tissues by decoupling
illumination and detection paths. We exploit the distinct modal propagation
properties of the FMF in concert with the long coherence lengths provided by
modern wavelength-swept lasers to achieve multiplexing of the different modal
responses into a combined OCT tomogram. We demonstrate BRAD sensing for
distinguishing differently sized microparticles and showcase the performance of
BRAD-OCT imaging with enhanced contrast for ex vivo tumorous tissue in
glioblastoma and neuritic plaques in Alzheimer's disease
Optimal control of the heave motion of marine cable subsea-unit systems
One of the key problems associated with subsea operations involving tethered subsea units is the motions of support vessels on the ocean surface which can be transmitted to the subsea unit through the cable and increase the tension. In this paper, a theoretical approach for heave compensation is developed. After proper modelling of each element of the system, which includes the cable/subsea-unit, the onboard winch, control theory is applied to design an optimal control law. Numerical simulations are carried out, and it is found that the proposed active control scheme appears to be a promising solution to the problem of heave compensation
Space Construction Experiment Definition Study (SCEDS), part 2. Volume 1: Executive summary
A baseline Space Construction Experiment (SCE) concept is defined. Five characteristics were incorporated: (1) large space system (LSS) element test, (2) shuttle mission payload of opportunity, (3) attachment to Orbiter with jettison capability, (4) Orbiter flight control capabilities, and (5) LSS construction and assembly operations
Identifying Position-Dependent Mechanical Systems: A Modal Approach Applied to a Flexible Wafer Stage
Increasingly stringent performance requirements for motion control
necessitate the use of increasingly detailed models of the system behavior.
Motion systems inherently move, therefore, spatio-temporal models of the
flexible dynamics are essential. In this paper, a two-step approach for the
identification of the spatio-temporal behavior of mechanical systems is
developed and applied to a lightweight prototype industrial wafer stage. The
proposed approach exploits a modal modeling framework and combines recently
developed powerful linear time invariant (LTI) identification tools with a
spline-based mode-shape interpolation approach to estimate the spatial system
behavior. The experimental results for the wafer stage application confirm the
suitability of the proposed approach for the identification of complex
position-dependent mechanical systems, and its potential for motion control
performance improvements
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