Developing Biosensor Technology to Monitor Biofilm Formation on Voice Prosthesis in Throat Cancer Patients Following Total Laryngectomy

Voice prostheses (used to replace an excised larynx in laryngectomy patients) are often colonised by the yeast Candida albicans, yet no monitoring technology for C. albicans biofilm growth until these devices fail. With the current interest in smart technology, understanding the electrical properties of C. albicans biofilm formation is necessary. There has been great interest in Passive Radio Frequency Identification (RFID) for use with implantable devices as they provide a cost-effective approach for sensing. The main drawback of RFID sensors is the need to overcome capacitive loading of human tissue and, thus, low efficiency to produce a high read range sensor design. This is further complicated by the size restriction on any RFID design to be implemented within a voice prosthesis as this medical device is limited to less than 3 cm in overall size. In order to develop such a voice prosthesis sensor, we looked at three separate aspects of C. albicans colonisation on medical devices within human tissue. To understand if it is possible to detect changes within a moist environment (such as the mouth), we developed a sensor capable of detecting minute dielectric changes (accuracy of ± 0.83 relative permittivity and ± 0.05 S·m-1 conductivity) within a closed system. Once we understood that detection of dielectric changes within a liquid solution were possible, to overcome human tissue capacitive loading of RFID sensors. Adjusting backing thickness or adding a capacitive shunt into the design could limit this tissue effect and even negate the variability seen between human tissues. Without developing these methods, implementation of any RFID device would be difficult as human tissue variability would not be compensated for properly. Finally, biofilm growth in terms electrical properties. As C. albicans biofilm matures, there is a loss in capacitance (the biofilm becomes increasingly hydrophobic) prior to 24 hours after which the biofilm thickness shifts the resonance leading to a slow gain in capacitance. Understanding all of these aspects allowed us to develop two final voice prosthesis sensors producing read ranges above 60 cm and 10 cm within a tissue phantom. Ultimately, this showed the possibility of developing cost-effective passive RFID sensor technology for monitoring microbial biofilm formation within human tissue, leading to more effective real-time clinical care

Assessment of foetal exposure to the homogeneous magnetic field harmonic spectrum generated by electricity transmission and distribution networks

During the last decades studies addressing the effects of exposure to Extremely Low Frequency Electromagnetic Fields (ELF-EMF) have pointed out a possible link between those fields emitted by power lines and childhood leukaemia. They have also stressed the importance of also including in the assessment the contribution of frequency components, namely harmonics, other than the fundamental one. Based on the spectrum of supply voltage networks allowed by the European standard for electricity quality assessment, in this study the exposure of high-resolution three-dimensional models of foetuses to the whole harmonic content of a uniform magnetic field with a fundamental frequency of 50 Hz, was assessed. The results show that the main contribution in terms of induced electric fields to the foetal exposure is given by the fundamental frequency component. The harmonic components add some contributions to the overall level of electric fields, however, due to the extremely low permitted amplitude of the harmonic components with respect to the fundamental, their amplitudes are low. The level of the induced electric field is also much lower than the limits suggested by the guidelines for general public exposure, when the amplitude of the incident magnetic field is set at the maximum permitted level

Searching for the perfect wave: the effect of radiofrequency electromagnetic fields on cells

There is a growing concern in the population about the effects that environmental exposure to any source of "uncontrolled" radiation may have on public health. Anxiety arises from the controversial knowledge about the effect of electromagnetic field (EMF) exposure to cells and organisms but most of all concerning the possible causal relation to human diseases. Here we reviewed those in vitro and in vivo and epidemiological works that gave a new insight about the effect of radio frequency (RF) exposure, relating to intracellular molecular pathways that lead to biological and functional outcomes. It appears that a thorough application of standardised protocols is the key to reliable data acquisition and interpretation that could contribute to clear the picture for scientists and lay public. Moreover, specific tuning of experimental and clinical RF exposure might lead to health beneficial effects

Selected Papers from the 5th International Electronic Conference on Sensors and Applications

This Special Issue comprises selected papers from the proceedings of the 5th International Electronic Conference on Sensors and Applications, held on 15–30 November 2018, on sciforum.net, an online platform for hosting scholarly e-conferences and discussion groups. In this 5th edition of the electronic conference, contributors were invited to provide papers and presentations from the field of sensors and applications at large, resulting in a wide variety of excellent submissions and topic areas. Papers which attracted the most interest on the web or that provided a particularly innovative contribution were selected for publication in this collection. These peer-reviewed papers are published with the aim of rapid and wide dissemination of research results, developments, and applications. We hope this conference series will grow rapidly in the future and become recognized as a new way and venue by which to (electronically) present new developments related to the field of sensors and their applications

Animal Welfare Assessment

This Special Issue provides a collection of recent research and reviews that investigate many areas of welfare assessment, such as novel approaches and technologies used to evaluate the welfare of farmed, captive, or wild animals. Research in this Special Issue includes welfare assessment related to pilot whales, finishing pigs, commercial turkey flocks, and dairy goats; the use of sensors or wearable technologies, such as heart rate monitors to assess sleep in dairy cows, ear tag sensors, and machine learning to assess commercial pig behaviour; non-invasive measures, such as video monitoring of behaviour, computer vision to analyse video footage of red foxes, remote camera traps of free-roaming wild horses, infrared thermography of effort and sport recovery in sport horses; telomere length and regulatory genes as novel biomarkers of stress in broiler chickens; the effect of environment on growth physiology and behaviour of laboratory rare minnows and housing system on anxiety, stress, fear, and immune function of laying hens; and discussions of natural behaviour in farm animal welfare and maintaining health, welfare, and productivity of commercial pig herds

Compact Reconfigurable Antennas for Wireless Systems and Wearable Applications

The fast growth of wireless communications has driven the necessity of exploiting technological solutions for the needs of faster connectivity. While bandwidth allocation and effective radiated power (ERP) are subjected to regulatory constrain, alternative solutions have been developed to overcome the challenges that arise in terms of wireless coverage and number of users. Reconfigurable antennas (RAs) technology is one of the hardware solutions developed to enhance the connectivity between wireless devices. These new class of radiating elements are able to adapt their physical characteristics in response to the environmental changes or users density and location. Reconfigurable antennas can be divided into two main categories: frequency reconfigurable antennas and pattern reconfigurable antennas. The former class of RAs are able to switch the operational frequency in order to move the communication within unoccupied channels. The latter category defines those antennas that are able to change their radiation characteristics (radiation pattern or polarization) in response to the dynamics of the surrounding environment. Unlike conventional static antennas where the energy is wasted around the surrounding space, the use of RAs allows for a smarter management of the radiated energy as the beam can be focused toward specific directions. As a result, not only data throughput between two devices can be improved but also the interference between adjacent networks can be reduced significantly. n this PhD thesis we focus on the design, prototyping and system application of compact RAs for wireless base stations and mobile devices. Specifically, the first task focuses on the design of a compact reconfigurable antenna capable of generating omnidirectional and directional beams in a single planar design. Next, we propose to apply a miniaturization technique in order to drastically reduce the size of Composite Right-Left Handed Reconfigurable Leaky Wave Antennas (CRLH RLWAs). The large beam steering capabilities along with the miniaturized dimension open new venues for the integration of this antenna technology into mobile devices such as laptop or tablets. Similarly for electrically reconfigurable antennas, characteristics such as input impedance and radiation properties of a radiating element can vary by mechanically change its physical dimension. In other words, instead of changing the metallic geometry through electrical components, the characteristics of an antenna can be changed through physical deformation of its geometry. This principle addresses the second main application of reconfigurable antennas this PhD thesis. Wearable technologies are gaining a lot of attentions due to their strong potential for sensing, communication and tactile interaction applications. Thanks to the progress in knitting facilities and techniques, smart fabrics are generally implemented through sewn-in sensors especially in the fields of medical and athletic applications. Such wearable sensors provide a means to monitor the wearers health through physiological measurements in a natural setting or can be used to detect or alert care providers to potential hazards around the wearer. The feasibility of building electrical devices using conductive fabrics has been analyzed through electrical characterization of textile transmission lines and antennas where conductive fabrics have been applied onto woven fabrics have been demonstrated in recent literature. Previous works show conductive copper foils or fabrics bonded to a flexible substrate. However, these techniques show limitations in terms of electrical losses caused by adhesives or glue chemicals. It is desirable to address these drawbacks by knitting conductive and non-conductive yarns in a single process resulting in smart textiles that are unobtrusively integrated into the host garment so as to eliminate the need for chemical adhesives that degrade electrical performance. The characteristics variations of a fabric-based antenna under physical deformations can be exploited to provide a fully wireless sensing of certain body movements. The second task of this PhD thesis, focuses on the design and testing of these purely textile wireless sensors for biomedical applications. The Radio-Frequency Identification (RFID) technology will be applied fordesigning fabric-based strain sensors through the use of novel inductively-coupled RFID microchips (MAGICSTRAP). As opposed to conventional surface-mount microchips, the MAGICSTRAP does not require any physical soldering connection as the RF energy is inductively coupled from the microchip pads to the antenna arms. A separate interrogator unit can communicate with this knit passive RFID architecture by sending a probing signal; the backscattered component received from the knit tag will indicate the level of stretch, and this information will be translated in the physical phenomenon being monitored. The change in the electrical characteristics of the textile antenna, along with the decoupling of the MAGICTRAP chip allow for more reliable detection of contraction/elongation movements. This study will include comprehensive design and characterization of the textile tag sensor along with performance analysis using a mechanical human mannequin.Ph.D., Electrical Engineering -- Drexel University, 201

The Largest Unethical Medical Experiment in Human History

This monograph describes the largest unethical medical experiment in human history: the implementation and operation of non-ionizing non-visible EMF radiation (hereafter called wireless radiation) infrastructure for communications, surveillance, weaponry, and other applications. It is unethical because it violates the key ethical medical experiment requirement for “informed consent” by the overwhelming majority of the participants. The monograph provides background on unethical medical research/experimentation, and frames the implementation of wireless radiation within that context. The monograph then identifies a wide spectrum of adverse effects of wireless radiation as reported in the premier biomedical literature for over seven decades. Even though many of these reported adverse effects are extremely severe, the true extent of their severity has been grossly underestimated. Most of the reported laboratory experiments that produced these effects are not reflective of the real-life environment in which wireless radiation operates. Many experiments do not include pulsing and modulation of the carrier signal, and most do not account for synergistic effects of other toxic stimuli acting in concert with the wireless radiation. These two additions greatly exacerbate the severity of the adverse effects from wireless radiation, and their neglect in current (and past) experimentation results in substantial under-estimation of the breadth and severity of adverse effects to be expected in a real-life situation. This lack of credible safety testing, combined with depriving the public of the opportunity to provide informed consent, contextualizes the wireless radiation infrastructure operation as an unethical medical experiment

Biomedical Engineering

Biomedical engineering is currently relatively wide scientific area which has been constantly bringing innovations with an objective to support and improve all areas of medicine such as therapy, diagnostics and rehabilitation. It holds a strong position also in natural and biological sciences. In the terms of application, biomedical engineering is present at almost all technical universities where some of them are targeted for the research and development in this area. The presented book brings chosen outputs and results of research and development tasks, often supported by important world or European framework programs or grant agencies. The knowledge and findings from the area of biomaterials, bioelectronics, bioinformatics, biomedical devices and tools or computer support in the processes of diagnostics and therapy are defined in a way that they bring both basic information to a reader and also specific outputs with a possible further use in research and development

2020 Student Symposium Research and Creative Activity Book of Abstracts

The UMaine Student Symposium (UMSS) is an annual event that celebrates undergraduate and graduate student research and creative work. Students from a variety of disciplines present their achievements with video presentations. It’s the ideal occasion for the community to see how UMaine students’ work impacts locally – and beyond. The 2020 Student Symposium Research and Creative Activity Book of Abstracts includes a complete list of student presenters as well as abstracts related to their works