A multi-view approach to cDNA micro-array analysis

The official published version can be obtained from the link below.Microarray has emerged as a powerful technology that enables biologists to study thousands of genes simultaneously, therefore, to obtain a better understanding of the gene interaction and regulation mechanisms. This paper is concerned with improving the processes involved in the analysis of microarray image data. The main focus is to clarify an image's feature space in an unsupervised manner. In this paper, the Image Transformation Engine (ITE), combined with different filters, is investigated. The proposed methods are applied to a set of real-world cDNA images. The MatCNN toolbox is used during the segmentation process. Quantitative comparisons between different filters are carried out. It is shown that the CLD filter is the best one to be applied with the ITE.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of the UK under Grant GR/S27658/01, the National Science Foundation of China under Innovative Grant 70621001, Chinese Academy of Sciences under Innovative Group Overseas Partnership Grant, the BHP Billiton Cooperation of Australia Grant, the International Science and Technology Cooperation Project of China under Grant 2009DFA32050 and the Alexander von Humboldt Foundation of Germany

Resource efficient on-node spike sorting

Current implantable brain-machine interfaces are recording multi-neuron activity by utilising multi-channel, multi-electrode micro-electrodes. With the rapid increase in recording capability has come more stringent constraints on implantable system power consumption and size. This is even more so with the increasing demand for wireless systems to increase the number of channels being monitored whilst overcoming the communication bottleneck (in transmitting raw data) via transcutaneous bio-telemetries. For systems observing unit activity, real-time spike sorting within an implantable device offers a unique solution to this problem. However, achieving such data compression prior to transmission via an on-node spike sorting system has several challenges. The inherent complexity of the spike sorting problem arising from various factors (such as signal variability, local field potentials, background and multi-unit activity) have required computationally intensive algorithms (e.g. PCA, wavelet transform, superparamagnetic clustering). Hence spike sorting systems have traditionally been implemented off-line, usually run on work-stations. Owing to their complexity and not-so-well scalability, these algorithms cannot be simply transformed into a resource efficient hardware. On the contrary, although there have been several attempts in implantable hardware, an implementation to match comparable accuracy to off-line within the required power and area requirements for future BMIs have yet to be proposed. Within this context, this research aims to fill in the gaps in the design towards a resource efficient implantable real-time spike sorter which achieves performance comparable to off-line methods. The research covered in this thesis target: 1) Identifying and quantifying the trade-offs on subsequent signal processing performance and hardware resource utilisation of the parameters associated with analogue-front-end. Following the development of a behavioural model of the analogue-front-end and an optimisation tool, the sensitivity of the spike sorting accuracy to different front-end parameters are quantified. 2) Identifying and quantifying the trade-offs associated with a two-stage hybrid solution to realising real-time on-node spike sorting. Initial part of the work focuses from the perspective of template matching only, while the second part of the work considers these parameters from the point of whole system including detection, sorting, and off-line training (template building). A set of minimum requirements are established which ensure robust, accurate and resource efficient operation. 3) Developing new feature extraction and spike sorting algorithms towards highly scalable systems. Based on waveform dynamics of the observed action potentials, a derivative based feature extraction and a spike sorting algorithm are proposed. These are compared with most commonly used methods of spike sorting under varying noise levels using realistic datasets to confirm their merits. The latter is implemented and demonstrated in real-time through an MCU based platform.Open Acces

Estimation of Analog Parametric Test Metrics Using Copulas

© 2011 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.International audienceA new technique for the estimation of analog parametric test metrics at the design stage is presented in this paper. This technique employs the copulas theory to estimate the distribution between random variables that represent the performances and the test measurements of the circuit under test (CUT). A copulas-based model separates the dependencies between these random variables from their marginal distributions, providing a complete and scale-free description of dependence that is more suitable to be modeled using well-known multivariate parametric laws. The model can be readily used for the generation of an arbitrarily large sample of CUT instances. This sample is thereafter used for estimating parametric test metrics such as defect level (or test escapes) and yield loss. We demonstrate the usefulness of the proposed technique to evaluate a built-in-test technique for a radio frequency low noise amplifier and to set test limits that result in a desired tradeoff between test metrics. In addition, we compare the proposed technique with previous ones that rely on direct density estimation

A performance evaluation of oscillation based test in continuous time filters

This work evaluates the ability of OBT for detecting parametric faults in continuous-time filters. To this end, we adopt two filters with quite different topologies as cases of study and a previously reported statistical fault model. In addition, we explore the behavior of the test schemes when a particular test condition is changed. The new data reported here, obtained from a fault simulation process, reveal a lower performance of OBT not observed in previous work using single-deviation faults, even under the change in the test condition.publishedVersionFil: Romero, Eduardo Abel. Universidad Tecnológica Nacional. Facultad Regional Villa María; Argentina.Fil: Romero, Eduardo Abel. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Costamagna, Marcelo. Universidad Tecnológica Nacional. Facultad Regional Villa María; Argentina.Fil: Peretti, Gabriela Marta. Universidad Tecnológica Nacional. Facultad Regional Villa María; Argentina.Fil: Peretti, Gabriela Marta. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Marqués, Carlos Alberto. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Otras Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Informació

Modeling and simulation of magnetic components in electric circuits

This thesis demonstrates how by using a variety of model constructions and parameter extraction techniques, a range of magnetic component models can be developed for a wide range of application areas, with different levels of accuracy appropriate for the simulation required. Novel parameter extraction and model optimization methods are developed, including the innovative use of Genetic Algorithms and Metrics, to ensure the accuracy of the material models used. Multiple domain modeling, including the magnetic, thermal and magnetic aspects are applied in integrated simulations to ensure correct and complete dynamic behaviour under a range of environmental conditions. Improvements to the original Jiles-Atherton theory to more accurately model loop closure and dynamic thermal behaviour are proposed, developed and tested against measured results. Magnetic Component modeling techniques are reviewed and applied in practical examples to evaluate the effectiveness of lumped models, 1D and 2D Finite Element Analysis models and coupling Finite Element Analysis with Circuit Simulation. An original approach, linking SPICE with a Finite Element Analysis solver is presented and evaluated. Practical test cases illustrate the effectiveness of the models used in a variety of contexts. A Passive Fault Current Limiter (FCL) was investigated using a saturable inductor with a magnet offset, and the comparison between measured and simulated results allows accurate prediction of the behaviour of the device. A series of broadband hybrid transformers for ADSL were built, tested, modeled and simulated. Results show clearly how the Total Harmonic Distortion (THD), Inter Modulation Distortion (IMD) and Insertion Loss (IL) can be accurately predicted using simulation.A new implementation of ADSL transformers using a planar magnetic structure is presented, with results presented that compare favourably with current wire wound techniques. The inclusion of transformer models in complete ADSL hybrid simulations demonstrate the effectiveness of the models in the context of a complete electrical system in predicting the overall circuit performance

Optimisation of Mobile Communication Networks - OMCO NET

The mini conference “Optimisation of Mobile Communication Networks” focuses on advanced methods for search and optimisation applied to wireless communication networks. It is sponsored by Research & Enterprise Fund Southampton Solent University. The conference strives to widen knowledge on advanced search methods capable of optimisation of wireless communications networks. The aim is to provide a forum for exchange of recent knowledge, new ideas and trends in this progressive and challenging area. The conference will popularise new successful approaches on resolving hard tasks such as minimisation of transmit power, cooperative and optimal routing

Design and application of reconfigurable circuits and systems

Open Acces