4,923 research outputs found

    Converging organoids and extracellular matrix::New insights into liver cancer biology

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    An Exploration of the Suitability of Pharmacy Education in Saudi Arabia to Prepare Graduates to Meet Healthcare Needs: a Mixed-Methods Study

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    The key role of pharmacists within the health system, particularly in optimising safe, responsible and effective use of medicines, underpins the demand for a highly skilled and competent workforce. Therefore, developing the capacity of pharmacists to attain and maintain essential competencies relevant to the population’s health needs is required to ensure a high standard of patient care, thereby helping to improve patient and population health. In Saudi Arabia, little evidence exists regarding the assessment of national educational programmes’ structure and outcomes. Moreover, no national competency framework exists for pharmacists in any sector or stage of practice. In the absence of such core quality elements to inform pharmacy education assessment and development, the extent to which pharmacy schools in Saudi Arabia prepare competent pharmacists to address societal needs from pharmacy services is unclear. Therefore, this study aimed to explore the extent to which pharmacy education can prepare competent pharmacists to address the healthcare needs for pharmacy practice in Saudi Arabia. An exploratory sequential mixed methods research design was used to address the aim of this study in three phases: individual interviews and focus groups were employed with a purposively selected sample of pharmacy policy makers, pharmacists and the public to explore societal healthcare needs and the roles required of pharmacists to meet those needs; a national online survey of pharmacists and an online nominal group consensus method of pharmacy experts were used to identify competencies considered essential to develop a profession-wide national foundation level competency framework; and a case study in which curriculum mapping of two purposively selected Doctor of Pharmacy (PharmD) curricula was used to assess the extent to which the current pharmacy programme in Saudi Arabia meets the identified competencies of the developed national competency framework. Based on qualitative and quantitative analyses of societal healthcare needs, pharmacists’ roles, core competencies and curricular contents within the local context of Saudi Arabia, findings showed that there is a mismatch between initial education and real practice needs and expectations. While the country’s current needs from pharmacists are to optimise health system capacity and increase access to primary care services and medicines expertise in community pharmacies, the study indicated local education is product-oriented with a focus of curricular content and experiential training opportunities in most schools on preparing future pharmacists for hospital pharmacy practice. The study also identified several gaps between current initial education programmes and the competencies required to practise the expected roles, suggesting that current initial education might not prepare the students sufficiently to provide the full range of quality pharmaceutical services as per the country’s pharmacy practice needs. The study provided a new understanding of graduates’ readiness to practise as per the country’s pharmacy practice needs, the quality of educational programmes and pharmacists' professional development opportunities in Saudi Arabia. Findings maybe used to inform the development of competency-based education and maximise graduates’ capacity to deliver and develop pharmaceutical services effectively to best meet societal healthcare needs in Saudi Arabia

    The relationship between the interactive behavior of industry–university–research subjects and the cooperative innovation performance: The mediating role of knowledge absorptive capacity

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    IntroductionIndustry–university–research cooperation innovation, which is often characterized by resource complementarity and the sharing technology, has become one of the most preferred innovation cooperation methods for enterprises. However, various problems still occur in the process of industry–university–research cooperations, such as poor innovation performance and difficulty in sustaining cooperation. Existing studies mostly focus on the macroscopic perspectives of geographic location, cooperation scale, concentration, and diversification of industry–university–research cooperation subjects, and fail to explore the microscopic behavioral mechanisms.MethodsTherefore, this paper establishes the interactive behavior of industry–university–research subjects and defines its concepts and dimensions in an attempt to provide a mechanism for improving the cooperative innovation performance of industry–university–research from the micro-behavioral perspective. On the basis of theoretical analysis, this paper develops a model of the relationship between cooperative trust, cooperative communication, and cooperative innovation performance for interactive behavior, while exploring the mediating role of knowledge absorptive capacity. The model was validated by stepwise regression using data from 325 questionnaires.ResultsThe paper found that cooperative trust and cooperative communication in the cooperative interactive behavior of industry–university–research positively contribute to the improvement of cooperative innovation performance. Knowledge absorptive capacity plays a partially mediating role between the interactive behaviors and cooperative innovation performance. More specifically, knowledge absorptive capacity partially mediates cooperative communication in cooperative innovation performance and completely mediates cooperative trust in cooperative innovation performance. The results are largely consistent with the results of the heterogeneity analysis of the sample.DiscussionThis paper not only explains why the cooperative innovation performance of industry–university–research is poor from the perspective of interactive behavior, but also enriches the research perspective of industry–university–research and provides theoretical support for enterprises to optimize the relationship between industry, university, and research institutes

    Geoarchaeological Investigations of Late Pleistocene Physical Environments and Impacts of Prehistoric Foragers on the Ecosystem in Northern Malawi and Austria

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    A growing body of research shows that not only did environmental changes play an important role in human evolution, but humans in turn have impacted ecosystems and landscape evolution since the Late Pleistocene. This thesis presents collaborative work on Late Pleistocene open-air sites in the Karonga District of northern Malawi, in which new aspects of forager behavior came to light through the reconstruction of physical environments. My work has helped recognize that late Middle Stone Age (MSA) activity and tool production occurred in locally more open riparian environments within evergreen gallery forest, surrounded by a regional vegetation dominated by miombo woodlands and savanna. Additionally, MSA hunter-gatherers exploited the confluence of river and wetland areas along the shores of Lake Malawi, which likely served as important corridors for the dispersal of biota. By comparing data from the archaeological investigations with lake core records, we were able to identify effects of anthropogenic burning on vegetation structures and sedimentation in the region as early as 80 thousand years ago. These findings not only proved it possible to uncover early impacts of human activity on the ecosystem, but also emphasize the importance of fire in the lives of early foragers. Publications contained within this dissertation: A. Wright, D.K., Thompson, J.C., Schilt, F.C., Cohen, A., Choi, J-H., Mercader, J., Nightingale, S., Miller, C.E., Mentzer, S.M., Walde, D., Welling, M., and Gomani-Chindebvu, E. “Approaches to Middle Stone Age landscape archaeology in tropical Africa”. Special issue Geoarchaeology of the Tropics of Journal of Archaeological Science 77:64-77. http://dx.doi.org/10.1016/j.jas.2016.01.014 B. Schilt, F.C., Verpoorte, A., Antl, W. “Micromorphology of an Upper Paleolithic cultural layer at Grub-Kranawetberg, Austria”. Journal of Archaeological Science: Reports 14:152-162. http://dx.doi.org/10.1016/j.jasrep.2017.05.041 C. Nightingale, S., Schilt, F.C., Thompson, J.C., Wright, D.K., Forman, S., Mercader, J., Moss, P., Clarke, S. Itambu, M., Gomani-Chindebvu, E., Welling, M. Late Middle Stone Age Behavior and Environments at Chaminade I (Karonga, Malawi). Journal of Paleolithic Archaeology 2-3:258-397. https://doi.org/10.1007/s41982-019-00035-3 D. Thompson, J.C.*, Wright, D.K.*, Ivory, S.J.*, Choi, J-H., Nightingale, S., Mackay, A., Schilt, F.C., Otárola-Castillo, E., Mercader, J., Forman, S.L., Pietsch, T., Cohen, A.S., Arrowsmith, J.R., Welling, M., Davis, J., Schiery, B., Kaliba, P., Malijani, O., Blome, M.W., O’Driscoll, C., Mentzer, S.M., Miller, C., Heo, S., Choi, J., Tembo, J., Mapemba, F., Simengwa, D., and Gomani-Chindebvu, E. “Early human impacts and ecosystem reorganization in southern-central Africa”. Science Advances 7(19): eabf9776. *equal contribution https://doi.org/10.1126/sciadv.abf9776 E. Schilt, F.C., Miller, C.M., Wright, D.K., Mentzer, S.M., Mercader, J., Moss, Choi, J.-H., Siljedal, G., Clarke, S., Mwambwiga, A., Thomas, K., Barbieri, A., Kaliba, P., Gomani-Chindebvu, E., Thompson, J.C. “Hunter-gatherer environments at the Late Pleistocene sites of Bruce and Mwanganda´s Village, northern Malawi”. Quaternary Science Reviews 292: 107638. https://www.sciencedirect.com/science/article/pii/S0277379122002694 [untranslated

    Tradition and Innovation in Construction Project Management

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    This book is a reprint of the Special Issue 'Tradition and Innovation in Construction Project Management' that was published in the journal Buildings

    Pathophysiology of Spinal Cord Injury (SCI)

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    Spinal cord injury (SCI) leads to paralysis, sensory, and autonomic nervous system dysfunctions. However, the pathophysiology of SCI is complex, and not limited to the nervous system. Indeed, several other organs and tissue are also affected by the injury, directly or not, acutely or chronically, which induces numerous health complications. Although a lot of research has been performed to repair motor and sensory functions, SCI-induced health issues are less studied, although they represent a major concern among patients. There is a gap of knowledge in pre-clinical models studying these SCI-induced health complications that limits translational applications in humans. This reprint describes several aspects of the pathophysiology of spinal cord injuries. This includes, but is not limited to, the impact of SCI on cardiovascular and respiratory functions, bladder and bowel function, autonomic dysreflexia, liver pathology, metabolic syndrome, bones and muscles loss, and cognitive functions

    Trustworthy Federated Learning: A Survey

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    Federated Learning (FL) has emerged as a significant advancement in the field of Artificial Intelligence (AI), enabling collaborative model training across distributed devices while maintaining data privacy. As the importance of FL increases, addressing trustworthiness issues in its various aspects becomes crucial. In this survey, we provide an extensive overview of the current state of Trustworthy FL, exploring existing solutions and well-defined pillars relevant to Trustworthy . Despite the growth in literature on trustworthy centralized Machine Learning (ML)/Deep Learning (DL), further efforts are necessary to identify trustworthiness pillars and evaluation metrics specific to FL models, as well as to develop solutions for computing trustworthiness levels. We propose a taxonomy that encompasses three main pillars: Interpretability, Fairness, and Security & Privacy. Each pillar represents a dimension of trust, further broken down into different notions. Our survey covers trustworthiness challenges at every level in FL settings. We present a comprehensive architecture of Trustworthy FL, addressing the fundamental principles underlying the concept, and offer an in-depth analysis of trust assessment mechanisms. In conclusion, we identify key research challenges related to every aspect of Trustworthy FL and suggest future research directions. This comprehensive survey serves as a valuable resource for researchers and practitioners working on the development and implementation of Trustworthy FL systems, contributing to a more secure and reliable AI landscape.Comment: 45 Pages, 8 Figures, 9 Table
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