Contributions of phase resetting and interlimb coordination to the adaptive control of hindlimb obstacle avoidance during locomotion in rats: a simulation study.

Obstacle avoidance during locomotion is essential for safe, smooth locomotion. Physiological studies regarding muscle synergy have shown that the combination of a small number of basic patterns produces the large part of muscle activities during locomotion and the addition of another pattern explains muscle activities for obstacle avoidance. Furthermore, central pattern generators in the spinal cord are thought to manage the timing to produce such basic patterns. In the present study, we investigated sensory-motor coordination for obstacle avoidance by the hindlimbs of the rat using a neuromusculoskeletal model. We constructed the musculoskeletal part of the model based on empirical anatomical data of the rat and the nervous system model based on the aforementioned physiological findings of central pattern generators and muscle synergy. To verify the dynamic simulation by the constructed model, we compared the simulation results with kinematic and electromyographic data measured during actual locomotion in rats. In addition, we incorporated sensory regulation models based on physiological evidence of phase resetting and interlimb coordination and examined their functional roles in stepping over an obstacle during locomotion. Our results show that the phase regulation based on interlimb coordination contributes to stepping over a higher obstacle and that based on phase resetting contributes to quick recovery after stepping over the obstacle. These results suggest the importance of sensory regulation in generating successful obstacle avoidance during locomotion

From spinal central pattern generators to cortical network: integrated BCI for walking rehabilitation

Success in locomotor rehabilitation programs can be improved with the use of brain-computer interfaces (BCIs). Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information regarding central pattern generation functioning. In addition, there is also a tight coordination between the upper and lower limbs, which can also be useful in controlling locomotion. The current paper critically investigates different approaches that are applicable to this field: the use of electroencephalogram (EEG), upper limb electromyogram (EMG), or a hybrid of the two neurophysiological signals to control assistive exoskeletons used in locomotion based on programmable central pattern generators (PCPGs) or dynamic recurrent neural networks (DRNNs). Plantar surface tactile stimulation devices combined with virtual reality may provide the sensation of walking while in a supine position for use of training brain signals generated during locomotion. These methods may exploit mechanisms of brain plasticity and assist in the neurorehabilitation of gait in a variety of clinical conditions, including stroke, spinal trauma, multiple sclerosis, and cerebral palsy

The Benefit of Combining Neuronal Feedback and Feed-Forward Control for Robustness in Step Down Perturbations of Simulated Human Walking Depends on the Muscle Function

It is often assumed that the spinal control of human locomotion combines feed-forward central pattern generation with sensory feedback via muscle reflexes. However, the actual contribution of each component to the generation and stabilization of gait is not well understood, as direct experimental evidence for either is difficult to obtain. We here investigate the relative contribution of the two components to gait stability in a simulation model of human walking. Specifically, we hypothesize that a simple linear combination of feedback and feed-forward control at the level of the spinal cord improves the reaction to unexpected step down perturbations. In previous work, we found preliminary evidence supporting this hypothesis when studying a very reduced model of rebounding behaviors. In the present work, we investigate if the evidence extends to a more realistic model of human walking. We revisit a model that has previously been published and relies on spinal feedback control to generate walking. We extend the control of this model with a feed-forward muscle activation pattern. The feed-forward pattern is recorded from the unperturbed feedback control output. We find that the improvement in the robustness of the walking model with respect to step down perturbations depends on the ratio between the two strategies and on the muscle to which they are applied. The results suggest that combining feed-forward and feedback control is not guaranteed to improve locomotion, as the beneficial effects are dependent on the muscle and its function during walking

A Bio-inspired architecture for adaptive quadruped locomotion over irregular terrain

Tese de doutoramento Programa Doutoral em Engenharia Electrónica e de ComputadoresThis thesis presents a tentative advancement on walking control of small quadruped and humanoid position controlled robots, addressing the problem of walk generation by combining dynamical systems approach to motor control, insights from neuroethology research on vertebrate motor control and computational neuroscience. Legged locomotion is a complex dynamical process, despite the seemingly easy and natural behavior of the constantly present proficiency of legged animals. Research on locomotion and motor control in vertebrate animals from the last decades has brought to the attention of roboticists, the potential of the nature’s solutions to robot applications. Recent knowledge on the organization of complex motor generation and on mechanics and dynamics of locomotion has been successfully exploited to pursue agile robot locomotion. The work presented on this manuscript is part of an effort on the pursuit in devising a general, model free solution, for the generation of robust and adaptable walking behaviors. It strives to devise a practical solution applicable to real robots, such as the Sony’s quadruped AIBO and Robotis’ DARwIn- OP humanoid. The discussed solutions are inspired on the functional description of the vertebrate neural systems, especially on the concept of Central Pattern Generators (CPGs), their structure and organization, components and sensorimotor interactions. They use a dynamical systems approach for the implementation of the controller, especially on the use of nonlinear oscillators and exploitation of their properties. The main topics of this thesis are divided into three parts. The first part concerns quadruped locomotion, extending a previous CPG solution using nonlinear oscillators, and discussing an organization on three hierarchical levels of abstraction, sharing the purpose and knowledge of other works. It proposes a CPG solution which generates the walking motion for the whole-leg, which is then organized in a network for the production of quadrupedal gaits. The devised solution is able to produce goal-oriented locomotion and navigation as directed through highlevel commands from local planning methods. In this part, active balance on a standing quadruped is also addressed, proposing a method based on dynamical systems approach, exploring the integration of parallel postural mechanisms from several sensory modalities. The solutions are all successfully tested on the quadruped AIBO robot. In the second part, is addressed bipedal walking for humanoid robots. A CPG solution for biped walking based on the concept of motion primitives is proposed, loosely based on the idea of synergistic organization of vertebrate motor control. A set of motion primitives is shown to produce the basis of simple biped walking, and generalizable to goal-oriented walking. Using the proposed CPG, the inclusion of feedback mechanisms is investigated, for modulation and adaptation of walking, through phase transition control according to foot load information. The proposed solution is validated on the humanoid DARwIn-OP, and its application is evaluated within a whole-body control framework. The third part sidesteps a little from the other two topics. It discusses the CPG as having an alternative role to direct motor generation in locomotion, serving instead as a processor of sensory information for a feedback based motor generation. In this work a reflex based walking controller is devised for the compliant quadruped Oncilla robot, to serve as purely feedback based walking generation. The capabilities of the reflex network are shown in simulations, followed by a brief discussion on its limitations, and how they could be improved by the inclusion of a CPG.Esta tese apresenta uma tentativa de avanço no controlo de locomoção para pequenos robôs quadrúpedes e bipedes controlados por posição, endereçando o problema de geração motora através da combinação da abordagem de sistemas dinâmicos para o controlo motor, e perspectivas de investigação neuroetologia no controlo motor vertebrado e neurociência computacional. Andar é um processo dinâmico e complexo, apesar de parecer um comportamento fácil e natural devido à presença constante de animais proficientes em locomoção terrestre. Investigação na área da locomoção e controlo motor em animais vertebrados nas últimas decadas, trouxe à atenção dos roboticistas o potencial das soluções encontradas pela natureza aplicadas a aplicações robóticas. Conhecimento recente relativo à geração de comportamentos motores complexos e da mecânica da locomoção tem sido explorada com sucesso na procura de locomoção ágil na robótica. O trabalho apresentado neste documento é parte de um esforço no desenho de uma solução geral, e independente de modelos, para a geração robusta e adaptável de comportamentos locomotores. O foco é desenhar uma solução prática, aplicável a robôs reais, tal como o quadrúpede Sony AIBO e o humanóide DARwIn-OP. As soluções discutidas são inspiradas na descrição funcional do sistema nervoso vertebrado, especialmente no conceito de Central Pattern Generators (CPGs), a sua estrutura e organização, componentes e interacção sensorimotora. Estas soluções são implementadas usando uma abordagem em sistemas dinâmicos, focandos o uso de osciladores não lineares e a explorando as suas propriedades. Os tópicos principais desta tese estão divididos em três partes. A primeira parte explora o tema de locomoção quadrúpede, expandindo soluções prévias de CPGs usando osciladores não lineares, e discutindo uma organização em três níveis de abstracção, partilhando as ideias de outros trabalhos. Propõe uma solução de CPG que gera os movimentos locomotores para uma perna, que é depois organizado numa rede, para a produção de marcha quadrúpede. A solução concebida é capaz de produzir locomoção e navegação, comandada através de comandos de alto nível, produzidos por métodos de planeamento local. Nesta parte também endereçado o problema da manutenção do equilíbrio num robô quadrúpede parado, propondo um método baseado na abordagem em sistemas dinâmicos, explorando a integração de mecanismos posturais em paralelo, provenientes de várias modalidades sensoriais. As soluções são todas testadas com sucesso no robô quadrupede AIBO. Na segunda parte é endereçado o problema de locomoção bípede. É proposto um CPG baseado no conceito de motion primitives, baseadas na ideia de uma organização sinergética do controlo motor vertebrado. Um conjunto de motion primitives é usado para produzir a base de uma locomoção bípede simples e generalizável para navegação. Esta proposta de CPG é usada para de seguida se investigar a inclusão de mecanismos de feedback para modulação e adaptação da marcha, através do controlo de transições entre fases, de acordo com a informação de carga dos pés. A solução proposta é validada no robô humanóide DARwIn-OP, e a sua aplicação no contexto do framework de whole-body control é também avaliada. A terceira parte desvia um pouco dos outros dois tópicos. Discute o CPG como tendo um papel alternativo ao controlo motor directo, servindo em vez como um processador de informação sensorial para um mecanismo de locomoção puramente em feedback. Neste trabalho é desenhado um controlador baseado em reflexos para a geração da marcha de um quadrúpede compliant. As suas capacidades são demonstradas em simulação, seguidas por uma breve discussão nas suas limitações, e como estas podem ser ultrapassadas pela inclusão de um CPG.The presented work was possible thanks to the support by the Portuguese Science and Technology Foundation through the PhD grant SFRH/BD/62047/2009

Identificación de intención de movimiento de marcha sobre diferentes terrenos -una aproximación bioinspirada-

En este documento se propone una aproximación al entendimiento del lenguaje neuromotor de una persona con una amputación por encima de rodilla, mediante la identificación de su intención de movimiento a partir de la percepción de las manifestaciones tanto internas como externas de los Patrones de Acción Fija (PAF) mediante el uso de una propiocepción artificial y la exterocepción de su prótesis durante el desarrollo de diferentes gestos (marcha, subir y bajar escaleras y subir y bajar rampas). Se presentan la formalización de una expresión General del Gesto Rítmico, los procedimientos para la generación de PAF artificiales y un Algoritmo de Respuesta ante el Desarrollo de Gestos. Mediante la identificación de la intención del usuario a través de la información propioceptiva y exteroceptiva, la prótesis discrimina entre un repertorio de PAF artificiales y selecciona el más adecuado para satisfacer las necesidades de movimiento del usuario. Los datos experimentales de las pruebas desarrolladas en individuos sanos y amputados mostraron un alto desempeño en la identificación de la intención del usuario (97.06% de identificaciones correctas) y un buen seguimiento de los gestos de movimiento independientemente de la velocidad con que fueron ejecutadosIn this paper we propose an approach to the neuromotor language of the transfemoral amputee user. We do this by identifying the user’s intention from the perception of both internal and external manifestations (to be explained into a next section) of Fixed Action Patterns (FAPs, by making use of artificial proprioception and exteroception of the prosthesis. The formalization of a General Expression of the Rhythmic Gesture, generation procedures for artificial FAPs, and a Response Algorithm for Gestures Development are presented. By identifying the user’s intention through proprioceptive and exteroceptive information, the prosthesis discriminates between repertories of artificial FAPs and chooses the most suitable one to meet the users’s requirements. Experimental data of tests carried out in healthy and amputee individuals showed high performance on identification (97.06 % of true identifications) of the user’s intention and good tracking of gestures such as gait, walking up stairs, down stairs, up hill and down hill, independently of the speed of execution of the gestur

Lower-Body Mechanical Perturbation of Gait to Identify Neural Control

Neural feedback plays a key role in maintaining locomotor stability in face of perturbations. In this study, we systematically identified properties of neural feedback that contribute to stabilizing human walking by examining how the nervous system responds to small kinematic deviations away from the desired gait pattern. We applied small continuous mechanical perturbation, forces at the ankles, as well as small continuous sensory perturbation, movement of a virtual visual scene, in order to compare how neural feedback responds to actual and illusory kinematic deviations. Computing phase-dependent impulse response functions (φIRFs) that describe kinematic and muscular responses to small brief perturbations (impulses), enabled us to identify critical phases of the gait cycle when the nervous system modulates muscle activity. In particular, our results suggest that an early-stance modulation of anterior leg-muscles is a general control mechanism that serves multiple functions, including controlling walking speed and compensating for errors in foot placement

Visual and Vestibular Inputs Affect Muscle Synergies Responsible for Body Extension and Stabilization in Sit-to-Stand Motion

The sit-to-stand motion is a common movement in daily life and understanding the mechanism of the sit-to-stand motion is important. Our previous study shows that four muscle synergies can characterize the sit-to-stand motion, and they have specific roles, such as upper body flexion, rising from a chair, body extension, and posture stabilization. The time-varying weight of these synergies are changed to achieve adaptive movement. However, the relationship between sensory input and the activation of the muscle synergies is not completely understood. In this paper, we aim to clarify how vestibular and visual inputs affect the muscle synergy in sit-to-stand motion. To address this, we conducted experiments as follows. Muscle activity, body kinematics, and ground reaction force were measured for the sit-to-stand motion under three different conditions: control, visual-disturbance, and vestibular-disturbance conditions. Under the control condition, the participants stood without any intervention. Under the visual-disturbance condition, the participants wore convex lens glasses and performed the sit-to-stand motion in a dark room. Under the vestibular-disturbance condition, a caloric test was performed. Muscle synergies were calculated for these three conditions using non-negative matrix factorization. We examined whether the same four muscle synergies were employed under each condition, and the changes in the time-varying coefficients were determined. These experiments were conducted on seven healthy, young participants. It was found that four muscle synergies could explain the muscle activity in the sit-to-stand motion under the three conditions. However, there were significant differences in the time-varying weight coefficients. When the visual input was disturbed, a larger amplitude was found for the muscle synergy that activated mostly in the final posture stabilization phase of the sit-to-stand motion. Under vestibular-disturbance condition, a longer activation was observed for the synergies that extended the entire body and led to posture stabilization. The results implied that during human sit-to-stand motion, visual input has less contribution to alter or correct activation of muscle synergies until the last phase. On the other hand, duration of muscle synergies after the buttocks leave are prolonged in order to adapt to the unstable condition in which sense of verticality is decreased under vestibular-disturbance

Subtask Control in Human Locomotion

Maintenance of upright posture during walking is one the most important tasks to ensure flexible and stable mobility, along with speed adjustment, wayfinding and obstacle avoidance. These underlying functions, or subtasks, are simultaneously coordinated by the nervous system, which relies heavily on sensory feedback to obtain continual estimates of self-motion. This dissertation reports the findings of four experiments which made use of visual and mechanical perturbations to probe the interplay of these subtasks during treadmill walking. To confront the inherent nonlinearity of human gait, novel frequency domain analyses and impulse response functions that take into account phase of the gait cycle were used to characterize perturbation-response relationships. In the first experiment, transient visual scene motion was used to probe how visual input simultaneously influenced multiple subtasks, but at different phases of the gait cycle. In the second experiment, kinematics and muscle activity response variables showed an amplitude dependency on visual scene motion during walking that indicates vision is reweighted in a manner similar to standing posture. The third experiment used a metronome to constrain walking, revealing two time scales of locomotive control. The final experiment made use of both visual and mechanical perturbations simultaneously to probe the subtasks of postural orientation upright and positional maintenance on the treadmill. Doing so revealed that the nervous system prioritizes control of postural orientation over positional maintenance. In sum, this dissertation shows that sensory and mechanical perturbations provide insight as to how the nervous system controls coexisting, underlying functions during walking