Communication channel analysis and real time compressed sensing for high density neural recording devices

Next generation neural recording and Brain- Machine Interface (BMI) devices call for high density or distributed systems with more than 1000 recording sites. As the recording site density grows, the device generates data on the scale of several hundred megabits per second (Mbps). Transmitting such large amounts of data induces significant power consumption and heat dissipation for the implanted electronics. Facing these constraints, efficient on-chip compression techniques become essential to the reduction of implanted systems power consumption. This paper analyzes the communication channel constraints for high density neural recording devices. This paper then quantifies the improvement on communication channel using efficient on-chip compression methods. Finally, This paper describes a Compressed Sensing (CS) based system that can reduce the data rate by > 10x times while using power on the order of a few hundred nW per recording channel

A 16-Channel Neural Recording System-on-Chip With CHT Feature Extraction Processor in 65-nm CMOS

Next-generation invasive neural interfaces require fully implantable wireless systems that can record from a large number of channels simultaneously. However, transferring the recorded data from the implant to an external receiver emerges as a significant challenge due to the high throughput. To address this challenge, this article presents a neural recording system-on-chip that achieves high resource and wireless bandwidth efficiency by employing on-chip feature extraction. Energy-area-efficient 10-bit 20-kS/s front end amplifies and digitizes the neural signals within the local field potential (LFP) and action potential (AP) bands. The raw data from each channel are decomposed into spectral features using a compressed Hadamard transform (CHT) processor. The selection of the features to be computed is tailored through a machine learning algorithm such that the overall data rate is reduced by 80% without compromising classification performance. Moreover, the CHT feature extractor allows waveform reconstruction on the receiver side for monitoring or additional post-processing. The proposed approach was validated through in vivo and off-line experiments. The prototype fabricated in 65-nm CMOS also includes wireless power and data receiver blocks to demonstrate the energy and area efficiency of the complete system. The overall signal chain consumes 2.6 μW and occupies 0.021 mm² per channel, pointing toward its feasibility for 1000-channel single-die neural recording systems

Structured Dictionary Learning and its applications in Neural Recording

Widely utilized in the field of neuroscience, implantable neural recording devices could capture neuron activities with an acquisition rate on the order of megabytes per second. In order to efficiently transmit neural signals through wireless channels, these devices require compression methods that reduce power consumption. Although recent Compressed Sensing (CS) approaches have successfully demonstrated their power, their full potential is yet to be explored, particularly towards exploring a more efficient representation of the neural signals. As a promising solution, sparse representation not only provides better signal compression for bandwidth/storage efficiency, but also leads to faster processing algorithms as well as more effective signal separation for classification purpose. However, current sparsity‐based approaches for neural recording are limited due to several critical drawbacks: (i) the lack of an efficient data‐driven representation to fully capture the characteristics of specific neural signal; (ii) most existing methods do not fully explore the prior knowledge of neural signals (e.g., labels), while such information is often known; and (iii) the capability to encode discriminative information into the representation to promote classification. Using neural recording as a case study, this dissertation presents new theoretical ideas and mathematical frameworks on structured dictionary learning with applications in compression and classification. Start with a single task setup, we provide theoretical proofs to show the benefits of using structured sparsity in dictionary learning. Then we provide various novel models for the representation of a single measurement, as well as multiple measurements where signals exhibit both with‐in class similarity as well as with‐in class difference. Under the assumption that the label information of the neural signal is known, the proposed models minimize the data fidelity term together with the structured sparsity terms to drive for more discriminative representation. We demonstrate that this is particularly essential in neural recording since it can further improve the compression ratio, classification accuracy and help deal with non‐ideal scenarios such as co-occurrences of neuron firings. Fast and efficient algorithms based on Bayesian inference and alternative direction method are proposed. Extensive experiments are conducted on both neural recording applications as well as some other classification task, such as image classification

Real-time signal detection and classification algorithms for body-centered systems

El principal motivo por el cual los sistemas de comunicación en el entrono corporal se desean con el objetivo de poder obtener y procesar señales biométricas para monitorizar e incluso tratar una condición médica sea ésta causada por una enfermedad o el rendimiento de un atleta. Dado que la base de estos sistemas está en la sensorización y el procesado, los algoritmos de procesado de señal son una parte fundamental de los mismos. Esta tesis se centra en los algoritmos de tratamiento de señales en tiempo real que se utilizan tanto para monitorizar los parámetros como para obtener la información que resulta relevante de las señales obtenidas. En la primera parte se introduce los tipos de señales y sensores en los sistemas en el entrono corporal. A continuación se desarrollan dos aplicaciones concretas de los sistemas en el entorno corporal así como los algoritmos que en las mismas se utilizan. La primera aplicación es el control de glucosa en sangre en pacientes con diabetes. En esta parte se desarrolla un método de detección mediante clasificación de patronones de medidas erróneas obtenidas con el monitor contínuo comercial "Minimed CGMS". La segunda aplicacióin consiste en la monitorizacióni de señales neuronales. Descubrimientos recientes en este campo han demostrado enormes posibilidades terapéuticas (por ejemplo, pacientes con parálisis total que son capaces de comunicarse con el entrono gracias a la monitorizacióin e interpretación de señales provenientes de sus neuronas) y también de entretenimiento. En este trabajo, se han desarrollado algoritmos de detección, clasificación y compresión de impulsos neuronales y dichos algoritmos han sido evaluados junto con técnicas de transmisión inalámbricas que posibiliten una monitorización sin cables. Por último, se dedica un capítulo a la transmisión inalámbrica de señales en los sistemas en el entorno corporal. En esta parte se estudia las condiciones del canal que presenta el entorno corporal para la transmisión de sTraver Sebastiá, L. (2012). Real-time signal detection and classification algorithms for body-centered systems [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/16188Palanci

Compressive Sensing and Multichannel Spike Detection for Neuro-Recording Systems

RÉSUMÉ Les interfaces cerveau-machines (ICM) sont de plus en plus importantes dans la recherche biomédicale et ses applications, tels que les tests et analyses médicaux en laboratoire, la cérébrologie et le traitement des dysfonctions neuromusculaires. Les ICM en général et les dispositifs d'enregistrement neuronaux, en particulier, dépendent fortement des méthodes de traitement de signaux utilisées pour fournir aux utilisateurs des renseignements sur l’état de diverses fonctions du cerveau. Les dispositifs d'enregistrement neuronaux courants intègrent de nombreux canaux parallèles produisant ainsi une énorme quantité de données. Celles-ci sont difficiles à transmettre, peuvent manquer une information précieuse des signaux enregistrés et limitent la capacité de traitement sur puce. Une amélioration de fonctions de traitement du signal est nécessaire pour s’assurer que les dispositifs d'enregistrements neuronaux peuvent faire face à l'augmentation rapide des exigences de taille de données et de précision requise de traitement. Cette thèse regroupe deux approches principales de traitement du signal - la compression et la réduction de données - pour les dispositifs d'enregistrement neuronaux. Tout d'abord, l’échantillonnage comprimé (AC) pour la compression du signal neuronal a été utilisé. Ceci implique l’usage d’une matrice de mesure déterministe basée sur un partitionnement selon le minimum de la distance Euclidienne ou celle de la distance de Manhattan (MDC). Nous avons comprimé les signaux neuronaux clairsemmés (Sparse) et non-clairsemmés et les avons reconstruit avec une marge d'erreur minimale en utilisant la matrice MDC construite plutôt. La réduction de données provenant de signaux neuronaux requiert la détection et le classement de potentiels d’actions (PA, ou spikes) lesquelles étaient réalisées en se servant de la méthode d’appariement de formes (templates) avec l'inférence bayésienne (Bayesian inference based template matching - BBTM). Par comparaison avec les méthodes fondées sur l'amplitude, sur le niveau d’énergie ou sur l’appariement de formes, la BBTM a une haute précision de détection, en particulier pour les signaux à faible rapport signal-bruit et peut séparer les potentiels d’actions reçus à partir des différents neurones et qui chevauchent. Ainsi, la BBTM peut automatiquement produire les appariements de formes nécessaires avec une complexité de calculs relativement faible.----------ABSTRACT Brain-Machine Interfaces (BMIs) are increasingly important in biomedical research and health care applications, such as medical laboratory tests and analyses, cerebrology, and complementary treatment of neuromuscular disorders. BMIs, and neural recording devices in particular, rely heavily on signal processing methods to provide users with nformation. Current neural recording devices integrate many parallel channels, which produce a huge amount of data that is difficult to transmit, cannot guarantee the quality of the recorded signals and may limit on-chip signal processing capabilities. An improved signal processing system is needed to ensure that neural recording devices can cope with rapidly increasing data size and accuracy requirements. This thesis focused on two signal processing approaches – signal compression and reduction – for neural recording devices. First, compressed sensing (CS) was employed for neural signal compression, using a minimum Euclidean or Manhattan distance cluster-based (MDC) deterministic sensing matrix. Sparse and non-sparse neural signals were substantially compressed and later reconstructed with minimal error using the built MDC matrix. Neural signal reduction required spike detection and sorting, which was conducted using a Bayesian inference-based template matching (BBTM) method. Compared with amplitude-based, energy-based, and some other template matching methods, BBTM has high detection accuracy, especially for low signal-to-noise ratio signals, and can separate overlapping spikes acquired from different neurons. In addition, BBTM can automatically generate the needed templates with relatively low system complexity. Finally, a digital online adaptive neural signal processing system, including spike detector and CS-based compressor, was designed. Both single and multi-channel solutions were implemented and evaluated. Compared with the signal processing systems in current use, the proposed signal processing system can efficiently compress a large number of sampled data and recover original signals with a small reconstruction error; also it has low power consumption and a small silicon area. The completed prototype shows considerable promise for application in a wide range of neural recording interfaces

A HIGHLY-SCALABLE DC-COUPLED DIRECT-ADC NEURAL RECORDING CHANNEL ARCHITECTURE WITH INPUT-ADAPTIVE RESOLUTION

This thesis presents the design, development, and characterization of a novel neural recording channel architecture with (a) quantization resolution that is adaptive to the input signal's level of activity, (b) fully-dynamic power consumption that is linearly proportional to the recording resolution, and (c) immunity to DC offset and drifts at the input. Our results demonstrate the proposed design's capability in conducting neural recording with near lossless input-adaptive data compression, leading to a significant reduction in the energy required for both recording and data transmission, hence allowing for a potential high scaling of the number of recording channels integrated on a single implanted microchip without the need to increase the power budget. The proposed channel with the implemented compression technique is implemented in a standard 130nm CMOS technology with overall power consumption of 7.6uW and active area of 92×92µm for the implemented digital-backend

A HIGHLY-SCALABLE DC-COUPLED DIRECT-ADC NEURAL RECORDING CHANNEL ARCHITECTURE WITH INPUT-ADAPTIVE RESOLUTION

This thesis presents the design, development, and characterization of a novel neural recording channel architecture with (a) quantization resolution that is adaptive to the input signal's level of activity, (b) fully-dynamic power consumption that is linearly proportional to the recording resolution, and (c) immunity to DC offset and drifts at the input. Our results demonstrate the proposed design's capability in conducting neural recording with near lossless input-adaptive data compression, leading to a significant reduction in the energy required for both recording and data transmission, hence allowing for a potential high scaling of the number of recording channels integrated on a single implanted microchip without the need to increase the power budget. The proposed channel with the implemented compression technique is implemented in a standard 130nm CMOS technology with overall power consumption of 7.6uW and active area of 9292m for the implemented digital-backend

A Closed-Loop Bidirectional Brain-Machine Interface System For Freely Behaving Animals

A brain-machine interface (BMI) creates an artificial pathway between the brain and the external world. The research and applications of BMI have received enormous attention among the scientific community as well as the public in the past decade. However, most research of BMI relies on experiments with tethered or sedated animals, using rack-mount equipment, which significantly restricts the experimental methods and paradigms. Moreover, most research to date has focused on neural signal recording or decoding in an open-loop method. Although the use of a closed-loop, wireless BMI is critical to the success of an extensive range of neuroscience research, it is an approach yet to be widely used, with the electronics design being one of the major bottlenecks. The key goal of this research is to address the design challenges of a closed-loop, bidirectional BMI by providing innovative solutions from the neuron-electronics interface up to the system level. Circuit design innovations have been proposed in the neural recording front-end, the neural feature extraction module, and the neural stimulator. Practical design issues of the bidirectional neural interface, the closed-loop controller and the overall system integration have been carefully studied and discussed.To the best of our knowledge, this work presents the first reported portable system to provide all required hardware for a closed-loop sensorimotor neural interface, the first wireless sensory encoding experiment conducted in freely swimming animals, and the first bidirectional study of the hippocampal field potentials in freely behaving animals from sedation to sleep. This thesis gives a comprehensive survey of bidirectional BMI designs, reviews the key design trade-offs in neural recorders and stimulators, and summarizes neural features and mechanisms for a successful closed-loop operation. The circuit and system design details are presented with bench testing and animal experimental results. The methods, circuit techniques, system topology, and experimental paradigms proposed in this work can be used in a wide range of relevant neurophysiology research and neuroprosthetic development, especially in experiments using freely behaving animals

Advances in Microelectronics for Implantable Medical Devices

Implantable medical devices provide therapy to treat numerous health conditions as well as monitoring and diagnosis. Over the years, the development of these devices has seen remarkable progress thanks to tremendous advances in microelectronics, electrode technology, packaging and signal processing techniques. Many of today’s implantable devices use wireless technology to supply power and provide communication. There are many challenges when creating an implantable device. Issues such as reliable and fast bidirectional data communication, efficient power delivery to the implantable circuits, low noise and low power for the recording part of the system, and delivery of safe stimulation to avoid tissue and electrode damage are some of the challenges faced by the microelectronics circuit designer. This paper provides a review of advances in microelectronics over the last decade or so for implantable medical devices and systems. The focus is on neural recording and stimulation circuits suitable for fabrication in modern silicon process technologies and biotelemetry methods for power and data transfer, with particular emphasis on methods employing radio frequency inductive coupling. The paper concludes by highlighting some of the issues that will drive future research in the field